公开(公告)号：US11709155B2

公开(公告)日：2023-07-25

申请号：US16133089

申请日：2018-09-17

Applicant: Waters Technologies Corporation

Inventor： Matthew A. Lauber ,  Mathew H. DeLano ,  Scott A. McCall ,  Jonathan L. Belanger ,  Theodore A. Dourdeville ,  Kerri M. Smith ,  Paul D. Rainville ,  Dimple D. Shah ,  Stephen J. Shiner ,  Catalin Doneanu ,  Michael Donegan

IPC: G01N30/56 ,  B01J20/32 ,  B05D1/00 ,  B01J20/291 ,  C23C16/04 ,  C23C16/30 ,  C23C14/04 ,  C23C14/12 ,  C23C14/24 ,  G01N30/60 ,  G01N30/72

CPC classification number: G01N30/56 ,  B01J20/291 ,  B01J20/3272 ,  B05D1/60 ,  C23C14/046 ,  C23C14/12 ,  C23C14/24 ,  C23C16/045 ,  C23C16/30 ,  G01N30/6052 ,  B05D2518/10 ,  G01N30/7266 ,  G01N2030/567

Abstract: A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I:




R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20—, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.

公开(公告)号：US10953346B2

公开(公告)日：2021-03-23

申请号：US15873280

申请日：2018-01-17

Applicant: Waters Technologies Corporation

Inventor： Xiangjin Song ,  James P. Murphy ,  Keith Fadgen ,  Wade P. Leveille ,  Joseph D. Michienzi ,  Jonathan L. Belanger ,  Moon Chul Jung ,  Abhijit Tarafder

IPC: B01D15/14 ,  B01L3/00 ,  B65D1/02 ,  B65D23/14 ,  G01N35/00 ,  G01N30/80 ,  B01L9/00 ,  G01N30/26

Abstract: Solvent containers and solvent container trays for chromatography systems are described for providing control over solvent supply and waste collection. Designated solvent containers and exclusively designated solvent containers provide solvents for use by chromatography systems. Control over solvent supply is achieved by requiring matched container shape and container receiving position shape within the tray, and additionally or alternatively, through solvent container coding readable by the solvent tray and chromatography system which provide information about the solvent container to the chromatography system.

公开(公告)号：US10823713B2

公开(公告)日：2020-11-03

申请号：US15847586

申请日：2017-12-19

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Wade P. Leveille ,  Jonathan L. Belanger ,  Moon Chul Jung ,  Abhijit Tarafder ,  Joseph Michienzi ,  Keith Fadgen ,  Kevin Wyndham ,  Xiangjin Song

IPC: G01N30/32 ,  B01D15/16 ,  B65D83/14 ,  G01N30/38

Abstract: The present disclosure generally relates to systems, methods and devices for providing pressurized solvent flow in chromatography systems.

公开(公告)号：US10774957B2

公开(公告)日：2020-09-15

申请号：US16049483

申请日：2018-07-30

Applicant: Waters Technologies Corporation

Inventor： Jonathan L. Belanger ,  Sylvain Cormier ,  Steven D. Trudeau ,  Paul Keenan ,  Daniel J. McCormick

IPC: F16L15/04 ,  F16J15/08 ,  G01N30/60 ,  B01D15/10 ,  B01D15/22 ,  B01D15/40 ,  F16L19/02 ,  F16J15/10

Abstract: Described is a mobile phase fitting having reduced corrosion and erosion. The fitting includes a coupling body, compression screw, compression member and gasket. The coupling body has a threaded bore at one end, a tapered cavity, a narrow bore and a fluid channel. The compression screw has an axial bore to receive a tube and a threaded outer surface in engagement with the threaded bore of the coupling body. The compression member is disposed in the tapered cavity and has an axial opening to pass the tube and a tapered surface to engage a surface of the tapered cavity. The gasket is disposed in the narrow bore and has one surface in contact with the first internal surface and has a parallel surface to receive an end face of the tube. Mobile phase flows along a path that includes the tube, an opening in the gasket and the fluid channel.

公开(公告)号：US10753916B2

公开(公告)日：2020-08-25

申请号：US15872842

申请日：2018-01-16

Applicant: Waters Technologies Corporation

Inventor： Moon Chul Jung ,  Jonathan L. Belanger ,  Xiangjin Song ,  Abhijit Tarafder ,  Joseph A. Jarrell ,  Wade P. Leveille

IPC: G01N30/88 ,  G01M3/20 ,  G01N30/60 ,  G01N30/86 ,  G01M3/26 ,  G01N30/02 ,  G01N30/26 ,  G01N30/04

Abstract: Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. The leak detection system includes a sealable compartment disposed to surround at least one component of a chromatography system. The detector is in communication, e.g., fluid communication, with an interior of the sealable compartment and configured to detect the leak by various mean including the presence of liquid or the presence of vapor, or both within the sealable compartment.

公开(公告)号：US10690563B2

公开(公告)日：2020-06-23

申请号：US15872755

申请日：2018-01-16

Applicant: Waters Technologies Corporation

Inventor： Abhijit Tarafder ,  Moon Chul Jung ,  Jonathan L. Belanger ,  Xiangjin Song ,  Wade P. Leveille ,  Darryl W. Brousmiche

IPC: G01N30/34 ,  G01N30/02 ,  G01M3/20

Abstract: Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. A coating is disposed to conform to at least one component of a chromatography system, such as a fitting or a section of tubing. The coating is made of or contains a responsive material that can undergo a detectable change when exposed to a chromatographic fluid or mobile phase. The change of the responsive material can indicate the presence of the fluid or mobile phase, a change in at least one physical property of the coating to prevent passage of the fluid or mobile phase, or a combination thereof.

公开(公告)号：US20180202983A1

公开(公告)日：2018-07-19

申请号：US15872842

申请日：2018-01-16

Applicant: Waters Technologies Corporation

Inventor： Moon Chul Jung ,  Jonathan L. Belanger ,  Xiangjin Song ,  Abhijit Tarafder ,  Joseph A. Jarrell ,  Wade P. Leveille, SR.

IPC: G01N30/88 ,  G01N30/86 ,  G01M3/20 ,  G01N30/60

CPC classification number: G01N30/88 ,  G01M3/202 ,  G01M3/26 ,  G01N30/02 ,  G01N30/04 ,  G01N30/26 ,  G01N30/6052 ,  G01N30/8675 ,  G01N2030/889

Abstract: Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. The leak detection system includes a sealable compartment disposed to surround at least one component of a chromatography system. The detector is in communication, e.g., fluid communication, with an interior of the sealable compartment and configured to detect the leak by various mean including the presence of liquid or the presence of vapor, or both within the sealable compartment.

公开(公告)号：US20180202980A1

公开(公告)日：2018-07-19

申请号：US15847586

申请日：2017-12-19

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Wade P. Leveille ,  Jonathan L. Belanger ,  Moon Chul Jung ,  Abhijit Tarafder ,  Joseph Michienzi ,  Keith Fadgen ,  Kevin Wyndham ,  Xiangjin Song

IPC: G01N30/32 ,  B01D15/16 ,  G01N30/38 ,  B65D83/14

Abstract: The present disclosure generally relates to systems, methods and devices for providing pressurized solvent flow in chromatography systems.

公开(公告)号：US20150211663A1

公开(公告)日：2015-07-30

申请号：US14414138

申请日：2013-06-25

Applicant: Waters Technologies Corporation

Inventor： Jonathan L. Belanger ,  Sylvain Cormier ,  Steven D. Trudeau ,  Paul Keenan ,  Daniel J. McCormick

IPC: F16L15/04 ,  F16J15/10 ,  F16J15/08 ,  B01D15/22 ,  B01D15/40

CPC classification number: F16L15/04 ,  B01D15/10 ,  B01D15/22 ,  B01D15/40 ,  F16J15/0806 ,  F16J15/102 ,  F16L19/0212 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026

Abstract: Described is a mobile phase fitting having reduced corrosion and erosion. The fitting includes a coupling body, compression screw, compression member and gasket. The coupling body has a threaded bore at one end, a tapered cavity, a narrow bore and a fluid channel. The compression screw has an axial bore to receive a tube and a threaded outer surface in engagement with the threaded bore of the coupling body. The compression member is disposed in the tapered cavity and has an axial opening to pass the tube and a tapered surface to engage a surface of the tapered cavity. The gasket is disposed in the narrow bore and has one surface in contact with the first internal surface and has a parallel surface to receive an end face of the tube. Mobile phase flows along a path that includes the tube, an opening in the gasket and the fluid channel.

Abstract translation: 描述了具有减少的腐蚀和侵蚀的流动相配件。 配件包括联接体，压缩螺钉，压缩构件和衬垫。 联接体在一端具有螺纹孔，锥形腔，窄孔和流体通道。 压缩螺杆具有轴向孔以接收管和与联接体的螺纹孔接合的螺纹外表面。 压缩构件设置在锥形空腔中并且具有轴向开口以使管和锥形表面接合以使锥形空腔的表面接合。 垫圈设置在狭窄的孔中并且具有与第一内表面接触的一个表面并且具有平行的表面以容纳管的端面。 流动相沿着包括管，垫圈中的开口和流体通道的路径流动。