公开(公告)号：US09212997B2

公开(公告)日：2015-12-15

申请号：US14405334

申请日：2012-07-29

Applicant: Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Huei Pei Kuo ,  Steven Barcelo ,  Zhang-Lin Zhou

Inventor： Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Huei Pei Kuo ,  Steven Barcelo ,  Zhang-Lin Zhou

IPC: G01J3/44 ,  G01N21/65 ,  B82Y15/00

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/4412 ,  G01N2021/651 ,  G01N2201/06113 ,  Y10S977/902

Abstract: A scattering spectroscopy nanosensor includes a nanoscale-patterned sensing substrate to produce an optical scattering response signal indicative of a presence of an analyte when interrogated by an optical stimulus. The scattering spectroscopy nanosensor further includes a protective covering to cover and protect the nanoscale-patterned sensing substrate. The protective covering is to be selectably removed by exposure to an optical beam incident on the protective covering. The protective covering is to prevent the analyte from interacting with the nanoscale-patterned sensing substrate prior to being removed.

Abstract translation: 散射光谱纳米传感器包括纳米级图案化的感测衬底，以产生指示当通过光学刺激询问的分析物存在时的光学散射响应信号。 散射光谱纳米传感器还包括覆盖并保护纳米级图案化感测基板的保护覆盖层。 通过暴露在入射到保护罩上的光束可选地去除保护罩。 保护性覆盖物是在去除之前防止分析物与纳米级图案化的感测基板相互作用。

公开(公告)号：US20150330902A1

公开(公告)日：2015-11-19

申请号：US14377524

申请日：2012-02-08

Applicant: Devin Alexander Mourey ,  James William Stasiak ,  James Elmer Abbott, Jr. ,  Zhiyong Li

Inventor： Devin Alexander Mourey ,  James William Stasiak ,  James Elmer Abbott, Jr. ,  Zhiyong Li

IPC: G01N21/65

CPC classification number: G01N21/658 ,  G01N2201/06113 ,  G01N2201/068

Abstract: Molecule sensing apparatus. The apparatus has first and second chambers, an input port extending into the first chamber, a fluid channel extending from the first chamber to the second chamber, and a surface-enhanced substrate in the second chamber.

Abstract translation: 分子感测装置。 该装置具有第一和第二腔室，延伸到第一腔室中的输入端口，从第一腔室延伸到第二腔室的流体通道，以及在第二腔室中的表面增强基底。

公开(公告)号：US20150065390A1

公开(公告)日：2015-03-05

申请号：US14394295

申请日：2012-04-20

Applicant: Alexandre M. Bratkovski ,  Zhiyong Li ,  Wei Wu ,  Min Hu ,  R. Stanley Williams ,  Ansoon Kim

Inventor： Alexandre M. Bratkovski ,  Zhiyong Li ,  Wei Wu ,  Min Hu ,  R. Stanley Williams ,  Ansoon Kim

IPC: G01N21/65 ,  G01N35/00 ,  B01L3/00

CPC classification number: G01N21/658 ,  B01L3/5088 ,  B01L2300/0627 ,  B01L2300/0819 ,  B01L2300/161 ,  G01N21/648 ,  G01N35/00009 ,  G01N2035/00019

Abstract: Examples of integrated sensors are disclosed herein. An example of an integrated sensor includes a substrate and a sensing member formed on a surface of the substrate. The sensing member includes collapsible signal amplifying structures and an area surrounding the collapsible signal amplifying structures that enables self-positioning of droplets exposed thereto toward the collapsible signal amplifying structures.

Abstract translation: 本文公开了集成传感器的示例。 集成传感器的示例包括形成在基板的表面上的基板和感测构件。 感测构件包括可折叠信号放大结构和围绕可折叠信号放大结构的区域，其使得能够将暴露于其的液滴自动定位到可折叠信号放大结构。

公开(公告)号：US08810788B2

公开(公告)日：2014-08-19

申请号：US13254897

申请日：2009-03-13

Applicant: Zhiyong Li ,  Min Hu

Inventor： Zhiyong Li ,  Min Hu

IPC: G01J3/44 ,  G01N21/65 ,  G01N21/55

CPC classification number: G01N21/554 ,  B82Y30/00 ,  G01N21/553 ,  G01N21/658

Abstract: Broad band structures for surface enhanced Raman spectroscopy are disclosed herein. Each embodiment of the structure is made up of a metal layer, and a dielectric layer established on at least a portion of the metal layer. The dielectric layer has a controlled thickness that varies from at least one portion of the dielectric layer to at least another portion of the dielectric layer. Nanostructures are established on the dielectric layer at least at the portion and the other portion, the nanostructures thus being configured to exhibit variable plasmon resonances.

Abstract translation: 本文公开了用于表面增强拉曼光谱的宽带结构。 结构的每个实施例由金属层和建立在金属层的至少一部分上的电介质层组成。 电介质层具有从电介质层的至少一部分到电介质层的至少另一部分变化的受控厚度。 至少在部分和另一部分，在电介质层上建立纳米结构，因此纳米结构被构造成表现出可变的等离子体共振。

公开(公告)号：US08808645B2

公开(公告)日：2014-08-19

申请号：US13281232

申请日：2011-10-25

Applicant: Warren Jackson ,  Zhiyong Li

Inventor： Warren Jackson ,  Zhiyong Li

IPC: B01D35/00 ,  B01D41/00 ,  B01D63/00 ,  C02F1/44 ,  B01D24/00 ,  B01D39/00 ,  B01D61/42 ,  A61M37/00

CPC classification number: G01N21/658 ,  B29D11/0074

Abstract: Molecular filters are disclosed herein. An example of the molecular filter includes a rolled substrate having an interior surface and opposed ends that are substantially orthogonal to the interior surface. The rolled substrate defines a layer and a fluid flow path extending from one of the opposed ends to another of the opposed ends. A template is positioned on the interior surface of the rolled substrate. The template includes a matrix, and molecule template locations formed in the matrix.

Abstract translation: 本文公开了分子过滤器。 分子过滤器的一个实例包括具有内表面和基本上正交于内表面的相对端的轧制衬底。 卷绕的基板限定了从相对端中的一个延伸到相对端中的另一个的层和流体流动路径。 模板位于轧制衬底的内表面上。 模板包括在矩阵中形成的矩阵和分子模板位置。

公开(公告)号：US20140199778A1

公开(公告)日：2014-07-17

申请号：US14239330

申请日：2011-09-30

Applicant: Wei Wu ,  Zhiyong Li ,  Ansoon Kim ,  Min Hu ,  Michael Josef Stuke

Inventor： Wei Wu ,  Zhiyong Li ,  Ansoon Kim ,  Min Hu ,  Michael Josef Stuke

IPC: G01N31/22

CPC classification number: G01N31/22 ,  B01L3/5085 ,  B01L3/50853 ,  B01L2200/141 ,  B01L2300/0636 ,  B01L2300/069 ,  B01L2300/0819 ,  B82Y15/00 ,  G01N21/648 ,  G01N21/658 ,  G01N2201/0227 ,  G01N2201/023 ,  Y10T436/25

Abstract: Devices to detect a substance and methods of producing such a device are disclosed. An example device to detect a substance includes a housing defining an externally accessible chamber and a seal to enclose at least a portion of the chamber. The example device also includes a substrate includes nanoparticles positioned within the chamber. The nanoparticles to react to the substance when exposed thereto. The example device also includes a non-analytic solution within the chamber to protect the nanoparticles from premature exposure.

Abstract translation: 公开了检测物质的装置和制造这种装置的方法。 用于检测物质的示例性装置包括限定外部可触及室的壳体和用于封闭室的至少一部分的密封件。 该示例性装置还包括基底，其包括位于腔室内的纳米颗粒。 纳米颗粒暴露于物质时与物质反应。 该示例性装置还包括室内的非分析溶液以保护纳米颗粒免于过早曝光。

公开(公告)号：US08780606B2

公开(公告)日：2014-07-15

申请号：US13120904

申请日：2008-12-23

Applicant: Zhiyong Li ,  Fung Suong Ou ,  William M. Tong

Inventor： Zhiyong Li ,  Fung Suong Ou ,  William M. Tong

IPC: G11C11/00 ,  G11C13/00 ,  B82Y10/00 ,  G11C11/56 ,  G11C13/02 ,  H01L45/00

CPC classification number: G11C13/0011 ,  B82Y10/00 ,  G11C11/56 ,  G11C13/00 ,  G11C13/0002 ,  G11C13/0069 ,  G11C13/02 ,  G11C13/025 ,  G11C2013/009 ,  G11C2213/35 ,  G11C2213/55 ,  G11C2213/56 ,  H01L45/08 ,  H01L45/1206 ,  H01L45/1226 ,  H01L45/1233 ,  H01L45/146

Abstract: A memristive device includes: a first electrode; a second electrode; a memristive matrix interposed between the first electrode and the second electrode; a porous dopant diffusion element in physical contact with the memristive matrix and in proximity to the first electrode and the second electrode; and a first mobile dopant species which moves through the porous dopant diffusion element in response to a programming electrical field. A method for using a memristive device having a porous dopant diffusion element includes applying a voltage bias to generate a programming electrical field such that dopants move through the porous dopant diffusion element, thereby changing the distribution of dopants within a memristive matrix to form a first state; removing the voltage bias, the dopants being substantially immobile in the absence of the programming electrical field; and applying a reading energy to the memristive device to sense the first state.

Abstract translation: 忆阻器包括：第一电极; 第二电极; 夹在第一电极和第二电极之间的忆阻矩阵; 与所述忆阻基体物理接触并且靠近所述第一电极和所述第二电极的多孔掺杂剂扩散元件; 以及响应于编程电场移动穿过多孔掺杂剂扩散元件的第一移动掺杂物种类。 使用具有多孔掺杂剂扩散元件的忆阻器件的方法包括施加电压偏置以产生编程电场，使得掺杂剂移动穿过多孔掺杂剂扩散元件，由此改变在忆阻矩阵内的掺杂剂的分布以形成第一状态 ; 去除电压偏压，掺杂剂在没有编程电场的情况下基本上是不可移动的; 以及向所述忆阻器施加读取能量以感测所述第一状态。

公开(公告)号：US20140125976A1

公开(公告)日：2014-05-08

申请号：US14118801

申请日：2011-05-20

Applicant: Ansoon Kim ,  Zhiyong Li

Inventor： Ansoon Kim ,  Zhiyong Li

IPC: G01N21/65 ,  G01J3/44

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/44

Abstract: A surface enhanced Raman spectroscopy (SERS) sensor, system and method employ nanorods and independent nanoparticles that interact. The sensor includes at least two spaced apart nanorods attached at first ends to a substrate and an independent nanoparticle. Second ends of the nanorods are movable into close proximity to one another and include a Raman active surface. The nanoparticle has a functionalized surface that includes a Raman signal generator. An interaction between the nanoparticle and the nanorod second ends in close proximity is detectable. The system includes the SERS sensor, an illumination source and a Raman signal detector. The method includes illuminating the interaction of the nanoparticle and the nanorods with an analyte, and detecting an effect on a Raman signal caused by the analyte.

Abstract translation: 表面增强拉曼光谱（SERS）传感器，系统和方法采用纳米棒和独立纳米粒子相互作用。 传感器包括至少两个间隔开的纳米棒，其在第一端附着到基底和独立的纳米颗粒。 纳米棒的第二端可以彼此靠近移动并且包括拉曼活性表面。 纳米颗粒具有包括拉曼信号发生器的官能化表面。 纳米颗粒和纳米棒第二末端之间的相互作用是可以接近的。 该系统包括SERS传感器，照明源和拉曼信号检测器。 该方法包括用分析物照射纳米颗粒和纳米棒的相互作用，并检测由分析物引起的对拉曼信号的影响。

公开(公告)号：US08547549B2

公开(公告)日：2013-10-01

申请号：US13129571

申请日：2008-11-17

Applicant: Huei Pei Kuo ,  Jing Tang ,  Fung Suong Ou ,  Zhiyong Li ,  Shih-Yuan Wang

Inventor： Huei Pei Kuo ,  Jing Tang ,  Fung Suong Ou ,  Zhiyong Li ,  Shih-Yuan Wang

IPC: G01J3/44 ,  G01N21/65

CPC classification number: B82Y20/00 ,  G01N21/658

Abstract: A substrate for Surface Enhanced Raman Scattering (SERS). The substrate comprises at least one nanostructure protruding from a surface of the substrate and a SERS active metal over the at least one nanostructure, wherein the SERS active metal substantially covers the at least one nanostructure and the SERS active metal creates a textured layer on the at least one nanostructure.

Abstract translation: 用于表面增强拉曼散射的衬底（SERS）。 衬底包括从衬底的表面突出的至少一个纳米结构和在至少一个纳米结构上的SERS活性金属，其中SERS活性金属基本上覆盖至少一个纳米结构，并且SERS活性金属在其上形成纹理化层 至少一个纳米结构。

公开(公告)号：US20130217143A1

公开(公告)日：2013-08-22

申请号：US13879255

申请日：2010-10-20

Applicant: Zhiyong Li ,  R. Stanley Williams

Inventor： Zhiyong Li ,  R. Stanley Williams

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01N21/648 ,  G01N21/658 ,  G01N33/54373

Abstract: A chemical-analysis device integrated with a metallic-nanofinger device for chemical sensing. The chemical-analysis device includes a metallic-nanofinger device, and a platform. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofinger of the plurality includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with at least one analyte molecule. A morphology of the metallic cap is to generate a shifted plasmonic-resonance peak associated with amplified luminescence from the analyte molecule. A method for using, and a chemical-analysis apparatus including the chemical-analysis device are also provided.