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    GLUCOSE SENSOR BASED ON OPEN CIRCUIT POTENTIAL (OCP) SIGNAL
    13.
    发明申请
    GLUCOSE SENSOR BASED ON OPEN CIRCUIT POTENTIAL (OCP) SIGNAL 有权

    公开(公告)号：US20230080129A1

    公开(公告)日：2023-03-16

    申请号：US17474921

    申请日：2021-09-14

    Applicant: Medtronic MiniMed, Inc.

    Inventor： Ellis Garai ,  Sarkis D. Aroyan ,  Anuj M. Patel ,  Michael E. Miller

    IPC: A61B5/145 ,  G01N27/04 ,  A61B5/1486

    Abstract: A device for determining a glucose level of a patient includes a set of electrodes comprising a first working electrode, a second working electrode, a counter electrode, and a reference electrode. The reference electrode is electrically coupled to the counter electrode. The device further includes a memory and one or more processors implemented in circuitry and in communication with the memory. The one or more processors configured to determine a sensor signal based on current flowing between the first working electrode and the counter electrode and determine an open circuit potential (OCP) signal based on a voltage across the second working electrode and the reference electrode. The one or more processors are further configured to determine the glucose level of the patient based on the sensor signal and the OCP signal and output an indication of the glucose level.

    PSEUDO-ORTHOGONAL REDUNDANT GLUCOSE SENSORS, SYSTEMS, AND METHODS
    19.
    发明申请
    PSEUDO-ORTHOGONAL REDUNDANT GLUCOSE SENSORS, SYSTEMS, AND METHODS 审中-公开

    公开(公告)号：US20190175082A1

    公开(公告)日：2019-06-13

    申请号：US15840785

    申请日：2017-12-13

    Applicant: MEDTRONIC MINIMED, INC.

    Inventor： ANDREA VARSAVSKY ,  Michael E. Miller

    IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/1495

    Abstract: A pseudo-orthogonally redundant glucose sensor device may include one or more electrochemical peroxide-based glucose sensor(s) and one or more electrochemical oxygen-based sensor(s). The electrochemical peroxide-based glucose sensor(s) may operate as traditional peroxide-based sensor(s), which may include a chemistry stack with glucose oxidase as a catalytic agent. The electrochemical oxygen-based sensor(s) may be used to measure oxygen, as well as to measure glucose by computing differences in oxygen between two working electrodes. In embodiments of the invention, one of the oxygen-based sensors may be used directly as a diagnostic to determine whether each peroxide-based glucose sensor is functioning properly, as well as to determine which modality of sensing to use. Because of the internal oxygen-based reference, the glucose sensor device provides oxygen-resistant glucose sensing, as well as near-orthogonal redundancy.

    METHODS, SYSTEMS, AND DEVICES FOR CALIBRATION AND OPTIMIZATION OF GLUCOSE SENSORS AND SENSOR OUTPUT
    20.
    发明申请
    METHODS, SYSTEMS, AND DEVICES FOR CALIBRATION AND OPTIMIZATION OF GLUCOSE SENSORS AND SENSOR OUTPUT 审中-公开

    公开(公告)号：US20190076070A1

    公开(公告)日：2019-03-14

    申请号：US16117733

    申请日：2018-08-30

    Applicant: MEDTRONIC MINIMED, INC.

    Inventor： Keith Nogueira ,  Peter Ajemba ,  Michael E. Miller ,  Steven C. Jacks ,  Jeffrey Nishida ,  Andy Y. Tsai ,  Andrea Varsavsky

    IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1486

    Abstract: A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects. Correction actors, fusion algorithms, EIS, and advanced ASICs may be used to implement the foregoing, thereby achieving the goal of improved accuracy and reliability without the need for blood-glucose calibration, and providing a calibration-free, or near calibration-free, sensor.

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