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    DEFORMED SHANK FASTENER
    11.
    发明申请
    DEFORMED SHANK FASTENER 有权
    变形山紧固件

    公开(公告)号：US20090155021A1

    公开(公告)日：2009-06-18

    申请号：US12138180

    申请日：2008-06-12

    申请人： Anthony M. Versino ,  Kenneth R. Levey ,  Jeffrey L. Trzaskus ,  Lawrence S. Shelton ,  Donald E. Bergstrom

    发明人： Anthony M. Versino ,  Kenneth R. Levey ,  Jeffrey L. Trzaskus ,  Lawrence S. Shelton ,  Donald E. Bergstrom

    IPC分类号： F16B15/00

    CPC分类号： F16B15/06

    摘要： A nail has a head, a penetrating tip and a shank extending from the head to the penetrating tip. The shank has a circumference and a longitudinal axis. A plurality of rows of deformations formed as teeth are formed in the shank extending outwardly of the shank. The rows are formed in a spiral pattern along the length of the shank from about the head to about the penetrating tip. The rows of teeth are formed parallel to one another and formed at an angle of at least 50 degrees relative to a cross-sectional plane perpendicular to a longitudinal axis of the nail.

    摘要翻译： 指甲具有头部，穿透尖端和从头部延伸至穿透尖端的柄部。 柄具有圆周和纵向轴线。 形成为齿的多排变形形成在柄上延伸到柄的外侧。 这些排沿着柄的长度从螺旋形状形成为从头部到穿透尖端。 齿排彼此平行地形成，并且相对于垂直于钉的纵向轴线的横截面为至少50度的角度形成。

    STUCCO FASTENER
    12.
    发明申请
    STUCCO FASTENER 审中-公开
    STUCCO紧固件

    公开(公告)号：US20110083396A1

    公开(公告)日：2011-04-14

    申请号：US12895224

    申请日：2010-09-30

    申请人： Lawrence S. Shelton ,  Donald E. Bergstrom ,  Tunjen Chu

    发明人： Lawrence S. Shelton ,  Donald E. Bergstrom ,  Tunjen Chu

    IPC分类号： E04B1/38 ,  F16B15/00 ,  F16B15/02

    CPC分类号： F16B43/001 ,  F16B15/00

    摘要： A fastener is configured for securing a lath to a surface for, for example, the application of stucco to the surface. The fastener includes a fastener having a head, a shank and a penetrating tip. The head has a diameter and the shank has a diameter less than the head diameter. The stucco fastener has a sealing/spacer assembly having spacer element and a sealing element. The spacer element is formed from a relatively incompressible material and has a diameter greater than the shank diameter. The spacer element has a bore therein having a diameter about equal to the shank diameter. The sealing element is formed from a resilient, water-resistant material and is positioned adjacent to and in contact with the spacer element. When the fastener is driven into the surface, the fastener penetrates the surface to secure the fastener to the surface and a portion of the lath is captured between the head of the fastener and the spacer element to space the lath from the surface. The sealing element contacts the surface to form a seal at the fastener penetration to prevent the incursion of liquid into the surface around the fastener penetration, and the sealing element, as least in part, conforms to the surface between the surface and the spacer element.

    摘要翻译： 紧固件被构造成用于将板条固定到表面，以便例如将灰泥施加到表面。 紧固件包括具有头部，柄部和穿透尖端的紧固件。 头部具有直径，柄部的直径小于头部直径。 灰泥紧固件具有具有间隔元件和密封元件的密封/间隔件组件。 间隔元件由相对不可压缩的材料形成并且具有大于柄直径的直径。 间隔元件具有其中具有大约等于柄直径的直径的孔。 密封元件由弹性防水材料形成，并且被定位成与间隔元件相邻并与之隔离。 当紧固件被驱动进入表面时，紧固件穿透表面以将紧固件固定到表面，并且一部分板条被捕获在紧固件的头部和间隔件元件之间以将板条与表面隔开。 密封元件接触表面以在紧固件穿透处形成密封，以防止液体进入紧固件穿透物周围的表面，并且密封元件至少部分地符合表面和间隔元件之间的表面。

    COFLUORONS AND METHODS OF MAKING AND USING THEM
    14.
    发明申请
    COFLUORONS AND METHODS OF MAKING AND USING THEM 审中-公开
    COFLORONS AND METHODS OF MAKING AND USING THEM

    公开(公告)号：US20140161729A1

    公开(公告)日：2014-06-12

    申请号：US14110019

    申请日：2012-04-09

    申请人： Francis Barany ,  Maneesh Pingle ,  Donald E. Bergstrom ,  Sarah F. Giardina ,  Lee Daniel Arnold

    发明人： Francis Barany ,  Maneesh Pingle ,  Donald E. Bergstrom ,  Sarah F. Giardina ,  Lee Daniel Arnold

    IPC分类号： G01N33/573 ,  C07D405/06 ,  C07D491/107 ,  C07D211/26 ,  C07D263/06 ,  C07F5/02 ,  C07D401/06

    CPC分类号： G01N33/573 ,  C07D211/26 ,  C07D263/06 ,  C07D401/06 ,  C07D405/06 ,  C07D491/107 ,  C07F5/025 ,  C40B30/04 ,  C40B30/06 ,  C40B50/10 ,  C40B50/16

    摘要： The present invention is directed to method of using a collection of monomers capable of forming multimers as a fluorescence reporter in different applications such as ligand detection/screening, disease diagnosis, drug discovery or screening, fluorescent labeling and imaging, or other fluorescent methodologies. Each monomer in the collection includes one or more ligand elements useful for binding to a target molecule with a dissociation constant of less than 300 μM and a linker element connected to the ligand elements directly or indirectly through a connector. Association of linker elements of different combinations of monomers, with their ligand elements bound to the target molecule to form a multimer, will generate a unique fluorescent signature different from that produced by those monomers either alone or in association with each other in the absence of the target molecule, when subjected to electromagnetic excitement.

    摘要翻译： 本发明涉及在不同应用如配体检测/筛选，疾病诊断，药物发现或筛选，荧光标记和成像或其它荧光方法中使用能够形成多聚体的单体的集合的方法。 收集物中的每个单体包括一个或多个配体元件，其用于结合具有小于300μM的解离常数的靶分子，以及通过连接器直接或间接连接到配体元件的连接体元件。 不同单体组合的连接体元件与其与靶分子结合以形成多聚体的连接体元件的关联将产生独特的荧光特征，其不同于单独或彼此相关联的单体，不存在 目标分子，当受到电磁兴奋时。

    APPARATUS AND METHOD OF MAKING AN OFFSET NAIL
    15.
    发明申请
    APPARATUS AND METHOD OF MAKING AN OFFSET NAIL 有权
    装备和制造偏心钉的方法

    公开(公告)号：US20100183403A1

    公开(公告)日：2010-07-22

    申请号：US12644890

    申请日：2009-12-22

    申请人： Zafar I. Ali ,  Donald E. Bergstrom ,  William L. Gabriel

    发明人： Zafar I. Ali ,  Donald E. Bergstrom ,  William L. Gabriel

    IPC分类号： F16B15/02 ,  B21G3/00

    CPC分类号： B21G3/12 ,  F16B15/02 ,  Y10S411/923

    摘要： A nail having an offset head is configured with a multi-step support gusset formed integrally between an undersurface of the offset head and a superior portion of a shank. The head of the nail is relatively thin, and the shank is positioned radially off center of the head. A first portion of the gusset defines an angle relative to the shank axis and the second portion of the gusset defines an angle relative to the shank axis different from that of the first portion. The support gusset reinforces the junction of the shank with the head, supports the toe of the head, and distributes the force of a load on the head through a longitudinal axis of the shank, preventing the toe from bending or yielding and prevents the shank from yielding to the stresses of the load applied.

    摘要翻译： 具有偏移头的钉构造为具有整体形成在偏移头的下表面和柄部的上部之间的多级支撑角撑板。 钉子的头部相对较薄，并且柄部位于头部的中心的径向偏心处。 角撑板的第一部分限定了相对于柄轴线的角度，并且角撑板的第二部分相对于与第一部分的轴线不同的柄轴线限定了一个角度。 支撑角撑板加强了柄与头部的连接处，支撑头部的脚趾，并通过柄的纵向轴线将负载的力分布在头部上，防止脚趾弯曲或屈曲，并防止柄部 屈服于施加的载荷的应力。

    Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
    17.
    发明授权
    Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process 有权
    耦合聚合酶链反应 - 限制性内切酶消化 - 连接酶检测反应过程

    公开(公告)号：US07014994B1

    公开(公告)日：2006-03-21

    申请号：US09528014

    申请日：2000-03-17

    申请人： Francis Barany ,  Joseph P. Day ,  Robert P. Hammer ,  Donald E. Bergstrom

    发明人： Francis Barany ,  Joseph P. Day ,  Robert P. Hammer ,  Donald E. Bergstrom

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04

    CPC分类号： C12Q1/683 ,  C12Q1/6816 ,  C12Q1/6853 ,  C12Q2531/137 ,  C12Q2563/179 ,  C12Q2565/125 ,  C12Q2565/501 ,  C12Q2537/149 ,  C12Q2535/125 ,  C12Q2525/155

    摘要： The present invention provides a method for identifying one or more low abundance sequences differing by one or more single-base changes, insertions, or deletions, from a high abundance sequence in a plurality of target nucleotide sequences. The high abundance wild-type sequence is selectively removed using high fidelity polymerase chain reaction analog conversion, facilitated by optimal buffer conditions, to create a restriction endonuclease site in the high abundance wild-type gene, but not in the low abundance mutant gene. This allows for digestion of the high abundance DNA. Subsequently the low abundant mutant DNA is amplified and detected by the ligase detection reaction assay. The present invention also relates to a kit for carrying out this procedure.

    摘要翻译： 本发明提供了一种用于从多个靶核苷酸序列中的高丰度序列鉴定一个或多个不同于一个或多个单碱基变化，插入或缺失的低丰度序列的方法。 使用高保真聚合酶链反应模拟转化，通过最佳缓冲条件促进高丰度野生型序列，在高丰度野生型基因中产生限制性内切核酸酶位点而不是在低丰度突变基因中产生限制性内切核酸酶位点。 这样可以消化高丰度DNA。 随后，通过连接酶检测反应测定扩增和检测低丰度突变体DNA。 本发明还涉及用于实施该方法的试剂盒。