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    Temperature control of chemical detection system
    203.
    发明授权
    Temperature control of chemical detection system 有权

    公开(公告)号：US10578578B2

    公开(公告)日：2020-03-03

    申请号：US15351253

    申请日：2016-11-14

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd Rearick ,  Jeremy Jordan ,  John Nobile ,  William Mileski ,  Chun Heen Ho

    IPC: G01N33/48 ,  G01N27/414 ,  G01N31/20 ,  G05D23/19 ,  B01L3/00

    Abstract: An apparatus for detecting chemical reactions may be provided. The apparatus may comprise a chemical detection device. The chemical detection device may include a chemical sensor, which may be mounted on the chemical detection device. The apparatus may further comprise a valve block. The valve block may fluidly couple a plurality of reagent containers to the chemical detection device. The apparatus may further comprise a heat exchanger and a controller. The controller may control a fluid connection between the valve block and the chemical detection device. The controller may be also configured to adjust a temperature of a selected reagent from the plurality of reagent containers via the heat exchanger. The temperature of the selected reagent may be adjusted prior to the reagent entering the chemical detection device.

    SYSTEMS AND METHODS FOR ANALYZING NUCLEIC ACID SEQUENCES
    205.
    发明申请
    SYSTEMS AND METHODS FOR ANALYZING NUCLEIC ACID SEQUENCES 审中-公开

    公开(公告)号：US20200051663A1

    公开(公告)日：2020-02-13

    申请号：US16279315

    申请日：2019-02-19

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Zheng ZHANG ,  Danwei GUO ,  Yuandan LOU ,  Asim SIDDIQUI ,  Dumitru BRINZA

    IPC: G16B30/00

    Abstract: Nucleic acid sequence mapping/assembly methods are disclosed. The methods initially map only a contiguous portion of each read to a reference sequence and then extends the mapping of the read at both ends of the mapped contiguous portion until the entire read is mapped (aligned). In various embodiments, a mapping score can be calculated for the read alignment using a scoring function, score (i, j)=M+mx, where M can be the number of matches in the extended alignment, x can be the number of mismatches in the alignment, and m can be a negative penalty for each mismatch. The mapping score can be utilized to rank or choose the best alignment for each read.

    LINKING METHODS, COMPOSITIONS, SYSTEMS, KITS AND APPARATUSES
    208.
    发明申请
    LINKING METHODS, COMPOSITIONS, SYSTEMS, KITS AND APPARATUSES 审中-公开

    公开(公告)号：US20200017846A1

    公开(公告)日：2020-01-16

    申请号：US16542121

    申请日：2019-08-15

    Applicant: Life Technologies Corporation

    Inventor： John DAVIDSON ,  Theo NIKIFOROV ,  Guobin LUO

    IPC: C12N11/10 ,  C12N9/12

    Abstract: In some embodiments, the disclosure relates generally to methods as well as related compositions, systems, kits and apparatus comprising linking proteins to target compounds and/or to locations of interest using tethers. For example, the tether can be used to link the protein to a target compound, for example, to link an enzyme to a substrate. Similarly, the tether can be used to link the protein at or near a desired location on a surface. In one group of embodiments, the tether includes a polynucleotide and the target compound or location on the surface includes another polynucleotide that is capable of hybridizing to the tether. In such embodiments, the tether can be used to link the protein to the target compound or location using nucleic acid hybridization.

    BIOLOGICAL ANALYSIS SYSTEMS, DEVICES, AND METHODS
    209.
    发明申请
    BIOLOGICAL ANALYSIS SYSTEMS, DEVICES, AND METHODS 审中-公开

    公开(公告)号：US20190390270A1

    公开(公告)日：2019-12-26

    申请号：US16246990

    申请日：2019-01-14

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Dennis Lehto ,  Steven J. Boege

    IPC: C12Q1/6874 ,  B01L7/00 ,  B01L3/00 ,  G01N21/05

    Abstract: A device for performing biological sample reactions may include a plurality of flow cells configured to be mounted to a common microscope translation stage, wherein each flow cell is configured to receive at least one sample holder containing biological sample. Each flow cell also may be configured to be selectively placed in an open position for positioning the at least one sample holder into the flow cell and a closed position for reacting biological sample contained in the at least one sample holder. The plurality of flow cells may be configured to be selectively placed in the open position and the closed position independently of each other.

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