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公开(公告)号：US06767928B1
公开(公告)日：2004-07-27
申请号：US09527636
申请日：2000-03-17
IPC分类号： C08J934
CPC分类号： A61L27/58 , A61L27/00 , A61L27/18 , A61L27/306 , A61L27/44 , A61L27/50 , A61L27/56 , A61L2400/18 , A61L2430/02 , C08L67/04
摘要： Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various methods of using the mineralized and/or patterned biomaterials in tissue engineering, such as bone tissue engineering, providing more control over ongoing biological processes, such as mineralization, growth factor release, cellular attachment and tissue growth.
摘要翻译： 公开了用于图案化和/或矿化生物材料表面的有利方法。 所描述的技术对于生成具有图案化表面或图案化的矿化表面的三维或轮廓生物植入物材料特别有用。 还提供了在组织工程中使用矿化和/或图案化生物材料的各种方法，例如骨组织工程，提供对正在进行的生物过程例如矿化，生长因子释放，细胞附着和组织生长的更多控制。
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12.发明授权公开(公告)号：US06642363B1
公开(公告)日：2003-11-04
申请号：US09147900
申请日：1999-05-03
IPC分类号： C08B3704
CPC分类号： C08G83/003 , A61K35/34 , A61K38/39 , A61K47/61 , A61L27/20 , A61L27/3839 , A61L27/3847 , A61L27/54 , A61L2300/232 , A61L2300/25 , A61L2300/252 , A61L2300/254 , A61L2300/414 , A61L2300/64 , C07H13/02 , C08B37/0084 , C08G81/00 , C08L5/04
摘要： Materials which contain polysaccharide chains, particularly alginate or modified alginate chains. The polysaccharide chains may be included as side chains or auxiliary chains from a backbone polymer chain, which may also be a polysaccharide. Further, the polysaccharide chains may be cross-linked between side chains, auxiliary chains and/or backbone chains. These materials and non-modified or otherwise modified alginate materials are advantageously modified by covalent bonding thereto of a biologically active molecule for cell adhesion or other cellular interaction. Processes for preparation of these alginate materials and methods for using them, particularly for cell transplantation and tissue engineering applications.
摘要翻译： 含有多糖链，特别是藻酸盐或改性藻酸盐链的材料。 多糖链可以作为侧链或辅链从主链聚合物链中包含，其也可以是多糖。 此外，多糖链可以在侧链，辅链和/或骨架链之间交联。 这些材料和非改性或其它改性的藻酸盐材料有利地通过与生物活性分子的共价键合来修饰，用于细胞粘附或其它细胞相互作用。 用于制备这些藻酸盐材料的方法及其使用方法，特别是用于细胞移植和组织工程应用。
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公开(公告)号：US06538732B1
公开(公告)日：2003-03-25
申请号：US09564953
申请日：2000-05-04
IPC分类号： G01N2100
CPC分类号： E03F7/12 , G01N21/954 , H04N7/183
摘要： A system comprises: (a) an imaging system having an imaging device for transmitting an electrical signal corresponding to an area being imaged, and magnification functionality adapted to magnify the imaged area; (b) a portable support system for supporting the imaging system having a power supply for supplying power to the imaging system, at least one controller for controlling the zooming functionality of the imaging device, and an image output device; and (c) a positioning system for positioning the imaging system independently of the support system; and a method of using the same which comprising: (a) positioning the imaging system independently of the support system such that a target area is in the field of view of said imaging system while at a first magnification level; (b) imaging the area at a second magnification level greater than the first magnification level; and (c) outputting an image of the area.
摘要翻译： 一种系统包括：（a）成像系统，其具有用于发送对应于被成像区域的电信号的成像装置和适于放大成像区域的放大功能; （b）用于支持成像系统的便携式支持系统，所述成像系统具有用于向所述成像系统供电的电源，用于控制所述成像装置的变焦功能的至少一个控制器和图像输出装置; 和（c）用于独立于支撑系统定位成像系统的定位系统; 及其使用方法，包括：（a）独立于支撑系统定位成像系统，使得目标区域处于第一放大级别的所述成像系统的视野内; （b）以大于第一放大级别的第二放大级别成像该区域; 和（c）输出该区域的图像。
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14.发明授权公开(公告)号：US10045947B2
公开(公告)日：2018-08-14
申请号：US14112096
申请日：2012-04-27
CPC分类号： A61K9/7007 , A61K39/0011 , A61K2039/55522 , A61K2039/55561 , A61K2039/64 , A61L27/20 , A61L27/50 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/258 , A61L2300/64 , A61L2400/06 , A61L2400/16 , A61L2430/34 , C08L5/04
摘要： The invention provides polymer compositions for cell and drug delivery.
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公开(公告)号：US09486512B2
公开(公告)日：2016-11-08
申请号：US14123615
申请日：2012-06-04
申请人： Jaeyun Kim , David J. Mooney , Weiwei Aileen Li , Praveen Arany , Or Gadish
发明人： Jaeyun Kim , David J. Mooney , Weiwei Aileen Li , Praveen Arany , Or Gadish
CPC分类号： A61K39/0011 , A61K38/193 , A61K41/0052 , A61K45/06 , A61K2039/5152 , A61K2039/5154 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/55511 , A61K2039/55561 , A61K2039/57 , A61K2039/572 , A61K2039/70 , B82Y5/00
摘要： The invention provides compositions and methods for utilizing scaffolds in cancer vaccines.
摘要翻译： 本发明提供了在癌症疫苗中利用支架的组合物和方法。
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公开(公告)号：US20140193488A1
公开(公告)日：2014-07-10
申请号：US14123615
申请日：2012-06-04
申请人： Jaeyun Kim , David J. Mooney , Weiwei Aileen Li , Praveen Arany , Or Gadish
发明人： Jaeyun Kim , David J. Mooney , Weiwei Aileen Li , Praveen Arany , Or Gadish
CPC分类号： A61K39/0011 , A61K38/193 , A61K41/0052 , A61K45/06 , A61K2039/5152 , A61K2039/5154 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/55511 , A61K2039/55561 , A61K2039/57 , A61K2039/572 , A61K2039/70 , B82Y5/00
摘要： The invention provides compositions and methods for utilizing scaffolds in cancer vaccines.
摘要翻译： 本发明提供了在癌症疫苗中利用支架的组合物和方法。
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17.发明申请公开(公告)号：US20140112990A1
公开(公告)日：2014-04-24
申请号：US14112096
申请日：2012-04-27
IPC分类号： A61K9/70
CPC分类号： A61K9/7007 , A61K39/0011 , A61K2039/55522 , A61K2039/55561 , A61K2039/64 , A61L27/20 , A61L27/50 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/258 , A61L2300/64 , A61L2400/06 , A61L2400/16 , A61L2430/34 , C08L5/04
摘要： The invention provides polymer compositions for cell and drug delivery.
摘要翻译： 本发明提供用于细胞和药物递送的聚合物组合物。
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18.发明申请公开(公告)号：US20130331343A1
公开(公告)日：2013-12-12
申请号：US13883005
申请日：2011-11-08
申请人： Lan Cao , Kamal H. Bouhadir , David J. Mooney
发明人： Lan Cao , Kamal H. Bouhadir , David J. Mooney
IPC分类号： A61K38/10
CPC分类号： A61K38/10 , A61K38/1709 , A61K47/61 , A61K47/64
摘要： The invention provides a solution to the problem of delivering molecules in a physiologically relevant manner to direct cell fate. For example, a Notch ligand molecule is presented in a microenvironment that mimics the environment encountered in vivo. Accordingly, the invention features a cell delivery vehicle comprising a biocompatible hydrogel or polymer and a composition that binds to a Notch receptor and methods of directing cell fate, e.g., stem cell differentiation, using such compositions.
摘要翻译： 本发明提供了以生理相关方式递送分子以引导细胞命运的问题的解决方案。 例如，Notch配体分子呈现在模拟体内遇到的环境的微环境中。 因此，本发明的特征在于包含生物相容性水凝胶或聚合物的细胞递送载体以及结合Notch受体的组合物和使用这种组合物引导细胞命运（例如干细胞分化）的方法。
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公开(公告)号：US20120122218A1
公开(公告)日：2012-05-17
申请号：US13264243
申请日：2010-04-13
IPC分类号： C12N5/071
CPC分类号： C12N11/04 , C12N5/0654 , C12N2533/50 , C12N2533/74
摘要： The invention features synthetic materials and methods for inducing cell behavior. Matrix materials induce cell differentiation and cell manipulation based on mechanical and physical characteristics of the materials rather than chemical characteristics.
摘要翻译： 本发明的特征在于诱导细胞行为的合成材料和方法。 基质材料基于材料的机械和物理特性而不是化学特性诱导细胞分化和细胞操作。
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公开(公告)号：US06773713B2
公开(公告)日：2004-08-10
申请号：US10081897
申请日：2002-02-21
IPC分类号： A61F202
CPC分类号： A61F2/30756 , A61K35/12 , A61L27/16 , A61L27/18 , A61L27/20 , A61L27/22 , A61L27/3817 , A61L27/383 , A61L27/3843 , A61L27/3886 , A61L27/3895 , A61L27/52 , C12N5/0068 , C12N5/0655 , C08L5/04 , C08L33/02 , C08L31/04 , C08L85/02 , C08L79/02 , C08L71/02
摘要： The invention features methods of making living tissue constructs having a predetermined shape by providing a negative mold having a defined shape; suspending isolated tissue precursor cells in a hydrogel to form a liquid hydrogel-precursor cell composition; introducing the liquid hydrogel-precursor cell composition into the mold; inducing gel formation to solidify the liquid hydrogel-precursor cell composition to form a living tissue construct; and removing the living tissue construct from the mold after gel formation.
摘要翻译： 本发明的特征在于通过提供具有规定形状的阴模制造具有预定形状的活组织构造物的方法; 将分离的组织前体细胞悬浮在水凝胶中以形成液体水凝胶前体细胞组合物; 将液体水凝胶前体细胞组合物引入模具中; 诱导凝胶形成以固化液体水凝胶前体细胞组合物以形成活组织构建体; 并且在凝胶形成之后从模具中去除活组织构建体。
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