公开(公告)号：US4962198A

公开(公告)日：1990-10-09

申请号：US376496

申请日：1989-07-07

Applicant: Mieczyslaw Makosza ,  Krzysztof Sienkiewicz

Inventor： Mieczyslaw Makosza ,  Krzysztof Sienkiewicz

IPC: C07B41/02 ,  C07B61/00 ,  C07C201/12 ,  C07C205/25 ,  C07C205/26 ,  C07C205/37 ,  C07C255/53 ,  C07D213/62 ,  C07D215/20

CPC classification number: C07D215/20 ,  C07C201/12 ,  C07C253/30

Abstract: The invention relates to a generally applicable process for the hydroxylation of electrophilic aromatic compounds, according to which the electrophilic aromatic compounds are reacted with organic hydroperoxides in the presence of bases.

Abstract translation: 本发明涉及一种普遍适用的亲电芳香族化合物的羟基化方法，根据该方法，亲电芳香族化合物在碱的存在下与有机氢过氧化物反应。

公开(公告)号：US4960950A

公开(公告)日：1990-10-02

申请号：US173905

申请日：1988-03-28

Applicant: Visweswara R. Durvasula

Inventor： Visweswara R. Durvasula

IPC: C07C201/12 ,  C07C67/00 ,  C07C201/00 ,  C07C205/36 ,  C07C205/37 ,  C07C205/38 ,  C07C319/02 ,  C07C319/14 ,  C07C323/09 ,  C07C323/12 ,  C08G65/333 ,  C08G85/00

CPC classification number: C08G85/004 ,  C08G65/33389

Abstract: Disclosed is a novel process for effecting an ether interchange reaction by heating together in the presence of a basic catalyst, a nitroaromatic ether or thioether and an organic compound containing at least one hydroxyl or mercapto group. The novelty resides particularly in carrying out the interchange in an inert solvent while sparging the heated reactants thereby to remove at least a portion of solvent along with an evolving alcohol or thiol.The process is particularly adapted to the capping of organic polyols with nitroaromatic ether groups. The capped products are useful as intermediates for the preparation of high molecular weight polyamines which in turn find utility in various polymer applications.

公开(公告)号：US4945100A

公开(公告)日：1990-07-31

申请号：US240441

申请日：1988-09-02

Applicant: Robert Nyfeler ,  Helmut Zondler ,  Elmar Sturm

Inventor： Robert Nyfeler ,  Helmut Zondler ,  Elmar Sturm

IPC: C07C41/03 ,  A01N31/04 ,  A01N31/14 ,  A01N43/653 ,  B01J27/10 ,  B01J31/10 ,  B01J31/22 ,  C07B61/00 ,  C07C41/00 ,  C07C43/13 ,  C07C43/178 ,  C07C43/23 ,  C07C43/295 ,  C07C43/315 ,  C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/34 ,  C07C253/00 ,  C07C253/30 ,  C07C255/54 ,  C07D249/08 ,  C07D521/00

CPC classification number: C07D231/12 ,  A01N43/653 ,  C07C309/00 ,  C07C43/1782 ,  C07D233/56 ,  C07D249/08

Abstract: Essentially, a process is described for the preparation of the 1-triazolylethyl ether derivatives, defined in claim 1, of the general formula I ##STR1## which consists in (a) reacting an oxirane of the formula II ##STR2## at temperatures of -20.degree. to +100.degree. C., in the presence of an acid catalyst or an acid condensation agent, with an alcohol of the formula IIIR.sub.3 --OH (III) to give a glycol monoether of the formula IV ##STR3## and (b) subsequently reacting the glycol monoether of the formula IV or one of its esters, in the presence of an acid-binding agent or condensation agent, at temperatures of 0.degree. to 150.degree. C., with a triazole of the formula V ##STR4## the substituents R.sub.1, R.sub.2 ; amd R.sub.3 in the formula II to IV being as defined under formula I and M in formula V being hydrogen or a metal atom. The novel compounds within the scope of formula I and their use are also described.

Abstract translation: 基本上描述了制备权利要求1中定义的通式I的（I）的1-三唑基乙醚衍生物的方法，其包括（a）使式II的环氧乙烷（IMAGE）（ II）在-20℃至+ 100℃的温度下，在酸催化剂或酸缩合剂的存在下与式III的R3-OH（III）的醇反应，得到式IV的二醇单醚 （IV）和（b）随后在0℃至150℃的温度下，在酸结合剂或缩合剂的存在下，使式IV的二醇单醚或其酯之一与式 （V）的取代基R 1，R 2; 式II至IV中的R 3如式I所定义，式V中的M为氢或金属原子。 还描述了式I范围内的新化合物及其用途。

公开(公告)号：US4937374A

公开(公告)日：1990-06-26

申请号：US242679

申请日：1988-09-09

Applicant: Kevin Beautement ,  John M. Clough ,  Christopher R. A. Godfrey

Inventor： Kevin Beautement ,  John M. Clough ,  Christopher R. A. Godfrey

IPC: B01J23/06 ,  A01N37/38 ,  A01N37/40 ,  A01N41/04 ,  A01N41/06 ,  A01N41/10 ,  A01N43/10 ,  A01N43/20 ,  A01N43/36 ,  A01N43/40 ,  A01N43/42 ,  A01N43/54 ,  A01N43/58 ,  A01N43/60 ,  A01N43/653 ,  A01N43/66 ,  A01N43/74 ,  A01N43/90 ,  A01N47/20 ,  A01N57/24 ,  B01J23/10 ,  B01J23/12 ,  B01J23/20 ,  B01J23/24 ,  B01J23/32 ,  B01J23/38 ,  B01J23/72 ,  B01J27/10 ,  C07B61/00 ,  C07C45/59 ,  C07C67/00 ,  C07C67/31 ,  C07C69/734 ,  C07C201/00 ,  C07C201/12 ,  C07C205/35 ,  C07C205/37 ,  C07C205/38 ,  C07C205/52 ,  C07C205/56 ,  C07C217/92 ,  C07C233/25 ,  C07C233/75 ,  C07C235/56 ,  C07C245/08 ,  C07C251/24 ,  C07C251/48 ,  C07C255/54 ,  C07C271/28 ,  C07C311/29 ,  C07C317/22 ,  C07C323/20 ,  C07C327/16 ,  C07D207/34 ,  C07D213/64 ,  C07D213/643 ,  C07D213/65 ,  C07D213/68 ,  C07D213/74 ,  C07D213/85 ,  C07D213/89 ,  C07D215/22 ,  C07D215/227 ,  C07D215/36 ,  C07D237/14 ,  C07D239/34 ,  C07D239/38 ,  C07D239/60 ,  C07D241/18 ,  C07D241/44 ,  C07D251/26 ,  C07D263/58 ,  C07D277/24 ,  C07D277/68 ,  C07D333/56 ,  C07D495/04 ,  C07D521/00 ,  C07F9/54

CPC classification number: C07D213/64 ,  A01N37/38 ,  A01N37/40 ,  A01N41/04 ,  A01N41/06 ,  A01N41/10 ,  A01N43/10 ,  A01N43/20 ,  A01N43/36 ,  A01N43/40 ,  A01N43/42 ,  A01N43/54 ,  A01N43/58 ,  A01N43/60 ,  A01N43/653 ,  A01N43/66 ,  A01N43/74 ,  A01N43/90 ,  A01N47/20 ,  A01N57/24 ,  C07C201/12 ,  C07C45/59 ,  C07C67/31 ,  C07D207/34 ,  C07D213/643 ,  C07D213/65 ,  C07D213/68 ,  C07D213/74 ,  C07D213/85 ,  C07D213/89 ,  C07D215/227 ,  C07D215/36 ,  C07D231/12 ,  C07D233/56 ,  C07D237/14 ,  C07D239/34 ,  C07D239/38 ,  C07D239/60 ,  C07D241/18 ,  C07D241/44 ,  C07D249/08 ,  C07D251/26 ,  C07D263/58 ,  C07D277/24 ,  C07D277/68 ,  C07D333/56 ,  C07D495/04 ,  C07F9/5456

Abstract: Process for the preparation of a compound of general formula (I): ##STR1## by reacting a compound of general formula (II) ##STR2## (X is halide; rings M and N are optionally substituted) with an optionally substituted phenol in the presence of a base, or with an optionally substituted phenolate salt; preferably in the presence of a catalyst which is a transition metal, a transition metal salt or compound or a mixture thereof.

公开(公告)号：US4892686A

公开(公告)日：1990-01-09

申请号：US275238

申请日：1988-11-22

Applicant: Walter Fischer ,  Tibor Somlo

Inventor： Walter Fischer ,  Tibor Somlo

IPC: B01J21/02 ,  B01J27/236 ,  B01J31/04 ,  C07B61/00 ,  C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/47

CPC classification number: C07C205/47 ,  C07C201/12 ,  C07C201/16 ,  C07C2103/24

Abstract: A process for the preparation of 1-nitroanthraquinone by oxidising 1-nitro-5,8,11,12-tetrahydroanthraquinone with oxygen, inorganic peroxo compounds or metal oxides.

Abstract translation: 通过用氧，无机过氧化合物或金属氧化物氧化1-硝基-5,8,11,12-四氢蒽醌来制备1-硝基蒽醌的方法。

公开(公告)号：US4873358A

公开(公告)日：1989-10-10

申请号：US246609

申请日：1988-09-20

Applicant: Jennifer M. Quirk ,  Charles G. Carter

Inventor： Jennifer M. Quirk ,  Charles G. Carter

IPC: C07C201/12 ,  C07C205/51 ,  C07C205/52 ,  C07C205/53 ,  C07C205/56

CPC classification number: C07C201/12

Abstract: A process to form alkyl nitroacetates by reacting, in a common solvent and in the presence of a base, a nitroparaffin and a cyanoformate. The desired product is formed by a simple one-step process using inexpensive and readily available reactants.

公开(公告)号：US4864061A

公开(公告)日：1989-09-05

申请号：US883208

申请日：1986-07-08

Applicant: Erich Cohnen

Inventor： Erich Cohnen

IPC: A61K31/135 ,  A61K31/165 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07C45/00 ,  C07C45/27 ,  C07C45/30 ,  C07C47/198 ,  C07C47/277 ,  C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/30 ,  C07C205/32 ,  C07C205/33 ,  C07C205/35 ,  C07C209/32 ,  C07C213/00 ,  C07C217/32 ,  C07C217/52 ,  C07C231/00 ,  C07C231/02 ,  C07C233/18 ,  C07C235/08

CPC classification number: C07C205/35 ,  C07C205/32 ,  C07C205/33 ,  C07C45/30 ,  C07C47/277

Abstract: New substituted phenoxyalkanolamines and phenoxyalkanol-cycloalkylamines of the general formula I ##STR1## in which R.sup.1 and R.sup.2, which can be identical or different, denote alkyl groups with in each case 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 together denote the group --(CH.sub.2).sub.n --, wherein n is the number 4 or 5, R.sup.3 denotes hydrogen, or an alkyl group or an acyl group with in each case 1 to 6 carbon atoms, R.sub.4 denotes an alkyl group with 1 to 4 carbon atoms or the cyclopropylmethyl group and R.sup.5 denotes hydrogen halogen or alkyl, and acid addition salts thereof, have a cardioselective .beta..sub.1 -adrenolytic and hypotensive action. They can be used as medicaments for the treatment of angina pectoris, hypertension and arrhythmias.

Abstract translation: 新的取代的苯氧基烷醇胺和通式I（I）的苯氧基烷醇 - 环烷基胺，其中可以相同或不同的R 1和R 2表示在每种情况下为1至4个碳原子的烷基，或者R 1和R 2一起表示 基团 - （CH 2）n - ，其中n是数4或5，R 3表示氢，或烷基或酰基，在每种情况下为1至6个碳原子，R 4表示具有1至4个碳原子的烷基 原子或环丙基甲基，R5表示氢卤素或烷基，及其酸加成盐具有心脏选择性β1-肾上腺素能和降压作用。 它们可以用作治疗心绞痛，高血压和心律失常的药物。

公开(公告)号：US4855517A

公开(公告)日：1989-08-08

申请号：US98717

申请日：1987-09-21

Applicant: Hans J. Metz ,  Klaus Warning

Inventor： Hans J. Metz ,  Klaus Warning

IPC: C07C43/29 ,  C07B39/00 ,  C07C17/00 ,  C07C17/093 ,  C07C25/02 ,  C07C41/00 ,  C07C51/00 ,  C07C63/10 ,  C07C63/24 ,  C07C67/00 ,  C07C69/78 ,  C07C201/12 ,  C07C205/12 ,  C07C233/65

CPC classification number: C07B39/00 ,  C07C17/093 ,  C07C201/12 ,  Y02P20/582

Abstract: Aromatic bromine compounds are prepared by reacting aromatic nitro compounds with elemental bromine in the gas phase at temperatures between about 310.degree. to 550.degree. C. In this reaction, the nitro groups are selectively replaced by bromine; further bromination of the aromatic system beyond that does not take place.

Abstract translation: 芳族溴化合物是通过芳香族硝基化合物与气相中的元素溴在约310℃至550℃之间的温度下反应制备的。在该反应中，硝基选择性地被溴取代; 芳香系统的进一步溴化不会发生。

公开(公告)号：US4847426A

公开(公告)日：1989-07-11

申请号：US198285

申请日：1988-05-25

Applicant: Dieter Heck ,  Hartmut Heise ,  Manfred Hintzmann

Inventor： Dieter Heck ,  Hartmut Heise ,  Manfred Hintzmann

IPC: C07C205/38 ,  C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/31 ,  C07C205/37

CPC classification number: C07C201/12

Abstract: A process for the preparation of 2,4-dinitrophenyl ethers of the general formula (1) ##STR1## in which R denotes an alkyl(C.sub.1 -C.sub.6) or alkoxy(C.sub.1 -C.sub.4)alky(C.sub.1 -C.sub.4) group by reacting 1 mole of 2,4-dinitrochlorobenzene in the anhydrous alcohol which is required for the ether formation and is of the general formula (2)R--OH (2)in which R has the abovementioned meaning, in the presence of 1.0 to 3.0 mole of an anhydrous alkali metal carbonate, at temperatures of 20.degree. C. to 150.degree. C., where appropriate under pressure.

Abstract translation: 一种制备通式（1）的2,4-二硝基苯基醚的方法，其中R表示烷基（C1-C6）或烷氧基（C1-C4）烷基（C1-C4）基团 通过使1摩尔2,4-二硝基氯苯在醚形成所需的无水醇中反应，并具有通式（2）R-OH（2），其中R具有上述含义，在1.0〜 3.0摩尔无水碱金属碳酸盐，温度为20℃至150℃，适当时在压力下。

公开(公告)号：US4837364A

公开(公告)日：1989-06-06

申请号：US845192

申请日：1986-03-28

Applicant: Michel Desbois ,  Bernard Langlois

Inventor： Michel Desbois ,  Bernard Langlois

IPC: B01J27/00 ,  B01J27/122 ,  B01J31/00 ,  B01J31/16 ,  C07B41/04 ,  C07B45/06 ,  C07B61/00 ,  C07C41/00 ,  C07C41/01 ,  C07C41/16 ,  C07C41/22 ,  C07C43/225 ,  C07C45/63 ,  C07C45/64 ,  C07C45/70 ,  C07C45/71 ,  C07C49/84 ,  C07C65/21 ,  C07C67/00 ,  C07C69/92 ,  C07C201/12 ,  C07C205/36 ,  C07C205/37 ,  C07C253/00 ,  C07C253/30 ,  C07C255/54 ,  C07C313/00 ,  C07C319/20 ,  C07C323/20 ,  C07F7/08 ,  C07F9/36

CPC classification number: C07C65/21 ,  C07C201/12 ,  C07C253/30 ,  C07C319/18 ,  C07C41/16 ,  C07C41/22 ,  C07C45/63 ,  C07C45/70 ,  C07C45/71 ,  C07C49/84

Abstract: A process for the preparation of (pentafluoroethoxy)- and (pentafluoroethylthio)benzene derivatives either from phenol, thiophenol or from halobenzene. A halobenzene is reacted with trifluoroethanol or a phenol or a thiophenol is reacted with a compound of the formula CF.sub.3 --CH.sub.2 --O--R'. The product is chlorinated and the chlorinated product is fluorinated in liquid hydrofluoric acid in the presence of a Lewis acid.The compounds obtained by the process of the present invention are used as synthesis intermediates in the phytosanitary, pharmaceutical and veterinary industries, and are used in lubricants.

Abstract translation: 一种由苯酚，苯硫酚或卤代苯制备（五氟乙氧基） - 和（五氟乙硫基）苯衍生物的方法。 使卤代苯与三氟乙醇反应，或苯酚或苯硫酚与式CF 3 -CH 2 -O-R'的化合物反应。 在路易斯酸存在下，将产物氯化并在液体氢氟酸中氟化产物。 通过本发明方法获得的化合物用作植物检疫，药用和兽医工业中的合成中间体，并用于润滑剂中。