公开(公告)号：US09463322B2

公开(公告)日：2016-10-11

申请号：US15135247

申请日：2016-04-21

Applicant: NeuroPace, Inc.

Inventor： Brett Wingeier ,  Barbara Gibb ,  Craig Baysinger ,  Thomas Tcheng ,  Suresh Gurunathan

IPC: A61N1/36 ,  A61B5/00

CPC classification number: A61N1/36128 ,  A61B5/0031 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/4836 ,  A61B2560/0242 ,  A61B2560/0266 ,  A61N1/36067 ,  A61N1/36142 ,  A61N1/3718

Abstract: A method and system is described for ensuring a state of an active implantable medical device based on the presence and persistence of a magnetic field. The output of a magnetic field sensor is monitored. The active implantable medical device is maintained in a first state, for so long as the presence of a magnetic field is detected by the magnetic field sensor, until a first interval is surpassed. If the first interval is surpassed, then a determination is made as to whether a second interval has been surpassed. If it is determined that the second interval has not been surpassed, then the active implantable medical device is transitioned into a second state. If it is determined that the second interval has been surpassed, then it is ensured that the active implantable medical device is in a predetermined one of the first and second states.

Abstract translation: 描述了一种方法和系统，用于基于磁场的存在和持续性确保主动植入式医疗装置的状态。 监测磁场传感器的输出。 只要磁场传感器检测到磁场的存在，直到超过第一间隔，则有源可植入医疗装置保持在第一状态。 如果超过第一间隔，则确定是否超过第二间隔。 如果确定第二间隔未被超越，则有源可植入医疗装置被转换到第二状态。 如果确定第二间隔已被超过，则确保有源可植入医疗装置处于第一状态和第二状态中的预定的一个。

公开(公告)号：US09345884B2

公开(公告)日：2016-05-24

申请号：US13631820

申请日：2012-09-28

Applicant: NeuroPace, Inc.

Inventor： Brett Wingeier ,  Barbara Gibb ,  Craig Baysinger ,  Thomas Tcheng ,  Suresh Gurunathan

IPC: A61N1/36 ,  A61B5/00 ,  A61B5/0476 ,  A61N1/37

CPC classification number: A61N1/36128 ,  A61B5/0031 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/4836 ,  A61B2560/0242 ,  A61B2560/0266 ,  A61N1/36067 ,  A61N1/36142 ,  A61N1/3718

Abstract: A method and system is described for ensuring a state of an active implantable medical device based on the presence and persistence of a magnetic field. The output of a magnetic field sensor is monitored. The active implantable medical device is maintained in a first state, for so long as the presence of a magnetic field is detected by the magnetic field sensor, until a first interval is surpassed. If the first interval is surpassed, then a determination is made as to whether a second interval has been surpassed. If it is determined that the second interval has not been surpassed, then the active implantable medical device is transitioned into a second state. If it is determined that the second interval has been surpassed, then it is ensured that the active implantable medical device is in a predetermined one of the first and second states.

公开(公告)号：US09302111B2

公开(公告)日：2016-04-05

申请号：US14282983

申请日：2014-05-20

Applicant: NeuroPace, Inc.

Inventor： Michael Sasha John ,  Benjamin D. Pless ,  Brett Wingeier

IPC: A61N1/36 ,  A61B5/1455 ,  A61F7/00 ,  A61N2/02 ,  A61N5/06 ,  A61N7/00 ,  A61B5/02 ,  A61F7/12 ,  A61B5/00 ,  A61B5/0476 ,  A61B5/1459 ,  A61B8/06

CPC classification number: A61N1/36139 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0476 ,  A61B5/14553 ,  A61B5/1459 ,  A61B5/4094 ,  A61B5/6868 ,  A61B5/7217 ,  A61B8/06 ,  A61B8/12 ,  A61B8/488 ,  A61F7/00 ,  A61F7/12 ,  A61N1/36057 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/36135 ,  A61N2/006 ,  A61N2/02 ,  A61N5/0622 ,  A61N7/00 ,  A61N2007/0043

Abstract: A system includes an implantable neurostimulator device capable of modulating cerebral blood flow to treat epilepsy and other neurological disorders. In one embodiment, the system is capable of modulating cerebral blood flow (also referred to as cerebral perfusion) in response to measurements and other observed conditions. Perfusion may be increased or decreased by systems and methods according to the invention as clinically required.

Abstract translation: 一种系统包括能够调节脑血流量以治疗癫痫和其他神经障碍的可植入神经刺激器装置。 在一个实施方案中，系统能够响应于测量和其他观察到的条件而调节脑血流量（也称为脑灌注）。 根据临床要求的根据本发明的系统和方法可以增加或减少灌注。

公开(公告)号：US20130102833A1

公开(公告)日：2013-04-25

申请号：US13714387

申请日：2012-12-13

Applicant: NEUROPACE, INC.

Inventor： Michael Sasha John ,  Benjamin D. Pless ,  Brett Wingeier

IPC: A61N2/02 ,  A61N7/00 ,  A61N1/36 ,  A61N5/06 ,  A61F7/00

CPC classification number: A61N1/36139 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0476 ,  A61B5/14553 ,  A61B5/1459 ,  A61B5/4094 ,  A61B5/6868 ,  A61B5/7217 ,  A61B8/06 ,  A61B8/12 ,  A61B8/488 ,  A61F7/00 ,  A61F7/12 ,  A61N1/36057 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/36135 ,  A61N2/006 ,  A61N2/02 ,  A61N5/0622 ,  A61N7/00 ,  A61N2007/0043

Abstract: A system including an implantable neurostimulator device capable of modulating cerebral blood flow to treat epilepsy and other neurological disorders. In one embodiment, the system is capable of modulating cerebral blood flow (also referred to as cerebral perfusion) in response to measurements and other observed conditions. Perfusion may be increased or decreased by systems and methods according to the invention as clinically required.

公开(公告)号：US09597494B2

公开(公告)日：2017-03-21

申请号：US15178525

申请日：2016-06-09

Applicant: NeuroPace, Inc.

Inventor： Brett Wingeier ,  Benjamin Pless

IPC: A61N7/02 ,  A61N7/00 ,  A61N1/05 ,  A61N1/36 ,  A61N5/06 ,  A61N1/30 ,  A61B5/0478 ,  A61B5/04 ,  A61N1/20 ,  A61F7/00 ,  A61F7/12 ,  A61N2/00 ,  A61B18/02 ,  A61B18/14 ,  A61B18/18

CPC classification number: A61N1/0539 ,  A61B5/04 ,  A61B5/0478 ,  A61B18/02 ,  A61B18/14 ,  A61B90/98 ,  A61B2018/1807 ,  A61F7/0085 ,  A61F7/12 ,  A61F2007/0002 ,  A61F2007/0056 ,  A61F2007/126 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0536 ,  A61N1/20 ,  A61N1/303 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N2/006 ,  A61N5/0601 ,  A61N5/0622 ,  A61N7/022 ,  A61N2007/0026

Abstract: Systems, methods and devices are disclosed for directing and focusing signals to the brain for neuromodulation and for directing and focusing signals or other energy from the brain for measurement, heat transfer and imaging. An aperture in the skull and/or a channel device implantable in the skull can be used to facilitate direction and focusing. Treatment and diagnosis of multiple neurological conditions may be facilitated with the disclosed systems, methods and devices.

公开(公告)号：US20160339243A1

公开(公告)日：2016-11-24

申请号：US15225741

申请日：2016-08-01

Applicant: NeuroPace, Inc.

Inventor： Brett Wingeier ,  Daniel Chao ,  Benjamin Pless ,  Thomas Tcheng

IPC: A61N1/36 ,  A61N1/20 ,  A61B90/10 ,  A61N5/06 ,  A61N1/05 ,  A61N1/04 ,  A61N1/30

CPC classification number: A61N1/36025 ,  A61B5/4064 ,  A61B5/4076 ,  A61B5/4094 ,  A61B5/6864 ,  A61B8/0808 ,  A61B18/02 ,  A61B18/14 ,  A61B90/10 ,  A61B2018/1807 ,  A61B2090/103 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0536 ,  A61N1/0539 ,  A61N1/205 ,  A61N1/303 ,  A61N1/36017 ,  A61N5/0601

Abstract: Methods, devices, and systems induce neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Methods, devices, and systems identify where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces include diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.

Abstract translation: 方法，装置和系统通过将颅骨/脑界面以颅骨形成的孔的形式，颅骨中的天然存在的开窗或经颅通道聚焦刺激源来诱导神经调节。 方法，设备和系统识别在哪里定位颅骨/脑界面，可以与界面一起使用的附件，以及用于控制通过界面传递的刺激的功能。 头颅/脑界面的多种适应症包括诊断和治疗神经障碍和疾病如癫痫，运动障碍，抑郁症，阿尔茨海默病，孤独症，昏迷和疼痛。

公开(公告)号：US09289143B2

公开(公告)日：2016-03-22

申请号：US14506817

申请日：2014-10-06

Applicant: NeuroPace, Inc.

Inventor： Brett Wingeier ,  Benjamin Pless

IPC: A61N1/05 ,  A61B5/04 ,  A61B5/0478 ,  A61B18/02 ,  A61B18/14 ,  A61B18/18 ,  A61N1/20 ,  A61N1/30 ,  A61N1/36 ,  A61N5/06

CPC classification number: A61N1/0539 ,  A61B5/04 ,  A61B5/0478 ,  A61B18/02 ,  A61B18/14 ,  A61B90/98 ,  A61B2018/1807 ,  A61F7/0085 ,  A61F7/12 ,  A61F2007/0002 ,  A61F2007/0056 ,  A61F2007/126 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0536 ,  A61N1/20 ,  A61N1/303 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N2/006 ,  A61N5/0601 ,  A61N5/0622 ,  A61N7/022 ,  A61N2007/0026

Abstract: Systems, methods and devices are disclosed for directing and focusing signals to the brain for neuromodulation and for directing and focusing signals or other energy from the brain for measurement, heat transfer and imaging. An aperture in the skull and/or a channel device implantable in the skull can be used to facilitate direction and focusing. Treatment and diagnosis of multiple neurological conditions may be facilitated with the disclosed systems, methods and devices.

公开(公告)号：US09167978B2

公开(公告)日：2015-10-27

申请号：US14506819

申请日：2014-10-06

Applicant: NeuroPace, Inc.

Inventor： Brett Wingeier ,  Benjamin Pless

IPC: A61N1/05 ,  A61N5/04 ,  A61B5/04 ,  A61B5/0478 ,  A61B18/02 ,  A61B18/14 ,  A61B18/18 ,  A61N1/20 ,  A61N1/30 ,  A61N1/36 ,  A61N5/06

CPC classification number: A61N1/0539 ,  A61B5/04 ,  A61B5/0478 ,  A61B18/02 ,  A61B18/14 ,  A61B90/98 ,  A61B2018/1807 ,  A61F7/0085 ,  A61F7/12 ,  A61F2007/0002 ,  A61F2007/0056 ,  A61F2007/126 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0536 ,  A61N1/20 ,  A61N1/303 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N2/006 ,  A61N5/0601 ,  A61N5/0622 ,  A61N7/022 ,  A61N2007/0026

Abstract: Systems, methods and devices are disclosed for directing and focusing signals to the brain for neuromodulation and for directing and focusing signals or other energy from the brain for measurement, heat transfer and imaging. An aperture in the skull and/or a channel device implantable in the skull can be used to facilitate direction and focusing. Treatment and diagnosis of multiple neurological conditions may be facilitated with the disclosed systems, methods and devices.