公开(公告)号：US11951146B2

公开(公告)日：2024-04-09

申请号：US17534292

申请日：2021-11-23

Applicant: Therapeutic Solutions International, Inc.

Inventor： Thomas Ichim ,  Timothy G. Dixon ,  Famela Ramos ,  Wais Kaihani

IPC: A61K36/82 ,  A61K31/09 ,  A61K31/122 ,  A61K31/155 ,  A61K31/26 ,  A61K31/352 ,  A61K36/31 ,  A61K36/45 ,  A61K36/71 ,  A61P31/14 ,  A61P37/04

CPC classification number: A61K36/82 ,  A61K31/09 ,  A61K31/122 ,  A61K31/155 ,  A61K31/26 ,  A61K31/352 ,  A61K36/31 ,  A61K36/45 ,  A61K36/71 ,  A61P37/04

Abstract: Disclosed are means, compounds, and compositions of matter useful for stimulation of natural killer cell activity. On one embodiment a composition termed QuadraMune™ comprised of pterostilbene, Nigella sativa extract, green tea extract, and broccoli. In some embodiments the invention teaches the administration of a therapeutic combination of ingredients comprising of metformin, pterostilbene, Nigella sativa, sulforaphane, and epigallocatechin-3-gallate (EGCG) to a mammal in need of natural killer cell immune modulation. In another embodiment, the invention teaches administration of said therapeutic combination to a mammal infected with said SARS-CoV-2. In some embodiments dosage of said therapeutic combination is based on inflammatory and/or immunological parameters observed in patients with COVID-19.

公开(公告)号：US11938151B1

公开(公告)日：2024-03-26

申请号：US18519662

申请日：2023-11-27

Applicant: KING FAISAL UNIVERSITY

Inventor： Enas Mohamed Ali ,  Basem Mohamed Abdallah ,  Peramaiyan B. Rajendran

IPC: A61K33/242 ,  A61K36/31 ,  B82Y5/00

CPC classification number: A61K33/242 ,  A61K36/31 ,  B82Y5/00

Abstract: In order to inhibit the growth of fungi, such as Madurella mycetomatis, gold nanoparticles are synthesized and capped with an extract of Reseda arabica. The gold nanoparticles capped with the extract of Reseda arabica are made by adding the extract of Reseda arabica to an aqueous sodium tetrachloroaurate (NaAuCl4) solution to reduce the sodium tetrachloroaurate and form a suspension of gold nanoparticles capped with the extract of Reseda arabica. The extract of Reseda arabica acts as a reducing and stabilizing agent while also functionalizing the surfaces of the gold nanoparticles to cap the surfaces. The suspension may be boiled, followed by removal of the gold nanoparticles capped with the extract of Reseda arabica from the suspension. To treat a Madurella mycetomatis infection, an effective dose of the gold nanoparticles capped with Reseda arabica extract may be administered to a patient in need thereof.

公开(公告)号：US20240091299A1

公开(公告)日：2024-03-21

申请号：US17947012

申请日：2022-09-16

Applicant: The Hidden Vault LLC

Inventor： Temeka Jones

IPC: A61K36/9068 ,  A61K9/00 ,  A61K31/05 ,  A61K36/068 ,  A61K36/185 ,  A61K36/258 ,  A61K36/31 ,  A61K36/41 ,  A61K36/63 ,  A61K36/746 ,  A61K36/79 ,  A61K36/82 ,  A61K36/8962

CPC classification number: A61K36/9068 ,  A61K9/0034 ,  A61K31/05 ,  A61K36/068 ,  A61K36/185 ,  A61K36/258 ,  A61K36/31 ,  A61K36/41 ,  A61K36/63 ,  A61K36/746 ,  A61K36/79 ,  A61K36/82 ,  A61K36/8962

Abstract: The present invention provides compositions formulated for topical administration to a penis of a person to enhance sexual responsiveness in the person, to enhance sexual performance, erection and stamina, and to increase the physical size of the penis, where the compositions comprise active components from herbal or plant origin including maca, tongkat ali, cordyceps, ginseng, fructus schisandrae. morinda root, rhodiola, rosea cordyceps sinensis, ginger, jasmine, sandalwood, leeks, camellia seed, jojoba oil and cannabidiol. The preferred composition is in the form of a massage oil, to be applied topically to the skin of the penis.

公开(公告)号：US20240041027A1

公开(公告)日：2024-02-08

申请号：US18257539

申请日：2020-12-14

Applicant: Javier Eduardo LÓPEZ MACÍAS

Inventor： Alejandro PÉREZ LARIOS

IPC: A01N25/08 ,  A61K36/9062 ,  A61P31/06 ,  A61K36/63 ,  A01N65/36 ,  A61K36/85 ,  A61K36/886 ,  A61K31/045 ,  A01N31/02 ,  A61K31/085 ,  A01N35/04 ,  A61K36/9068 ,  A61K36/54 ,  A61K36/53 ,  A61K36/61 ,  A01N65/08 ,  A61K36/24 ,  A61K36/282 ,  A01N65/38 ,  A01N31/08 ,  A01N35/02 ,  A01N65/48 ,  A61P31/12 ,  A61K36/28 ,  A61K31/122 ,  A01N27/00 ,  A61K31/231 ,  A61K36/232 ,  A61K36/268 ,  A61K36/9066 ,  A61K36/35 ,  A01P3/00 ,  A01P1/00 ,  A01N65/12 ,  A61K36/185 ,  A61K36/30 ,  A61K36/52 ,  A61K36/746 ,  A61K36/235 ,  A61K36/66 ,  A61K36/14 ,  A61K31/015 ,  A61K31/11 ,  A61K31/121 ,  A61K31/01 ,  A61K36/288 ,  A61K36/87 ,  A01N65/24 ,  A61K36/484 ,  A61P31/04 ,  A01N65/22 ,  A61K36/738 ,  A01N65/28 ,  A61K36/21 ,  A61K36/537 ,  A61K36/81 ,  A01N35/06 ,  A61K36/31 ,  A01N65/44 ,  A61P31/10 ,  A61K36/752 ,  A61K36/68 ,  A61K36/534 ,  A61K36/67 ,  A01N37/06 ,  A01N65/10 ,  A61K36/899 ,  A01N65/34 ,  A61K36/75 ,  A61K36/15 ,  A61K31/05 ,  A01N31/14

CPC classification number: A01N25/08 ,  A61K36/9062 ,  A61P31/06 ,  A61K36/63 ,  A01N65/36 ,  A61K36/85 ,  A61K36/886 ,  A61K31/045 ,  A01N31/02 ,  A61K31/085 ,  A01N35/04 ,  A61K36/9068 ,  A61K36/54 ,  A61K36/53 ,  A61K36/61 ,  A01N65/08 ,  A61K36/24 ,  A61K36/282 ,  A01N65/38 ,  A01N31/08 ,  A01N35/02 ,  A01N65/48 ,  A61P31/12 ,  A61K36/28 ,  A61K31/122 ,  A01N27/00 ,  A61K31/231 ,  A61K36/232 ,  A61K36/268 ,  A61K36/9066 ,  A61K36/35 ,  A01P3/00 ,  A01P1/00 ,  A01N65/12 ,  A61K36/185 ,  A61K36/30 ,  A61K36/52 ,  A61K36/746 ,  A61K36/235 ,  A61K36/66 ,  A61K36/14 ,  A61K31/015 ,  A61K31/11 ,  A61K31/121 ,  A61K31/01 ,  A61K36/288 ,  A61K36/87 ,  A01N65/24 ,  A61K36/484 ,  A61P31/04 ,  A01N65/22 ,  A61K36/738 ,  A01N65/28 ,  A61K36/21 ,  A61K36/537 ,  A61K36/81 ,  A01N35/06 ,  A61K36/31 ,  A01N65/44 ,  A61P31/10 ,  A61K36/752 ,  A61K36/68 ,  A61K36/534 ,  A61K36/67 ,  A01N37/06 ,  A01N65/10 ,  A61K36/899 ,  A01N65/34 ,  A61K36/75 ,  A61K36/15 ,  A61K31/05 ,  A01N31/14

Abstract: The instant invention refers to nanosystems comprising nanocomposites for adsorption or support of natural extracts; a process for the preparation thereof; formulations containing thereof, as well as a nanomaterial that adsorbs one or more essential oils in its surface. Specially, one object of the invention is the encapsulation of natural extracts, i.e., essential oils and/or natural pure bioactive compounds and optionally terpenoid, sesquiterpenoid, diterpenoid, sesterterpenoid, triterpenoid, carotenoid, and ricinoid compounds; complementary acids, and polysaccharides; vitamins, and other organic compounds, in mesoporous materials for application in different industries such as food, agricultural, veterinary, aquacultural, pharmaceutical, cosmetic, cleaning, sanitizing, and disinfection industries, as well as in medicine.

公开(公告)号：US20230321126A1

公开(公告)日：2023-10-12

申请号：US18021201

申请日：2021-08-13

Applicant: MATTHIAS W RATH

Inventor： Aleksandra Niedzwiecki ,  MATTHIAS W Rath ,  Vadim Ivanov ,  Anna Goc

IPC: A61K31/7048 ,  A61K31/05 ,  A61K31/12 ,  A61K36/82 ,  A61K36/31 ,  A61K31/375 ,  A61K31/708 ,  A61K45/06 ,  A61P31/14

CPC classification number: A61K31/7048 ,  A61K31/05 ,  A61K31/12 ,  A61K36/82 ,  A61P31/14 ,  A61K31/375 ,  A61K31/708 ,  A61K45/06 ,  A61K36/31

Abstract: The way the SARS-CoV-2 virus infects the cell is a complex process and comprises four main stages: attachment to the cognate receptor, cellular entry, replication and cellular egress. Targeting binding of the virus to the host receptor in order to prevent its entry has been of particular interest. We tested 56 polyphenols, including plant extracts, brazilin, theaflavin-3,3′-digallate, and curcumin displayed the highest binding with the receptor-binding domain of spike protein, inhibiting viral attachment to the human angiotensin-converting enzyme 2 receptor, and thus cellular entry of pseudo-typed SARS-CoV-2 virions. Both, theaflavin-3,3′-digallate at 25 μg/ml and curcumin above 10 μg/ml concentration, showed binding with the angiotensin-converting enzyme 2 receptor reducing at the same time its activity in both cell-free and cell-based assays. Our study also demonstrates that brazilin and theaflavin-3, 3′-digallate, curcumin, decrease the activity of transmembrane serine protease 2 both in cell-free and cell-based assays and moderately increased endosomal/lysosomal pH.

公开(公告)号：US20230293615A1

公开(公告)日：2023-09-21

申请号：US18162300

申请日：2023-01-31

Applicant: BASF PLANT SCIENCE COMPANY GMBH ,  Bioriginal Food & Science Corporation

Inventor： Toralf Senger ,  Laurent Marty ,  Irene Kunze ,  Heiko Haertel ,  Steven Craig Bremmer ,  Steven D. Breazeale ,  Joerg Bauer ,  Patricia Vrinten ,  Sten Stymne ,  Jenny Lindberg Yilmaz ,  John A. McElver ,  Dietrich Rein ,  Carl Andre

IPC: A61K36/31 ,  C12Q1/6895

CPC classification number: A61K36/31 ,  C12Q1/6895 ,  C12N15/8247

Abstract: T-DNA for expression of a target gene in a plant, wherein the T-DNA comprises a left and a right border element and at least one expression cassette comprising a promoter, operatively linked thereto a target gene, and downstream thereof a terminator, wherein the length of the T-DNA, measured from left to right border element and comprising the target gene, has a length of at least 30000 bp.

公开(公告)号：US11752183B2

公开(公告)日：2023-09-12

申请号：US16499990

申请日：2018-04-03

Applicant: TCI CO., LTD

Inventor： Yung-Hsiang Lin ,  I-Hui Chen ,  Kai-Wen Kan ,  Fu Chen Liu ,  Ciao-Ting Chen

IPC: A61K36/185 ,  A23L33/105 ,  A61K9/00 ,  A61K9/08 ,  A61K9/48 ,  A61P3/04 ,  A61K31/01 ,  A61K31/015 ,  A61K36/21 ,  A61K36/258 ,  A61K36/31 ,  A61K36/45 ,  A61K36/48 ,  A61K36/53 ,  A61K36/67 ,  A61K36/73 ,  A61K36/74 ,  A61K36/752 ,  A61K36/815 ,  A61K36/82 ,  A61K36/87 ,  A61K36/886 ,  A61K36/8962 ,  A61K36/9066 ,  A61K8/9789 ,  A61P17/16 ,  A61Q19/00 ,  A23F3/16 ,  A61K8/97 ,  A61Q17/04 ,  A61P19/04 ,  A61Q19/08

CPC classification number: A61K36/185 ,  A23F3/163 ,  A23L33/105 ,  A61K8/97 ,  A61K8/9789 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/48 ,  A61K31/01 ,  A61K31/015 ,  A61K36/21 ,  A61K36/258 ,  A61K36/31 ,  A61K36/45 ,  A61K36/48 ,  A61K36/53 ,  A61K36/67 ,  A61K36/73 ,  A61K36/74 ,  A61K36/752 ,  A61K36/815 ,  A61K36/82 ,  A61K36/87 ,  A61K36/886 ,  A61K36/8962 ,  A61K36/9066 ,  A61P3/04 ,  A61P17/16 ,  A61P19/04 ,  A61Q17/04 ,  A61Q19/007 ,  A61Q19/08 ,  A23V2002/00

Abstract: Provided is a plant extract-containing composition for reducing skin damage caused by ultraviolet radiation. The composition includes a combination of extracts of spinach, black tea, green tea, Pu-erh tea, Four Seasons Spring tea, red wine, blueberry, grape seeds, citrus, or green coffee beans.

公开(公告)号：US20230226131A1

公开(公告)日：2023-07-20

申请号：US18156364

申请日：2023-01-18

Applicant: KARALLIEF, INC.

Inventor： Krishna RAJENDRAN

IPC: A61K36/19 ,  A61K36/9068 ,  A61K36/31 ,  A61K36/42 ,  A61K36/8965 ,  A61P1/16

CPC classification number: A61K36/19 ,  A61K36/9068 ,  A61K36/31 ,  A61K36/42 ,  A61K36/8965 ,  A61P1/16 ,  A61K2236/15 ,  A61K2236/333 ,  A61K2236/51 ,  A61K2236/331

Abstract: Compositions including herbal extracts, such as an Andrographis paniculata extract, a Zingiber officinale (ginger) extract, a Momordica charantia extract, a Brassica rapa (turnip) extract, an Asparagus racemosus extract, and a Phyllanthus niruri extract, and methods using such compositions are disclosed. For example, compositions and methods may be used to support, maintain, or improve liver health.

公开(公告)号：US20230181660A1

公开(公告)日：2023-06-15

申请号：US18066035

申请日：2022-12-14

Applicant: Zachary G. Rucker, JR.

Inventor： Zachary G. Rucker, JR.

IPC: A61K36/04 ,  A61K36/752 ,  A61K36/54 ,  A61K36/31 ,  A61K36/185 ,  A61K47/10

CPC classification number: A61K36/04 ,  A61K36/752 ,  A61K36/54 ,  A61K36/31 ,  A61K36/185 ,  A61K47/10

Abstract: A tincture composition includes gel-free sea moss extract; about 80-90% by volume glycerin; about 10-18% by volume ethanol; and about 0.5-1.5% cinnamon oil. The total amount of glycerin, ethanol, and cinnamon oil is 100%. A method of producing the composition includes soaking sea moss in water; drying the sea moss; immersing the sea moss fully in glycerin; providing an extraction blend; blending the sea moss, the glycerin, and the extraction blend to form a suspension; straining the suspension to extract a tincture; and heating the tincture at 50-200 degrees Fahrenheit for 1-24 hours. The extraction blend includes, per 1 part by volume glycerin: 1/16 to 2 parts by volume ethanol and 1/100 to ¼ parts by volume of cinnamon oil. The tincture composition has an excellent shelf life and improved palatability. A binding agent may be added to prevent separation.

公开(公告)号：US11623911B2

公开(公告)日：2023-04-11

申请号：US16146469

申请日：2018-09-28

Applicant: Commonwealth Scientific and Industrial Research Organisation ,  Grains Research and Development Corporation ,  Nuseed Nutritional Australia Pty Ltd

Inventor： James Robertson Petrie ,  Surinder Pal Singh ,  Pushkar Shrestha ,  Jason Timothy McAllister ,  Robert Charles de Feyter ,  Malcolm David Devine

IPC: C07C69/587 ,  C12N15/82 ,  A61K36/31 ,  A23D9/00 ,  A61K31/20 ,  A61K31/201 ,  A61K31/202 ,  C11B1/10

Abstract: The present invention relates to extracted plant lipid or microbial lipid comprising docosapentaenoic acid, and processes for producing the extracted lipid.