公开(公告)号：US20090139353A1

公开(公告)日：2009-06-04

申请号：US11948491

申请日：2007-11-30

Applicant: Daniel S. Kline ,  Anthony David Barghini ,  Scott Wayne Beaver ,  James Coleman Lee ,  William Michael Lafferty

Inventor： Daniel S. Kline ,  Anthony David Barghini ,  Scott Wayne Beaver ,  James Coleman Lee ,  William Michael Lafferty

IPC: G01N1/04

CPC classification number: G01N1/08 ,  G01N1/04 ,  G01N33/0098 ,  G01N2001/288

Abstract: A device for collecting plant samples includes a punch and die mechanism for taking leaf plugs from plants. The punch itself includes a punch rod coaxially mounted inside a punch tube. In use, the punch tube has a distal end with two, diametrically opposed projections that interact with the formed aperture to cut a plug from a plant leaf. The punch rod then follows to remove a cut leaf plug from the formed aperture. Also included is a hydraulic subsystem for periodically delivering liquid on the punch and die mechanism to prevent plant debris from clogging the device.

Abstract translation: 用于收集植物样品的装置包括用于从植物取出叶片的冲头和模具机构。 冲头本身包括同轴地安装在冲头管内的冲杆。 在使用中，冲头管具有远端，其具有与形成的孔相互作用的两个直径相对的突起，以从植物叶切割塞子。 接下来的打孔杆从形成的孔中移除切割的叶片。 还包括液压子系统，用于在冲头和模具机构上周期性地输送液体，以防止植物碎屑堵塞装置。

公开(公告)号：US06798520B2

公开(公告)日：2004-09-28

申请号：US10103977

申请日：2002-03-22

Applicant: William Michael Lafferty

Inventor： William Michael Lafferty

IPC: G01N2100

CPC classification number: B01L3/5085 ,  B01L2300/161 ,  B01L2400/0487 ,  B01L2400/049 ,  G01N13/02 ,  G01N21/0303 ,  G01N2021/0346

Abstract: A system and method for optically detecting samples held in a solution requires the use of a holding plate that has as many as one-thousand through-hole wells, or more. The solution is suspended in these through-hole wells under surface tension between opposed surfaces of the holding plate. A pneumatic pump is then engaged with the plate to establish a differential pressure (&Dgr;p) between the upper and lower surfaces of the solution that is equal to approximately two tenths of a pound per square inch (0.2 psi). The result is the formation of a convex meniscus on a surface of the solution that causes light passing into the solution to converge and concentrate. This concentration of light, in turn, facilitates optical detection of samples in the solution.

公开(公告)号：US06794127B1

公开(公告)日：2004-09-21

申请号：US09687219

申请日：2000-10-12

Applicant: William Michael Lafferty ,  Jay M. Short ,  Martin Keller

Inventor： William Michael Lafferty ,  Jay M. Short ,  Martin Keller

IPC: C12Q100

CPC classification number: C40B40/02 ,  B01J19/0046 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00416 ,  B01J2219/00479 ,  B01J2219/00481 ,  B01J2219/00522 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00722 ,  B01J2219/0074 ,  B01J2219/00743 ,  B01L3/5085 ,  B01L3/50857 ,  B82Y30/00 ,  C12N15/1037 ,  C12N15/1055 ,  C12Q1/6811 ,  C12Q1/6837 ,  C40B40/06 ,  C40B60/14

Abstract: Provided are methods of screening and identification of bio activities and bioactive molecules of interest using a capillary array system. More specifically, disclosed are methods of using optical detection and capillary array-based techniques for screening libraries and recovering bioactive molecules having a desired activity or a nucleic acid sequence encoding such bioactive molecules.

Abstract translation: 提供了使用毛细管阵列系统筛选和鉴定生物活性和生物活性分子的方法。 更具体地，公开了使用光学检测和毛细管阵列技术来筛选文库和回收具有所需活性的生物活性分子或编码这种生物活性分子的核酸序列的方法。

公开(公告)号：US5818573A

公开(公告)日：1998-10-06

申请号：US796744

申请日：1997-02-06

Applicant: W. Michael Lafferty ,  Charles S. Slemon ,  W. James Frandsen

Inventor： W. Michael Lafferty ,  Charles S. Slemon ,  W. James Frandsen

IPC: G01M11/02 ,  G01B11/27

CPC classification number: G01M11/0221

Abstract: An ophthalmic lens inspection system includes an illumination assembly which generates diffuse light and transmits the diffuse light through an ophthalmic lens disposed in an inspection position, the diffuse light having a diffusivity of between 30.degree. and 50.degree.. An imaging assembly generates a set of signals representing selected portions of the diffuse light transmitted through the ophthalmic lens in the inspection position. A moving mechanism supports the imaging and illumination assemblies for common movement relative to the contact lens, to bring a reference point into alignment with the center of the imaging assembly.

Abstract translation: 一种眼科镜检查系统，包括产生漫射光并通过设置在检查位置的眼镜透射漫射光的照明组件，扩散光的扩散系数在30°至50°之间。 成像组件在检查位置产生表示通过眼科镜片透射的漫射光的所选部分的一组信号。 移动机构支持用于相对于隐形眼镜共同移动的成像和照明组件，以使参考点与成像组件的中心对准。

公开(公告)号：US5680104A

公开(公告)日：1997-10-21

申请号：US652913

申请日：1996-05-31

Applicant: Charles S. Slemon ,  William Michael Lafferty ,  Anthony E. Diamond

Inventor： Charles S. Slemon ,  William Michael Lafferty ,  Anthony E. Diamond

IPC: G08B13/186 ,  G08B13/14

CPC classification number: G08B13/186

Abstract: An optical fiber security system includes an optical emitter connected to one end of an optical fiber and a detector connected to the other end. A random signal generator triggers the emitter to output a light pulse signal through the fiber. This generator also simultaneously triggers the detector to receive the light pulse signal. A comparator compares the light pulse signal that is received by the detector with an optimum reference to adjust and conform the emitter output with the reference. Also, a monitor determines whether a particular identifiable characteristic of the light pulse signal is within a predetermined range of values. Whenever there is not a simultaneous emission and detection of the light pulse signal, or whenever the light pulse characteristic is outside the predetermined range of values, the system alarms.

Abstract translation: 光纤安全系统包括连接到光纤一端的光发射器和连接到另一端的检测器。 随机信号发生器触发发射器通过光纤输出光脉冲信号。 该发生器还同时触发检测器接收光脉冲信号。 比较器将检测器接收的光脉冲信号与最佳参考值进行比较，以调整发射器输出并使其符合参考。 此外，监视器确定光脉冲信号的特定可识别特性是否在预定值范围内。 每当光脉冲信号没有同时发射和检测时，或者每当光脉冲特性超出预定值范围时，系统就会报警。

公开(公告)号：US5188093A

公开(公告)日：1993-02-23

申请号：US650066

申请日：1991-02-04

Applicant: Michael Lafferty ,  Daniel Kline ,  Charles S. Slemon

Inventor： Michael Lafferty ,  Daniel Kline ,  Charles S. Slemon

IPC: A61B1/00 ,  A61B1/04 ,  A61B1/055 ,  A61B1/317 ,  A61B19/08 ,  G02B23/26

CPC classification number: A61B1/317 ,  A61B1/00096 ,  A61B1/00165 ,  A61B1/00179 ,  A61B1/00183 ,  A61B1/042 ,  A61B1/055 ,  A61B46/10 ,  A61B1/00188

Abstract: A hand-held portable arthroscope has a camera assembly and a disposable scope assembly rotatably attached to the distal end of the camera assembly. A probe which includes a fiber optic image guide and a plurality of optical illuminating fibers is rotatably mounted on the scope assembly, and is insertable into a body for imaging the internal structure of the body. The illuminating fibers extend through the scope assembly and are connected in light communication with a quartz halogen lamp for illuminating the internal body structure being imaged. To gather light from the illuminated internal structure of a body into which the probe has been inserted, a GRIN rod is attached to the distal end of the image guide. The image guide is bent near its distal end to offset the axis of the GRIN rod from the axis of the camera assembly, to enhance the field of view of the arthroscope when the scope assembly, which supports the image guide with GRIN rod, is rotated. Focussing optics are mounted in the camera assembly in light communication with the image guide. These focussing optics are axially movable within the camera assembly for focussing the image from the image guide. Light which passes through the focussing optics enters a camera head which is also mounted in the camera assembly. The camera head is in turn electrically connected to a video display device for producing an image of the internal structure of the body.

公开(公告)号：US20100172968A1

公开(公告)日：2010-07-08

申请号：US11929781

申请日：2007-10-30

Applicant: Jay Short ,  Eric J. Mathur ,  W. Michael Lafferty ,  Nelson Barton ,  Kevin Chow

Inventor： Jay Short ,  Eric J. Mathur ,  W. Michael Lafferty ,  Nelson Barton ,  Kevin Chow

IPC: A61K9/48 ,  A61K9/10 ,  C12N15/63 ,  C07K14/00 ,  C07K16/00

CPC classification number: B82Y30/00 ,  A61K9/0092 ,  A61K9/1274 ,  C07K14/195

Abstract: A polymer is prepared by self-assembly of a plurality of monomeric polypeptide units. The polymer tends to form a nanotube and is capable of encapsulating a particular drug molecule. Once encapsulated in the polymer of the present invention, the drug molecule may be delivered to a particular location of human body to effectively cure a disease or treat a symptom.Generally, the monomeric polypeptide unit of the present invention has a sequence found in Pyrodictium abyssi, a microorganism that produces an extracellular network having hollow protein tubes, or a sequence substantially identical thereto. The monomeric polypeptide may be mass produced using recombinant biotechnologies and be polymerized into the polymer of the present invention. One or more additional targeting vector may be attached to the monomeric polypeptide unit or the polymer to facilitate the targeting of the drug molecule that may be held there within. The sequence contained in the monomeric polypeptide unit may be further optimized using one or more technique selected from Gene Site Saturation Mutagenesis and GeneReasembly.

Abstract translation: 通过多个单体多肽单元的自组装制备聚合物。 聚合物倾向于形成纳米管并且能够封装特定的药物分子。 一旦包封在本发明的聚合物中，药物分子可以被递送到人体的特定位置以有效治愈疾病或治疗症状。 通常，本发明的单体多肽单元具有在黑腹果蝇（Pyrodictium abyssi）中发现的序列，该菌株产生具有中空蛋白管的细胞外网络或与其基本相同的序列。 单体多肽可以使用重组生物技术大规模生产并聚合成本发明的聚合物。 一个或多个另外的靶向载体可以连接到单体多肽单元或聚合物，以促进可能在其中保持的药物分子的靶向。 可以使用选自基因位点饱和诱变和基因重组的一种或多种技术进一步优化单体多肽单元中所含的序列。

公开(公告)号：US5873130A

公开(公告)日：1999-02-23

申请号：US996443

申请日：1997-12-22

Applicant: Michael Lafferty

Inventor： Michael Lafferty

IPC: A41D13/08

CPC classification number: A41D13/088 ,  C08L2201/12

Abstract: A one-piece wrap-around wrist guard is provided that includes a plurality of flexible plastic supports or stays positioned above and below the wrist. The wrap-around support structure helps absorb and distribute forces from a fall rather than transmitting them to the wrist, arm, elbow and shoulder.

Abstract translation: 提供了一体的环绕护腕，其包括位于手腕上方和下方的多个柔性塑料支撑件或支撑件。 环绕支撑结构有助于从秋天吸收和分配力，而不是将其传递到手腕，手臂，肘部和肩部。

公开(公告)号：US5329936A

公开(公告)日：1994-07-19

申请号：US6510

申请日：1993-01-21

Applicant: Michael Lafferty ,  Daniel Kline ,  Charles S. Slemon

Inventor： Michael Lafferty ,  Daniel Kline ,  Charles S. Slemon

IPC: A61B1/00 ,  A61B1/04 ,  A61B1/055 ,  A61B1/317 ,  A61B19/08 ,  A61B1/06

CPC classification number: A61B1/042 ,  A61B1/00096 ,  A61B1/00165 ,  A61B1/00179 ,  A61B1/00183 ,  A61B1/055 ,  A61B1/0623 ,  A61B1/317 ,  A61B46/10 ,  A61B1/00188

Abstract: A disposable arthroscope for examining the interior of a joint and for carrying out diagnostic and therapeutic procedures within the joint includes an elongated needle and a cap housing which has a base plate. The proximal end of the needle is mounted on the cap opposite the base plate, and the distal end of the needle extends outwardly from the cap. The needle is a hollow tube which surrounds an image guide and a bundle of illuminating fibers that extend through the tube. A lens is attached to the distal end of the image guide and is slightly angled relative to the longitudinal axis of the needle. The proximal ends of both the image guide and the bundle of illuminating fibers extend from the proximal end of the tube and through the cap for exposure at the surface of the base plate. The base plate of the disposable arthroscope is engageable with a camera and with a light source to position the camera in light communication with the image guide, and to position the light source in light communication with the bundle. With these engagements, the combination of disposable arthroscope, light source and camera generate a visual display of an object that is illuminated by the light source through the bundle of illuminating fibers.

公开(公告)号：US5323767A

公开(公告)日：1994-06-28

申请号：US970969

申请日：1992-11-03

Applicant: Michael Lafferty ,  Daniel Kline ,  Charles S. Slemon

Inventor： Michael Lafferty ,  Daniel Kline ,  Charles S. Slemon

IPC: A61B1/00 ,  A61B1/04 ,  A61B1/055 ,  A61B1/317 ,  A61B19/08 ,  A61B1/06

CPC classification number: A61B1/317 ,  A61B1/00096 ,  A61B1/00165 ,  A61B1/00179 ,  A61B1/00183 ,  A61B1/042 ,  A61B1/055 ,  A61B1/0623 ,  A61B46/10 ,  A61B1/00188

Abstract: A disposable arthroscope for examining the interior of a joint and for carrying out diagnostic and therapeutic procedures within the joint includes an elongated needle and a cap housing which has a base plate. The proximal end of the needle is mounted on the cap opposite the base plate, and the distal end of the needle extends outwardly from the cap. The needle is a hollow tube which surrounds an image guide and a bundle of illuminating fibers that extend through the tube. A lens is attached to the distal end of the image guide and is slightly angled relative to the longitudinal axis of the needle. The proximal ends of both the image guide and the bundle of illuminating fibers extend from the proximal end of the tube and through the cap for exposure at the surface of the base plate. The base plate of the disposable arthroscope is engageable with a camera and with a light source to position the camera in light communication with the image guide, and to position the light source in light communication with the bundle. With these engagements, the combination of disposable arthroscope, light source and camera generate a visual display of an object that is illuminated by the light source through the bundle of illuminating fibers.

Abstract translation: 用于检查关节内部并用于在关节内执行诊断和治疗过程的一次性关节镜包括细长针和具有底板的帽壳体。 针的近端安装在与基板相对的帽上，并且针的远端从帽向外延伸。 针是围绕图像引导件和延伸穿过管的照明纤维束的中空管。 透镜附着到图像引导件的远端并且相对于针的纵向轴线稍微成角度。 图像引导件和照明光纤束的近端从管的近端延伸并且穿过盖，用于在基板的表面处暴露。 一次性关节镜的基板可与照相机和光源接合，以将照相机与图像引导件轻微连通，并将光源定位成与光束轻微连通。 通过这些接合，一次性关节镜，光源和相机的组合产生由光源通过照明光束照射的物体的视觉显示。