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69 条记录 (耗时 0.033 秒)

    Ultrasonic time-domain method for sensing fluid flow
    11.
    发明授权
    Ultrasonic time-domain method for sensing fluid flow 失效
    用于检测流体流动的超声时域法

    公开(公告)号：US5373848A

    公开(公告)日：1994-12-20

    申请号：US104514

    申请日：1993-08-09

    申请人： Hewlett E. Melton, Jr. ,  King-Wah W. Yeung ,  Michael Greenstein

    发明人： Hewlett E. Melton, Jr. ,  King-Wah W. Yeung ,  Michael Greenstein

    IPC分类号： A61B8/06 ,  A61B8/14 ,  G01P5/00 ,  G01P13/00 ,  G01S15/58

    CPC分类号： G01S15/8984 ,  A61B8/06 ,  G01S15/582

    摘要： Pulses of ultrasound are focused in the patient's body to create an interrogation volume where either the magnitude of velocity or the direction of blood flow is to be measured. The strength of the back-scattered signal is measured for each pulse and the mean squared rate of change of the envelope of the range-gated signal is estimated. In order to measure flow velocity independent of direction, the interrogation volume is generated substantially as a sphere by creating an ultrasonic wave envelope in which the components of the mean square spatial gradient are equal in all directions. The estimated mean square rate of change of the envelope of the back-scattered signal is then scaled to provide a direction-independent measurement of flow velocity. In order to determine the direction of flow, the interrogation volume is generated substantially as an ellipsoid. The long axis of the ellipsoidal interrogation volume is then rotated until the measured mean square rate of change of the envelope of the return signal is at a minimum, which is reached when the long axis is aligned with the flow direction. The interrogation volume is preferably rotated and translated using differential phasing of the ultrasonic signals from different transducer elements in a two-dimensional phased array.

    摘要翻译： 超声波的脉冲聚焦在患者的身体中以产生要测量速度的大小或血流方向的询问体积。 对每个脉冲测量反向散射信号的强度，并估计范围门控信号的包络线的平均变化率。 为了独立于方向测量流速，通过产生均方根空间梯度的分量在所有方向上相等的超声波包络，基本上产生询问体积。 然后对后向散射信号的包络的估计均方根值进行缩放，以提供与流速无关的方向测量。 为了确定流动的方向，询问体积基本上产生为椭圆体。 然后旋转椭圆询问体积的长轴，直到所测量的返回信号的包络线的均方根变化率处于最小值，当长轴与流动方向对齐时达到最小。 询问体积优选地使用来自二维相控阵列中的来自不同换能器元件的超声波信号的微分相位来旋转和平移。

    Macrolide antibiotic compounds
    12.
    发明授权
    Macrolide antibiotic compounds 失效
    麦角抗生素化合物

    公开(公告)号：US5169956A

    公开(公告)日：1992-12-08

    申请号：US543290

    申请日：1990-06-25

    申请人： Guy T. Carter ,  Margaret J. Torrey ,  Michael Greenstein

    发明人： Guy T. Carter ,  Margaret J. Torrey ,  Michael Greenstein

    IPC分类号： A01N63/02 ,  C07H19/01 ,  C12P1/06

    CPC分类号： C07H19/01 ,  A01N63/02 ,  C12P1/06 ,  Y10S435/88 ,  Y10S435/886

    摘要： This invention relates to new agents designated LL-F28249.alpha., LL-F28249.beta., LL-F28249.gamma., LL-F28249.delta., LL-F28249.epsilon., LL-F28249.zeta., LL-F28249.eta., LL-F28249.theta., LL-F28249.iota., LL-F28249.kappa., LL-F28249.lambda., LL-F28249.mu., LL-F28249.nu., and LL-F2924.omega., to their production by fermentation, to methods for their recovery and concentration from crude solutions, to processes for their purification and to pharmaceutically and pharmacologically-acceptable salts thereof. The present invention includes within its scope the biologically pure culture which produces there agents, derived from a newly-discovered and previously uncultured microorganism, Streptomyces cyaneogriseus subsp. noncyanogenus, NRRL 15773.

    Portable Preparation, Analysis, and Detection Apparatus for Nucleic Acid Processing
    15.
    发明申请
    Portable Preparation, Analysis, and Detection Apparatus for Nucleic Acid Processing 审中-公开
    用于核酸加工的便携式制备，分析和检测装置

    公开(公告)号：US20090321259A1

    公开(公告)日：2009-12-31

    申请号：US12433201

    申请日：2009-04-30

    申请人： Charles S. Vann ,  Michael Greenstein ,  yuh-Min Chiang

    发明人： Charles S. Vann ,  Michael Greenstein ,  yuh-Min Chiang

    IPC分类号： C12Q1/68 ,  G01N27/447

    CPC分类号： G01N27/447 ,  C12M47/06 ,  C12Q1/6806 ,  C12Q1/686

    摘要： The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge.

    摘要翻译： 本教导包括用于裂解和/或纯化生物样品的装置和方法。 该装置可以包括具有包含生物样品接收区域，多个电极和一个或多个筛分基质的腔室的药筒。 电极可以被配置成通过产生脉冲电场来裂解生物样品。 电极也可以被配置为热裂解生物样品。 电极还可以被配置成通过一个或多个筛分基质电泳移动生物样品。 样品的一部分可以在膜上分离。 可以扩增和检测在膜上分离的样品的部分。 样品的一部分可以在存在于盒中的收集区域中分离。 分离在收集区域中的样品的部分可以从盒中取出。