公开(公告)号：US20150289821A1

公开(公告)日：2015-10-15

申请号：US14659263

申请日：2015-03-16

Applicant: DexCom, Inc.

Inventor： Anna Leigh Rack-Gomer ,  Hari Hampapuram ,  Apurv Ullas Kamath ,  Eli Reihman ,  Leif N. Bowman ,  Arturo Garcia ,  Katherine Yerre Grubstein ,  Naresh C. Bhavaraju ,  Rian Draeger ,  Paul Kramer ,  Paul Noble-Campbell

IPC: A61B5/00 ,  A61B5/11 ,  A61B5/01 ,  A61B5/145 ,  A61B5/16

CPC classification number: A61B5/7282 ,  A61B5/01 ,  A61B5/1112 ,  A61B5/1118 ,  A61B5/14532 ,  A61B5/165 ,  A61B5/168 ,  A61B5/4306 ,  A61B5/4839 ,  A61B5/4866 ,  A61B5/6898 ,  A61B5/7239 ,  A61B5/7275 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/743 ,  A61B5/7435 ,  A61B5/746 ,  A61B5/7475 ,  A61B2505/07 ,  A61B2560/0295 ,  A61B2560/0475 ,  A61M5/1723 ,  A61M5/5086 ,  A61M2005/1726 ,  G06F3/04817 ,  G06F3/04847 ,  G06F19/3468 ,  G16H40/63

Abstract: Systems and methods are disclosed that employ several or numerous factors in the determination of a glycemic urgency index (GUI), which may be based on a measured blood glucose level as well as other factors. The other factors may include time derivatives of the glucose level and/or other factors, e.g., user—entered data, data measured by other sensors or received from a network source, or historical data. The GUI is then presented to the user in an interesting way, e.g., via a background color or other inconspicuous notifier, e.g., on a mobile device such as a smart phone. The GUI may also be employed in the triggering of actionable alerts and alarms on an electronic device for the user. The GUI, or another index calculated from combinations of the variables and parameters described, may further be employed to drive a medicament delivery device such as a pump.

Abstract translation: 公开了在确定血糖紧急指数（GUI）中的几个或多个因素的系统和方法，其可以基于测量的血糖水平以及其他因素。 其他因素可以包括葡萄糖水平的时间导数和/或其他因素，例如用户输入的数据，由其他传感器测量或从网络源接收的数据或历史数据。 然后，以有趣的方式，例如通过背景颜色或其他不显眼的通知器（例如，诸如智能电话的移动设备）将GUI呈现给用户。 GUI也可以用于在用户的电子设备上触发可操作的警报和警报。 GUI或由所述变量和参数的组合计算出的另一指标可进一步用于驱动药物输送装置例如泵。

公开(公告)号：US20150164391A1

公开(公告)日：2015-06-18

申请号：US14569512

申请日：2014-12-12

Applicant: DexCom, Inc.

Inventor： Jose Hector Hernandez-Rosas ,  Mark Dervaes ,  Peter C. Simpson ,  Apurv Ullas Kamath ,  Tom Miller ,  Shawn Larvenz ,  Stephen J. Vanslyke

IPC: A61B5/145 ,  A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/0022 ,  A61B5/14546 ,  A61B5/6802 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/7475 ,  A61B2560/0204 ,  A61B2560/0209 ,  A61B2560/0214 ,  H04W52/0277 ,  Y02D70/1222 ,  Y02D70/142 ,  Y02D70/144 ,  Y02D70/22 ,  Y02D70/26

Abstract: Systems and methods for analyte monitoring, particularly systems and methods for monitoring and managing life of a battery in an analyte sensor system worn by a user, are provided.

Abstract translation: 提供了用于分析物监测的系统和方法，特别是用于监测和管理由用户佩戴的分析物传感器系统中的电池寿命的系统和方法。

公开(公告)号：US20140378793A1

公开(公告)日：2014-12-25

申请号：US14483092

申请日：2014-09-10

Applicant: DexCom, Inc.

Inventor： Apurv Ullas Kamath ,  Peter C. Simpson ,  Mark Brister

IPC: A61B5/1455 ,  A61B5/145 ,  A61B5/1459

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/14551 ,  A61B5/1459 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4094 ,  A61B5/6852 ,  A61B5/7203 ,  A61B2560/0223

Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

Abstract translation: 提供了用于宿主血管系统的连续分析物测量的系统和方法。 在一些实施例中，连续葡萄糖测量系统包括血管通路装置，传感器和传感器电子装置，所述系统被配置为插入与主机的循环系统的通信。

公开(公告)号：US20140182350A1

公开(公告)日：2014-07-03

申请号：US13733742

申请日：2013-01-03

Applicant: DEXCOM, INC.

Inventor： Naresh C. Bhavaraju ,  Arturo Garcia ,  Hari Hampapuram ,  Apurv Ullas Kamath ,  Aarthi Mahalingam ,  Dmytro Sokolovskyy ,  Stephen J. Vanslyke

IPC: G01M99/00

CPC classification number: G01N33/48792 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/7221 ,  A61B2560/0223 ,  A61B2560/0266 ,  A61B2560/0276 ,  A61B2560/028 ,  G01M99/008 ,  G01N33/49 ,  G01N33/66 ,  G06F19/70 ,  G06F19/708

Abstract: Systems and methods for processing sensor data and end of life detection are provided. In some embodiments, a method for determining the end of life of a continuous analyte sensor includes evaluating a plurality of risk factors using an end of life function to determine an end of life status of the sensor and providing an output related to the end of life status of the sensor. The plurality of risk factors may be selected from the list including the number of days the sensor has been in use, whether there has been a decrease in signal sensitivity, whether there is a predetermined noise pattern, whether there is a predetermined oxygen concentration pattern, and error between reference BG values and EGV sensor values.

Abstract translation: 提供了用于处理传感器数据和寿命终止检测的系统和方法。 在一些实施例中，用于确定连续分析物传感器的寿命终止的方法包括使用寿命终止功能评估多个危险因素以确定传感器的寿命状态并提供与寿命结束相关的输出 传感器的状态 可以从包括传感器已经使用的天数的列表中选择多个危险因素，信号灵敏度是否下降，是否存在预定的噪声模式，是否存在预定的氧浓度模式， 参考BG值和EGV传感器值之间的误差。

公开(公告)号：US20140128803A1

公开(公告)日：2014-05-08

申请号：US14144360

申请日：2013-12-30

Applicant: DexCom, Inc.

Inventor： John Michael Dobbles ,  Apurv Ullas Kamath ,  Aarthi Mahalingam ,  James H. Brauker

IPC: A61M5/172

CPC classification number: A61M5/1723 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14546 ,  A61M5/003 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/178 ,  A61M5/20 ,  A61M5/30 ,  A61M11/00 ,  A61M15/00 ,  A61M15/0065 ,  A61M15/0068 ,  A61M15/008 ,  A61M15/0083 ,  A61M35/00 ,  A61M2005/14296 ,  A61M2205/3569 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/587 ,  A61M2205/8206 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H40/63

Abstract: Systems and methods for integrating a continuous glucose sensor 12, including a receiver 14, a medicament delivery device 16, a controller module, and optionally a single point glucose monitor 18 are provided. Integration may be manual, semi-automated and/or fully automated.

公开(公告)号：US20140121989A1

公开(公告)日：2014-05-01

申请号：US14148512

申请日：2014-01-06

Applicant: DexCom, Inc.

Inventor： Apurv Ullas Kamath ,  Ying Li

IPC: A61B5/00

CPC classification number: A61B5/7207 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/6833 ,  A61B5/7203 ,  A61B5/7221 ,  G16H40/40 ,  Y02A90/22 ,  Y02A90/26

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for processing sensor data, including calculating a rate of change of sensor data and/or determining an acceptability of sensor or reference data.

Abstract translation: 本发明一般涉及用于测量宿主中分析物的系统和方法。 更具体地，本发明涉及用于处理传感器数据的系统和方法，包括计算传感器数据的变化率和/或确定传感器或参考数据的可接受性。

公开(公告)号：US20140058235A1

公开(公告)日：2014-02-27

申请号：US14072659

申请日：2013-11-05

Applicant: DexCom, Inc.

Inventor： Ying Li ,  Apurv Ullas Kamath ,  Richard C. Yang ,  Mark C. Brister

IPC: A61B5/157 ,  A61B5/15 ,  A61B5/145 ,  A61B5/1495 ,  A61B5/1473

CPC classification number: A61B5/157 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/14735 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150992 ,  A61B5/155 ,  A61B5/412 ,  A61B5/4839 ,  A61B5/6848 ,  A61B5/6849 ,  A61B5/7275 ,  A61B5/743 ,  A61B2560/0223 ,  A61B2560/04 ,  A61B2562/085 ,  A61M5/14 ,  A61M5/16804 ,  A61M5/1723 ,  A61M2005/14296 ,  A61M2230/201 ,  C12Q1/001 ,  C12Q1/006 ,  G06F19/3468 ,  G16H20/17 ,  G16H40/40 ,  Y02A90/26

Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

公开(公告)号：US20140052092A1

公开(公告)日：2014-02-20

申请号：US14063790

申请日：2013-10-25

Applicant: DexCom, Inc.

Inventor： John Michael Dobbles ,  Apurv Ullas Kamath ,  Aarthi Mahalingam ,  James H. Brauker

IPC: A61M5/172

CPC classification number: A61M5/1723 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14546 ,  A61M5/003 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/178 ,  A61M5/20 ,  A61M5/30 ,  A61M11/00 ,  A61M15/00 ,  A61M15/0065 ,  A61M15/0068 ,  A61M15/008 ,  A61M15/0083 ,  A61M35/00 ,  A61M2005/14296 ,  A61M2205/3569 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/587 ,  A61M2205/8206 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H40/63

Abstract: Systems and methods for integrating a continuous glucose sensor 12, including a receiver 14, a medicament delivery device 16, a controller module, and optionally a single point glucose monitor 18 are provided. Integration may be manual, semi-automated and/or fully automated.

公开(公告)号：US20140052091A1

公开(公告)日：2014-02-20

申请号：US14063753

申请日：2013-10-25

Applicant: DexCom, Inc.

Inventor： John Michael Dobbles ,  Apurv Ullas Kamath ,  Aarthi Mahalingam ,  James H. Brauker

IPC: A61M5/172

CPC classification number: A61M5/1723 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14546 ,  A61M5/003 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/178 ,  A61M5/20 ,  A61M5/30 ,  A61M11/00 ,  A61M15/00 ,  A61M15/0065 ,  A61M15/0068 ,  A61M15/008 ,  A61M15/0083 ,  A61M35/00 ,  A61M2005/14296 ,  A61M2205/3569 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/587 ,  A61M2205/8206 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H40/63

Abstract: Systems and methods for integrating a continuous glucose sensor 12, including a receiver 14, a medicament delivery device 16, a controller module, and optionally a single point glucose monitor 18 are provided. Integration may be manual, semi-automated and/or fully automated.

Abstract translation: 提供了用于集成包括接收器14，药物输送装置16，控制器模块和任选的单点葡萄糖监测器18的连续葡萄糖传感器12的系统和方法。 集成可以是手动，半自动化和/或完全自动化。

公开(公告)号：US20130324824A1

公开(公告)日：2013-12-05

申请号：US13963416

申请日：2013-08-09

Applicant: DexCom, Inc.

Inventor： Apurv Ullas Kamath ,  Richard C. Yang ,  Jacob S. Leach ,  Nelson Quintana

IPC: A61B5/145

CPC classification number: G06T11/206 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0406 ,  A61B2560/0431 ,  A61B2560/0443 ,  A61M5/003 ,  A61M5/14244 ,  A61M5/1723 ,  A61M5/24 ,  A61M5/3129 ,  A61M5/31525 ,  A61M2205/3569 ,  A61M2205/505 ,  A61M2209/086 ,  G06F19/00

Abstract: An integrated system for the monitoring and treating diabetes is provided, including an integrated receiver/hand-held medicament injection pen, including electronics, for use with a continuous glucose sensor. In some embodiments, the receiver is configured to receive continuous glucose sensor data, to calculate a medicament therapy (e.g., via the integrated system electronics) and to automatically set a bolus dose of the integrated hand-held medicament injection pen, whereby the user can manually inject the bolus dose of medicament into the host. In some embodiments, the integrated receiver and hand-held medicament injection pen are integrally formed, while in other embodiments they are detachably connected and communicated via mutually engaging electrical contacts and/or via wireless communication.

Abstract translation: 提供了一种用于监测和治疗糖尿病的综合系统，包括用于与连续葡萄糖传感器一起使用的集成接收器/手持药物注射笔，包括电子器件。 在一些实施例中，接收器被配置为接收连续的葡萄糖传感器数据，以计算药物治疗（例如，经由集成系统电子设备）并且自动设置一体式手持药物注射笔的推注剂量，由此使用者可以 将大剂量的药物手动注射入宿主体内。 在一些实施例中，集成的接收器和手持式药物注射笔是整体形成的，而在其它实施例中，它们通过相互接合的电触点和/或经由无线通信可拆卸地连接和连通。