Abstract:
Compositions and methods for improving cellular internalization of one or more compounds are disclosed. The compositions include a compound to be delivered and a biocompatible viscous material, such as a hydrogel, lipogel, or highly viscous sol. The composition also include, or are administered in conjunction with, an enhancer in an amount effective to maximize expression of or binding to receptors and enhance RME of the compound into the cells. This leads to high transport rates of compounds to be delivered across cell membranes, facilitating more efficient delivery of drugs and diagnostic agents. Compositions are applied topically orally, nasally, vaginally, rectally, and ocularly. The enhancer is administered with the composition or separately, either systemically or preferably locally. The compound to be delivered can also be the enhancer.
Abstract:
A process for cutting or perforating a water-soluble or water-dispersible film or stack of films in the form of a web comprising a plurality of compartments by which each compartment is cut or perforated by applying a laser beam to the film or stack of films. The process for producing a water-soluble or water-dispersible container containing a composition comprises: a producing a base web water-soluble or water-dispersible film containing a plurality of pockets; b. filling each pocket with a composition; c. sealing the pockets with a top web water-soluble or water-dispersible film to produce closed containers; and d. separating at least one container from the plurality of containers by cutting or perforating the combined web with a laser beam.
Abstract:
The present invention relates to a support structure for a spare tire on a vehicle. A shell is attached to the vehicle and includes first and second end portions and a bottom portion extending at least partially between the first and second end portions. The shell at least partially defines a spare tire storage chamber and includes an opening providing access to the storage chamber, wherein the opening is adjacent to the first end portion. A support member is adapted to support a spare tire. The support member is slidably positioned above the bottom portion and is movable back and forth along a movement path from a first position in which the support member is substantially disposed within the shell and a second position in which the support member is at least partially disposed outside the shell. The support member includes a lower interface surface for directly contacting an upper interface surface of the bottom portion of the shell in sliding engagement as the support member is moved along the movement path. In certain embodiments, a retention member can be fixedly attached to the shell. In further embodiments, the support member and the shell have a cooperative locking configuration. A support structure adapted to support a spare tire for a vehicle is also disclosed.
Abstract:
An MR system isolation impedance mismatch apparatus (12) includes an impedance mismatch layer (24). The impedance mismatch layer (24) performs as a mechanical notch filter and isolates an MR system component (14) from a surrounding structure (18). A method of tuning the impedance mismatch apparatus (12) includes determining a default notch filter frequency range. The impedance mismatch apparatus (12) is formed and performs as a notch filter having the default notch filter frequency range. The impedance mismatch apparatus (12) is installed and tested between the MR system component (14) and the surrounding structure (18). Vibrations are detected in the MR system component (14) and in the surrounding structure (18). The impedance mismatch apparatus is adjusted in response to the detected vibrations.
Abstract:
Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures.
Abstract:
Compositions of the current invention are directed toward inhibiting the growth of microorganisms, particularly fungi. The compositions consist of chemically-synthesized antibiotics comprising certain amino acids. Methods of identifying particular antibiotic compositions from libraries of such compositions are disclosed. In addition, methods for preventing microbial growth in plants and animals are disclosed.
Abstract:
Method/apparatus for extracting substance from carrier liquid in first container into an immiscible extraction liquid of different density in second container receiving and locating the first. Substance transfers to extraction liquid at liquids admixture in second container aided by flow control and fine division of carrier liquid force supplied into extraction liquid. Separated liquids receive separator member cooperating with second container as physical barrier with only separated extraction and acquired substance at one side. Centrifuging produces three-stage dividing flow of carrier liquid on the second container wall. Moulded parts suit single use in centrifuge.
Abstract:
A security article such as a banknote, credit card, identity card or travel document includes a security element which is visually detectable in transmitted light to display portions which transmit light and portions which are opaque, the security element including a plurality of layers that include a light-transmitting support layer and two or more series of opaque regions. The arrangement of the opaque regions is such that at certain parts of the security element the regions overlap to prevent light transmission and elsewhere along its length the opaque regions do not overlap or only partially overlap such that light transmission through the security element occurs.
Abstract:
Ion beam apparatus provides beam blanking by utilizing an aperture through which the beam passes during unblanked periods, and elements for deflecting the beam during blanking so that the beam is deflected away from the aperture. Electrodes between the aperture element and the deflecting elements generate a potential exceeding the kinetic energy of charged particles emitted from the aperture element due to ions striking the aperture element during blanking. Charged particles emitted from the aperture element are thus prevented from striking the beam deflecting elements, thereby reducing hydrocarbon cracking, insulator accumulation, and charge accumulation on the deflecting elements. Beam stability is thereby enhanced. Charged particles emitted from the aperture element are also returned to the aperture element, so that an accurate measure of ion beam current is obtained by measuring current flow to the aperture element.