公开(公告)号：US10993931B2

公开(公告)日：2021-05-04

申请号：US16215400

申请日：2018-12-10

申请人： Allergan, Inc.

发明人： Richard L. Beard ,  Tien T. Duong ,  John E. Donello ,  Veena Viswanath ,  Michael E. Garst

IPC分类号： C07C275/30 ,  C07C317/42 ,  C07C317/50 ,  C07C323/44 ,  C07C323/60 ,  A61K31/17 ,  A61K31/197 ,  A61K31/198 ,  A61K31/216 ,  A61K31/4045 ,  A61K31/417 ,  C07D209/20 ,  C07D233/64 ,  C07K5/062 ,  C07K5/072 ,  C07K5/078

摘要： The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.

公开(公告)号：US20210015098A1

公开(公告)日：2021-01-21

申请号：US17042988

申请日：2019-03-21

申请人： DOW AGROSCIENCES LLC

发明人： TIMOTHY P. MARTIN ,  RONALD ROSS, Jr. ,  RONALD J. HEEMSTRA ,  JOSEPH D. ECKELBARGER ,  TONY K. TRULLINGER ,  RICKY HUNTER ,  MARTIN J. WALSH

IPC分类号： A01N43/40 ,  C07C323/60 ,  C07D213/70 ,  C07C317/48 ,  A01N53/00

摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US10688193B2

公开(公告)日：2020-06-23

申请号：US15746544

申请日：2016-07-21

申请人： GNT BIOTECH & MEDICALS CORPORATION

发明人： Yu-Jung Liao ,  Wei-Jan Huang ,  Chia-Nan Chen ,  Huan-Yu Lin ,  Ching-Yi Lin ,  Meng-Ju Tsai ,  Wan-Yi Hsu ,  Li-Ling Chi ,  Ye-Su Chao ,  Yi-Hong Wu

IPC分类号： A61K47/64 ,  A61K47/60 ,  A61K47/69 ,  C07C243/26 ,  C07C271/22 ,  C07C323/60 ,  C07K5/062 ,  A61K9/14 ,  C07C323/52 ,  C07D339/04 ,  C07K5/103 ,  A61P35/00 ,  A61K47/20 ,  A61K31/351 ,  A61K31/437 ,  A61K33/24 ,  A61K47/22

摘要： The invention provides a pH-sensitive linker that can simultaneously bind metallic nanoparticles and one or more agents with various molecular size. The linker of the invention can deliver the agents into cells involved in disease processes or close to cells so that the agents can selectively target and effect on the cells. The target delivery provided by the linker of the invention can be used for example for disease sensing, imaging, drug delivery, and therapy.

公开(公告)号：US10675359B2

公开(公告)日：2020-06-09

申请号：US15702586

申请日：2017-09-12

申请人： Innate Pharma ,  Paul Scherrer Institut

发明人： Patrick Dennler ,  Delphine Bregeon ,  Laurent Gauthier ,  François Romagné ,  Christian Belmant ,  Eliane Fischer ,  Roger Schibli

IPC分类号： A61K47/68 ,  C07K16/00 ,  A61K47/60 ,  C07C217/08 ,  C07C223/02 ,  C07C229/26 ,  C07C233/62 ,  C07C247/04 ,  C07C323/12 ,  C07C323/60 ,  C07D225/08 ,  C07D257/08 ,  C07D277/06 ,  C07F9/50 ,  C07K19/00 ,  C12N9/10 ,  C12P21/00 ,  G01N33/68

摘要： The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.

公开(公告)号：US20200009090A1

公开(公告)日：2020-01-09

申请号：US16511577

申请日：2019-07-15

申请人： The University of Melbourne

发明人： Paul Stephen DONNELLY ,  Stacey Erin RUDD ,  Spencer John WILLIAMS

IPC分类号： A61K31/18 ,  C07K17/06 ,  A61K51/10 ,  C07C259/06 ,  C07C309/14 ,  C07C311/19 ,  C07C311/29 ,  C07C311/42 ,  C07C311/46 ,  C07D207/48 ,  C07D211/60 ,  C07D211/96 ,  C07D213/42 ,  C07D213/74 ,  C07D213/89 ,  C07D215/36 ,  C07D223/06 ,  C07D277/06 ,  C07D277/80 ,  C07D279/12 ,  C07D295/13 ,  C07D309/06 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D453/06 ,  C07D471/08 ,  C07D487/08 ,  C07C323/60

摘要： The invention discussed in this application relates to hydroxamic acid-based compounds that are useful as imaging agents when bound to an appropriate metal centre, particularly for the imaging of tumours.

公开(公告)号：US20200000762A1

公开(公告)日：2020-01-02

申请号：US16480773

申请日：2018-01-25

申请人： ADARE PHARMACEUTICALS, INC.

发明人： Stephen PERRETT

IPC分类号： A61K31/25 ,  C07C323/60 ,  A61K31/573

摘要： Described herein are prodrugs of cysteamine and pharmaceutically acceptable salts, solvates, and esters thereof. Also described herein are pharmaceutical compositions comprising prodrugs of cysteamine, or pharmaceutically acceptable salts, solvates, and esters thereof, and methods of treatment comprising administering prodrugs of cysteamine, or pharmaceutically acceptable salts, solvates, and esters thereof.

公开(公告)号：US10508081B2

公开(公告)日：2019-12-17

申请号：US15870014

申请日：2018-01-12

申请人： PFIZER INC.

发明人： Robert Wayne Dugger ,  Leo Joseph Letendre ,  Vimalkumar Babubhai Patel ,  Amarnauth Shastrie Prashad ,  Chunchun Zhang

IPC分类号： C07C323/48 ,  C07C319/20 ,  C07C323/60 ,  C07C319/28 ,  A61K47/68 ,  C07C319/06 ,  C07D207/46 ,  C07H1/06 ,  C07H15/26

摘要： The present invention relates to intermediates of Formula I and to methods of synthesizing and purifying calicheamicin derivatives.

公开(公告)号：US10441659B2

公开(公告)日：2019-10-15

申请号：US14872951

申请日：2015-10-01

申请人： Nitto Denko Corporation

发明人： Joseph E. Payne ,  John A. Gaudette ,  Zheng Hou ,  Mohammad Ahmadian ,  Lei Yu ,  Victor Knopov ,  Violetta Akopian ,  Priya Karmali ,  Richard P. Witte ,  Neda Safarzadeh ,  Wenbin Ying ,  Jun Zhang

IPC分类号： A61K47/14 ,  A61K47/20 ,  A61K47/18 ,  A61K47/22 ,  C07C271/16 ,  C07D333/40 ,  C07C317/44 ,  C07C333/04 ,  C07C235/08 ,  C07C237/08 ,  C07D207/16 ,  A61K9/127 ,  C07D333/38 ,  C07C323/60 ,  C07C237/16

摘要： The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.

公开(公告)号：US10351492B2

公开(公告)日：2019-07-16

申请号：US15551394

申请日：2016-02-16

申请人： B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY

发明人： Doron Pappo ,  Regev Parnes

IPC分类号： C07C15/04 ,  C07C319/18 ,  C07C321/20 ,  C07B31/00 ,  C07B37/04 ,  C07B45/06 ,  A61K31/015 ,  A61K31/10 ,  A61K31/335 ,  A61K31/565 ,  C07C317/14 ,  C07C327/06 ,  C07C253/30 ,  C07C39/14 ,  C07C39/38 ,  C07C43/225 ,  C07C43/23 ,  C07J1/00 ,  C07J31/00 ,  C07D317/64 ,  C07D209/10 ,  A61K31/47 ,  C07C323/16 ,  C07C323/56 ,  C07C323/60 ,  C07C319/14 ,  C07C323/63

摘要： Novel selective synthesis route to introduce primary alkyl groups on aromatic compounds is disclosed. The synthesis route is based on electrophilic aromatic substitutions of thionium ion species that are generated in-situ from aldehydes and thiols, affording benzyl sulfide that can be reduced with triethylsilane.

公开(公告)号：US20190111009A1

公开(公告)日：2019-04-18

申请号：US15943236

申请日：2018-04-02

申请人： Glenn A. Goldstein

发明人： Glenn A. Goldstein

IPC分类号： A61K31/16 ,  A61K31/375 ,  A61K31/167 ,  A61K9/00 ,  C07C323/41 ,  C07C233/26 ,  C07C233/36 ,  C07C233/18 ,  C07C323/60

摘要： Methods and compositions comprising N-acetylcysteine amide (NAC amide) and derivatives thereof are used in treatments and therapies for human and non-human mammalian diseases, disorders, conditions and pathologies. Pharmaceutically or physiologically acceptable compositions of NAC amide or derivatives thereof are administered alone, or in combination with other suitable agents, to reduce, prevent, or counteract oxidative stress and free radical oxidant formation and overproduction in cells and tissues, as well as to provide a new source of glutathione.