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21.发明授权公开(公告)号：US10592793B2
公开(公告)日：2020-03-17
申请号：US14595073
申请日：2015-01-12
申请人： LABCYTE INC.
发明人： Lars Majlof , Richard N. Ellson
摘要： A container may include a tubular sidewall defining interior and exterior surfaces of the container, and including first and second regions disposed relative to one another along a major axis of the tubular sidewall. The container further may include an identification mark embedded within the tubular sidewall at a plurality of sectors about the tubular sidewall within the first region. Each sector may have a width, and the identification mark is machine readable by a reader viewing any arbitrary one or more of the sectors. An exemplary method for preparing such a container is also provided.
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公开(公告)号：US09939352B2
公开(公告)日：2018-04-10
申请号：US14887320
申请日：2015-10-19
申请人： Labcyte Inc.
CPC分类号： G01N1/28 , C12Q1/68 , G01N33/6848 , G01N33/6851 , H01J49/04 , H01J49/0422 , H01J49/0431 , Y10T436/24 , Y10T436/25875
摘要： A method and system are provided for detecting the concentration of an analyte in a fluid sample. The method and system involve analysis of a volatilized, ionized fluid sample using a mass spectrometer or other ionic analyte detection device that provides a signal proportional in intensity to the quantity of ionized analyte detected. The improvement involves replacement of a necessary non-analyte component in the fluid sample with a substitute component that serves the same purpose as the original component but is either more volatile than the original component and/or the analyte or undergoes a reaction to provide lower molecular weight reaction products, and results in an increased intensity in signal and signal-to-noise ratio. Acoustic fluid ejection is a preferred method of generating nanoliter-sized droplets of fluid sample that are then volatilized, ionized, and analyzed. Also provided are zwitterionic compounds suitable as the substitute components that when ionized and heated decompose to provide carbonic dioxide, a nitrogenous species such as ammonia, an amine, or nitrogen gas, and a volatile aromatic compound.
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23.发明授权公开(公告)号：US09908133B2
公开(公告)日：2018-03-06
申请号：US14944874
申请日：2015-11-18
申请人： LABCYTE INC.
CPC分类号： B05B12/004 , B01J2219/00362 , B01J2219/00378 , B01J2219/00527 , B01J2219/00677 , B01L3/0268 , B01L2200/143 , B01L2200/148 , B01L2300/0819 , B01L2400/0436 , B01L2400/0439 , B41J2/04541 , B41J2/04563 , B41J2/04575 , B41J2/0458 , B41J2/14008
摘要： The invention provides apparatuses and methods for acoustically ejecting the fluid from a reservoir contained in or disposed on a substrate. The reservoir has a portion adapted to contain a fluid, and an acoustic radiation generator is positioned in acoustic coupling relationship to the reservoir. Acoustic radiation generated by the acoustic radiation generator is transmitted through at least the portion of the reservoir to an analyzer. The analyzer is capable of determining the energy level of the transmitted acoustic radiation and raising the energy level of subsequent pulses to a level sufficient to eject fluid droplets from the reservoir. The invention is particularly suited for delivering fluid from a plurality of reservoirs in an accurate and efficient manner.
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公开(公告)号：US09586215B2
公开(公告)日：2017-03-07
申请号：US13752077
申请日：2013-01-28
申请人： Labcyte Inc.
CPC分类号： B05B5/005 , B01L3/0268 , B01L2300/0819 , B01L2300/0829 , B01L2400/027 , B01L2400/0415 , B01L2400/0436 , B01L2400/0487 , B05B17/06 , G01N35/1009 , G01N35/1074 , G01N2035/1034 , Y10T436/2575
摘要： A system for fluid transport is provided where a quantity of fluid is held in a reservoir. A droplet generator is employed to generate droplets from the fluid, for example a nozzle-based system or a nozzleless system such as an acoustic ejection system. A generated droplet has a trajectory whereby it arrives at a target. A circuit is used to modify one or more characteristics of the generated droplet in a way which increases the likelihood that the droplet will not splash or bounce when it arrives at the target. The circuit may in different embodiments control the speed of the droplet or the Weber number of the droplet. The circuit may create an electric field in an area of space where the droplet passes. The circuit may charge the droplet by causing it to contact ions.
摘要翻译： 提供一种用于流体输送的系统，其中将一定量的流体保持在储存器中。 液滴发生器用于从流体产生液滴，例如基于喷嘴的系统或无喷射系统，例如声弹射系统。 产生的液滴具有到达目标的轨迹。 电路用于以增加液滴在到达目标时不会飞溅或反弹的可能性的方式来修改产生的液滴的一个或多个特性。 电路可以在不同的实施例中控制液滴的速度或微波的韦伯数。 电路可以在液滴通过的空间区域中产生电场。 该电路可通过使其与离子接触来对液滴进行充电。
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公开(公告)号：US08882226B2
公开(公告)日：2014-11-11
申请号：US14016909
申请日：2013-09-03
申请人： Labcyte Inc.
发明人： Richard N. Ellson
CPC分类号： B01L3/56 , B41J2/04536 , B41J2/04575 , B41J2/04596
摘要： To ejecting a droplet from a reservoir, the reservoir holding a fluid is moved with respect to an acoustic ejector. As the reservoir and ejector move closer together, the acoustic ejector sends one or more interrogation pulses towards the reservoir. Based on the interrogation pulses, the system determines when the movement of the reservoir has placed a free surface of the fluid in a position where a droplet can be ejected.
摘要翻译： 为了从储存器喷射液滴，保持流体的储存器相对于声学喷射器移动。 当储存器和喷射器靠近在一起时，声学喷射器向贮存器发送一个或多个询问脉冲。 基于询问脉冲，系统确定储存器的运动何时将流体的自由表面放置在可以喷射液滴的位置。
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公开(公告)号：US08389295B2
公开(公告)日：2013-03-05
申请号：US12944364
申请日：2010-11-11
IPC分类号： G01N1/10
CPC分类号： B05B5/005 , B01L3/0268 , B01L2300/0819 , B01L2300/0829 , B01L2400/027 , B01L2400/0415 , B01L2400/0436 , B01L2400/0487 , B05B17/06 , G01N35/1009 , G01N35/1074 , G01N2035/1034 , Y10T436/2575
摘要： A system for fluid transport is provided where a quantity of fluid is held in a reservoir. A droplet generator is employed to generate droplets from the fluid, for example a nozzle-based system or a nozzleless system such as an acoustic ejection system. A generated droplet has a trajectory whereby it arrives at a target. A circuit is used to modify one or more characteristics of the generated droplet in a way which increases the likelihood that the droplet will not splash or bounce when it arrives at the target. The circuit may in different embodiments control the speed of the droplet or the Weber number of the droplet. The circuit may create an electric field in an area of space where the droplet passes. The circuit may charge the droplet by causing it to contact ions.
摘要翻译： 提供一种用于流体输送的系统，其中将一定量的流体保持在储存器中。 液滴发生器用于从流体产生液滴，例如基于喷嘴的系统或无喷射系统，例如声弹射系统。 产生的液滴具有到达目标的轨迹。 电路用于以增加液滴在到达目标时不会飞溅或反弹的可能性的方式来修改产生的液滴的一个或多个特性。 电路可以在不同的实施例中控制液滴的速度或微波的韦伯数。 电路可以在液滴通过的空间区域中产生电场。 该电路可通过使其与离子接触来对液滴进行充电。
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27.发明申请公开(公告)号：US20110108555A1
公开(公告)日：2011-05-12
申请号：US12944384
申请日：2010-11-11
CPC分类号： B01L3/50853 , B01L3/50855 , B01L2200/142 , B01L2300/0829 , B01L2300/10 , G01N2035/00455 , Y10T436/25
摘要： Fluid containers are disclosed which have fluid reservoirs in their closures. These reservoirs are advantageous to hold sacrificial fluid which lessens the loss of the fluid of interest to the outside through evaporation. The reservoirs may have openings to the inside or outside of the container, or to both. Reservoirs with openings to the outside serve to reduce evaporative loss by raising the partial pressure of fluid in the vicinity of the contact between the closure and the remainder of the container. The reservoirs may be refillable without opening the container. In one embodiment a fluid reservoir allows the zone of contact between the closure and the remainder of the container to be immersed in fluid, so that gases seeking to escape the interior of the container must pass through fluid.
摘要翻译： 公开了在其封闭件中具有流体储存器的流体容器。 这些储存器有利于保持牺牲流体，其通过蒸发减少感兴趣的流体的损失。 储存器可以具有到容器的内部或外部的开口，或者具有到两者的开口。 具有向外部开口的容器用于通过提高封闭件和容器的其余部分之间的接触附近的流体的分压来减少蒸发损失。 储存器可以在不打开容器的情况下重新填充。 在一个实施例中，流体储存器允许封闭件和容器的其余部分之间的接触区浸没在流体中，使得试图逃离容器内部的气体必须通过流体。
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28.发明授权Acoustic determination of properties of reservoirs and of fluids contained therein 有权储存器及其中所含流体的性质的声学测定公开(公告)号：US07784331B2
公开(公告)日：2010-08-31
申请号：US12187122
申请日：2008-08-06
IPC分类号： G01N29/07
CPC分类号： B01L3/0268 , B01J2219/00362 , B01J2219/00702 , B01L2200/143 , B01L2300/0819 , B01L2400/0436 , B01L2400/0439 , C40B60/14 , G01F23/296 , G01F23/2968 , G01N29/02 , G01N29/22 , G01N29/222 , G01N29/28 , G01N35/1016 , G01N2035/00158 , G01N2291/02818 , G01N2291/02836 , G01N2291/02881 , G01N2291/2695
摘要： The invention provides devices and methods for acoustically determining the properties of the contents of one or more reservoirs in a plurality of reservoirs. Each reservoir is adapted to contain a fluid. An acoustic radiation generator can be positioned in acoustic coupling relationship to each of the reservoirs. Acoustic radiation generated by the acoustic radiation generator is transmitted through each reservoir to an analyzer. The analyzer is capable of analyzing a characteristic of the transmitted acoustic radiation and optionally correlating the characteristic to a property of the reservoirs' contents. Properties that may be determined include volume, temperature, and composition. The invention is particularly suited to determining the properties of the contents of a plurality of reservoirs to allow for accuracy and control over the dispensing of fluids therefrom.
摘要翻译： 本发明提供用于声学确定多个储存器中的一个或多个储存器的内容物的性质的装置和方法。 每个储存器适于容纳流体。 声辐射发生器可以定位成与每个储存器的声耦合关系。 由声辐射发生器产生的声辐射通过每个储存器传送到分析器。 分析仪能够分析所发射的声辐射的特性，并且可选地将特征与储层内容物性相关联。 可以确定的属性包括体积，温度和组成。 本发明特别适合于确定多个储存器的内容物的性质，以允许精确度和控制从其中分配流体。
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29.发明授权Acoustic determination of properties of reservoirs and of fluids contained therein 有权储存器及其中所含流体的性质的声学测定公开(公告)号：US07454958B2
公开(公告)日：2008-11-25
申请号：US10946141
申请日：2004-09-20
CPC分类号： G01F23/296 , B01J2219/00362 , B01J2219/00702 , B01L3/0268 , B01L2200/143 , B01L2300/0819 , B01L2400/0436 , B01L2400/0439 , C40B60/14 , G01F23/2968 , G01N29/02 , G01N29/22 , G01N29/222 , G01N29/28 , G01N35/1016 , G01N2035/00158 , G01N2291/02818 , G01N2291/02836 , G01N2291/02881 , G01N2291/2695
摘要： The invention provides devices and methods for acoustically determining the properties of the contents of one or more reservoirs in a plurality of reservoirs. Each reservoir is adapted to contain a fluid. An acoustic radiation generator can be positioned in acoustic coupling relationship to each of the reservoirs. Acoustic radiation generated by the acoustic radiation generator is transmitted through each reservoir to an analyzer. The analyzer is capable of analyzing a characteristic of the transmitted acoustic radiation and optionally correlating the characteristic to a property of the reservoirs' contents. Properties that may be determined include volume, temperature, and composition. The invention is particularly suited to determining the properties of the contents of a plurality of reservoirs to allow for accuracy and control over the dispensing of fluids therefrom.
摘要翻译： 本发明提供用于声学确定多个储存器中的一个或多个储存器的内容物的性质的装置和方法。 每个储存器适于容纳流体。 声辐射发生器可以定位成与每个储存器的声耦合关系。 由声辐射发生器产生的声辐射通过每个储存器传送到分析器。 分析仪能够分析所发射的声辐射的特性，并且可选地将特征与储层内容物性相关联。 可能确定的属性包括体积，温度和组成。 本发明特别适合于确定多个储存器的内容物的性质，以允许精确度和控制从其中分配流体。
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公开(公告)号：US20070175897A1
公开(公告)日：2007-08-02
申请号：US11698004
申请日：2007-01-24
申请人： Richard Ellson
发明人： Richard Ellson
CPC分类号： C12M23/34 , B01L3/508 , B01L3/50853 , B01L2200/0689 , B01L2300/041 , B01L2300/0809 , B01L2300/0829 , C12M23/10 , C12M23/12 , C12M23/26 , C12M23/38
摘要： In a preferred embodiment of the invention, a closure for a container comprises at least two closure members. The relative position of the closure members with respect to each other is altered upon mating of the closure and container. The alteration of the relative position of the closure members may result in one or more of the members approaching the container more closely. The alteration may result in one or more of the members pressing against the container. The pressing may take place in such a way that exit paths for vapor from fluid in the container would require passage through the pressed surfaces.
摘要翻译： 在本发明的优选实施例中，用于容器的封闭件包括至少两个闭合构件。 封闭件相对于彼此的相对位置在封盖和容器配合时被改变。 关闭构件的相对位置的改变可能导致一个或多个构件更接近容器。 改变可能导致一个或多个构件压靠容器。 按压可以以这样一种方式进行：用于来自容器中的流体的蒸气的出口路径将需要通过压制表面。
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