Human hydrolase family members and uses thereof
    13.
    发明授权
    Human hydrolase family members and uses thereof 失效
    人类水解酶家族成员及其用途

    公开(公告)号:US07160693B2

    公开(公告)日:2007-01-09

    申请号:US11244219

    申请日:2005-10-05

    申请人: Rachel E. Meyers

    发明人: Rachel E. Meyers

    摘要: The invention provides isolated nucleic acids molecules, designated 26443 and 46873 nucleic acid molecules, which encode novel human hydrolase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26443 and 46873 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26443 and 46873 gene has been introduced or disrupted. The invention still further provides isolated 26443 and 46873 proteins, fusion proteins, antigenic peptides and anti-26443 or 46873 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译: 本发明提供编码新的人水解酶家族成员的分离的核酸分子,命名为26443和46873核酸分子。 本发明还提供了反义核酸分子,含有26443和46873核酸分子的重组表达载体,已经引入表达载体的宿主细胞,以及引入或破坏了26443和46873基因的非人类转基因动物。 本发明还进一步提供分离的26443和46873蛋白,融合蛋白,抗原肽和抗26443或46873抗体。 还提供了利用本发明组合物的诊断方法。

    Human protein kinase, phosphatase, and protease family members and uses thereof
    15.
    发明授权
    Human protein kinase, phosphatase, and protease family members and uses thereof 失效
    人蛋白激酶,磷酸酶和蛋白酶家族成员及其用途

    公开(公告)号:US07070947B2

    公开(公告)日:2006-07-04

    申请号:US10170789

    申请日:2002-06-13

    摘要: The invention provides isolated nucleic acids molecules, designated 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, hexokinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译: 本发明提供编码新的人蛋白激酶家族成员,丝氨酸/苏氨酸蛋白激酶家族的分离的核酸分子,命名为2504,15977,14760,53070,15985,5042,56583,21953,m32404,14089和23436核酸分子 成员,己糖激酶家族成员,丝氨酸/苏氨酸磷酸酶家族成员,脯氨酰寡肽酶家族成员,胰蛋白酶家族成员,胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。 本发明还提供了反义核酸分子,含有2504,15977,14760,53070,15985,5042,26583,21953,m32404,14089或23436核酸分子的重组表达载体,已经引入表达载体的宿主细胞, 和非人类转基因动物,其中引入或破坏了2504,15977,14760,53070,15985,550365,26583,21953,m32404,14089或23436基因。 本发明还进一步提供分离的2504,15977,14760,53070,15985,5038,26583,21953,m32404,14089或23436蛋白,融合蛋白,抗原肽和抗2504,15977,14760,53070,15985,50365, 26583,21953,m32404,14089或23436抗体。 还提供了利用本发明组合物的诊断方法。

    33945, a human glycosyltransferase family member and uses therefor
    16.
    发明授权
    33945, a human glycosyltransferase family member and uses therefor 失效
    33945,人类糖基转移酶家族成员和用途

    公开(公告)号:US06939698B2

    公开(公告)日:2005-09-06

    申请号:US10074527

    申请日:2002-02-12

    摘要: The invention provides isolated nucleic acids molecules, designated 33945 nucleic acid molecules, which encode novel glycosyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33945 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33945 gene has been introduced or disrupted. The invention still further provides isolated 33945 proteins, fusion proteins, antigenic peptides and anti-33945 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译: 本发明提供编码新的糖基转移酶家族成员的分离的核酸分子,命名为33945核酸分子。 本发明还提供了反义核酸分子,含有33945个核酸分子的重组表达载体,其中引入了表达载体的宿主细胞,以及引入或破坏了33945基因的非人转基因动物。 本发明还进一步提供了分离的33945蛋白,融合蛋白,抗原肽和抗33945抗体。 还提供了利用本发明组合物的诊断和治疗方法。

    25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 molecules and uses therefor
    20.
    发明授权
    25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 molecules and uses therefor 失效
    25869,25934,26335,50365,211117,38692,46508,16816,16839,49937,49931和49933分子及其用途

    公开(公告)号:US07411054B2

    公开(公告)日:2008-08-12

    申请号:US11445606

    申请日:2006-06-02

    摘要: The invention provides isolated nucleic acids molecules, designated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 gene has been introduced or disrupted. The invention still further provides isolated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 proteins, fusion proteins, antigenic peptides and anti-25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译: 本发明提供分离的核酸分子,命名为25869,25934,26335,50516,21117,38692,46508,16816,16839,49937,49931和49933核酸分子。 本发明还提供反义核酸分子,包含25869,25934,26335,50521,21117,38692,46508,16816,16839,4467,49931或49933核酸分子的重组表达载体,已经引入了表达载体的宿主细胞 ,以及引入或破坏25869,25934,26335,50365,21117,38692,46508,16816,16839,49937,49931或49933基因的非人类转基因动物。 本发明还进一步提供了分离的25869,2593,26335,50365,21117,38692,46508,16816,16839,49937,49931或49933蛋白,融合蛋白,抗原肽和抗-25869,25934,26335,50365,211117,38692 ,46508,16816,16839,49937,49931或49933抗体。 还提供了利用本发明组合物的诊断和治疗方法。