公开(公告)号：US12194466B2

公开(公告)日：2025-01-14

申请号：US17229086

申请日：2021-04-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Thorsten Brueckner ,  Thomas Fischer ,  Eloisa Lopez-Calle ,  Sascha Lutz ,  Josef Roedl ,  Juergen Spinke ,  Pamela Espindola ,  Thomas Manuel Keller ,  Thomas Dolbinow ,  Sabrina Adler ,  Erik Beiersdorf ,  Domenik Wensorra

IPC: B01L3/00 ,  G01N35/00 ,  G01N35/10

Abstract: A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.

公开(公告)号：US11709145B2

公开(公告)日：2023-07-25

申请号：US17643463

申请日：2021-12-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Sascha Lutz ,  Gregor Ocvirk ,  Christoph Boehm ,  Wolfgang Burkhardt ,  Miriam Ruf ,  Heinz Kontschieder

IPC: G01N27/06 ,  G01N33/487

CPC classification number: G01N27/06 ,  G01N33/48707

Abstract: The present disclosure refers to a sensor assembly for an IVD analyzer, the sensor comprising two opposite substrates with at least one fluidic conduit for receiving a sample. The electrodes of different types of electrochemical sensors are arranged on the two opposite substrates facing the at least one fluidic conduit for coming in contact with the sample and determining sample parameters, wherein the counter electrodes and the reference electrodes are formed on one substrate and the working electrodes are formed on the opposite substrate. This achieves optimal sensor-working conditions in terms of a homogeneous and symmetrical electric field density and enables a sensor assembly with simpler geometry and smaller size.

公开(公告)号：US11673138B2

公开(公告)日：2023-06-13

申请号：US17804013

申请日：2022-05-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Thorsten Brueckner ,  Sascha Lutz

IPC: B01L3/00 ,  B01J20/281 ,  G01N30/74

CPC classification number: B01L3/502715 ,  B01J20/281 ,  B01L3/50273 ,  B01L3/502723 ,  G01N30/482 ,  G01N30/74 ,  B01L2200/027 ,  B01L2200/0621 ,  B01L2200/0684 ,  B01L2200/142 ,  B01L2300/04 ,  B01L2300/0636 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0409

Abstract: A method of performing an optical measurement of an analyte in a processed biological sample using a cartridge is provided. The cartridge is operable for being spun around a rotational axis. The method comprises: placing the biological sample into a sample inlet; controlling the rotational rate of the cartridge to process a biological sample into the processed biological sample using a fluidic structure; controlling the rotational rate of the cartridge to allow the processed biological sample to flow from the measurement structure inlet to an absorbent structure via a chromatographic membrane, and performing an optical measurement of a detection zone on the chromatographic membrane with an optical instrument. An inlet air baffle reduces evaporation of the processed biological sample from the chromatographic membrane during rotation of the cartridge.

公开(公告)号：US11000848B2

公开(公告)日：2021-05-11

申请号：US15982009

申请日：2018-05-17

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Thomas Dolbinow ,  Sabrina Adler ,  Erik Beiersdorf ,  Domenik Wensorra ,  Thorsten Brueckner ,  Thomas Fischer ,  Eloisa Lopez-Calle ,  Sascha Lutz ,  Josef Roedl ,  Juergen Spinke ,  Pamela Espindola ,  Thomas Manuel Keller

IPC: B01L3/00 ,  G01N35/00 ,  G01N35/10

Abstract: A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.

公开(公告)号：US20210069715A1

公开(公告)日：2021-03-11

申请号：US17099970

申请日：2020-11-17

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Thorsten Brueckner ,  Sascha Lutz ,  Alexander Keuchel

IPC: B01L3/00

Abstract: A cartridge including a structural part with a hole surrounded at least partially by a recess, so that a wall is formed that separates the hole from the recess. The cartridge includes a liquid pack, wherein the liquid pack comprises a surrounding seal portion and a liquid containing portion. The liquid pack is arranged at least partially in the hole, in that a circumferential outer line of the seal portion protrudes over the hole.

公开(公告)号：US09469464B2

公开(公告)日：2016-10-18

申请号：US14530861

申请日：2014-11-03

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Timo Klein ,  Peter Koltay ,  Nadine Losleben ,  Juergen Spinke ,  Chris Steinert

IPC: B65D83/14 ,  B01L3/02 ,  B01L3/00 ,  G01N35/10

CPC classification number: B65D83/14 ,  B01L3/0265 ,  B01L3/502738 ,  B01L3/505 ,  B01L3/523 ,  B01L3/527 ,  B01L2300/123 ,  B01L2400/0611 ,  G01N35/1016

Abstract: A dispenser for dispensing a fluid is presented. The dispenser comprises a compressible elastomeric fluid conduit having a first end and a second end for flowing the fluid from the first end to the second end, a first check valve and a second check valve distanced in the conduit for forming a fluid chamber, and an actor for compressing the fluid chamber for dispensing a portion of the fluid. At least the second check valve is a duckbill valve. The second check valve is located at the second end of the conduit. The second check valve has sealing lips that extend beyond the second end of the conduit.

Abstract translation: 呈现用于分配流体的分配器。 分配器包括可压缩弹性体流体导管，其具有第一端和用于使流体从第一端流到第二端的第二端，在导管中间隔开形成流体室的第一止回阀和第二止回阀，以及 演员，用于压缩流体室以分配一部分流体。 至少第二止回阀是鸭嘴阀。 第二止回阀位于导管的第二端。 第二止回阀具有延伸超出导管第二端的密封唇。

公开(公告)号：US12042795B2

公开(公告)日：2024-07-23

申请号：US17099970

申请日：2020-11-17

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Thorsten Brueckner ,  Sascha Lutz ,  Alexander Keuchel

IPC: B01L3/00

CPC classification number: B01L3/523 ,  B01L2200/026 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2400/0478

Abstract: A cartridge including a structural part with a hole surrounded at least partially by a recess, so that a wall is formed that separates the hole from the recess. The cartridge includes a liquid pack, wherein the liquid pack comprises a surrounding seal portion and a liquid containing portion. The liquid pack is arranged at least partially in the hole, in that a circumferential outer line of the seal portion protrudes over the hole.

公开(公告)号：US20230304953A1

公开(公告)日：2023-09-28

申请号：US18326379

申请日：2023-05-31

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Sascha Lutz ,  Gregor Ocvirk ,  Christoph Boehm ,  Wolfgang Burkhardt ,  Miriam Ruf ,  Heinz Kontschieder

IPC: G01N27/06 ,  G01N33/487

CPC classification number: G01N27/06 ,  G01N33/48707

Abstract: The present disclosure refers to a sensor assembly for an IVD analyzer, the sensor comprising two opposite substrates with at least one fluidic conduit for receiving a sample. The electrodes of different types of electrochemical sensors are arranged on the two opposite substrates facing the at least one fluidic conduit for coming in contact with the sample and determining sample parameters, wherein the counter electrodes and the reference electrodes are formed on one substrate and the working electrodes are formed on the opposite substrate. This achieves optimal sensor-working conditions in terms of a homogeneous and symmetrical electric field density and enables a sensor assembly with simpler geometry and smaller size.

公开(公告)号：US10416054B2

公开(公告)日：2019-09-17

申请号：US15387007

申请日：2016-12-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Thorsten Brueckner ,  Sascha Lutz ,  Bruntje Esrom ,  Michael Herbel

IPC: G01N1/40 ,  G01N1/10 ,  G01N1/28 ,  G01N33/49 ,  G01N21/07 ,  G01N21/84 ,  B01L3/00 ,  B01D17/02 ,  A61B5/15 ,  A61B5/157 ,  A61B10/00

Abstract: System and method of determining an amount of an analyte in a blood sample using a cartridge and blood collector are disclosed. The blood collector has a mounting surface, a capillary structure with a curved portion, and a capillary inlet. The cartridge has a receiving surface, a cartridge inlet, a microfluidic structure, and a measurement structure. The method includes placing the blood sample into the capillary inlet; attaching the mounting surface to the receiving surface; rotating the cartridge about a rotational axis to transport the blood sample from the capillary structure to the cartridge inlet and into the microfluidic structure; controlling the rotation of the cartridge to process the blood sample into the processed sample using the microfluidic structure; controlling the rotation of the cartridge to transfer the processed sample to the measurement structure; and measuring the amount of the analyte using the measurement structure and a measurement system.

公开(公告)号：US20180369812A1

公开(公告)日：2018-12-27

申请号：US16116174

申请日：2018-08-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Thorsten Brueckner ,  Sascha Lutz

IPC: B01L3/00 ,  G01N30/74 ,  B01J20/281

Abstract: A method of performing an optical measurement of an analyte in a processed biological sample using a cartridge is provided. The cartridge is operable for being spun around a rotational axis. The method comprises: placing the biological sample into a sample inlet; controlling the rotational rate of the cartridge to process a biological sample into the processed biological sample using a fluidic structure; controlling the rotational rate of the cartridge to allow the processed biological sample to flow from the measurement structure inlet to an absorbent structure via a chromatographic membrane, and performing an optical measurement of a detection zone on the chromatographic membrane with an optical instrument. An inlet air baffle reduces evaporation of the processed biological sample from the chromatographic membrane during rotation of the cartridge.