Abstract:
The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.
Abstract:
An example process for controlling a processor may include: (i) obtaining parameters associated with operation of a processor, where each of the parameters has a different time scale; (ii) performing an iterative process to identify ones of the parameters that achieve a particular energy efficiency in the processor, where the energy efficiency of the processor corresponds to a quasi-concave function having a maximum that corresponds to the ones of the parameters; and (iii) controlling the processor using the ones of the parameters.
Abstract:
An ionic liquid catholyte includes an ionic liquid, such as 1-ethyl-3-methylimidazolium chloride (EMICl), at least one half of a redox couple, and a sodium salt. The ionic liquid catholyte is suitable for use as a liquid cathode in an electrochemical device including an anode current collector, an anode in contact with the anode current collector, a cathode current collector, a liquid cathode in contact with the cathode current collector, and a solid electrolyte separating the anode and cathode current collectors. The one half of the redox couple includes a metal in a first oxidation state that is oxidized or reduced to yield the metal in a second oxidation state, and the redox couple includes the metal in the first oxidation state and the metal in the second oxidation state. The solid electrolyte is permeable to sodium ions and is in contact with the liquid anode and the liquid cathode.
Abstract:
Plant viral vectors have great potential in rapid production of proteins, but no simple Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.
Abstract:
The present disclosure relates to novel fusion proteins that bind to the HIV-1 gp120 antigen. The present disclosure also relates to nucleic acids, plasmids and host cells that comprise a sequence that encodes the fusion proteins of the disclosure. The fusion proteins of the disclosure can be used in applications to detect the presence of HIV-1 gp120 protein, to detect an HIV-1 infection and to monitor treatment of an HIV-1 infection.
Abstract:
A multi-nodal wireless communication system comprises a system controller configured to create a link layer communication network. The system controller comprises a set of hardware finite state machines configured to receive a frame from a device associated with the link layer communication network as a request for data transmission, identify that the frame includes a unique ID value, transmit the unique ID value to an associated hardware queue, the hardware queue configured to construct at least one frame header associated with a base station to facilitate data transmission between the base station and the first device or between the first device and the network using one frame header, and process the frame in the link layer communication network by facilitating communication between the first device and the base station using the at least one frame header or between the first device and the network using one frame header.
Abstract:
The present disclosure relates to sugar-linker-drug conjugates, of the formula [A-B-]n-L-D, wherein A is a saccharide; B is a spacer, n is an integer selected from 1 to 3; L is a linker group and D is a drug having a chemically reactive functional group selected from the group consisting of a primary or secondary amine, hydroxyl, sulfhydryl, carboxyl, aldehyde and ketone. Pharmaceutical compositions comprising the conjugates and methods of using them are also provided.
Abstract:
Embodiments of a coupling system include a brace member, a plurality of coupling members, and a plurality of magnetic bodies that permit an individual to be attached or detached from a robotic device. The coupling system may serve as a detachable interface between an individual engaged to the robotic device.