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公开(公告)号：US20080070910A1
公开(公告)日：2008-03-20
申请号：US11880743
申请日：2007-07-24
IPC分类号： C07D493/04 , A61K31/341 , A61K31/352 , A61K31/357 , A61K31/427 , A61K31/536 , C12N9/99 , A61P31/18 , C07D277/22 , C07D307/02 , C07D307/77 , C07D413/00
CPC分类号： C07D493/04
摘要： The present invention provides compounds of Formula (I): wherein A, X, Q, R2-R6, m, and W have the values described herein, as well as compositions comprising such compounds. The compounds are protease inhibitors and are useful for inhibiting the development of drug resistance in animals.
摘要翻译： 本发明提供式（I）的化合物：其中A，X，Q，R 2，R 6，M和W也具有本文所述的值 作为包含这些化合物的组合物。 这些化合物是蛋白酶抑制剂，可用于抑制动物耐药性的发展。
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公开(公告)号：US20060035866A1
公开(公告)日：2006-02-16
申请号：US10833295
申请日：2004-04-26
申请人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Manoj Desai , Maria Fardis , Alan Huang , Thorsten Kirschberg , Christopher Lee , Richard Mackman , Peter Nelson , Hyung-Jung Pyun , Adrian Ray , William Watkins , Jennifer Zhang , Sundaramoorthi Swaminathan
发明人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Manoj Desai , Maria Fardis , Alan Huang , Thorsten Kirschberg , Christopher Lee , Richard Mackman , Peter Nelson , Hyung-Jung Pyun , Adrian Ray , William Watkins , Jennifer Zhang , Sundaramoorthi Swaminathan
IPC分类号： A61K31/66
CPC分类号： A61K47/548 , A61K47/542
摘要： The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及具有免疫调节活性的膦酸酯取代的化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US06727273B2
公开(公告)日：2004-04-27
申请号：US09954039
申请日：2001-09-18
申请人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Beata Krywult , Rajinder Singh , Liang Wang
发明人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Beata Krywult , Rajinder Singh , Liang Wang
IPC分类号： A61K31416
CPC分类号： C07D261/08 , C07D231/12 , C07D231/54 , C07D261/10 , C07D261/18 , C07D261/20 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04 , C07D413/12
摘要： Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.
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公开(公告)号：US06291505B1
公开(公告)日：2001-09-18
申请号：US09369747
申请日：1999-08-06
申请人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Beata Krywult , Rajinder Singh , Liang Wang
发明人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Beata Krywult , Rajinder Singh , Liang Wang
IPC分类号： A61K31415
CPC分类号： C07D261/08 , C07D231/12 , C07D231/54 , C07D261/10 , C07D261/18 , C07D261/20 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04 , C07D413/12
摘要： Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.
摘要翻译： 除了用于治疗或预防雌激素受体介导的病症的方法和组合物之外还描述了雌激素受体调节性吡唑化合物。 已经发现所描述的化合物在调节雌激素受体活性方面具有意想不到的和惊人的活性。 因此，本发明的化合物可用于预防或治疗雌激素受体介导的疾病如骨质疏松症，乳腺癌和子宫内膜癌，动脉粥样硬化和阿尔茨海默氏病。
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公开(公告)号：US07645747B2
公开(公告)日：2010-01-12
申请号：US11258621
申请日：2005-10-25
申请人： Constantine G. Boojamra , Carina E. Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Craig S. Gibbs , Ralph F. Hirschmann , Alan X. Huang , Haolun Jin , Choung U. Kim , Thorsten A. Kirschberg , Steven Krawczyk , Christopher P. Lee , William A. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang
发明人： Constantine G. Boojamra , Carina E. Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Craig S. Gibbs , Ralph F. Hirschmann , Alan X. Huang , Haolun Jin , Choung U. Kim , Thorsten A. Kirschberg , Steven Krawczyk , Christopher P. Lee , William A. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang
IPC分类号： A61K31/661 , A61K31/662 , C07F9/06 , C07F9/28
CPC分类号： C07F9/65616 , C07F9/4006 , C07F9/4465 , C07F9/5304 , C07F9/650952 , C07F9/653 , C07F9/65507 , C07F9/65515 , C07F9/65517 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.
摘要翻译： 本发明涉及磷取代的治疗剂，含有这种磷取代剂的组合物，以及包括施用这种磷取代剂的治疗方法，以及可用于制备这种药剂的方法和中间体。
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公开(公告)号：US20090227543A1
公开(公告)日：2009-09-10
申请号：US12166145
申请日：2008-07-01
申请人： Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Alan X. Huang , Thorsten Kirschberg , Christopher P. Lee , Richard L. Mackman , Peter H. Nelson , Hyung-Jung Pyun , Adrian S. Ray , William J. Watkins , Jennifer R. Zhang , Sundaramoorthi Swaminathan
发明人： Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Alan X. Huang , Thorsten Kirschberg , Christopher P. Lee , Richard L. Mackman , Peter H. Nelson , Hyung-Jung Pyun , Adrian S. Ray , William J. Watkins , Jennifer R. Zhang , Sundaramoorthi Swaminathan
IPC分类号： A61K31/665 , C07F9/655
CPC分类号： A61K47/548 , A61K47/542
摘要： The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及具有免疫调节活性的膦酸酯取代的化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20060089369A1
公开(公告)日：2006-04-27
申请号：US11220400
申请日：2005-09-06
申请人： John Nuss , Stephen Harrison , David Ring , Rustum Boyce , Kirk Johnson , Keith Pfister , Savithri Ramurthy , Lynn Seely , Allan Wagman , Manoj Desai , Barry Levine
发明人： John Nuss , Stephen Harrison , David Ring , Rustum Boyce , Kirk Johnson , Keith Pfister , Savithri Ramurthy , Lynn Seely , Allan Wagman , Manoj Desai , Barry Levine
IPC分类号： A61K31/52 , A61K31/497 , A61K31/4439 , A61K31/506 , C07D473/12 , C07D401/02 , C07D403/02 , C07D405/02 , C07D409/02
CPC分类号： C07D213/74 , C07D213/75 , C07D213/80 , C07D213/85 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
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公开(公告)号：US06262098B1
公开(公告)日：2001-07-17
申请号：US09369748
申请日：1999-08-06
申请人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Jennifer C. Moore , Beata Krywult , Thayalan Navaratnam , Rajinder Singh , Rob Trainor , Liang Wang
发明人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Jennifer C. Moore , Beata Krywult , Thayalan Navaratnam , Rajinder Singh , Rob Trainor , Liang Wang
IPC分类号： A61K3142
CPC分类号： C07D261/10 , C07D261/08 , C07D261/18 , C07D261/20 , C07D413/04 , C07D413/12
摘要： Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.
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公开(公告)号：US20080108617A1
公开(公告)日：2008-05-08
申请号：US11825605
申请日：2007-07-06
申请人： Manoj Desai , Allen Hong , Hongtao Liu , Randall Vivian , Lianhong Xu
发明人： Manoj Desai , Allen Hong , Hongtao Liu , Randall Vivian , Lianhong Xu
IPC分类号： A61K31/5377 , C07D417/12 , A61K31/426 , A61K31/454 , A61K31/4402 , A61P31/18 , A61P31/12 , A61P43/00 , A61K31/47 , A61K31/496 , C07D417/14
CPC分类号： A61K31/427 , A61K31/426 , A61K31/4402 , A61K31/4535 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K38/005 , A61K38/05 , A61K45/00 , A61K45/06 , C07C209/78 , C07C227/16 , C07C227/18 , C07C315/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D417/14 , C07K5/06 , C07K5/06026 , C07K5/06034 , C07K5/06052 , A61K2300/00
摘要： The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式I化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US20080008682A1
公开(公告)日：2008-01-10
申请号：US11825377
申请日：2007-07-06
申请人： Lee Chong , Manoj Desai , Brian Gallagher , Michael Graupe , Randall Halcomb , Hong Yang , Jennifer Zhang
发明人： Lee Chong , Manoj Desai , Brian Gallagher , Michael Graupe , Randall Halcomb , Hong Yang , Jennifer Zhang
IPC分类号： A61K38/21 , A61K31/192 , A61K31/4184 , A61K31/4196 , A61K39/395 , C07D239/70 , C12N5/00 , C07D295/00 , A61P31/12 , A61K31/426 , A61K31/5415 , A61K31/675
CPC分类号： C07F9/65616
摘要： The present application provides for a compound of Formula I or II: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods that include the administration of such compounds with at least one additional active agent.
摘要翻译： 本申请提供了式I或II化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予 这种化合物与至少一种另外的活性剂。
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