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11.发明授权Oligopeptides comprising p18 protein of human immunodeficiency virus (HIV), compositions comprising peptides of p18 protein of HIV, and diagnostic kits and methods for detecting acquired immune deficiency syndrome (AIDS) 失效包含人免疫缺陷病毒（HIV）的p18蛋白的寡肽，包含HIV的p18蛋白的肽的组合物和用于检测获得性免疫缺陷综合征（AIDS）的诊断试剂盒和方法，
公开(公告)号：US5374519A
公开(公告)日：1994-12-20
申请号：US952252
申请日：1992-09-28
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Vezinet-Brun , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Theresa Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Vezinet-Brun , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Theresa Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret
CPC分类号： C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222 , Y10S435/974
摘要： Protein compositions containing the p18 and p25 proteins of the lymphadenopathy virus are used for detecting antibodies in blood serum as indicative of infection by such virus. The proteins can be used in various conventional ways to perform immunoassays for the detection of the antibodies.
摘要翻译： 含有淋巴结病毒病毒的p18和p25蛋白质的蛋白质组合物用于检测血清中的抗体，作为这种病毒感染的指示。 蛋白质可以以各种常规方式用于进行用于检测抗体的免疫测定。
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12.发明授权Human Immunodeficiency Virus (HIV) associated with Acquired Immunual Deficiency Syndrome (AIDS), a diagnostic method for aids and pre-aids, and a kit therefor 失效与获得性免疫缺陷综合征（AIDS）相关的人类免疫缺陷病毒（HIV），辅助和预辅助的诊断方法及其工具包
公开(公告)号：US5135864A
公开(公告)日：1992-08-04
申请号：US117937
申请日：1987-11-05
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
CPC分类号： C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222 , Y10S435/974
摘要： Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS), including Lymphadenopathy Associated Virus (LAV), are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. LAV is a Human Immunodeficiency Virus (HIV). Viral extract, structural proteins and other fractions of the retrovirus immunologically recognize the sera of such patients. Immunological reaction is used to detect antibodies that specifically bind to antigenic sites of the retrovirus in samples of body fluids from patients with AIDS or risk of AIDS. A kit for in vitro assay of LAS or AIDS is provided.
摘要翻译： 与获得性免疫缺陷综合征（AIDS）相关的逆转录病毒，包括淋巴结病相关病毒（LAV），从患有淋巴结病综合征（LAS）或AIDS的患者血清中分离。 LAV是人类免疫缺陷病毒（HIV）。 病毒提取物，结构蛋白和其他部分的逆转录病毒免疫识别这些患者的血清。 免疫反应用于检测具有艾滋病或艾滋病风险的患者体液样品中特异性结合逆转录病毒抗原位点的抗体。 提供了用于LAS或AIDS的体外测定的试剂盒。
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公开(公告)号：US06600023B1
公开(公告)日：2003-07-29
申请号：US08019297
申请日：1993-02-18
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
IPC分类号： C07K1600
CPC分类号： C07K16/1045 , C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222 , G01N2333/16
摘要： Antibodies which bind with antigens of human immunodeficiency virus type 1 (HIV-1), such as Lymphadenopathy Associated Virus (LAV), are disclosed. Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS) are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. Viral extracts, structural proteins and other fractions of the retrovirus immunologically recognize the sera of such patients.
摘要翻译： 公开了与人类免疫缺陷病毒1型（HIV-1）的抗原结合的抗体，例如淋巴结病相关病毒（LAV）。 与获得性免疫缺陷综合征（AIDS）相关的逆转录病毒从患有淋巴结病综合征（LAS）或AIDS的患者的血清中分离。 逆转录病毒的病毒提取物，结构蛋白和其他部分免疫识别这些患者的血清。
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14.发明授权Retrovirus associated with lymphadenopathies and adapted to continuous lines of lymphoblastoid B cells, capable of producing retrovirus continuously and process for their production 失效与淋巴结病相关的逆转录病毒并适应连续的淋巴母细胞样B细胞系，能够连续生产逆转录病毒并进行生产
公开(公告)号：US4798797A
公开(公告)日：1989-01-17
申请号：US922764
申请日：1986-10-24
IPC分类号： A61K35/76 , A61K35/12 , A61K35/28 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K14/005 , C07K14/155 , C07K14/16 , C07K14/195 , C12N5/10 , C12N7/00 , C12N7/02 , C12N15/09 , C12Q1/70 , C12R1/92 , G01N33/569 , C12N5/00
CPC分类号： C07K14/005 , C12N7/00 , G01N33/56988 , C12N2740/16021 , C12N2740/16051 , C12N2740/16222 , Y10S435/81 , Y10S435/948 , Y10S435/974 , Y10S436/804 , Y10S436/808 , Y10S436/811
摘要： A retrovirus B-LAV associated with lymphadenopathies and with Acquire Immune Deficiency Syndrome, being adapted to B lymphocytes and capable of being continuously produced by continuous cell lines of B lymphoblastoid cells; continuous cell lines of B lymphoblastoid cells which produce the B-LAV retrovirus and a process for producing such cell lines are disclosed.
摘要翻译： 与淋巴结病相关的逆转录病毒B-LAV和获得免疫缺陷综合征，适应于B淋巴细胞，并能够由B淋巴母细胞细胞的连续细胞系连续产生; 公开了产生B-LAV逆转录病毒的B淋巴母细胞细胞的连续细胞系和产生这种细胞系的方法。
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15.发明授权Methods and kits employing LAV antigens for the detection of HIV-1-specific antibodies 失效用于检测针对HIV变体的抗体的方法和试剂盒公开(公告)号：US06428952B1
公开(公告)日：2002-08-06
申请号：US08424631
申请日：1995-04-19
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , G. Sarngadharan
IPC分类号： C12Q170
CPC分类号： C07K16/1045 , G01N2333/16
摘要： Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS), including Lymphadenopathy Associated Virus (LAV), are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. LAV is a Human Immunodeficiency Virus (HIV). Viral extract, structural proteins and other fractions of the retrovirus immunologically recongize the sera of such patients. Immunological reaction is used to detect antibodies that specifically bind to antigenic sites of the retrovirus in samples of body fluids from patients with AIDS or risk of AIDS.
摘要翻译： 与获得性免疫缺陷综合征（AIDS）相关的逆转录病毒，包括淋巴结病相关病毒（LAV），从患有淋巴结病综合征（LAS）或AIDS的患者血清中分离。 LAV是人类免疫缺陷病毒（HIV）。 病毒提取物，结构蛋白和其他部分的逆转录病毒免疫学上述了这些患者的血清。 免疫反应用于检测具有艾滋病或艾滋病风险的患者体液样品中特异性结合逆转录病毒抗原位点的抗体。
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公开(公告)号：US06395495B1
公开(公告)日：2002-05-28
申请号：US09437126
申请日：1999-11-10
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Robert C Gallo , Mikulas Popovic , Mangalasseril G Sarngadhar , Claudine Axler-Blin , Solange Chamaret
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Robert C Gallo , Mikulas Popovic , Mangalasseril G Sarngadhar , Claudine Axler-Blin , Solange Chamaret
IPC分类号： G01N3353
CPC分类号： C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222
摘要： The invention concerns a retrovirus extract containing a p25 protein which recognizes immunologically sera of patients afflicted with lymphadenopathy syndrom (LAS) or acquired immune deficiency syndrom (AIDS). It relates to a method and kit for in vivo assay of LAS or AIDS involving contacting sera from patients to be diagnosed for such diseases with said retrovirus extract and by detecting the immunological reaction, if any.
摘要翻译： 本发明涉及含有p25蛋白的逆转录病毒提取物，其识别患有淋巴结肿大综合征（LAS）或获得性免疫缺陷综合征（AIDS）的患者的免疫血清。 其涉及用于LAS或AIDS的体内测定的方法和试剂盒，其涉及将待诊断患者的血清与所述逆转录病毒提取物接触并通过检测免疫反应（如果有的话）接触。
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17.发明授权Human immunodeficiency viruses associated with Acquired Immune Deficiency Syndrome (AIDS), a diagnostic method for AIDS and pre-AIDS, and a kit therefor 失效与获得性免疫缺陷综合征（AIDS）相关的人体免疫机能丧失病毒，艾滋病和艾滋病前期的诊断方法及其试剂盒
公开(公告)号：US4708818A
公开(公告)日：1987-11-24
申请号：US785638
申请日：1985-10-08
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
IPC分类号： A61K35/76 , A61K35/12 , A61K35/28 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K14/005 , C07K14/155 , C07K14/16 , C07K14/195 , C12N5/10 , C12N7/00 , C12N7/02 , C12N15/09 , C12Q1/70 , C12R1/92 , G01N33/569 , G01N33/535 , G01N33/543
CPC分类号： C07K14/005 , C12N7/00 , G01N33/56988 , C12N2740/16021 , C12N2740/16051 , C12N2740/16222 , Y10S435/81 , Y10S435/948 , Y10S435/974 , Y10S436/804 , Y10S436/808 , Y10S436/811
摘要： Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS), including Lymphadenopathy Associated Virus (LAV), are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. LAV is a Human Immunodeficiency Virus (HIV). Viral extract, structural proteins and other fractions of the retrovirus immunologically recognize the sera of such patients. Immunological reaction is used to detect antibodies that specifically bind to antigenic sites of the retrovirus in samples of body fluids from patients with AIDS or risk of AIDS. A kit for in vitro assay of LAS or AIDS is provided.
摘要翻译： 与获得性免疫缺陷综合征（AIDS）相关的逆转录病毒，包括淋巴结病相关病毒（LAV），从患有淋巴结病综合征（LAS）或AIDS的患者血清中分离。 LAV是人类免疫缺陷病毒（HIV）。 病毒提取物，结构蛋白和其他部分的逆转录病毒免疫识别这些患者的血清。 免疫反应用于检测具有艾滋病或艾滋病风险的患者体液样品中特异性结合逆转录病毒抗原位点的抗体。 提供了用于LAS或AIDS的体外测定的试剂盒。
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18.发明授权Antibodies which bind with proteins of human immunodeficiency virus type 1 (HIV-1), and immune complexes comprising proteins of HIV-1 失效与人类免疫缺陷病毒1型（HIV-1）的蛋白质结合的抗体和包含HIV-1蛋白的免疫复合物公开(公告)号：US07122188B1
公开(公告)日：2006-10-17
申请号：US08067148
申请日：1993-05-26
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Vezinet-Bruil , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Theresa Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Vezinet-Bruil , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Theresa Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret
IPC分类号： A61K39/42
CPC分类号： C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222 , Y10S435/974 , Y10S930/221
摘要： This invention provides antibodies which bind with p12 and p18 proteins of a human immunodeficiency virus type 1 (HIV-1), antibodies which bind with immune complexes comprising p12 or p18 proteins of HIV-1, mixtures of antibodies which bind with p12, p15, p18, p25, p36, p42, and p80 proteins of HIV-1, mixtures of antibodies which bind with immune complexes comprising the HIV-1 proteins, immune complexes comprising p12 or p18 proteins of HIV-1, and methods for production of antibodies against p2 or p18 proteins of HIV-1.
摘要翻译： 本发明提供了与人免疫缺陷病毒1型（HIV-1）的p12和p18蛋白结合的抗体，其与包含HIV-1的p12或p18蛋白的免疫复合物结合的抗体，与p12，p15结合的抗体混合物， HIV-1的p18，p25，p36，p42和p80蛋白，与包含HIV-1蛋白的免疫复合物结合的抗体的混合物，包含HIV-1的p12或p18蛋白的免疫复合物，以及用于产生针对 p2或p18蛋白。
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19.发明授权Methods for the propagation, isolation, identification, and preparation of human immunodeficiency virus type 1 (HIV-1) 失效人类免疫缺陷病毒1型（HIV-1）的繁殖，分离，鉴定和制备方法公开(公告)号：US06627395B1
公开(公告)日：2003-09-30
申请号：US08466256
申请日：1995-06-06
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
IPC分类号： C12Q170
CPC分类号： C07K16/1045 , C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222 , G01N2333/16
摘要： The identification, separation, purification, and propagation of the HIV-1 virus is provided. Moreover, the preparation of antigens from HIV-1 is further provided. The identification of HIV-1 involves the purification of a virus sample from lymphocytes and contacting the sample with antibodies, which bind to HIV-1 viruses, is provided. The propagation of HIV-1 virus involves infecting uninfected T lymphocytes with the virus. Moreover, the preparation of antigens from HIV-1 involves the separation of protein components of a purified HIV-1 virus under denaturing conditions.
摘要翻译： 提供HIV-1病毒的鉴定，分离，纯化和扩增。 此外，还提供了来自HIV-1的抗原的制备。 HIV-1的鉴定涉及从淋巴细胞中纯化病毒样品并使样品与结合HIV-1病毒的抗体接触。 HIV-1病毒的传播涉及用病毒感染未感染的T淋巴细胞。 此外，HIV-1抗原的制备涉及在变性条件下分离纯化的HIV-1病毒的蛋白质组分。
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20.发明授权Methods for the preparation of hybridomas producing lymphadenopathy-associated virus (LAV) GP110-specific monoclonal antibodies and methods for the purification of GP110 employing said monoclonal antibodies 失效制备产生淋巴结病变相关病毒（LAV）的杂交瘤的方法GP110特异性单克隆抗体及使用所述单克隆抗体纯化GP110的方法
公开(公告)号：US5610035A
公开(公告)日：1997-03-11
申请号：US313572
申请日：1994-09-27
申请人： Luc Montagnier , Bernard Krust , Solange Chamaret , Francois Clavel , Jean-Claude Chermann , Francoise Barre-Sinoussi
发明人： Luc Montagnier , Bernard Krust , Solange Chamaret , Francois Clavel , Jean-Claude Chermann , Francoise Barre-Sinoussi
摘要： A novel human retrovirus which is the aetiological agent of acquired immune deficiency syndrome (AIDS), designated lymphadenopathy-associated virus (LAV), was isolated from the lymph nodes of a patient suffering from generalized persistant lymphadenopathy. LAV displays a tropism for CD4.sup.+ lymphocytes, a Mg.sup.2+ -dependent reverse transcriptase (RT) activity, a density of 1.16-1.17 as determined by sucrose gradient centrifugation, a particle diameter of 139 nm, and a p25 antigen that is immunologically distinct from the HTLV-I/II p24 protein. Radioimmunoprecipitation analysis (RIPA) of .sup.35 S-cysteine-labeled viral or cellular lysates employing patient antisera resulted in the identification of a viral antigen having a molecular weight of 110 kDa. Endoglycosidase treatment of this antigen produces a protein with a molecular weight of 90 kDa. Methods are disclosed for the preparation of hybridomas producing LAV gp110-specific monoclonal antibodies (Mabs). Methods are also disclosed employing these MAbs in the purification of the LAV envelope glycoprotein, gp110.
摘要翻译： 从患有广泛性持续性淋巴结病的患者的淋巴结中分离出一种新的人类逆转录病毒，其是获得性免疫缺陷综合征（AIDS）的病原体，称为淋巴结病伴相关病毒（LAV）。 LAV显示CD4 +淋巴细胞趋向性，Mg2 +依赖性逆转录酶（RT）活性，通过蔗糖梯度离心测定的密度为1.16-1.17，粒径为139nm，与HTLV免疫区别的p25抗原 -I / II p24蛋白。 使用患者抗血清的35S-半胱氨酸标记的病毒或细胞裂解物的放射免疫沉淀分析（RIPA）导致鉴定分子量为110kDa的病毒抗原。 该抗原的糖苷内切酶处理产生分子量为90kDa的蛋白质。 公开了制备产生LAV gp110特异性单克隆抗体（Mabs）的杂交瘤的方法。 还公开了使用这些MAb来纯化LAV包膜糖蛋白gp110的方法。
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