公开(公告)号：US20230184768A1

公开(公告)日：2023-06-15

申请号：US17997267

申请日：2021-04-30

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Jacob N. WOHLSTADTER ,  George SIGAL ,  Anu MATHEW ,  James WILBUR ,  Jeffery DEBAD ,  Christopher CAMPBELL ,  Hans BIEBUYCK ,  Priscilla KRAI ,  Alan KISHBAUGH ,  Leonid DZANTIEV ,  Christopher SHELBURNE ,  Pu LIU ,  Paul GOODWIN

IPC: G01N33/569 ,  G01N33/68

CPC classification number: G01N33/56983 ,  G01N33/6854 ,  G01N2333/11 ,  G01N2333/165 ,  G01N2469/20

Abstract: The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.

公开(公告)号：US20160370359A1

公开(公告)日：2016-12-22

申请号：US15256364

申请日：2016-09-02

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： George B. SIGAL ,  Jacob N. WOHLSTADTER ,  Satyanarayana GUDIBANDE ,  Mark T. MARTIN ,  James L. WILBUR

IPC: G01N33/543 ,  G01N33/553 ,  G01N33/552

CPC classification number: G01N33/54346 ,  B82Y30/00 ,  C07B2200/11 ,  C07H21/00 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6834 ,  G01N33/532 ,  G01N33/533 ,  G01N33/54306 ,  G01N33/54366 ,  G01N33/5438 ,  G01N33/552 ,  G01N33/553 ,  G01N33/582 ,  G01N33/587 ,  G01N2458/30 ,  C12Q2563/149 ,  C12Q2563/113 ,  C12Q2537/125

Abstract: A method and apparatus for performing electrochemiluminescence assays are presented. In exemplary embodiments of the present invention an apparatus comprises an ECL-inactive electrode surface having a first assay-ligand immobilized thereon and an ECL-active microparticle having a second assay ligand immobilized thereon. In exemplary embodiments of the present invention a method comprises (a) forming a mixture comprising an electrochemiluminescent label and a microparticle having a first assay-ligand immobilized thereon, (b) applying electrochemical energy to an electrode surface in the presence of said mixture, and (c) measuring emitted electrochemiluminescence, where the microparticle is ECL-active and where the electrode surface is ECL-inactive when electrochemical energy is applied to it in the presence of said mixture.

Abstract translation: 提出了一种用于进行电化学发光测定的方法和装置。 在本发明的示例性实施方案中，一种装置包括其上固定有第一测定配体的ECL非活性电极表面和其上固定有第二测定配体的ECL活性微粒。 在本发明的示例性实施方案中，方法包括（a）形成包含电化学发光标记和其上固定有第一测定配体的微粒的混合物，（b）在所述混合物存在下将电化学能施加到电极表面，以及 （c）测量发射的电化学发光，其中微粒是ECL-活性的，并且当在所述混合物的存在下施加电化学能时，电极表面是ECL-无活性的。

公开(公告)号：US20140274805A1

公开(公告)日：2014-09-18

申请号：US14250054

申请日：2014-04-10

Applicant: MESO SCALE TECHNOLOGIES LLC

Inventor： Jacob N. WOHLSTADTER ,  James L. WILBUR ,  George B. SIGAL ,  Mark T. MARTIN ,  Liang-Hong GUO ,  Alan FISCHER ,  Jon LELAND ,  Mark A. BILLADEAU ,  Larry R. HELMS ,  Ramin DARVARI

IPC: G01N21/76 ,  C12Q1/68

CPC classification number: G01N21/76 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2300/0636 ,  B01L2300/0645 ,  B82Y15/00 ,  B82Y30/00 ,  C12Q1/6825 ,  G01N21/253 ,  G01N21/66 ,  G01N33/54313 ,  G01N33/5438 ,  G01N33/582 ,  G01N33/585 ,  Y10S435/808 ,  Y10S435/817 ,  Y10S436/805 ,  Y10S436/806 ,  Y10S436/807

Abstract: Materials and Methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.

Abstract translation: 提供材料和方法用于生产用于诊断的图案化多阵列多特异性表面。 本发明提供了用于检测或测量感兴趣分析物的电化学发光方法。 它还提供用于ECL测定的新型电极。 提供材料和方法用于化学和/或物理控制导电域和试剂沉积，以便使用多重特定的测试程序。

公开(公告)号：US20240362654A1

公开(公告)日：2024-10-31

申请号：US18601034

申请日：2024-03-11

Applicant: Meso Scale Technologies, LLC.

Inventor： Xinri CONG ,  Jerome JACKSON ,  Carl STEVENS ,  Michael VOCK ,  Jacob N. WOHLSTADTER

IPC: G06Q30/0201 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  G06F16/21 ,  G06F16/951 ,  G06Q10/06 ,  G06Q10/10 ,  G06Q30/0601 ,  G07C9/27 ,  G16B50/00 ,  G16H10/40 ,  G16Z99/00

CPC classification number: G06Q30/0201 ,  G01N35/00871 ,  G01N35/0099 ,  G01N35/04 ,  G01N35/1002 ,  G06F16/21 ,  G06F16/951 ,  G06Q10/06 ,  G06Q10/10 ,  G06Q30/0625 ,  G07C9/27 ,  G16H10/40 ,  G16Z99/00 ,  G01N2035/00881 ,  G01N2035/0425 ,  G01N2035/0475 ,  G16B50/00

Abstract: In examples, a method of controlling customer access to an assay system comprises (a) receiving a system identifier; (b) identifying said system identifier, and (c) utilizing information obtained from the system identifier to perform one or more operations selected from: (i) enabling full access to said system and/or a consumable used in said system; (ii) enabling partial access to said system and/or a consumable used in said system; or (iii) denying access to said system and/or a consumable used in said system.

公开(公告)号：US20240339225A1

公开(公告)日：2024-10-10

申请号：US18748589

申请日：2024-06-20

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Jacob N. WOHLSTADTER ,  Michael VOCK ,  Charles M. CLINTON ,  George SIGAL

IPC: G16H50/80 ,  G01N21/76 ,  G06Q50/40 ,  G16H10/40 ,  G16H40/20 ,  G16H40/67 ,  G16H50/20

CPC classification number: G16H50/80 ,  G01N21/76 ,  G06Q50/40 ,  G16H10/40 ,  G16H40/20 ,  G16H40/67 ,  G16H50/20

Abstract: Provided herein are systems, methods, and apparatuses for providing a real-time global bio-surveillance and response solution. The systems and apparatuses may include one or more sentinel subsystems and one or more surge subsystems that each include a real-time, cloud-based, distributed, interconnected set of hardware, software, and/or firmware for comprehensive surveillance, complete detection, and immediate response various to biological, chemical, and/or bio-chemical anomalies, for example, a new or emerging pathogen or other health condition.

公开(公告)号：US20240094233A1

公开(公告)日：2024-03-21

申请号：US18354382

申请日：2023-07-18

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Jacob N. WOHLSTADTER ,  Manish KOCHAR ,  Peter J. BOSCO ,  Ian D. CHAMBERLIN ,  Bandele JEFFREY-COKER ,  Eric M. JONES ,  Gary I. KRIVOY ,  Don E. KRUEGER ,  Aaron H. LEIMKUEHLER ,  Pei-Ming WU ,  Kim-Xuan NGUYEN ,  Pankaj OBEROI ,  Louis W. PANG ,  Jennifer PARKER ,  Victor PELLICIER ,  Nicholas SAMMONS ,  George SIGAL ,  Michael L. VOCK ,  Stanley T. SMITH ,  Carl C. STEVENS ,  Rodger D. OSBORNE ,  Kenneth E. PAGE ,  Michael T. WADE ,  Jon WILLOUGHBY ,  Lei WANG ,  Xinri CONG ,  Kin NG

IPC: G01N35/00 ,  B01L3/00 ,  B01L9/00 ,  F24F11/30 ,  G06K7/14 ,  G06Q10/087 ,  G06Q10/10 ,  G16H10/40 ,  G16H40/40 ,  G16H40/67

CPC classification number: G01N35/0099 ,  B01L3/50853 ,  B01L9/523 ,  F24F11/30 ,  G06K7/1413 ,  G06Q10/087 ,  G06Q10/10 ,  G16H10/40 ,  G16H40/40 ,  G16H40/67 ,  B01L2200/143 ,  B01L2300/021 ,  G01N2035/00356 ,  G05B2219/40269 ,  H04B1/3827

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

公开(公告)号：US20240003925A1

公开(公告)日：2024-01-04

申请号：US18323082

申请日：2023-05-24

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Manish KOCHAR ,  Peter J. BOSCO ,  Ian D. CHAMBERLIN ,  Bandele JEFFREY-COKER ,  Eric M. JONES ,  Gary I. KRIVOY ,  Aaron H. LEIMKUEHLER ,  Pei-Ming WU ,  Kim-Xuan NGUYEN ,  Pankaj OBEROI ,  Louis W. PANG ,  Jennifer PARKER ,  Victor PELLICIER ,  Nicholas SAMMONS ,  George SIGAL ,  Jacob N. WOHLSTADTER ,  Michael L. VOCK ,  Stanley Todd SMITH ,  Carl C. STEVENS ,  Rodger D. OSBORNE ,  Kenneth E. PAGE ,  Michael T. WADE ,  Jon WILLOUGHBY ,  Lei WANG ,  Don E. KRUEGER

IPC: G01N35/00 ,  B01L3/00 ,  B01L9/00 ,  G16H40/67 ,  G16H10/40 ,  G16H40/40 ,  F24F11/30 ,  G06K7/14 ,  G06Q10/087 ,  G06Q10/10

CPC classification number: G01N35/0099 ,  B01L3/50853 ,  B01L9/523 ,  G16H40/67 ,  G16H10/40 ,  G16H40/40 ,  F24F11/30 ,  G06K7/1413 ,  G06Q10/087 ,  G06Q10/10 ,  B01L2200/143 ,  B01L2300/021 ,  G01N2035/00356 ,  G05B2219/40269 ,  H04B1/3827

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

公开(公告)号：US20230229713A1

公开(公告)日：2023-07-20

申请号：US18122955

申请日：2023-03-17

Applicant: Meso Scale Technologies, LLC.

Inventor： Xinri CONG ,  Jerome JACKSON ,  Carl STEVENS ,  Michael VOCK ,  Jacob N. WOHLSTADTER

IPC: G06F16/951 ,  G16H10/40 ,  G06F16/21 ,  G06Q10/10 ,  G06Q10/06 ,  G07C9/27 ,  G16Z99/00 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  G06Q30/0201 ,  G06Q30/0601

CPC classification number: G06F16/951 ,  G16H10/40 ,  G06F16/21 ,  G06Q10/10 ,  G06Q10/06 ,  G07C9/27 ,  G16Z99/00 ,  G01N35/00871 ,  G01N35/0099 ,  G01N35/04 ,  G01N35/1002 ,  G06Q30/0201 ,  G06Q30/0625 ,  G16B50/00

Abstract: In examples, a method of controlling customer access to an assay system comprises (a) receiving a system identifier; (b) identifying said system identifier; and (c) utilizing information obtained from the system identifier to perform one or more operations selected from: (i) enabling full access to said system and/or a consumable used in said system; (ii) enabling partial access to said system and/or a consumable used in said system; or (iii) denying access to said system and/or a consumable used in said system.

公开(公告)号：US20210356482A1

公开(公告)日：2021-11-18

申请号：US17321099

申请日：2021-05-14

Applicant: Meso Scale Technologies, LLC.

Inventor： Dimitri Mikael MOFFITT ,  Aaron LEIMKUEHLER ,  Victor PELLICIER ,  Todd SMITH ,  Gary KRIVOY ,  Eric JONES ,  Jennifer PARKER ,  Slavi MIRTCHEV ,  Nicholas SAMMONS ,  Manish KOCHAR ,  Jacob N. WOHLSTADTER

IPC: G01N35/00 ,  B01L3/00

Abstract: The present disclosure relates to an automated assay system adapted to receive consumables in the conduct of an assay. The assay system includes at least one of a loading cart, a door support system, a waste storage unit, and a robotic subsystem. The loading cart is configured to organize and transport consumables necessary for the performance of the assay system. The door support system is configured to maintain stability of doors of the automated assay system. The waste storage unit is configured to provide convenient disposal of consumables associated with the automated assay system. The robotic subsystem is configured to transport consumables within the automated assay system.

公开(公告)号：US20210072160A1

公开(公告)日：2021-03-11

申请号：US17099281

申请日：2020-11-16

Applicant: MESO SCALE TECHNOLOGIES, LLC

Inventor： Charles M. CLINTON ,  Jacob N. WOHLSTADTER

IPC: G01N21/76 ,  G01N21/64 ,  B01L3/00 ,  G01N33/543

Abstract: We describe a detection module useful with an apparatus and/or system for conducting luminescence assays, and a kit, a system, an apparatus, and a method incorporating the detection module.