-
11.发明申请公开(公告)号：US20170068018A1
公开(公告)日：2017-03-09
申请号：US15249577
申请日：2016-08-29
Applicant: Novartis AG
Inventor： Xinming Qian , Frank Chang , Yasuo Matsuzawa , Venkat Shankar
CPC classification number: G02B1/043 , A61F2/14 , A61F2/1451 , A61F2/16 , A61F9/00781 , A61F2210/0061 , A61L12/04 , A61L27/18 , A61L27/34 , A61L2400/10 , A61L2400/18 , A61L2430/16 , C08L83/04
Abstract: The invention is related to a medical device comprising a core material made of a crosslinked silicone material and a hydrogel coating which is thermodynamically stable. The invention is also related to a method for producing such a medical device, especially a soft contact lens.
Abstract translation: 本发明涉及一种医疗装置，其包括由交联的硅氧烷材料制成的芯材料和热力学稳定的水凝胶涂层。 本发明还涉及一种用于制造这种医疗装置，特别是软性隐形眼镜的方法。
-
公开(公告)号：US09541676B2
公开(公告)日：2017-01-10
申请号：US14793767
申请日：2015-07-08
Applicant: Novartis AG
Inventor： Frank Chang
CPC classification number: G02B1/043 , B29D11/00038 , C07F7/0838 , C07F7/089 , C08F30/08 , C08L83/04 , C08L33/26 , C08L101/14
Abstract: The invention provides an amphiphilic siloxane-containing vinylic monomer which comprises one sole ethylenically unsaturated group and a siloxane-containing group covalently linked to the ethylenically-unsaturated group through a hydrophilic linker. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing vinylic monomer of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an amphiphilic siloxane-containing vinylic monomer of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention.
Abstract translation: 本发明提供了一种含两个含硅氧烷的乙烯基单体，其包括一个唯一的烯键式不饱和基团和通过亲水接头与烯键式不饱和基团共价连接的含硅氧烷基团。 本发明还涉及包含衍生自本发明的两亲性硅氧烷的乙烯基单体的单体单元的聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜。 此外，本发明提供了一种使用包含本发明的两亲性含硅氧烷的乙烯基单体和/或本发明的可光化交联的含硅氧烷预聚物的水性透镜形成剂制备硅酮水凝胶隐形眼镜的方法。
-
公开(公告)号：US20160326395A1
公开(公告)日：2016-11-10
申请号：US15216125
申请日：2016-07-21
Applicant: Novartis AG
Inventor： Troy Vernon Holland , Frank Chang , Yongxing Qiu , John Dallas Pruitt , Chung-Yuan Chiang , Venkat Shankar , Robert Scott , Yash Kapoor
IPC: C09D133/24 , C07D205/04 , C08F220/56 , B29D11/00 , C08F224/00 , C09D137/00 , C08F283/12 , C09D151/08 , C08F220/54 , C09D133/26
CPC classification number: C09D133/24 , B29D11/00865 , C07D205/04 , C08F20/00 , C08F26/00 , C08F220/54 , C08F220/56 , C08F224/00 , C08F283/124 , C08F2500/26 , C09D133/26 , C09D137/00 , C09D139/04 , C09D151/085
Abstract: The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.
-
公开(公告)号：US09329306B2
公开(公告)日：2016-05-03
申请号：US14694590
申请日：2015-04-23
Applicant: Novartis AG
Inventor： Jinyu Huang , Frank Chang
CPC classification number: G02B1/043 , C07F7/0838 , C07F7/1804 , C08F30/08 , C08F230/08 , C08G77/12 , C08G77/26 , C08L83/04 , C08L101/14
Abstract: The invention provides a carbosiloxane vinylic monomer which comprises one sole ethylenically unsaturated group, one sole terminal butyl group; and one oligo(carbosiloxane)-containing linkage between the ethylenically unsaturated terminal group and the terminal butyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from a carbosiloxane vinylic monomer of the invention.
Abstract translation: 本发明提供一种碳硅氧烷乙烯基单体，其包含一个唯一的烯键式不饱和基团，一个唯一的末端丁基基团; 和烯键式不饱和端基和末端丁基之间的一个低聚（碳硅氧烷）键。 本发明还涉及包含衍生自本发明的碳硅氧烷乙烯基单体的单体单元的聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜。
-
公开(公告)号：US09315669B2
公开(公告)日：2016-04-19
申请号：US14494186
申请日：2014-09-23
Applicant: Novartis AG
Inventor： Troy Vernon Holland , Frank Chang , Uwe Haken , Joseph I. Weinschenk, III
IPC: C08F2/46 , C08F2/50 , C08G61/04 , C08L83/04 , G02B1/04 , C08F220/54 , C08F230/08
CPC classification number: C08L83/04 , C08F2/48 , C08F220/54 , C08F230/08 , G02B1/043 , C08L33/26
Abstract: Described herein is a method for producing UV-absorbing silicone hydrogel contact lenses, which is free or substantially free of internal stress and also is capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 381 nm to 440 nm, according to a photocuring technology, preferably according to the Lightstream Technology™. This invention also provides UV-absorbing contact lenses made according to a method of the invention.
Abstract translation: 本文描述了一种生产紫外线吸收硅酮水凝胶隐形眼镜的方法，该隐形眼镜是游离的或基本上没有内应力的，并且还能够阻挡紫外线（“UV”）辐射和任选（但优选地）紫色辐射，其波长从 381nm至440nm，根据光固化技术，优选根据Lightstream Technology TM。 本发明还提供了根据本发明的方法制造的紫外线吸收隐形眼镜。
-
Patent Agency Ranking
公开(公告)号：US09268064B2
公开(公告)日：2016-02-23
申请号：US14755060
申请日：2015-06-30
Applicant: Novartis AG
Inventor： Frank Chang , Jian S. Zhou
CPC classification number: G02B1/043 , C07F7/0838 , C08F220/58 , C08F220/60 , C08F230/08 , C08F2220/585 , C08F2220/606 , C08L43/04 , C08L101/14 , C08L33/26 , C08L83/04
Abstract: The invention provides an amphiphilic siloxane-containing (meth)acrylamide which comprises one sole (meth)acrylamido group, one sole tris(trimethylsiloxy)silyl group, and one polyethylene glycol segment which is either dangling polymer chain or a hydrophilic linker between the (meth)acrylamido group and the tris(trimethylsiloxy)silyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing (meth)acrylamido group, one tris(trimethylsiloxy)silyl group of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an amphiphilic siloxane-containing (meth)acrylamido group, one tris(trimethylsiloxy)silyl group of the invention and/or an actinically-crosslinkable silicone -containing prepolymer of the invention.
Abstract translation: 本发明提供了一种两亲硅氧烷（甲基）丙烯酰胺，其包括一个底部（甲基）丙烯酰胺基，一个底部三（三甲基甲硅烷氧基）甲硅烷基和一个聚乙二醇链段，其是悬挂聚合物链或在（甲基） ）丙烯酰胺基和三（三甲基甲硅烷氧基）甲硅烷基。 本发明还涉及聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜，其包含衍生自两亲硅氧烷的（甲基）丙烯酰胺基的单体单元，一个 三（甲基甲硅烷氧基）甲硅烷基。 另外，本发明提供一种使用包含本发明的两亲性硅氧烷（甲基）丙烯酰胺基，一个三（三甲基甲硅烷氧基）甲硅烷基和/或光化学反应的水性透镜形成剂的硅酮水凝胶隐形眼镜的制备方法 - 可交联的含硅氧烷的预聚物。
-
公开(公告)号：US20150309211A1
公开(公告)日：2015-10-29
申请号：US14694590
申请日：2015-04-23
Applicant: Novartis AG
Inventor： Jinyu Huang , Frank Chang
IPC: G02B1/04 , C08F230/08 , C07F7/18 , C08F30/08
CPC classification number: G02B1/043 , C07F7/0838 , C07F7/1804 , C08F30/08 , C08F230/08 , C08G77/12 , C08G77/26 , C08L83/04 , C08L101/14
Abstract: The invention provides a carbosiloxane vinylic monomer which comprises one sole ethylenically unsaturated group, one sole terminal butyl group; and one oligo(carbosiloxane)-containing linkage between the ethylenically unsaturated terminal group and the terminal butyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from a carbosiloxane vinylic monomer of the invention.
Abstract translation: 本发明提供一种碳硅氧烷乙烯基单体，其包含一个唯一的烯键式不饱和基团，一个唯一的末端丁基基团; 和烯键式不饱和端基和末端丁基之间的一个低聚（碳硅氧烷）键。 本发明还涉及包含衍生自本发明的碳硅氧烷乙烯基单体的单体单元的聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜。
-
公开(公告)号：US20150301228A1
公开(公告)日：2015-10-22
申请号：US14755060
申请日：2015-06-30
Applicant: Novartis AG
Inventor： Frank Chang , Jian S. Zhou
IPC: G02B1/04
CPC classification number: G02B1/043 , C07F7/0838 , C08F220/58 , C08F220/60 , C08F230/08 , C08F2220/585 , C08F2220/606 , C08L43/04 , C08L101/14 , C08L33/26 , C08L83/04
Abstract: The invention provides an amphiphilic siloxane-containing (meth)acrylamide which comprises one sole (meth)acrylamido group, one sole tris(trimethylsiloxy)silyl group, and one polyethylene glycol segment which is either dangling polymer chain or a hydrophilic linker between the (meth)acrylamido group and the tris(trimethylsiloxy)silyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing (meth)acrylamido group, one tris(trimethylsiloxy)silyl group of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an amphiphilic siloxane-containing (meth)acrylamido group, one tris(trimethylsiloxy)silyl group of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention.
Abstract translation: 本发明提供了一种两亲硅氧烷（甲基）丙烯酰胺，其包括一个底部（甲基）丙烯酰胺基，一个底部三（三甲基甲硅烷氧基）甲硅烷基和一个聚乙二醇链段，其是悬挂聚合物链或在（甲基） ）丙烯酰胺基和三（三甲基甲硅烷氧基）甲硅烷基。 本发明还涉及聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜，其包含衍生自两亲硅氧烷的（甲基）丙烯酰胺基的单体单元，一个 三（甲基甲硅烷氧基）甲硅烷基。 另外，本发明提供一种使用包含本发明的两亲性硅氧烷（甲基）丙烯酰胺基，一个三（三甲基甲硅烷氧基）甲硅烷基和/或光化反应的水性透镜形成剂的硅酮水凝胶隐形眼镜的制备方法 - 本发明的可交联的含硅氧烷预聚物。
-
公开(公告)号：US20140171543A1
公开(公告)日：2014-06-19
申请号：US14105295
申请日：2013-12-13
Applicant: Novartis AG
Inventor： Frank Chang , Manivakkam J. Shankernarayanan
IPC: G02B1/04
CPC classification number: G02B1/043 , B29C35/08 , B29C39/006 , B29C39/026 , B29K2083/00 , B29L2011/0041 , C08G18/61 , C08G18/755 , C08G73/0233 , C08G73/0246 , C08G77/452 , G02C7/049 , C08L83/04 , C08L101/14 , C08G18/10 , C08G18/6453 , C08G18/6415 , C08G18/2825 , C08G18/4833
Abstract: The invention provide a class of actinically-crosslinkable amphiphilic prepolymers which comprise at least one polysiloxane segment, at least one polyoxazoline segment, and two terminal ene groups. The present invention is also related to a medical device comprising a silicone hydrogel material obtained from step-growth polymerization of a polymerizable material comprising a prepolymer of the invention and to a method for producing contact lenses from a prepolymer of the invention.
Abstract translation: 本发明提供一类包含至少一个聚硅氧烷链段，至少一个聚恶唑啉链段和两个末端烯基的可光化交联的两亲性预聚物。 本发明还涉及包含由包含本发明的预聚物的可聚合材料的步进生长聚合获得的硅酮水凝胶材料和由本发明的预聚物制备隐形眼镜的方法的医疗装置。
-
公开(公告)号：US11001647B2
公开(公告)日：2021-05-11
申请号：US16280081
申请日：2019-02-20
Applicant: Novartis AG
Inventor： Frank Chang , Troy Vernon Holland , Xinming Qian , Robert Scott , Joseph Michael Lindacher , Uwe Haken
Abstract: The invention is related to a method for producing silicone medical devices, in particular, silicone contact lenses, having consistent mechanical properties in a cost-effective manner. The invention is also related to a silicone medical device, especially a soft silicone contact lens.
-
-
-
-
-
-
-
-
-
Search Results
110
records
(took 0.033 seconds)
