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    OPTIONAL SENSOR CALIBRATION IN CONTINUOUS GLUCOSE MONITORING
    11.
    发明申请
    OPTIONAL SENSOR CALIBRATION IN CONTINUOUS GLUCOSE MONITORING 有权

    公开(公告)号：US20220095964A1

    公开(公告)日：2022-03-31

    申请号：US17546112

    申请日：2021-12-09

    Applicant: Medtronic MiniMed, Inc.

    Inventor： Jeffrey Nishida ,  Andrea Varsavsky ,  Taly G. Engel ,  Keith Nogueira ,  Andy Y. Tsai ,  Peter Ajemba

    IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/1473 ,  A61B5/145 ,  G01N27/327

    Abstract: A method for optional external calibration of a calibration-free glucose sensor uses values of measured working electrode current (Isig) and EIS data to calculate a final sensor glucose (SG) value. Counter electrode voltage (Vcntr) may also be used as an input. Raw Isig and Vcntr values may be preprocessed, and low-pass filtering, averaging, and/or feature generation may be applied. SG values may be generated using one or more models for predicting SG calculations. When an external blood glucose (BG) value is available, the BG value may also be used in calculating the SG values. A SG variance estimate may be calculated for each predicted SG value and modulated, with the modulated SG values then fused to generate a fused SG. A Kalman filter, as well as error detection logic, may be applied to the fused SG value to obtain a final SG, which is then displayed to the user.

    Optional sensor calibration in continuous glucose monitoring
    12.
    发明授权
    Optional sensor calibration in continuous glucose monitoring 有权

    公开(公告)号：US11213230B2

    公开(公告)日：2022-01-04

    申请号：US15840515

    申请日：2017-12-13

    Applicant: MEDTRONIC MINIMED, INC.

    Inventor： Jeffrey Nishida ,  Andrea Varsavsky ,  Taly G. Engel ,  Keith Nogueira ,  Andy Y. Tsai ,  Peter Ajemba

    IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/1473 ,  A61B5/145 ,  G01N27/327 ,  A61M5/172 ,  A61B5/1486

    Abstract: A method for optional external calibration of a calibration-free glucose sensor uses values of measured working electrode current (Isig) and EIS data to calculate a final sensor glucose (SG) value. Counter electrode voltage (Vcntr) may also be used as an input. Raw Isig and Vcntr values may be preprocessed, and low-pass filtering, averaging, and/or feature generation may be applied. SG values may be generated using one or more models for predicting SG calculations. When an external blood glucose (BG) value is available, the BG value may also be used in calculating the SG values. A SG variance estimate may be calculated for each predicted SG value and modulated, with the modulated SG values then fused to generate a fused SG. A Kalman filter, as well as error detection logic, may be applied to the fused SG value to obtain a final SG, which is then displayed to the user.

    GENERATIVE MODELING METHODS AND SYSTEMS FOR SIMULATING SENSOR MEASUREMENTS
    13.
    发明申请
    GENERATIVE MODELING METHODS AND SYSTEMS FOR SIMULATING SENSOR MEASUREMENTS 有权

    公开(公告)号：US20210174960A1

    公开(公告)日：2021-06-10

    申请号：US16848710

    申请日：2020-04-14

    Applicant: MEDTRONIC MINIMED, INC.

    Inventor： Elaine Gee ,  Peter Ajemba ,  Bahman Engheta ,  Jeffrey Nishida ,  Andrea Varsavsky ,  Keith Nogueira

    IPC: G16H50/20 ,  A61B5/145 ,  A61M5/172 ,  A61B5/00 ,  G16H50/30 ,  G16H70/60 ,  G16H40/67 ,  G16H50/50 ,  G16H20/17 ,  G06N3/08 ,  G06N3/04

    Abstract: Medical devices and related systems and methods are provided. A method of estimating a physiological condition involves obtaining reference measurement data for the physiological condition, obtaining first measurement data corresponding to the reference measurement data from one or more instances of the first sensing arrangement, determining a generative model associated with the first sensing arrangement based on relationships between the first measurement data and the reference measurement data, obtaining second reference measurement data for the physiological condition, generating simulated measurement data corresponding to the second reference measurement data by applying the generative model to the second reference measurement data, and determining an estimation model for the physiological condition based on relationships between the simulated measurement data and the second reference measurement data, wherein the estimation model is applied to subsequent measurement output provided by an instance of the first sensing arrangement to obtain an estimated value for the physiological condition.

    METHODS AND SYSTEMS FOR REAL-TIME SENSOR MEASUREMENT SIMULATION
    14.
    发明申请
    METHODS AND SYSTEMS FOR REAL-TIME SENSOR MEASUREMENT SIMULATION 有权

    公开(公告)号：US20210170103A1

    公开(公告)日：2021-06-10

    申请号：US16848695

    申请日：2020-04-14

    Applicant: MEDTRONIC MINIMED, INC.

    Inventor： Elaine Gee ,  Peter Ajemba ,  Bahman Engheta ,  Jeffrey Nishida ,  Andrea Varsavsky ,  Keith Nogueira

    IPC: A61M5/172 ,  A61B5/145 ,  A61B5/00 ,  G16H50/50 ,  G16H20/17

    Abstract: Medical devices and related systems and methods are provided. A method of estimating a physiological condition using a first sensing arrangement involves obtaining a sensor translation model associated with a relationship between the first sensing arrangement and a second sensing arrangement, wherein the second sensing arrangement is different from the first sensing arrangement, obtaining one or more measurements from a sensing element coupled to the processing system of the first sensing arrangement, determining simulated measurement data for the second sensing arrangement by applying the sensor translation model to the one or more measurements from the sensing element of the first sensing arrangement, and determining an estimated value for the physiological condition by applying an estimation model associated with the second sensing arrangement to the simulated measurement data.

    METHODS, SYSTEMS, AND DEVICES FOR CALIBRATION AND OPTIMIZATION OF GLUCOSE SENSORS AND SENSOR OUTPUT
    20.
    发明申请
    METHODS, SYSTEMS, AND DEVICES FOR CALIBRATION AND OPTIMIZATION OF GLUCOSE SENSORS AND SENSOR OUTPUT 有权

    公开(公告)号：US20230000402A1

    公开(公告)日：2023-01-05

    申请号：US17939067

    申请日：2022-09-07

    Applicant: Medtronic MiniMed, Inc.

    Inventor： Peter Ajemba ,  Keith Nogueira ,  Jeffrey Nishida ,  Andy Y. Tsai

    IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  G06N5/02 ,  G16H50/30 ,  G01N27/02 ,  G16H20/17 ,  G16H50/70 ,  A61B5/1468 ,  G16H40/40

    Abstract: A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects. Correction actors, fusion algorithms, EIS, and advanced ASICs may be used to implement the foregoing, thereby achieving the goal of improved accuracy and reliability without the need for blood-glucose calibration, and providing a calibration-free, or near calibration-free, sensor.

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