公开(公告)号：US20120059455A1

公开(公告)日：2012-03-08

申请号：US13216371

申请日：2011-08-24

Applicant: Jan Weber ,  Aiden Flanagan ,  Torsten Scheuermann

Inventor： Jan Weber ,  Aiden Flanagan ,  Torsten Scheuermann

IPC: A61L27/54 ,  A61F2/82 ,  C22C23/02

CPC classification number: A61L31/022 ,  A61F2/04 ,  A61F2/07 ,  A61F2/915 ,  A61F2002/91516 ,  A61F2002/91583 ,  A61F2250/0067 ,  A61F2250/0098 ,  A61L31/088 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2420/08 ,  C22C23/02

Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy. The bioerodible magnesium alloy includes magnesium, between 7 and 8 weight percent aluminum, between 0.4 and 0.8 weight percent zinc, and between 0.05 and 0.8 weight percent manganese.

Abstract translation: 生物腐蚀性内置假体包括生物腐蚀性镁合金。 生物腐蚀性镁合金包括镁，7至8重量％的铝，0.4至0.8重量％的锌和0.05至0.8重量％的锰。

公开(公告)号：US20100217370A1

公开(公告)日：2010-08-26

申请号：US12389792

申请日：2009-02-20

Applicant: Torsten Scheuermann ,  Jan Weber ,  Peter Albrecht

Inventor： Torsten Scheuermann ,  Jan Weber ,  Peter Albrecht

IPC: A61F2/06 ,  A61M25/00 ,  B28B21/58 ,  C25F3/24

CPC classification number: A61L31/022 ,  A61L29/02 ,  A61L29/148 ,  A61L31/148

Abstract: A bioerodible stent, having a composition comprising Fe, Mn, Si and C has desirable mechanical, erosion, and physiological characteristics.

Abstract translation: 具有包含Fe，Mn，Si和C的组成的生物可蚀解支架具有期望的机械，侵蚀和生理特性。

公开(公告)号：US20090227949A1

公开(公告)日：2009-09-10

申请号：US12399548

申请日：2009-03-06

Applicant: David Knapp ,  Timothy J. Mickley ,  John Chen ,  Derek Sutermeister ,  Toby Freyman ,  Gordon Kocur ,  Daniel Horn ,  Jim Anderson ,  Ben Arcand ,  Jay Rassat ,  Raed Rizq ,  Irina Nazarova ,  Dan Quillin ,  Jan Weber ,  Torsten Scheuermann

Inventor： David Knapp ,  Timothy J. Mickley ,  John Chen ,  Derek Sutermeister ,  Toby Freyman ,  Gordon Kocur ,  Daniel Horn ,  Jim Anderson ,  Ben Arcand ,  Jay Rassat ,  Raed Rizq ,  Irina Nazarova ,  Dan Quillin ,  Jan Weber ,  Torsten Scheuermann

IPC: A61M25/10

CPC classification number: A61M25/1029 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/416 ,  A61M25/0045 ,  A61M25/10 ,  A61M2025/0056 ,  A61M2025/1031 ,  A61M2025/105 ,  B29L2009/005 ,  C08L53/02

Abstract: Catheter devices having an expandable balloon for delivering a therapeutic agent to a body site. The balloon has one or more folds which serve as a reservoir for containing the therapeutic agent. The fold may have any of various configurations to hold the therapeutic agent. In some cases, the balloon comprises one or more lobes that forms the fold(s). The therapeutic agent may be provided in various ways. For example, the therapeutic agent may be contained in packets that rupture upon expansion of the balloon, or as a plurality of discrete bulk masses, or sealed within compartments.

Abstract translation: 具有用于将治疗剂递送到身体部位的可膨胀气囊的导管装置。 气囊具有一个或多个折叠，其用作容纳治疗剂的储存器。 折叠可以具有保持治疗剂的各种构造中的任何一种。 在一些情况下，气囊包括形成褶皱的一个或多个凸起。 治疗剂可以以各种方式提供。 例如，治疗剂可以包含在囊膨胀时破裂的包装中，或者作为多个离散的体积块，或者密封在隔室内。

公开(公告)号：US20090118809A1

公开(公告)日：2009-05-07

申请号：US11934342

申请日：2007-11-02

Applicant: Torsten Scheuermann ,  Jan Weber

Inventor： Torsten Scheuermann ,  Jan Weber

IPC: A61F2/82

CPC classification number: A61L31/146 ,  A61L31/022 ,  A61L31/082

Abstract: An endoprosthesis such as a coronary stent includes a porous reservoir of drug, e.g. directly in the body of the stent, and an overlayer formed of ceramic or metal for controlling elution of drug from the reservoir

Abstract translation: 诸如冠状动脉支架的内假体包括多孔的药物储库，例如， 直接在支架的体内，以及由陶瓷或金属形成的用于控制药物从储存器洗脱的覆盖层

公开(公告)号：US08071156B2

公开(公告)日：2011-12-06

申请号：US12397509

申请日：2009-03-04

Applicant: Jan Weber ,  Torsten Scheuermann

Inventor： Jan Weber ,  Torsten Scheuermann

IPC: A61L33/00

CPC classification number: A61L33/00 ,  A61L31/088 ,  A61L31/14 ,  A61L31/146

Abstract: A hydrophilic ceramic coating is formed on an endoprosthesis preform. The hydrophilic ceramic coating is porous and can store nano-sized drug particles.

Abstract translation: 在内置假体预成型件上形成亲水性陶瓷涂层。 亲水陶瓷涂层是多孔的，可以存储纳米尺寸的药物颗粒。

公开(公告)号：US20110022158A1

公开(公告)日：2011-01-27

申请号：US12507171

申请日：2009-07-22

Applicant: Liliana Atanasoska ,  Jonathan S. Stinson ,  Charles Deng ,  Dennis A. Boismier ,  Jan Weber ,  Torsten Scheuermann

Inventor： Liliana Atanasoska ,  Jonathan S. Stinson ,  Charles Deng ,  Dennis A. Boismier ,  Jan Weber ,  Torsten Scheuermann

IPC: A61F2/06

CPC classification number: A61L31/022 ,  A61L31/124 ,  A61L31/127 ,  A61L31/148

Abstract: A medical implant includes a bioerodible portion adapted to degrade under physiological conditions. The bioerodible portion includes a bioerodible metal matrix and a salt or clay within the bioerodible metal matrix.

Abstract translation: 医疗植入物包括适于在生理条件下降解的生物可蚀解部分。 生物可蚀解部分包括生物腐蚀性金属基质和生物可腐蚀金属基质内的盐或粘土。

公开(公告)号：US20090123517A1

公开(公告)日：2009-05-14

申请号：US12109677

申请日：2008-04-25

Applicant: Aiden Flanagan ,  Robert Herrmann ,  Ken Merdan ,  Michael Kuehling ,  Barry O'Brien ,  Rajesh Radhakishnan ,  Torsten Scheuermann ,  Scott Schewe ,  Anurag Singhai ,  Young-Ho Song ,  Mary Joe Timm ,  Jan Weber ,  Yixin Xu

Inventor： Aiden Flanagan ,  Robert Herrmann ,  Ken Merdan ,  Michael Kuehling ,  Barry O'Brien ,  Rajesh Radhakishnan ,  Torsten Scheuermann ,  Scott Schewe ,  Anurag Singhai ,  Young-Ho Song ,  Mary Joe Timm ,  Jan Weber ,  Yixin Xu

IPC: A61F2/82 ,  A61L27/00

CPC classification number: A61F2/91 ,  A61F2/3094 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2210/0076 ,  A61F2230/0013 ,  A61F2240/001 ,  A61F2250/0067 ,  A61F2250/0068

Abstract: An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted.

Abstract translation: 一种用于释放具有医疗装置主体的治疗剂的可植入医疗装置和设置在身体表面上的多个储存器限定结构。 储存器可以由储存器限定结构限定，并且治疗剂可以位于储存器中。 覆盖物可以延伸到储存器上方，使得当植入医疗装置时治疗剂从储存器释放。 用于制造医疗装置的方法还可以包括提供医疗装置主体，在身体的表面上定位多个储存器限定结构以形成储存器，将治疗剂装载到储存器中并覆盖储存器，使得治疗剂 当植入医疗器械时可能释放。 或者，储存器可覆盖有形成在盖中的盖和开口，使得治疗剂可以在植入医疗装置时释放。

公开(公告)号：US08920491B2

公开(公告)日：2014-12-30

申请号：US12425791

申请日：2009-04-17

Applicant: Aiden Flanagan ,  John Kilcooley ,  Tim O'Connor ,  Barry O'Brien ,  Dominique Seidel ,  Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber

Inventor： Aiden Flanagan ,  John Kilcooley ,  Tim O'Connor ,  Barry O'Brien ,  Dominique Seidel ,  Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber

IPC: A61F2/06 ,  A61L29/10 ,  A61L29/16 ,  A61L31/08 ,  A61L31/16

CPC classification number: A61L29/10 ,  A61L29/16 ,  A61L31/082 ,  A61L31/16 ,  A61L2300/602 ,  A61L2300/61

Abstract: In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating. In yet another aspect, a medical device has a polymer layer comprising a block co-polymer, wherein the polymer layer contains a therapeutic agent, and a barrier layer disposed over the polymer layer, wherein the barrier layer comprises an inorganic material, and wherein the barrier layer has a plurality of discontinuities. Methods of forming coatings on medical devices and methods of delivering therapeutic agents to body sites are also disclosed.

Abstract translation: 在一个方面，医疗装置具有第一构造和第二构造，包含治疗剂的贮存器和设置在贮存器上方的阻挡层，其中阻挡层包括无机材料。 在另一方面，医疗装置具有容纳治疗剂的储存器，设置在贮存器上方的阻挡层，其中所述阻挡层包括无机材料，以及设置在所述阻挡层和所述医疗装置的表面之间的可溶胀材料，其中 可膨胀材料是暴露于含水环境时膨胀的材料。 在另一方面，医疗装置具有多层涂层，其具有交替的储层和阻挡层，以及穿透多层涂层的至少部分厚度的多个挖掘区域。 在另一方面，医疗装置具有包含嵌段共聚物的聚合物层，其中聚合物层含有治疗剂，以及设置在聚合物层上的阻挡层，其中阻挡层包含无机材料，其中， 阻挡层具有多个不连续性。 还公开了在医疗装置上形成涂层的方法和将治疗剂递送到身体部位的方法。

公开(公告)号：US20140073903A1

公开(公告)日：2014-03-13

申请号：US13720514

申请日：2012-12-19

Applicant: Jan Weber ,  Torsten Scheuermann ,  Roger Hastings

Inventor： Jan Weber ,  Torsten Scheuermann ,  Roger Hastings

IPC: A61B18/12 ,  A61B5/00 ,  A61B5/05

CPC classification number: A61B18/1233 ,  A61B5/0059 ,  A61B5/04009 ,  A61B5/05 ,  A61B5/40 ,  A61B5/6852 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/00994 ,  A61B2018/1273 ,  A61B2018/1861 ,  A61B2090/3966 ,  A61N7/022

Abstract: Described herein is an apparatus for locally monitoring nerve activity that may be incorporated into a nerve ablation catheter. Such a catheter is equipped with magnetic sensing for both identifying nerves and assessing the success of the ablation. The catheter is also equipped with an ablation instrument for both stimulating and destroying nerve tissue.

Abstract translation: 本文描述的是用于局部监测可并入神经消融导管中的神经活动的装置。 这样的导管配备有用于识别神经的磁感应并且评估消融的成功。 导管还配备有用于刺激和破坏神经组织的消融仪器。

公开(公告)号：US20100292776A1

公开(公告)日：2010-11-18

申请号：US12466110

申请日：2009-05-14

Applicant: Jan Weber ,  Torsten Scheuermann

Inventor： Jan Weber ,  Torsten Scheuermann

IPC: A61F2/06

CPC classification number: A61F2/91 ,  A61F2/852 ,  A61F2210/0004 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2250/003 ,  A61F2250/0063

Abstract: A stent includes a first tubular element formed of a first bioerodible metal composition and second tubular element formed of a second biodegradable metal composition. The first and second tubular elements are concentrically arranged; and the first and second bioerodible metal compositions are different.

Abstract translation: 支架包括由第一生物腐蚀性金属组合物形成的第一管状元件和由第二生物可降解金属组合物形成的第二管状元件。 第一和第二管状元件同心地布置; 并且第一和第二生物腐蚀性金属组合物是不同的。