公开(公告)号：US06288440B1

公开(公告)日：2001-09-11

申请号：US09342697

申请日：1999-06-29

申请人： Ulrich Sieben ,  Günter Igel ,  Mirko Lehmann ,  Hans-Jürgen Gahle ,  Bernhard Wolf ,  Werner Baumann ,  Ralf Ehret

发明人： Ulrich Sieben ,  Günter Igel ,  Mirko Lehmann ,  Hans-Jürgen Gahle ,  Bernhard Wolf ,  Werner Baumann ,  Ralf Ehret

IPC分类号： H01L23495

CPC分类号： H01L23/5385 ,  A61B5/14532 ,  A61B5/1473 ,  G01N33/48707 ,  H01L2924/0002 ,  H01L2924/00

摘要： A chip arrangement (1) has a substrate board (2) with an opening (3), into which a carrier chip (4) is inserted, which has an electrical or electronic structural component (5). At least one conductor path (7) is integrated into the carrier chip (4), which connects the structural component (5) to the electrical connection contact (8). The carrier chip (4) is inserted into the opening (3) in such a way that its ends project beyond the opposite-facing, flat-sided surfaces (9, 9′) of the substrate board (2), and thereby form overhangs (10, 10′). Here, the structural component is arranged on the overhang (10) projecting beyond the one surface (9), and the connection contact (8) is arranged on the overhang (10′) projecting beyond the other surface (9′), and the conductor path (7) connecting the structural component (5) and the connection contact (8) passes through the opening (3). A seal is arranged between the substrate board (2) and the carrier chip (4).

摘要翻译： 芯片装置（1）具有带有开口（3）的基板（2），其中插入有载体芯片（4），其具有电或电子结构部件（5）。 至少一个导体路径（7）集成到载体芯片（4）中，其将结构部件（5）连接到电连接触点（8）。 载体芯片（4）以这样的方式插入到开口（3）中，使得其端部突出超过衬底板（2）的相对面对的平坦表面（9,9'），从而形成突出部 （10,10'）。 这里，结构部件布置在突出超过一个表面（9）的伸出部（10）上，并且连接触点（8）布置在突出超过另一个表面（9'）的伸出部（10'）上，并且 连接结构部件（5）和连接触点（8）的导体路径（7）穿过开口（3）。 在基板（2）和载体芯片（4）之间设置密封件。

公开(公告)号：US06245057B1

公开(公告)日：2001-06-12

申请号：US09425598

申请日：1999-10-22

申请人： Ulrich Sieben ,  Bernhard Wolf

发明人： Ulrich Sieben ,  Bernhard Wolf

IPC分类号： A61K922

CPC分类号： A61B5/145 ,  A61B5/14539 ,  A61B5/1473 ,  A61M31/002

摘要： A device (1) functions for treating malignant, tumorous tissue areas. The device has at least one measuring sensor for determining chemical or physical signal patterns in the immediate vicinity of the tumor cells or similar tissue part, a control unit and at least one treatment assembly, which has as an active agent release element for chemically influencing and/or treatment electrodes for physically influencing the tumorous tissue area to be treated. The sensor(s), the active agent release element, and the treatment electrodes are connected to the control unit for a physical and/or chemical treatment of the tumorous tissue area, controlled as a function of the measured values of the tumor cells. The device is constructed in the form of a swallowable capsule or dragée, and a sensor is provided for detecting release parameters. The control unit is designed with a threshold value switch for activating the active agent release element and/or the electrodes when a predetermined target value is exceeded.

摘要翻译： 装置（1）用于治疗恶性肿瘤组织区域。 该装置具有至少一个用于确定肿瘤细胞或类似组织部分附近的化学或物理信号图案的测量传感器，控制单元和至少一个处理组件，其具有用于化学影响的活性剂释放元件和 /或用于物理影响待治疗的肿瘤组织区域的治疗电极。 传感器，活性剂释放元件和处理电极连接到控制单元，用于根据肿瘤细胞的测量值来控制肿瘤组织区域的物理和/或化学处理。 该装置以吞咽胶囊或拖把的形式构造，并且提供用于检测释放参数的传感器。 当超过预定目标值时，控制单元设计有用于激活活性剂释放元件和/或电极的阈值开关。

公开(公告)号：US6104495A

公开(公告)日：2000-08-15

申请号：US86111

申请日：1998-05-27

申请人： Ulrich Sieben ,  Bernhard Wolf

发明人： Ulrich Sieben ,  Bernhard Wolf

IPC分类号： G01N33/48 ,  C12M1/34 ,  G01N21/27 ,  G01N33/483 ,  G01N21/59

CPC分类号： C12M41/46

摘要： A measuring apparatus (1) for measuring physiological and/or chemical and/or physical properties of at least one living cell (3) contains, in addition to further sensors (4.1, 4.2), a plurality of optical sensors (4) on a support (2), particularly a support made of semiconductor material. By means of a controller (6) and a switching facility (8) which are integrated on the same support (2), the individual optical sensors (4) and the further sensors (4.1, 4.2) can be selectively interrogated. An external signal-analyzing facility (7) with a screen represents a sort of near-field microscope.

摘要翻译： 用于测量至少一个活细胞（3）的生理和/或化学和/或物理性质的测量装置（1）除了还有传感器（4.1,4.2）之外还包含多个光学传感器（4） 支撑件（2），特别是由半导体材料制成的支撑件。 通过集成在同一支撑件（2）上的控制器（6）和切换设备（8），可以选择性询问各个光学传感器（4）和另外的传感器（4.1,4.2）。 具有屏幕的外部信号分析设备（7）表示一种近场显微镜。

公开(公告)号：US20090017505A1

公开(公告)日：2009-01-15

申请号：US11805242

申请日：2007-05-22

申请人： Ulrich Sieben ,  Holger Klapproth

发明人： Ulrich Sieben ,  Holger Klapproth

IPC分类号： C12P19/34 ,  C12M1/40 ,  C12M1/34

CPC分类号： B01L3/0262 ,  B01F13/0071 ,  B01F13/0084 ,  B01F15/06 ,  B01L3/5085 ,  B01L3/5088 ,  B01L3/563 ,  B01L2200/025 ,  B01L2200/143 ,  B01L2300/0819 ,  B01L2300/1822

摘要： In a process for mixing microdroplets (2a, 2b, 2c), at least two carriers (3a, 3b) are provided whose surfaces (4a, 4b) are each structured in such a way that at least one hydrophilic surface domain (5a, 5b) is delimited by at least one hydrophobic surface domain (6a, 6b). A first microdroplet (2a, 2b, 2c) is disposed on a hydrophilic surface domain (5a) of a first carrier (3a), and a second microdroplet (2a, 2b, 3c) is disposed on a hydrophilic surface domain (5b) of a second carrier (3b). The carriers (3a, 3b), with their first and second hydrophilic surfaces (4a, 4b) facing each other, are positioned adjacent to each other and sufficiently close to each other by being moved toward each other that the microdroplets (2a, 2b, 2c) come into contact with each other.

摘要翻译： 在混合微滴（2a，2b，2c）的方法中，提供至少两个载体（3a，3b），其表面（4a，4b）各自构造成使得至少一个亲水性表面区域（5a，5b） ）由至少一个疏水性表面结构域（6a，6b）界定。 第一微滴（2a，2b，2c）设置在第一载体（3a）的亲水性表面区域（5a）上，第二微滴（2a，2b，3c）设置在亲水性表面区域 第二载体（3b）。 其第一和第二亲水表面（4a，4b）彼此面对的载体（3a，3b）通过彼此移动彼此相邻并且彼此靠近彼此，使得微滴（2a，2b， 2c）相互接触。

公开(公告)号：US20080286882A1

公开(公告)日：2008-11-20

申请号：US11960090

申请日：2007-12-19

申请人： Ulrich Sieben ,  Holger Klapproth

发明人： Ulrich Sieben ,  Holger Klapproth

IPC分类号： G01N33/543 ,  B01J19/00

CPC分类号： G01N33/54366

摘要： In a method for measuring the concentration of a ligand contained in a sample that is to be tested, at a plurality of test sites that are located on the surface of at least one substrate, in each case at least one receptor that is suitable upon contact with the ligand for specifically binding to said ligand, is immobilized. The sample is brought into contact for a predetermined time with the test sites in such a way that in the sample differently sized diffusion volumes are adjacent to the receptors from which at least one ligand can diffuse to the respective receptor during the predetermined time. After the predetermined time has passed, for each test site a measured signal for the number or density of the binding events at the test site is acquired.

摘要翻译： 在用于测量待测试样品中所含配体浓度的方法中，在位于至少一个底物表面上的多个测试位点，在每种情况下至少一种适合接触的受体 与特异性结合所述配体的配体被固定化。 使样品与测试位置接触预定时间，使得在样品中不同尺寸的扩散体积与受体相邻，在预定时间内至少一种配体可以从该受体扩散到相应的受体。 在预定时间过去之后，对于每个测试站点，获取测试点处的绑定事件的数量或密度的测量信号。

公开(公告)号：US20050062126A1

公开(公告)日：2005-03-24

申请号：US10471467

申请日：2003-01-31

申请人： Klaus Heberle ,  Ulrich Sieben

发明人： Klaus Heberle ,  Ulrich Sieben

IPC分类号： H01L23/31 ,  H01L23/49 ,  H01L23/52 ,  H01L25/065 ,  H01L25/07 ,  H01L25/18 ,  H01L29/00

CPC分类号： H01L24/49 ,  H01L23/3128 ,  H01L23/49838 ,  H01L24/48 ,  H01L25/0655 ,  H01L25/18 ,  H01L2224/48091 ,  H01L2224/48137 ,  H01L2224/48227 ,  H01L2224/49171 ,  H01L2224/49175 ,  H01L2924/00014 ,  H01L2924/01004 ,  H01L2924/01006 ,  H01L2924/01015 ,  H01L2924/01033 ,  H01L2924/01078 ,  H01L2924/01082 ,  H01L2924/014 ,  H01L2924/14 ,  H01L2924/15311 ,  H01L2924/181 ,  H01L2924/19041 ,  H01L2924/19042 ,  H01L2924/3025 ,  H01L2924/00 ,  H01L2224/45099 ,  H01L2224/05599 ,  H01L2924/00012

摘要： A mount for a programmable electronic processing device is disclosed. It is divided into at least a first functional unit (7) and a second functional unit (8) which represent separate, particularly monolithic integrated, components. The first functional unit (7) defines all input and output interfaces of the processing device with respect to their electrical properties. All essential connections of the second functional unit (8) are accessible from outside only via the first functional unit (7). To this end, the first functional unit (7) includes matching circuits which serve to electrically adapt the connections of the second functional unit (8) to the external conditions.

摘要翻译： 公开了一种用于可编程电子处理装置的安装座。 它分成至少第一功能单元（7）和第二功能单元（8），其代表分离的，特别是整体的集成组件。 第一功能单元（7）相对于它们的电气特性定义了处理装置的所有输入和输出接口。 第二功能单元（8）的所有基本连接只能通过第一功能单元（7）从外部访问。 为此，第一功能单元（7）包括用于将第二功能单元（8）的连接电适配到外部条件的匹配电路。

公开(公告)号：US06376233B1

公开(公告)日：2002-04-23

申请号：US09310003

申请日：1999-05-11

申请人： Bernhard Wolf ,  Ulrich Sieben

发明人： Bernhard Wolf ,  Ulrich Sieben

IPC分类号： C12M134

CPC分类号： G01N35/028 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01L3/5085 ,  B01L3/50851 ,  B01L2200/147 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/1827 ,  C40B60/14

摘要： A device (1) serves for conducting investigations on cell specimens, wherein the device has a microtiter plate or similar receiving device with a plurality of individual containers for the cell specimens. Furthermore, a measuring facility for recording changes in individual specimens is provided. On the underside the microtiter plate or similar receiving device has a measuring structure which carries at least one sensor allocated to each receiving vessel. The measuring structure can either be combined with a bottomless upper part of a conventional microtiter plate, or instead it is a semiconductor substrate plate (2) with a plurality of bowl-shaped receptacle depressions (3) situated therein and provided as containers. At least one sensor is allocated to each depression.

摘要翻译： 装置（1）用于对细胞试样进行研究，其中装置具有微量滴定板或类似的接收装置，其具有用于细胞样品的多个单独的容器。 此外，提供了用于记录各个样本的变化的测量设备。 在底侧，微量滴定板或类似的接收装置具有承载分配给每个接收容器的至少一个传感器的测量结构。 测量结构可以与常规微量滴定板的无底上部组合，或者替代地是具有位于其中并且设置为容器的多个碗形容器凹部（3）的半导体衬底板（2）。 至少有一个传感器被分配给每个凹陷。

公开(公告)号：US06280586B1

公开(公告)日：2001-08-28

申请号：US08930657

申请日：1997-10-06

申请人： Bernhard Wolf ,  Ralf Ehret ,  Ulrich Sieben ,  Werner Baumann

发明人： Bernhard Wolf ,  Ralf Ehret ,  Ulrich Sieben ,  Werner Baumann

IPC分类号： G01N33543

CPC分类号： G01N33/54373 ,  G01N27/3276 ,  G01N27/4145

摘要： A measuring device (1) for measuring or investigating physiological parameters using biological cells or chemical and biologically active substances contained in an analyte (2). The measuring device comprises a sensor (4) with an electronic measurement structure (6) located on a substrate (5). Function-specific receptor cells and/or target cells (7) form part of the sensor (4) and are in direct contact with the measurement structure (6). For measurement, the medium under investigation can be brought into contact with the target cells or receptor cells (7). The measuring device (1) is especially compact in its design and facilitates largely feedback-free investigation of biological or chemical components contained in the analyte.

摘要翻译： 一种用于使用分析物（2）中包含的生物细胞或化学和生物活性物质来测量或调查生理参数的测量装置（1）。 测量装置包括具有位于基板（5）上的电子测量结构（6）的传感器（4）。 功能特异性受体细胞和/或靶细胞（7）形成传感器（4）的一部分并与测量结构（6）直接接触。 为了测量，所研究的培养基可以与靶细胞或受体细胞接触（7）。 测量装置（1）在其设计中特别紧凑，并且对于分析物中包含的生物或化学成分进行大量无反馈的调查。

公开(公告)号：US5844674A

公开(公告)日：1998-12-01

申请号：US771132

申请日：1996-12-20

申请人： Ulrich Sieben

发明人： Ulrich Sieben

IPC分类号： G06F3/00 ,  G06F3/01 ,  G06F3/033 ,  G06F3/042 ,  G01B11/26

CPC分类号： G06F3/012 ,  G06F3/0304

摘要： A virtual reality system permanently connected with a device to be worn by a user is disclosed which has an optical position-sensing facility that contains at least one radiation source defining a fixed reference point in space and an optical receiving system permanently connected with the device. The optical receiving system includes three radiation detectors, whose optical axes are parallel to each other. The first radiation detector has a reception pattern which shows a rising/falling sensitivity characteristic in a first angular range. The second radiation detector has a reception pattern which shows a rising/falling sensitivity characteristic in a second angular range. The third radiation detector has a reception pattern which shows a slowly varying sensitivity characteristic within at least the first and second angular ranges.

摘要翻译： 公开了一种与要由用户佩戴的设备永久连接的虚拟现实系统，其具有光学位置感测设备，其包含限定空间中的固定参考点的至少一个辐射源和与设备永久连接的光学接收系统。 光接收系统包括三个辐射检测器，其光轴彼此平行。 第一辐射检测器具有在第一角度范围内示出上升/下降灵敏度特性的接收图案。 第二辐射检测器具有在第二角度范围内示出上升/下降灵敏度特性的接收图案。 第三辐射检测器具有在至少第一和第二角度范围内显示缓慢变化的灵敏度特性的接收图案。

公开(公告)号：US5820548A

公开(公告)日：1998-10-13

申请号：US784845

申请日：1997-01-15

申请人： Ulrich Sieben ,  Michael Kraus ,  Bernhard Wolf

发明人： Ulrich Sieben ,  Michael Kraus ,  Bernhard Wolf

IPC分类号： A61M31/00 ,  A61N1/30 ,  A61N1/40 ,  A61N2/00 ,  A61M5/00

CPC分类号： A61N1/30 ,  A61N1/40 ,  A61N2/002

摘要： An apparatus 1 serves for treating tumors in particular. This apparatus has, for example, a sensor-actuator head 3 with at least one sensor 10 for determining the acidification of the immediate surroundings of the tumor cells. An active ingredient dispensing device for exerting chemical influence and/or electrodes for exerting physical influence through electrical and/or electromagnetic fields on the tumorous tissue area to be treated are provided on the sensor-actuator head. The sensor(s) 10 as well as the active ingredient dispensing facility and/or the treatment electrodes are connected with a control facility for controlling chemical and/or physical treatment of the tumorous tissue area as a function of measured values.

摘要翻译： 装置1特别用于治疗肿瘤。 该装置具有例如具有至少一个传感器10的传感器 - 致动器头3，用于确定肿瘤细胞的周围环境的酸化。 用于施加化学影响的活性成分分配装置和/或用于通过电疗和/或电磁场对待治疗的肿瘤组织区域施加物理影响的活性成分分配装置设置在传感器致动头上。 传感器10以及活性成分分配设备和/或治疗电极与控制设备连接，用于根据测量值控制肿瘤组织区域的化学和/或物理治疗。