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    MEDICAL DEVICES WITH DEFINABLE POROSITY PRODUCED BY BACTERIAL POLYMER BIO-SYNTHESIS
    11.
    发明申请
    MEDICAL DEVICES WITH DEFINABLE POROSITY PRODUCED BY BACTERIAL POLYMER BIO-SYNTHESIS 有权
    通过细菌聚合物生物合成生产的具有可定义孔隙度的医疗装置

    公开(公告)号：US20110263841A1

    公开(公告)日：2011-10-27

    申请号：US13125647

    申请日：2009-11-06

    Applicant: Yves Bayon ,  Sébastien Ladet ,  Olivier Lefranc ,  Philippe Gravagna

    Inventor： Yves Bayon ,  Sébastien Ladet ,  Olivier Lefranc ,  Philippe Gravagna

    IPC: C08B15/00 ,  C12P19/04

    CPC classification number: A61L27/20 ,  A61L27/56 ,  C12P19/04 ,  C08L1/02

    Abstract: The present invention relates to a method of forming an implantable medical device comprising: culturing polymer-producing bacteria preferably Acetobacter xylinum in the presence of a degradable support; and removing the degradable support to recover an implant having pores of a configuration determined at least in part by the configuration of the degradable support. The invention also relates to a medical device obtained by such a method.

    Abstract translation: 本发明涉及一种形成可植入医疗器械的方法，包括：在可降解支持物的存在下培养聚合物产生细菌优选醋酸醋杆菌; 以及去除所述可降解载体以回收具有至少部分地由所述可降解载体的构型确定的构型的孔的植入物。 本发明还涉及通过这种方法获得的医疗装置。

    Surgical fasteners and methods for sealing wounds
    14.
    发明授权
    Surgical fasteners and methods for sealing wounds 有权
    手术紧固件和密封伤口的方法

    公开(公告)号：US09272074B2

    公开(公告)日：2016-03-01

    申请号：US13070598

    申请日：2011-03-24

    Applicant: Sébastien Ladet

    Inventor： Sébastien Ladet

    IPC: A61B17/00 ,  A61L31/04 ,  A61L31/08 ,  A61L31/10 ,  A61B17/064 ,  A61B17/122

    CPC classification number: A61B17/0644 ,  A61B17/064 ,  A61B17/122 ,  A61B2017/00884 ,  A61L31/04 ,  A61L31/08 ,  A61L31/10 ,  A61L31/16

    Abstract: A method for closing a wound in tissue is provided which includes providing a surgical fastener having a plurality of reactive members of a specific binding pair attached on a surface of the surgical fastener, and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the surface of the surgical fastener with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the device to the tissue.

    Abstract translation: 提供了一种用于闭合组织中的伤口的方法，其包括提供外科紧固件，所述手术紧固件具有附接在手术紧固件的表面上的特定结合对的多个反应性构件，并且向组织提供特定结合物的多个互补的反应性成员 其中当外科紧固件的表面上的反应性构件与组织上的互补的反应构件接触时，在反应构件和互补的反应构件之间形成共价键，从而将该装置粘附到组织上。

    Apparatus and method of reacting polymers passing through metal ion chelated resin matrix to produce injectable medical devices
    20.
    发明授权
    Apparatus and method of reacting polymers passing through metal ion chelated resin matrix to produce injectable medical devices 有权
    使通过金属离子螯合树脂基质的聚合物反应产生可注射医疗器械的装置和方法

    公开(公告)号：US09039979B2

    公开(公告)日：2015-05-26

    申请号：US13202348

    申请日：2010-02-22

    Applicant: Sébastien Ladet ,  Philippe Gravagna

    Inventor： Sébastien Ladet ,  Philippe Gravagna

    IPC: B01J19/18 ,  B01J19/00 ,  B01J14/00 ,  A61B17/00 ,  B01F5/06 ,  B01F13/00 ,  B01J23/72 ,  B01J35/04

    CPC classification number: B01J19/18 ,  A61B17/00491 ,  A61B2017/00495 ,  B01F5/0615 ,  B01F5/0683 ,  B01F5/0688 ,  B01F13/002 ,  B01F13/0023 ,  B01J14/005 ,  B01J19/0053 ,  B01J19/0066 ,  B01J23/72 ,  B01J35/04 ,  B01J2219/00761 ,  C08G63/66

    Abstract: The present disclosure relates to an apparatus and process for forming medical devices from an injectable composition. The apparatus includes a supply assembly configured to maintain and selective dispense a first precursor and a second precursor, a mixing assembly configured to mix the first and second precursors, and at least one catalyzing element including a transition metal ion to aid in the polymerization of the first and second precursors. The process includes dispensing a volume of the first precursor and a volume of the second precursor into a mixing assembly and mixing the first and second precursors. The first and second precursors each possess a core and at least one functional group known to have click reactivity with each other. The mixed precursors are contacted with a transition metal catalyst to produce a flowable composition for use as a medical device.

    Abstract translation: 本公开涉及一种用于从可注射组合物形成医疗装置的装置和方法。 该设备包括供应组件，其被配置为维持和选择性地分配第一前体和第二前体，配置成混合第一和第二前体的混合组件和包含过渡金属离子的至少一个催化元素以有助于聚合 第一和第二前体。 该方法包括将体积的第一前体和体积的第二前体分配到混合组件中并混合第一和第二前体。 第一和第二前体各自具有核心和至少一个已知具有彼此具有点击反应性的官能团。 混合的前体与过渡金属催化剂接触以产生用作医疗装置的可流动组合物。

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