公开(公告)号：US11712495B2

公开(公告)日：2023-08-01

申请号：US17167492

申请日：2021-02-04

申请人： Omrix Biopharmaceuticals Ltd. ,  Ethicon, Inc.

发明人： Erez Ilan ,  Omri Faingold ,  Nataly Freizus ,  Ronen Eavri ,  Dwayne Looney ,  Sridevi Dhanaraj ,  James Galloway ,  Walter Danker

IPC分类号： A61L26/00 ,  A61L24/00 ,  A61L24/04 ,  A61L24/06 ,  A61L24/02 ,  A61L24/08

CPC分类号： A61L26/0023 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/02 ,  A61L24/043 ,  A61L24/06 ,  A61L24/08 ,  A61L26/00 ,  A61L26/0004 ,  A61L2300/106 ,  A61L2300/232 ,  A61L2300/25 ,  A61L2300/418 ,  A61L2300/802 ,  A61L2400/04 ,  A61L24/043 ,  C08L1/04 ,  A61L24/06 ,  C08L1/04

摘要： The invention relates to a hemostatic composition comprising a mixture of cellulose-based short and long fibers, preparation and use thereof.

公开(公告)号：US20230211042A1

公开(公告)日：2023-07-06

申请号：US18146081

申请日：2022-12-23

申请人： The Brigham and Women's Hospital, Inc.

发明人： Steven James Mentzer ,  Cristian David Valenzuela ,  Alexandra Brooke Ysasi ,  Andrew Barrett Servais

IPC分类号： A61L24/04 ,  A61L24/00

CPC分类号： A61L24/043 ,  A61L24/0042 ,  A61L24/001 ,  A61L24/0015 ,  A61L2300/414

摘要： This disclosure relates to pectin-based polymer compositions and methods of use thereof to cover, protect, and seal injuries, e.g., surgical wounds, in a mesothelial tissue. The methods include obtaining a bioadhesive pectin-based polymer composition including a complex of high-methoxyl pectin (HMP) and carboxymethylcellulose (CMC) in a ratio from about 10 to 1 to 1 to 10 by weight; applying the composition to an injured mesothelial tissue; and applying pressure for at least one minute to enable the composition to bind to the mesothelial tissue.

公开(公告)号：US20190201575A1

公开(公告)日：2019-07-04

申请号：US16038118

申请日：2018-07-17

申请人： DRAGON CROWN MEDICAL CO., LTD.

发明人： WEI-XING SHAO

IPC分类号： A61L24/06 ,  A61L24/00

CPC分类号： A61L24/06 ,  A61L24/001 ,  A61L2430/02 ,  C08F299/04 ,  C08K2003/3045 ,  C08K2201/006

摘要： The present invention provides a bone cement composition. The bone cement composition includes a developing particle, an acrylic polymer, and an acrylic monomer, wherein a specific surface area of the developing particle is in a range from about 0.1 m2/g to about 5 m2/g. The present invention further provides a bone cement composition kit. The bone cement composition kit includes a power component and a liquid component, respectively stored in separate containers, wherein the power component includes a developing particle and an acrylic polymer, and the liquid component includes an acrylic monomer. A specific surface area of the developing particle is in a range from about 0.1 m2/g to about 5 m2/g.

公开(公告)号：US20190192727A1

公开(公告)日：2019-06-27

申请号：US16289469

申请日：2019-02-28

申请人： MediBeacon Inc.

发明人： Bob O. Basore ,  William L. Neumann ,  Richard B. Dorshow ,  Raghavan Rajagopalan

IPC分类号： A61L24/10 ,  A61L24/04 ,  A61L24/00

CPC分类号： A61L24/102 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/046 ,  A61L24/106 ,  A61L24/108 ,  A61L2300/418 ,  A61L2300/442 ,  A61L2300/604 ,  A61L2400/04 ,  A61L2430/20 ,  A61L2430/34

摘要： The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures.

公开(公告)号：US20180236087A1

公开(公告)日：2018-08-23

申请号：US15962458

申请日：2018-04-25

申请人： COSMO TECHNOLOGIES LTD.

发明人： Luigi MORO ,  Luigi Maria LONGO ,  Enrico FRIMONTI ,  Alessandro REPICI

IPC分类号： A61K47/34 ,  A61K47/14 ,  A61K47/02 ,  A61L24/00 ,  A61L24/04 ,  A61K9/00 ,  A61K49/00 ,  A61L31/14 ,  A61L31/06 ,  A61K47/22 ,  A61K47/10 ,  A61K9/107 ,  C08L71/02

CPC分类号： A61K47/34 ,  A61K9/0019 ,  A61K9/107 ,  A61K9/1075 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K49/006 ,  A61L24/0005 ,  A61L24/001 ,  A61L24/046 ,  A61L31/06 ,  A61L31/14 ,  A61L2300/442 ,  A61L2400/06 ,  C08L71/02

摘要： The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.

公开(公告)号：US20180193010A1

公开(公告)日：2018-07-12

申请号：US15399968

申请日：2017-01-06

申请人： Ethicon, Inc.

发明人： Jerome B. Riebman ,  Leo B. Kriksunov

IPC分类号： A61B17/00 ,  B29C65/48 ,  B29C65/02

CPC分类号： B29C65/02 ,  A61B17/0057 ,  A61B17/07292 ,  A61B2017/00004 ,  A61B2017/00526 ,  A61B2017/00659 ,  A61B2017/00884 ,  A61B2017/00893 ,  A61F13/00008 ,  A61F2013/00463 ,  A61L15/28 ,  A61L15/32 ,  A61L15/42 ,  A61L15/425 ,  A61L15/64 ,  A61L24/001 ,  A61L24/0036 ,  A61L24/0042 ,  A61L24/08 ,  A61L24/104 ,  A61L24/106 ,  A61L24/108 ,  A61L2400/04 ,  B29C65/48 ,  B29L2031/753 ,  C08L1/04

摘要： The present invention relates generally to agents and devices for promoting hemostasis and, more particularly, to bioresorbable hemostatic pads or patches releasably supported on non-resorbable scaffolds for ease of delivery in the field. A sealant and/or hemostat delivery device comprises a resorbable hemostatic pad having a wound facing side and an opposite back side, with a hemostatic and/or wound sealing agent disposed on the wound facing side; a non-resorbable scaffold having an attachment zone on said scaffold; wherein said hemostatic pad is releasably attached with the back side to the attachment zone. The bond between the scaffold and the resorbable hemostatic pad or wound dressing is either (i) severed prior to removal of the scaffold or (ii) is weakened due to the adhesive bonding them together being moisture-deactivated, or (iii) is released by mechanical disentanglement.

公开(公告)号：US09987297B2

公开(公告)日：2018-06-05

申请号：US13192007

申请日：2011-07-27

申请人： Sébastien Ladet

发明人： Sébastien Ladet

IPC分类号： A61L24/04 ,  C07K2/00 ,  C07K17/02 ,  A61K31/7088 ,  A61K38/02 ,  A61K31/722 ,  C08B37/08 ,  A61K38/39 ,  C07K14/78 ,  A61K31/37 ,  C08B3/00 ,  A61K31/717 ,  A61P17/02 ,  A61P41/00 ,  A61K31/737 ,  A61K31/745 ,  A61K31/765 ,  A61K31/78 ,  A61K31/785 ,  A61K31/79 ,  A61L17/00 ,  A61L24/00 ,  A61L31/04 ,  A61L31/14 ,  D01F11/14

CPC分类号： A61K31/7088 ,  A61K31/717 ,  A61K31/722 ,  A61K31/737 ,  A61K31/745 ,  A61K31/765 ,  A61K31/78 ,  A61K31/785 ,  A61K31/79 ,  A61L17/00 ,  A61L24/001 ,  A61L24/04 ,  A61L31/04 ,  A61L31/14 ,  D01F11/14

摘要： A method for bonding a polymeric fiber to tissue is provided which includes providing a polymeric fiber having a plurality of tissue reactive members linked to a surface of the fiber via a specific binding pair, and contacting the polymeric fiber to biological tissue, to covalently bond the fiber to the tissue.

公开(公告)号：US09968369B2

公开(公告)日：2018-05-15

申请号：US14869335

申请日：2015-09-29

申请人： Genzyme Corporation ,  The General Hospital Corporation

发明人： W. Scott McDougal ,  Dianne E. Sacco ,  Alexander Schwarz ,  Jean-Marie Vogel

IPC分类号： A61K31/77 ,  A61B17/22 ,  A61B17/3205 ,  A61K9/00 ,  A61K47/10 ,  A61K47/36 ,  A61L24/00 ,  A61L24/04 ,  A61K49/00 ,  A61B18/00 ,  A61B17/00

CPC分类号： A61B17/22 ,  A61B17/32056 ,  A61B2017/00818 ,  A61B2017/00849 ,  A61B2017/00853 ,  A61B2017/22037 ,  A61B2017/22082 ,  A61B2018/005 ,  A61B2018/00511 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/36 ,  A61K49/0002 ,  A61L24/001 ,  A61L24/046 ,  A61L2400/06 ,  C08L71/02

摘要： One aspect of the present invention relates to a method of using peristalsis to force a polymer plug through a mammalian lumen, thereby removing any calculi and/or calculi fragments present in the lumen. In one embodiment, the method is used as an alternative to conventional lithotripsy. In another embodiment, the method is used in conjunction with lithotripsy, thereby removing the small calculi fragments that result from such procedures.

公开(公告)号：US20180021474A1

公开(公告)日：2018-01-25

申请号：US15547810

申请日：2016-02-02

申请人： Coloplast A/S

发明人： Esben Stroebech ,  Michael Hansen

IPC分类号： A61L24/04 ,  A61F5/448 ,  A61L24/00 ,  A61F5/443

CPC分类号： A61L24/043 ,  A61F5/443 ,  A61F5/448 ,  A61L24/001 ,  A61L2400/14

摘要： Disclosed is an ostomy device with an adhesive wafer for attachment to a skin surface (S) of a user and a collecting bag (8) or collecting output from a stoma. The collecting bag is connected to the adhesive wafer, and the adhesive wafer has a through-going hole (6) for accommodating the stoma (7) of the user. The adhesive wafer includes a backing layer (3), a first switchable adhesive composition (2), a second absorbent adhesive composition (1), and a release liner, and the second adhesive layer has a central portion with a first thickness and an edge portion with a second thickness, the first thickness being larger than the second thickness.

公开(公告)号：US09814799B2

公开(公告)日：2017-11-14

申请号：US14560329

申请日：2014-12-04

申请人： Omrix Biopharmaceuticals Ltd.

发明人： Yair Pilpel ,  Ashley Deanglis ,  Yuri Zherdev ,  Sivan Doron ,  Israel Nur

IPC分类号： A61L24/00 ,  A61L24/10

CPC分类号： A61L24/001 ,  A61L24/0015 ,  A61L24/106 ,  A61L24/108 ,  A61L2300/25 ,  A61L2300/434 ,  A61L2400/06

摘要： Provided herein are stable liquid sealant formulations comprising fibrin monomers and a reversible fibrin polymerization blocking agent, methods of preparing and using the formulations.