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21.发明授权System and process for measuring, compensating and testing numerically controlled machine tool heads and/or tables 有权用于测量，补偿和测试数控机床头和/或台的系统和过程公开(公告)号：US07245982B2
公开(公告)日：2007-07-17
申请号：US10525927
申请日：2003-09-19
申请人： Giuseppe Morfino
发明人： Giuseppe Morfino
IPC分类号： G06F19/00
CPC分类号： G05B19/4015 , G05B2219/39007 , G05B2219/49181 , G05B2219/50026
摘要： A system and a process are disclosed, that are automated and integrated with numerically controlled systems, for measuring, compensating and testing numerically controlled machine tool heads (1) and/or tables. The system comprises: at least one support base (11) equipped with a plurality of distance sensors (14); at least one device (16) of the gage tool type composed of an elongated cylinder (17) that is equipped at one of its ends with connection means (18) for the heads (1) and is equipped at another opposite end with a ball (20), wherein the ball (20) is placed next to the sensors (14) so that they are able, always and in any position, to measure the distance that separates them from the ball (20) and determine thereby the position in the Cartesian space.
摘要翻译： 公开了一种系统和过程，其被自动化并与数控系统集成，用于测量，补偿和测试数控机床头（1）和/或表。 该系统包括：配备有多个距离传感器（14）的至少一个支撑基座（11）; 所述量规工具类型的至少一个装置（16）由细长的圆柱体（17）组成，所述细长的圆柱体（17）的一端具有用于所述头部（1）的连接装置（18），并且在另一相对端设置有球 （20），其中所述球（20）放置在传感器（14）旁边，使得它们能够总是和在任何位置测量将它们与球（20）分开的距离，从而确定球 笛卡尔空间。
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22.发明授权Biocompatible perforated membranes, processes for their preparation, their use as a support in the in vitro growth of epithelial cells, the artificial skin obtained in this manner, and its use in skin grafts 失效生物相容性穿孔膜，其制备方法，它们作为上皮细胞体外生长中的载体的用途，以这种方式获得的人造皮肤及其在皮肤移植物中的用途
公开(公告)号：US5658331A
公开(公告)日：1997-08-19
申请号：US478541
申请日：1995-06-07
CPC分类号： C12N5/0629 , A61F2/105 , A61L27/60 , C12N5/0062 , C12N5/0068 , A61K35/12 , C12N2533/70 , C12N2533/80 , C12N2539/10 , Y10T428/24273
摘要： The invention relates to biocompatible membranes constructed of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500.mu., characterized by containing an ordered series of holes of a constant size between 10 and 1000.mu., separated from each other by a constant distance of between 50 and 1000.mu., and obtained by perforation by mechanical, thermal laser or ultraviolet radiation means, they being suitable for use as a support for the in vitro growth of epithelial cells, the invention also relating to the artificial skin obtained thereby and its use in grafts.
摘要翻译： 本发明涉及由天然，合成或半合成来源的材料构成的生物相容性膜，其厚度为10至500微米，其特征在于包含彼此分离的10至1000微米的恒定尺寸的有序系列的孔 通过50至1000微米之间的恒定距离，并且通过机械，热激光或紫外线辐射手段穿孔获得，它们适合用作上皮细胞的体外生长的载体，本发明还涉及人造皮肤 由此获得并在移植中的应用。
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23.发明授权
公开(公告)号：US5521164A
公开(公告)日：1996-05-28
申请号：US116268
申请日：1993-09-03
IPC分类号： A61K31/70 , A61K31/7028 , A61P25/00 , C07H1/08 , C07H15/04 , C07H15/10 , C07H15/12 , A61K35/30 , A61K31/715
摘要： The process of the invention relates to a process for the preparation of a ganglioside mixture, free from contaminants associated with non-conventional, life-threatening viruses, without altering the biological and pharmacological characteristics of the mixture on the central and peripheral nervous systems.
摘要翻译： 本发明的方法涉及一种制备神经节苷脂混合物的方法，所述神经节苷脂混合物没有与非传统的危及生命的病毒相关的污染物，而不改变中枢和周围神经系统上混合物的生物学和药理学特性。
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24.发明授权Salts and mixtures of hyaluronic acid with pharmaceutically active substances, pharmaceutical compositions containing the same and methods for administration of such compositions 失效盐和透明质酸与药物活性物质的混合物，含有它们的药物组合物以及用于施用这些组合物的方法
公开(公告)号：US5442053A
公开(公告)日：1995-08-15
申请号：US931949
申请日：1992-08-19
IPC分类号： A61K20060101 , A61K9/00 , A61K9/06 , A61K9/08 , A61K9/12 , A61K31/715 , A61K38/18 , A61K45/06 , A61K45/08 , A61K47/26 , A61K47/36 , A61K47/48 , C01F20060101 , C08B37/08 , F17C1/02 , C07H5/04
CPC分类号： A61K31/715 , A61K38/1808 , A61K45/06 , A61K47/26 , A61K47/36 , A61K9/0014 , A61K9/0019 , A61K9/0048 , C08B37/0072 , A61K9/0043 , A61K9/0046 , A61K9/0051 , A61K9/12 , Y10S514/912
摘要： Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intraarticular injections.In addition, pharmaceutical preparations for topical administration are provided containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.
摘要翻译： 获得透明质酸的两种药学上可用的级分，其包含分子量在50,000和100,000之间的用于伤口愈合的第一级分，以及分子量在500,000和730,000之间的第二级分，其用于眼内和关节内注射。 此外，提供了用于局部给药的药物制剂，其含有药理活性物质以及透明质酸或其分子量级分。 透明质酸可以是游离酸的形式，或者可以是与碱金属或碱土金属，镁，铝或铵的盐，或者是与一种或多种药理学活性物质形式的盐。
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公开(公告)号：US5424294A
公开(公告)日：1995-06-13
申请号：US138184
申请日：1993-10-20
CPC分类号： C07H15/10
摘要： N-acyl-N,N'-di-lysogangliosides, N'-acyl-N,N'-di-lysogangliosides and N,N'-diacyl-N,N'-di-lysogangliosides, in which the acyl groups are derived from an organic acid of the aliphatic, aromatic, araliphatic, alicyclic or heterocyclic series and in which at least one of the two acyl groups is not aliphatic, and their preparation are disclosed. Also disclosed is the preparation of the esters, inner esters, amides and hydroxy peracylates of these compounds and salts thereof. These compounds are useful in the treatment of pathologies of the central and peripheral nervous systems.
摘要翻译： N-酰基-N，N'-二溶菌索双胞苷，N'-酰基-N，N'-二溶菌索双胍和N，N'-二酰基-N，N'-二赖藻糖苷，其中酰基衍生 来自脂族，芳族，芳脂族，脂环族或杂环系列的有机酸，其中两个酰基中的至少一个不是脂族的，并且其公开。 还公开了这些化合物的酯，内酯，酰胺和羟基过酰基化物及其盐的制备。 这些化合物可用于治疗中枢和周围神经系统的病理。
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公开(公告)号：US5377420A
公开(公告)日：1995-01-03
申请号：US171667
申请日：1993-12-22
申请人： Mario Vesco , Giancarlo Zaramella
发明人： Mario Vesco , Giancarlo Zaramella
CPC分类号： G01B11/007 , G01B5/012
摘要： A feeler device comprises a support structure in which a movable assembly is movably mounted along three axes, the movable assembly carrying at one end a feeler member. The movable assembly is suspended in the support structure by means of laminar elements which have respective slots of spiral, preferably logarithmic, form.
摘要翻译： 探针装置包括支撑结构，其中可移动组件沿着三个轴线可移动地安装，所述可移动组件在一端承载探头构件。 可移动组件通过层状元件悬挂在支撑结构中，层状元件具有螺旋形，优选对数形状的相应狭槽。
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公开(公告)号：US5350841A
公开(公告)日：1994-09-27
申请号：US922383
申请日：1992-07-31
申请人： Aurelio Romeo , Gino Toffano , Alberta Leon
发明人： Aurelio Romeo , Gino Toffano , Alberta Leon
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/715 , A61P25/00 , C07H15/10 , C07H5/06 , C12P19/04
CPC分类号： C07H15/10
摘要： Novel ganglioside derivatives comprised of a basic natural or semisynthetic ganglioside, in which the carboxyl group in the sialic part of the natural or semisynthetic ganglioside is converted into a carboxylamide with an aliphatic amino acid with a carboxylic or sulfonic acid function, and salts thereof are prepared. The semisynthetic ganglioside components can be chosen from the group consisting of N-acyl-N-lyso-gangliosides, N'-acyl-N'-lyso-gangliosides and N,N'-diacyl-N,N'-di-lyso-gangliosides, wherein "acyl" designates a moiety of an optionally substituted aliphatic acid. The ganglioside derivatives can be used in pharmaceutical preparations to be used in nervous system pathologies.
摘要翻译： 由天然或半合成神经节苷脂的唾液酸部分中的羧基转变成具有羧酸或磺酸功能的脂族氨基酸的羧酰胺及其盐的碱性天然或半合成神经节苷脂组成的新型神经节苷脂衍生物被制备 。 半合成神经节苷脂组分可以选自N-酰基-N-溶血神经节苷脂，N'-酰基-N'-溶解神经节苷脂和N，N'-二酰基-N，N'-二 - 神经节苷脂，其中“酰基”表示任选取代的脂族酸的部分。 神经节苷脂衍生物可用于用于神经系统病理学的药物制剂中。
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公开(公告)号：US5336668A
公开(公告)日：1994-08-09
申请号：US722398
申请日：1991-06-20
IPC分类号： A23L29/00 , A61K8/00 , A61K8/30 , A61K8/64 , A61K8/72 , A61K8/73 , A61K9/00 , A61K47/00 , A61K47/36 , A61K47/48 , A61L15/00 , A61L15/16 , A61L15/28 , A61L17/00 , A61L17/10 , A61L27/00 , A61L27/20 , A61Q19/00 , C08B37/04 , C11D3/48 , A61K9/70 , A61K31/725 , C07H1/00
CPC分类号： A61K9/0014 , A61K47/36 , A61K47/4823 , A61K8/733 , A61K9/0019 , A61L15/28 , A61L17/10 , A61L27/20 , A61Q19/00 , C08B37/0084 , Y10S514/912
摘要： Total and partial esters of alginic acid which possess important bioplastic and pharmaceutical qualities and are useful in various fields including medical, surgical, cosmetics and foods.
摘要翻译： 藻酸的全部和部分酯具有重要的生物塑料和药物特性，可用于包括医疗，外科，化妆品和食品在内的各个领域。
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公开(公告)号：US5300493A
公开(公告)日：1994-04-05
申请号：US945495
申请日：1992-09-16
申请人： Aurelio Romeo , Gino Toffano , Lanfranco Callegaro
发明人： Aurelio Romeo , Gino Toffano , Lanfranco Callegaro
IPC分类号： A61K20060101 , A61K31/045 , A61K31/715 , A61K31/73
CPC分类号： A61K31/045 , A61K31/715 , Y10S514/925 , Y10S514/926
摘要： Acidic polysaccharide esters containing carboxylic groups are useful for protecting against and curing ulcers of the gastro-enteric system. These esters include choline esters with acidic polysaccharide selected from the group consisting of hyaluronic acid, alginic acid, gellan, oxidized cellulose, oxidized chitin, carboxy-hydrocarbyl-cellulose, carboxy-hydrocarbyl-starch and carboxy-hydrocarbyl-chitin, wherein the term hydrocarbyl means the residue of a hydrocarbon selected from the group consisting of by alkyl, aralkyl and cycloalkyl.
摘要翻译： 含有羧基的酸性多糖酯可用于防止和治疗胃肠系统的溃疡。 这些酯包括选自透明质酸，海藻酸，结冷胶，氧化纤维素，氧化几丁质，羧基 - 烃基 - 纤维素，羧基 - 烃基 - 淀粉和羧基 - 烃基几丁质的酸性多糖的胆碱酯，其中术语烃基 是指选自烷基，芳烷基和环烷基的烃的残基。
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30.发明授权Use of monosialoganglioside GM, to prevent the development of tolerance to the analgesic effect of morphine and related drugs 失效单核苷酸通用的使用，以防止对吗啡和相关药物的有效作用的耐受性的发展
公开(公告)号：US5183807A
公开(公告)日：1993-02-02
申请号：US723280
申请日：1991-06-28
IPC分类号： A61K31/715 , A61K31/70 , A61K35/30
摘要： The use of monosialoganglioside GM.sub.1, of its pharmacologically acceptable salts and of its internal ester derivative for the preparation of pharmaceutical compositions for preventing the development in man of tolerance to the analgesic effect of morphine, of chemically correlated opiates, and of methadone and its derivatives is described.
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