公开(公告)号：US07129053B1

公开(公告)日：2006-10-31

申请号：US10110410

申请日：2000-10-12

申请人： Christian Reiter ,  Gerhard Cullman ,  Meret Lakner ,  Andreas Trüe ,  Sonja Dehnert ,  Georg Schwartz

发明人： Christian Reiter ,  Gerhard Cullman ,  Meret Lakner ,  Andreas Trüe ,  Sonja Dehnert ,  Georg Schwartz

IPC分类号： G01N1/30 ,  G01N33/53 ,  G01N33/567 ,  G01N33/569

CPC分类号： C07K16/121 ,  C07K16/40 ,  C07K2317/565 ,  G01N33/558 ,  G01N33/56911 ,  G01N33/56922 ,  G01N33/5695 ,  G01N33/573 ,  G01N2333/908 ,  G01N2333/96486 ,  G01N2333/98 ,  Y10S435/975

摘要： The invention relates to a method for detecting an infection of a mammal with an acid-resistant microorganism comprising the following steps: (a) provision of an immunochromatographic test with a sample application area for the application of a stool sample of the mammal with an antigen and application of the stool sample, (b) incubation of the stool sample using (i) a first receptor under conditions permitting a complex formation of the antigen from the acid resistant microorganism with the receptor; or (ii) at least two different first receptors under conditions permitting a complex formation of the antigen from the acid-resistant microorganism with the at least two first receptors and wherein the first receptor according to (i) or the first receptors according to (ii) specifically bind(s) an antigen which shows, at least with some mammals, a structure after passage through the intestine that corresponds to the native structure or the structure against which a mammal produces antibodies against after being infected or immunized with the acid-resistant microorganism or an extract or lysate thereof or a protein therefrom or a fragment thereof or a synthetic peptide produces antibodies; and (c) provision of a second receptor immobilized at an analysis region, wherein the second receptor binds an antigen receptor complex according to (b) and (d) transport and detection of the formation of at least one antigen receptor complex according to (b) by accumulation of the antigen receptor complex at the second receptor in the analysis area. The invention further relates to an immunochromatographic test which is particularly suitable and designed to carry out the method of the invention.

摘要翻译： 本发明涉及一种用耐酸微生物检测哺乳动物感染的方法，包括以下步骤：（a）提供具有样品施用区域的免疫层析试验，以用于将哺乳动物的粪便样品与抗原 和粪便样品的施用，（b）使用（i）第一受体在允许来自抗酸微生物的抗原与受体复合形成的条件下温育粪便样品; 或（ii）至少两种不同的第一受体，其条件是允许具有至少两个第一受体的抗酸微生物的抗原复合形成，并且其中根据（i）的第一受体或根据（ii）的第一受体 ）特异性结合至少与一些哺乳动物通过肠道的结构，该结构对应于天然结构或结构，其中哺乳动物产生针对感染后的抗体或用耐酸性免疫的结构 微生物或其提取物或裂解物或其蛋白质或其片段或合成肽产生抗体; （c）提供固定在分析区域的第二受体，其中所述第二受体根据（b）和（d）结合抗原受体复合物，根据（b）的转运和检测至少一种抗原受体复合物的形成 ）通过在分析区域中的第二受体处的抗原受体复合物的积累。 本发明还涉及一种特别适合和设计用于实施本发明方法的免疫层析试验。

公开(公告)号：US20060172426A1

公开(公告)日：2006-08-03

申请号：US10539562

申请日：2003-12-22

申请人： Kristopher Buchanan

发明人： Kristopher Buchanan

IPC分类号： G01N35/00

CPC分类号： G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

摘要： Systems and methods of sample processing and temperature control are disclosed. The invention may especially relate to temperature control, and may in some embodiments be methods of temperature control of an automated sample processing system and methods of automated sample processing. Specifically, the present invention provides temperature control in relation to sample processing systems and methods of processing samples, and in some embodiments provides temperature control in relation to sample carriers and processing materials such as reagents. Corresponding systems and devices are disclosed, including sample processing systems (1), sample carrier temperature regulation systems (60), reagent temperature regulation systems, sample processing control systems, and temperature regulation devices, among other embodiments. Scientific fields to which the present invention may have particular applicability include immunohistochemistry, in-situ hybridization, fluorescent in-situ hybridization, special staining, such as special staining of histological samples, microarray sample processing, and cytology, as well as potentially other chemical and biological applications.

摘要翻译： 公开了样品处理和温度控制的系统和方法。 本发明可以特别涉及温度控制，并且在一些实施例中可以是自动化样品处理系统的温度控制方法和自动样品处理方法。 具体地，本发明提供了与样品处理系统和处理样品的方法相关的温度控制，并且在一些实施例中提供了与样品载体和加工材料如试剂相关的温度控制。 公开了相应的系统和装置，包括样品处理系统（1），样品载体温度调节系统（60），试剂温度调节系统，样品处理控制系统和温度调节装置。 本发明可能具有特定适用性的科学领域包括免疫组织化学，原位杂交，荧光原位杂交，特殊染色，例如组织学样品的特殊染色，微阵列样品处理和细胞学，以及潜在的其它化学和 生物应用。

公开(公告)号：US20060105359A1

公开(公告)日：2006-05-18

申请号：US11156760

申请日：2005-06-20

申请人： John Favuzzi ,  Kristopher Buchanan ,  Michael Barber ,  Loren Bland ,  Dawn Rohrbacker ,  Robert Clark ,  Gordon Feingold ,  Benno Guggenheimer ,  Marc Key ,  Merritt Martin ,  Robert Lathrop ,  Jeffery Rau ,  Jonathan Sweda ,  Douglas Sweet ,  John Van Bosch ,  Lars Winther ,  Rosanne Welcher

发明人： John Favuzzi ,  Kristopher Buchanan ,  Michael Barber ,  Loren Bland ,  Dawn Rohrbacker ,  Robert Clark ,  Gordon Feingold ,  Benno Guggenheimer ,  Marc Key ,  Merritt Martin ,  Robert Lathrop ,  Jeffery Rau ,  Jonathan Sweda ,  Douglas Sweet ,  John Van Bosch ,  Lars Winther ,  Rosanne Welcher

IPC分类号： C12Q1/68 ,  G06F19/00 ,  C12M1/34

CPC分类号： G01N35/0092 ,  B01L3/508 ,  B01L7/00 ,  B01L9/06 ,  B01L2200/025 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/0822 ,  B01L2300/1822 ,  G01N1/312 ,  G01N35/00029 ,  G01N35/00871 ,  G01N35/0095 ,  G01N35/0099 ,  G01N35/1002 ,  G01N35/1004 ,  G01N35/1011 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00445 ,  G01N2035/00455 ,  G01N2035/00534 ,  G01N2035/00633 ,  G01N2035/00673 ,  G01N2035/00752 ,  G01N2035/00861 ,  G01N2035/00881 ,  G01N2035/102 ,  G01N2035/1058 ,  Y02A90/26 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/12 ,  Y10T436/2575

摘要： The present invention concerns a method and apparatus for automatic processing a biological sample on a carrier, perhaps robotically, by applying predetermined amounts of reagents in a predetermined sequence according to a processing protocol, the processing including pre-treatment steps, under the control of an adaptive processing control system using a sample process parameter input that may be independent and an independent process parameter memory that does not interrupt process operation when being used, such that samples may be added or removed without interrupting the processing of other samples. Also included is an image capture function for sample and reagent identification and process monitoring, as well as temperature regulation and environmental control functions.

摘要翻译： 本发明涉及一种用于通过根据处理方案以预定顺序施加预定量的试剂来自动地处理载体上的生物样品的方法和装置，所述方法和装置可以机器人地处理，所述处理包括预处理步骤，在 自适应处理控制系统使用可以是独立的样本过程参数输入和在使用时不中断处理操作的独立过程参数存储器，使得可以添加或移除样本而不中断其他样本的处理。 还包括用于样品和试剂识别和过程监测以及温度调节和环境控制功能的图像捕获功能。

公开(公告)号：US20040266015A1

公开(公告)日：2004-12-30

申请号：US10741628

申请日：2003-12-19

申请人： DakoCytomation Denmark A/S

发明人： John Favuzzi ,  Marc Key ,  Lars Winther ,  Ole F. Rasmussen ,  Bob Lathrop

IPC分类号： G01N035/02

CPC分类号： G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

摘要： An automated staining apparatus and a method for treating samples arranged on a carrier is disclosed, in which portions of two or more selected reagents from a first station containing the reagents are collected individually by a robot arm handling a probe and dispensed in a mixing station of the apparatus. After mixing the reagents in the mixing station, e.g. by shaking or rotating the mixing cup containing the reagents, the reagent mixture is applied to selected samples by the robot arm and a probe.

摘要翻译： 公开了一种自动染色装置和用于处理布置在载体上的样品的方法，其中来自含有试剂的第一站的两种或更多种选择的试剂的部分由处理探针的机器人手臂分别收集并分配在 该装置。 将混合站中的试剂混合后， 通过摇动或旋转含有试剂的混合杯，将试剂混合物通过机器人手臂和探针施加到选定的样品。

公开(公告)号：US20030138967A1

公开(公告)日：2003-07-24

申请号：US10349710

申请日：2003-01-22

申请人： DakoCytomation Denmark A/S

发明人： Brian R. Hall ,  Kristopher S. Buchanan ,  Benjamin H. Kaanta ,  Nathan M. Fox

IPC分类号： G01N001/00 ,  B01L003/00

CPC分类号： B01L1/50 ,  B01L9/52 ,  B01L2300/10 ,  G01N15/1456 ,  G01N15/1459 ,  G01N2015/149 ,  G01N2015/1497 ,  G01N2035/00277 ,  Y10T436/25 ,  Y10T436/25875

摘要： A environmental containment system (16) for a flow cytometer (21) which provides a adjustably controllable environment in which biological particles can be differentiated and droplets separated into collection containers (15).

摘要翻译： 一种用于流式细胞仪（21）的环境容纳系统（16），其提供可调节的可控制的环境，其中生物颗粒可以被分化并且液滴分离成收集容器（15）。

公开(公告)号：US08645167B2

公开(公告)日：2014-02-04

申请号：US13690032

申请日：2012-11-30

申请人： DAKO Denmark A/S

发明人： Laura Chirica ,  Mats Grahn ,  Stephen Jones

IPC分类号： G06Q50/00

CPC分类号： G06Q10/0633 ,  G06F19/00 ,  G06Q10/06 ,  G16H10/40 ,  G16H40/20 ,  G16H40/67

摘要： A tangible computer-readable storage device storing computer-executable program instructions that generate a user interface for displaying workflow information associated with a tissue specimen in a pathology laboratory. The program instructions may be configured to perform a method including displaying a virtual laboratory component representing a physical pathology laboratory having one or more laboratory stations for processing the tissue specimen, wherein the tissue specimen is processed by the one or more laboratory stations according to a workflow, and displaying a specimen indicator that indicates a current specimen state based on a current relationship of the tissue specimen to the workflow. The method may further include enabling a first active component associated with the virtual laboratory component, wherein the first active component is configured to receive a user selection of a laboratory station and generating a supplemental view component of the selected laboratory station in response to the user selection, wherein the supplemental view provides supplemental information on processing by the selected laboratory station of the tissue specimen.

摘要翻译： 存储计算机可执行程序指令的有形计算机可读存储设备，其生成用于在病理学实验室中显示与组织标本相关联的工作流信息的用户界面。 程序指令可以被配置为执行一种方法，包括显示代表具有用于处理组织样本的一个或多个实验室的物理病理学实验室的虚拟实验室部件，其中根据工作流程由所述一个或多个实验室站处理所述组织标本 并且基于组织样本与工作流的当前关系，显示指示当前样本状态的样本指示符。 该方法还可以包括启用与虚拟实验室组件相关联的第一活动组件，其中第一活动组件被配置为接收实验室的用户选择并响应于用户选择生成所选实验室的补充视图组件 其中补充视图提供了所选实验室对组织标本进行加工的补充信息。

公开(公告)号：US20120330564A1

公开(公告)日：2012-12-27

申请号：US13605228

申请日：2012-09-06

申请人： Loren L. BLAND ,  Marc E. KEY ,  Lars WINTHER ,  David A. STANFORTH ,  Martin N. LINDBERG

发明人： Loren L. BLAND ,  Marc E. KEY ,  Lars WINTHER ,  David A. STANFORTH ,  Martin N. LINDBERG

IPC分类号： G06F19/00

CPC分类号： G01N1/30 ,  B01L3/545 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/0822 ,  G01N1/312 ,  G01N35/00732 ,  G01N2035/00782 ,  Y10T436/255

摘要： There is disclosed a method of pre-treatment and staining, according to a protocol, of a biological sample disposed upon the surface of a carrier, the method comprising the step of recording at least one parameter relating to at least one protocol step in a non-volatile memory located either upon or within the carrier or a device incorporating the carrier. Also disclosed is a device comprising: a non-volatile memory; a surface of the device adapted to carry a biological sample; and communications means electrically coupled to the memory for enabling data transmission to or from an external apparatus. Also disclosed is a method of controlling processing of a biological sample disposed upon a carrier, comprising: providing, upon or within the carrier or an apparatus holding the carrier, a non-volatile memory having information relating to sample processing priority or protocol; reading the information; and scheduling the processing based upon the information.

摘要翻译： 公开了根据方案对设置在载体表面上的生物样品进行预处理和染色的方法，所述方法包括以下步骤：将与至少一个方案步骤相关的至少一个参数记录在非 - 位于载体上或载体内的易失性存储器或包含载体的装置。 还公开了一种装置，包括：非易失性存储器; 所述装置的表面适于携带生物样品; 以及电连接到存储器的通信装置，用于使能到外部设备的数据传输。 还公开了一种控制设置在载体上的生物样品的处理的方法，包括：在载体或保持载体的装置的上方或内部提供具有与样品处理优先级或方案有关的信息的非易失性存储器; 阅读信息; 并基于该信息调度处理。

公开(公告)号：US20060152823A1

公开(公告)日：2006-07-13

申请号：US11033858

申请日：2005-01-12

申请人： Megan Sauter ,  Johnathan Sharpe ,  Sean Pieper

发明人： Megan Sauter ,  Johnathan Sharpe ,  Sean Pieper

IPC分类号： G02B9/00

CPC分类号： G02B21/02 ,  G01N2015/144

摘要： A lens system for collecting and focusing light emanating from an object comprises: a cuvette housing the object and having a wall of thickness not greater than 1.5 millimeters; a plano-convex lens having a planar surface affixed to the wall; a sequence of at least three meniscus lenses, each meniscus lens having a concave surface toward the object and a convex surface, each successive meniscus lens receiving the light from the immediately preceding meniscus lens and having radii of curvature of its concave and convex surfaces greater than corresponding radii of the preceding meniscus lens; and at least one compound lens chosen from the group consisting of a doublet lens and a triplet lens, the compound lens receiving the light from a last meniscus lens, wherein an image of a geometrical point on the object has a root-mean square spot size equal to or less than 63 μm.

摘要翻译： 用于收集和聚焦从物体发出的光的透镜系统包括：容纳物体并具有厚度不大于1.5毫米的壁的比色皿; 具有固定在该壁上的平坦表面的平凸透镜; 至少三个弯月透镜的序列，每个弯月透镜具有朝向物体的凹面和凸面，每个连续的弯月透镜接收来自刚刚前面的弯月透镜的光，并且其凹面和凸面的曲率半径大于 上述弯月透镜的相应半径; 以及选自由双重透镜和三重透镜组成的组的至少一个复合透镜，所述复合透镜接收来自最后弯月透镜的光，其中所述物体上的几何点的图像具有均方根光斑尺寸 等于或小于63个妈妈。

公开(公告)号：US20060093524A1

公开(公告)日：2006-05-04

申请号：US11300405

申请日：2005-12-15

申请人： Stefan Sanner

发明人： Stefan Sanner

IPC分类号： G01N1/10

CPC分类号： B01L3/502 ,  A61B10/0038 ,  A61B10/0096 ,  B01L3/5055 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2400/0478

摘要： The invention relates to a device for taking and examining samples, comprising a tube-shaped housing (50) in which a cartridge (30), a testing means (40) and a sample-taking means (10) are positioned, wherein a sample introduced by means of the sample-taking means (10) can be mixed with a content of the cartridge (30), and the testing means (40) is used to analyze the sample mixture.

摘要翻译： 本发明涉及一种用于取样和检查样品的装置，包括管状壳体（50），其中定位有盒（30），测试装置（40）和取样装置（10），其中样品 通过采样装置（10）引入的装置可以与盒（30）的内​​容物混合，并且使用测试装置（40）来分析样品混合物。

公开(公告)号：US20060088940A1

公开(公告)日：2006-04-27

申请号：US10539192

申请日：2003-12-22

申请人： Gordon Feingold ,  Marc Key

发明人： Gordon Feingold ,  Marc Key

IPC分类号： G01N35/00

CPC分类号： G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

摘要： A sample processing system 101 that may be automated and methods are disclosed where a number of sample processing systems 101, such as stainer, maybe connected to a number of separate full function computers 181 through a stainer network 183 that may be isolated from other communication traffic. A network configuration may permit scalability and addressability so that additional sample processing systems 101, additional separate full function computers 181, and additional other devices such as label printers 200 may be easily added to the system. One or more remote information links 171 may be provided so that information transfer on a continuous or perhaps constant basis can be accommodated.

摘要翻译： 公开了可以是自动化的样本处理系统101和方法，其中诸如染色剂的多个样本处理系统101可以通过染色剂网络183连接到多个单独的全功能计算机181，染色剂网络183可以与其他通信流量隔离 。 网络配置可以允许可扩展性和可寻址性，使得附加的样本处理系统101，附加的单独的全功能计算机181以及诸如标签打印机200的附加的其他设备可以容易地添加到系统中。 可以提供一个或多个远程信息链路171，使得可以适应连续或可能恒定的信息传输。