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公开(公告)号：US09493429B2
公开(公告)日：2016-11-15
申请号：US14772726
申请日：2014-03-14
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Chien-An Chen , Sultan Chowdhury , Christoph Martin Dehnhardt , Shaoyi Sun
IPC: C07D261/20 , C07D413/12 , A61K31/423 , A61K31/4439 , A61P9/00 , A61P25/24 , A61P25/18 , A61P11/00
CPC classification number: C07D261/20 , C07D413/12
Abstract: The invention provides compounds having the general formula (I): and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20130317000A1
公开(公告)日：2013-11-28
申请号：US13899469
申请日：2013-05-21
Applicant: XENON PHARMACEUTICALS INC. , GENENTECH, INC
Inventor： Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Qi Jia , Daniel Ortwine , Brian Safina , Shaoyi Sun , Daniel P. Sutherlin , Alla Yurevna Zenova
IPC: C07C311/51 , C07D213/82 , C07D213/64 , C07D205/04 , C07D413/12 , C07D295/26 , C07D233/84 , C07D207/48 , C07D451/02 , C07C307/06 , C07D311/70
CPC classification number: C07D491/107 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/44 , A61K31/5375 , C07B2200/05 , C07C307/06 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/18 , C07C2602/20 , C07C2602/42 , C07C2602/44 , C07C2602/50 , C07C2603/66 , C07C2603/68 , C07C2603/74 , C07D205/04 , C07D207/46 , C07D207/48 , C07D209/52 , C07D211/22 , C07D211/96 , C07D213/64 , C07D213/82 , C07D233/84 , C07D257/04 , C07D265/30 , C07D295/192 , C07D295/26 , C07D307/12 , C07D307/18 , C07D309/08 , C07D311/58 , C07D311/70 , C07D311/72 , C07D403/12 , C07D405/12 , C07D413/12 , C07D451/02 , C07D471/08
Abstract: The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10899732B2
公开(公告)日：2021-01-26
申请号：US15779065
申请日：2016-11-22
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Chien-an Chen , Sultan Chowdhury , Shannon Marie Decker , Christoph Martin Dehnhardt , Ivan William Hemeon , Steven McKerrall , Brian Salvatore Safina , Tao Sheng , Dan Sutherlin
IPC: C07D401/04 , C07D401/14 , C07D405/14 , C07D231/56 , C07D403/04 , C07D405/04 , C07D403/06 , C07D403/12 , A61P29/00
Abstract: The invention provides compounds having the general formula (I): and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, n, ring A, X2, L, m, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10125098B2
公开(公告)日：2018-11-13
申请号：US15988956
申请日：2018-05-24
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D207/16 , C07D277/06 , C07D413/14 , C07D413/12 , C07D401/10 , C07D401/12 , C07C235/54 , C07D405/10 , C07D403/14 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10071957B2
公开(公告)日：2018-09-11
申请号：US14413218
申请日：2013-07-05
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Christoph Martin Dehnhardt , Sultan Chowdhury , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Brian Safina , Daniel P. Sutherlin
IPC: C07D205/04 , C07D209/08 , C07D213/63 , C07D213/64 , C07D213/69 , C07D213/74 , C07D215/20 , C07D217/02 , C07D231/56 , C07D277/24 , C07D277/34 , C07D277/62 , C07D305/08 , C07D401/12 , C07D405/12 , C07D413/12 , C07C307/06
CPC classification number: C07C307/06 , A61K31/44 , A61K31/4439 , A61K31/444 , C07C2601/04 , C07D205/04 , C07D209/08 , C07D213/63 , C07D213/64 , C07D213/69 , C07D213/74 , C07D215/20 , C07D217/02 , C07D231/56 , C07D277/24 , C07D277/34 , C07D277/62 , C07D305/08 , C07D401/12 , C07D405/12 , C07D413/12
Abstract: The invention provides novel compounds having the general formula (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, ring D, R1, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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Patent Agency Ranking
公开(公告)号：US10005724B2
公开(公告)日：2018-06-26
申请号：US15321335
申请日：2015-07-07
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07C235/54 , C07D207/16 , C07D405/10 , C07D401/12 , C07D471/08 , C07D403/14 , C07D401/10 , C07D413/12 , C07D413/14 , C07D277/06
CPC classification number: C07D207/16 , C07C235/42 , C07C235/52 , C07C235/54 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/02 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D221/22 , C07D231/06 , C07D263/04 , C07D263/26 , C07D265/30 , C07D277/06 , C07D305/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US08952169B2
公开(公告)日：2015-02-10
申请号：US13899526
申请日：2013-05-21
Applicant: Genentech, Inc. , Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , Sultan Chowdhury , Shannon Marie Decker , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Qi Jia , Jun Li , Daniel F. Ortwine , Brian Safina , Tao Sheng , Shaoyi Sun , Daniel P. Sutherlin , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07C311/51 , C07D403/12 , C07D213/82 , C07D213/64 , C07D205/04 , C07D311/58 , A61K31/445 , A61K31/44 , A61K31/18 , C07D265/30 , C07D233/84 , C07D257/04 , C07C307/06 , C07D295/26 , C07D207/48 , C07D311/70 , C07D413/12 , C07D451/02 , C07D307/12 , C07D309/08 , C07D311/72 , C07D405/12 , C07D491/107 , C07D211/22 , C07D295/192 , C07D211/96 , C07D307/18
CPC classification number: C07D491/107 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/44 , A61K31/5375 , C07B2200/05 , C07C307/06 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/18 , C07C2602/20 , C07C2602/42 , C07C2602/44 , C07C2602/50 , C07C2603/66 , C07C2603/68 , C07C2603/74 , C07D205/04 , C07D207/46 , C07D207/48 , C07D209/52 , C07D211/22 , C07D211/96 , C07D213/64 , C07D213/82 , C07D233/84 , C07D257/04 , C07D265/30 , C07D295/192 , C07D295/26 , C07D307/12 , C07D307/18 , C07D309/08 , C07D311/58 , C07D311/70 , C07D311/72 , C07D403/12 , C07D405/12 , C07D413/12 , C07D451/02 , C07D471/08
Abstract: The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US11149002B2
公开(公告)日：2021-10-19
申请号：US16702286
申请日：2019-12-03
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Salvatore Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D207/16 , C07D403/12 , C07D413/14 , C07D221/22 , C07D401/12 , C07D413/12 , C07C235/52 , C07D205/04 , C07D277/06 , C07D209/02 , C07D305/08 , C07D401/14 , C07D231/06 , C07D403/04 , C07D403/14 , C07D409/06 , C07D417/12 , C07D451/02 , C07D263/04 , C07D263/26 , C07C235/42 , C07C235/54 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D401/10 , C07D405/10 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10526285B2
公开(公告)日：2020-01-07
申请号：US16150070
申请日：2018-10-02
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Salvatore Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D207/16 , C07D403/12 , C07D413/14 , C07D221/22 , C07D401/12 , C07D413/12 , C07C235/52 , C07D205/04 , C07D277/06 , C07D209/02 , C07D305/08 , C07D401/14 , C07D231/06 , C07D403/04 , C07D403/14 , C07D409/06 , C07D417/12 , C07D451/02 , C07D263/04 , C07D263/26 , C07C235/42 , C07C235/54 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D401/10 , C07D405/10 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10179767B2
公开(公告)日：2019-01-15
申请号：US15161085
申请日：2016-05-20
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Sultan Chowdhury , Christoph Martin Dehnhardt , Abid Hasan , Ivan William Hemeon , Qi Jia , Jun Li , Zhiguo Liu , Daniel F. Ortwine , Brian Safina , Daniel Sutherlin , Shaoyi Sun , Andrew D. White , Wei Gong , Alla Yurevna Zenova , Jiuxiang Zhu
IPC: A01N43/00 , A61K31/00 , C07D211/22 , C07D211/48 , C07D211/34 , C07D405/08 , C07D401/12 , C07D401/08 , C07D211/42 , C07D221/20 , C07D401/04 , C07D211/38 , C07D211/62
Abstract: The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.
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