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公开(公告)号：US5658780A
公开(公告)日：1997-08-19
申请号：US291932
申请日：1994-08-15
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N9/64 , C12N15/10 , C12N15/113 , C12Q1/68 , C07H21/04 , C12N15/85
CPC分类号： C12N15/101 , C07K14/4702 , C12N15/113 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3517 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535
摘要： Enzymatic RNA molecules which cleave rel A mRNA.
摘要翻译： 分解相关A mRNA的酶RNA分子。
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12.发明授权Method and reagent for treatment of diseases by expression of the c-Myc gene 失效通过c-Myc基因表达治疗疾病的方法和试剂公开(公告)号：US06544755B1
公开(公告)日：2003-04-08
申请号：US08192943
申请日：1994-02-07
IPC分类号： C07H2104
CPC分类号： C12N15/113 , C12N15/1135 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126
摘要： An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of Burkitt's lymphoma or acute lymphocytic leukemia.
摘要翻译： 一种酶切RNA分子，其切割与发展或维持伯基特氏淋巴瘤或急性淋巴细胞性白血病相关的mRNA。
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公开(公告)号：US5869253A
公开(公告)日：1999-02-09
申请号：US774306
申请日：1996-12-26
申请人： Kenneth G. Draper
发明人： Kenneth G. Draper
IPC分类号： C12N15/09 , A61K35/12 , A61K38/00 , A61K39/29 , A61K48/00 , A61P1/16 , A61P31/12 , C07H21/02 , C07K14/08 , C12N5/10 , C12N7/00 , C12N9/00 , C12N15/113 , C12N15/51 , C12N15/85 , C12N15/86 , C12Q1/70 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/1131 , C07K14/005 , C12N15/85 , C12N15/86 , C12Q1/701 , C12Q1/707 , A61K38/00 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2770/24222 , C12N2770/24243
摘要： An enzymatic RNA molecule which specifically cleaves RNA of a hepatitis C virus.
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14.发明授权
公开(公告)号：US5622854A
公开(公告)日：1997-04-22
申请号：US192941
申请日：1994-02-07
申请人： Kenneth G. Draper
发明人： Kenneth G. Draper
IPC分类号： A61K38/00 , C12N15/113 , C12N15/85 , A61K48/00 , C12Q1/68
CPC分类号： C12N15/1132 , A61K38/00 , C12N2310/111 , C12N2310/121 , C12N2310/53
摘要： An enzymatic RNA molecule which specifically cleaves RNA of HTLV-1.
摘要翻译： 一种特异性切割HTLV-1 RNA的酶RNA分子。
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15.发明授权
公开(公告)号：US5514577A
公开(公告)日：1996-05-07
申请号：US31147
申请日：1993-03-12
申请人： Kenneth G. Draper , Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Ronnie C. Hanecak , Kevin P. Anderson , Vickie L. Brown-Driver , Jacqueline R. Wyatt
发明人： Kenneth G. Draper , Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Ronnie C. Hanecak , Kevin P. Anderson , Vickie L. Brown-Driver , Jacqueline R. Wyatt
IPC分类号： C12N15/09 , A61K31/70 , A61K31/7088 , A61K38/00 , A61P31/12 , A61P31/22 , C07H21/00 , C07H21/04 , C07K14/03 , C12N15/113 , C12N15/117 , C12Q1/70 , C12N7/06
CPC分类号： C12N15/1133 , A61K31/70 , C07H21/00 , C07K14/005 , C12N15/1137 , C12N15/117 , C12Q1/701 , C12Y207/07049 , C12Y301/01004 , A61K38/00 , C12N2310/151 , C12N2310/18 , C12N2310/3125 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/346 , C12N2310/3517 , C12N2310/3521 , C12N2710/16622
摘要： Compositions and methods are provided for the treatment and diagnosis of herpesvirus infections. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with RNA or DNA deriving from a herpesvirus gene corresponding to one of the open reading frames UL5, UL8, UL9, UL20, UL27, UL29, UL30, UL42, UL52 and IE175 of herpes simplex virus type 1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a translation initiation site, a coding region or a 5'-untranslated region. Methods of treating animals suspected of being infected with herpesvirus comprising contacting the animal with an oligonucleotide of the invention are disclosed. Methods for treatment of infections caused by herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, human herpes virus 6, Epstein Barr virus or varicella zoster virus are disclosed.
摘要翻译： 提供组合物和方法用于治疗和诊断疱疹病毒感染。 根据优选实施方案，提供寡核苷酸，其与衍生自对应于开放阅读框UL5，UL8，UL9，UL20，UL27，UL29，UL20，UL27，UL29，UL30，UL42，UL52和IE175之一的疱疹病毒基因的RNA或DNA特异性杂交 单纯疱疹病毒1型。寡核苷酸包含足以实现所述特异性杂交的同一性和数目的核苷酸单元。 在其它优选实施方案中，寡核苷酸与翻译起始位点，编码区或5'-非翻译区具体杂交。 公开了治疗疑似被疱疹病毒感染的动物的方法，包括使动物与本发明的寡核苷酸接触。 公开了用于治疗由单纯疱疹病毒1型，2型单纯疱疹病毒，巨细胞病毒，人疱疹病毒6，爱泼斯坦巴尔病毒或水痘带状疱疹病毒引起的感染的方法。
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公开(公告)号：US5248670A
公开(公告)日：1993-09-28
申请号：US485297
申请日：1990-02-26
IPC分类号： A61K31/70 , A61K38/00 , A61K48/00 , A61P31/12 , A61P31/22 , C07H21/00 , C07K14/03 , C12N7/04 , C12N15/09 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1133 , C07K14/005 , A61K38/00 , C12N2310/3125 , C12N2310/315 , C12N2710/16622
摘要： Antisense oligonucleotides are disclosed having a length of 15-30 nucleotides containing the CAT sequence and hybridizable to herpes simplex virus type I gene UL13, UL39, or UL40. These antisense oligomers inhibit the replication of the virus at least three-fold. Pharmaceutical compositions containing these oligonucleotides as the active ingredients are also disclosed.
摘要翻译： 公开了具有长度为15-30个核苷酸的反义寡核苷酸，其含有CAT序列并可与单纯疱疹病毒I型基因UL13，UL39或UL40杂交。 这些反义寡聚体抑制病毒复制至少三倍。 还公开了含有这些寡核苷酸作为活性成分的药物组合物。
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公开(公告)号：US5004810A
公开(公告)日：1991-04-02
申请号：US252225
申请日：1988-09-30
申请人： Kenneth G. Draper
发明人： Kenneth G. Draper
IPC分类号： C07H21/00 , C12N15/113
CPC分类号： A61K31/70 , C07H21/00 , C12N15/1133
摘要： Oligomers that are complementary in base sequence to the initiation region on mRNA coding for herpes simplex virus transactivating proteins inhibit the replication of the virus.
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公开(公告)号：US6153595A
公开(公告)日：2000-11-28
申请号：US838715
申请日：1997-04-09
IPC分类号： C12N15/09 , A61K31/712 , A61K38/00 , A61K48/00 , A61P31/22 , C07H21/00 , C07H21/04 , C07K14/045 , C12N9/12 , C12N15/113 , C12Q1/70 , C12Q1/68
CPC分类号： C12N15/1133 , A61K31/70 , A61K31/711 , C07H21/00 , C07K14/005 , C12N9/1252 , C12Q1/705 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/334 , C12N2310/346 , C12N2310/3521 , C12N2310/3525 , C12N2710/16122
摘要： This invention concerns compositions and methods for the treatment of CMV infections. Antisense oligonucleotides are provided which are effective antiviral agents. In preferred embodiments, the oligonucleotides contain at least one 2'-methoxyethoxy modification and may be chimeric oligonucleotides.
摘要翻译： 本发明涉及用于治疗CMV感染的组合物和方法。 提供反义寡核苷酸是有效的抗病毒剂。 在优选实施方案中，寡核苷酸含有至少一个2'-甲氧基乙氧基修饰，并且可以是嵌合寡核苷酸。
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公开(公告)号：US06017756A
公开(公告)日：2000-01-25
申请号：US193627
申请日：1994-02-07
申请人： Kenneth G. Draper
发明人： Kenneth G. Draper
CPC分类号： C12N15/1131 , C12Q1/6876 , A61K38/00 , C12N2310/121
摘要： An enzymatic RNA molecule which specifically cleaves RNA of a hepatitis B virus.
摘要翻译： 一种特异性切割乙型肝炎病毒RNA的酶RNA分子。
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公开(公告)号：US5795778A
公开(公告)日：1998-08-18
申请号：US623891
申请日：1996-03-25
申请人： Kenneth G. Draper
发明人： Kenneth G. Draper
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K38/43 , A61K39/125 , A61K39/13 , A61K39/135 , A61K39/145 , A61K39/21 , A61K39/23 , A61K39/245 , A61K39/29 , A61K48/00 , A61P1/16 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/22 , A61P35/02 , C07H19/06 , C07H21/02 , C07K14/08 , C12N5/10 , C12N7/00 , C12N9/00 , C12N9/22 , C12N15/10 , C12N15/113 , C12N15/85 , C12N15/86 , C12Q1/68 , C12Q1/70 , C12R1/91 , C12R1/93 , G01N33/569 , C07H19/10
CPC分类号： C12N15/86 , C07H19/06 , C07K14/005 , C12N15/1003 , C12N15/113 , C12N15/1131 , C12N15/85 , C12Q1/706 , A61K38/00 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2310/53 , C12N2710/16622 , C12N2740/14043
摘要： An enzymatic RNA molecule which specifically cleaves a herpes simplex virus mRNA molecule.
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