公开(公告)号：US20210386335A1

公开(公告)日：2021-12-16

申请号：US17458643

申请日：2021-08-27

Applicant: Medtronic MiniMed, Inc.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N21/84 ,  G01N27/27 ,  C12Q1/00 ,  G01N21/59 ,  G01N27/327

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US11160477B2

公开(公告)日：2021-11-02

申请号：US16170901

申请日：2018-10-25

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Rajiv Shah

IPC: A61B5/1495 ,  G01N27/416 ,  G01N27/02 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/1459 ,  A61B5/145 ,  A61B5/1473 ,  G01N33/66 ,  A61M5/158 ,  A61M5/142 ,  G01R35/00 ,  A61B5/0537 ,  A61M5/172 ,  A61B5/0538 ,  G01N33/96 ,  G01N33/49

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US10952651B2

公开(公告)日：2021-03-23

申请号：US15903332

申请日：2018-02-23

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N21/84 ,  G01N27/27 ,  C12Q1/00 ,  G01N21/59 ,  G01N27/327

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US10426385B2

公开(公告)日：2019-10-01

申请号：US15481868

申请日：2017-04-07

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1455 ,  A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  A61B5/145 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1468 ,  G01N21/84 ,  G01N27/27 ,  C12Q1/00 ,  G01N21/59 ,  G01N27/327

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20190059793A1

公开(公告)日：2019-02-28

申请号：US16170901

申请日：2018-10-25

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Rajiv Shah

IPC: A61B5/1495 ,  G01R35/00 ,  A61B5/053 ,  G01N33/96 ,  G01N33/66 ,  G01N33/49 ,  G01N27/416 ,  G01N27/02 ,  A61B5/145 ,  A61M5/172 ,  A61M5/158 ,  A61M5/142 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/1473 ,  A61B5/1459

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US09861746B2

公开(公告)日：2018-01-09

申请号：US13778559

申请日：2013-02-27

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Raghavendhar Gautham ,  Ning Yang ,  Rajiv Shah

IPC: A61B5/05 ,  A61M5/172 ,  G01N27/416 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/00 ,  A61B5/053 ,  A61B5/1495 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  A61M5/142 ,  G01N27/02 ,  G01N33/96 ,  G01N33/49

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US09649059B2

公开(公告)日：2017-05-16

申请号：US14261043

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1455 ,  A61B5/1495 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20150300969A1

公开(公告)日：2015-10-22

申请号：US14256229

申请日：2014-04-18

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Benyamin Grosman ,  Desmond Barry Keenan ,  John J. Mastrototaro ,  Rajiv Shah ,  Andrea Varsavsky ,  Ning Yang

IPC: G01N27/02

CPC classification number: G01N27/026

Abstract: A method of measuring blood glucose of a patient is presented here. In accordance with certain embodiments, the method applies a constant voltage potential to a glucose sensor and obtains a constant potential sensor current from the glucose sensor, wherein the constant potential sensor current is generated in response to applying the constant voltage potential to the glucose sensor. The method continues by performing an electrochemical impedance spectroscopy (EIS) procedure for the glucose sensor to obtain EIS output measurements. The method also performs a nonlinear mapping operation on the constant potential sensor current and the EIS output measurements to generate a blood glucose value.

Abstract translation: 这里给出了测量患者血糖的方法。 根据某些实施例，该方法向葡萄糖传感器施加恒定电压电位，并从葡萄糖传感器获得恒定的电位传感器电流，其中响应于向葡萄糖传感器施加恒定电压电位而产生恒定电位传感器电流。 该方法通过对葡萄糖传感器执行电化学阻抗谱（EIS）程序来获得EIS输出测量结果。 该方法还对恒定电位传感器电流和EIS输出测量执行非线性映射操作以产生血糖值。

公开(公告)号：US20150164389A1

公开(公告)日：2015-06-18

申请号：US14261043

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/145 ,  A61M5/172 ,  A61B5/1495 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/1468

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20130328573A1

公开(公告)日：2013-12-12

申请号：US13778514

申请日：2013-02-27

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Rajiv Shah

IPC: G01R35/00 ,  G01N27/02

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.