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    LUBRICIOUS MEDICAL DEVICE COATING WITH LOW PARTICULATES
    22.
    发明申请
    LUBRICIOUS MEDICAL DEVICE COATING WITH LOW PARTICULATES 审中-公开

    公开(公告)号：US20170304506A1

    公开(公告)日：2017-10-26

    申请号：US15643564

    申请日：2017-07-07

    Applicant: Surmodics, Inc.

    Inventor： David E. Babcock

    IPC: A61L29/08 ,  A61L31/10 ,  A61L27/34 ,  A61L29/14

    Abstract: Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.

    KITS AND METHODS FOR IN VITRO ANALYTE DETECTION USING PRECIPITATING COMPOUND AND POLARIZERS
    27.
    发明申请
    KITS AND METHODS FOR IN VITRO ANALYTE DETECTION USING PRECIPITATING COMPOUND AND POLARIZERS 审中-公开
    使用预处理化合物和极化剂进行体内分析检测的试剂盒和方法

    公开(公告)号：US20140242575A1

    公开(公告)日：2014-08-28

    申请号：US14190367

    申请日：2014-02-26

    Applicant: SurModics, Inc.

    Inventor： Gary Opperman

    IPC: G01N33/543

    CPC classification number: G01N33/582

    Abstract: The invention provides inexpensive kits and methods for determination of an analyte in a sample with very high sensitivity. Analyte can be determined using an analyte binding member such as an antibody or an oligonucleotide, which can be directly or indirectly linked to an enzyme. The kit and method uses a compound that is altered in the presence of the enzyme, and that precipitates into crystalline particulates. The reaction composition with crystalline particulates is placed between two polarizers which are in an orthogonal arrangement, and the presence of particulates is observed, correlating to the analyte in the sample.

    Abstract translation: 本发明提供了用于以非常高的灵敏度测定样品中的分析物的便宜的试剂盒和方法。 可以使用可以直接或间接连接到酶的分析物结合成员例如抗体或寡核苷酸来测定分析物。 试剂盒和方法使用在酶存在下改变的化合物，并且沉淀成结晶微粒。 将具有结晶微粒的反应组合物放置在正交排列的两个偏振器之间，并且观察到与样品中的分析物相关的颗粒的存在。

    CELL ATTACHMENT COATINGS AND METHODS USING PHOSPHOROUS-CONTAINING PHOTOREAGENT
    28.
    发明申请
    CELL ATTACHMENT COATINGS AND METHODS USING PHOSPHOROUS-CONTAINING PHOTOREAGENT 有权
    使用含磷光电池的电池附着涂料和方法

    公开(公告)号：US20140004158A1

    公开(公告)日：2014-01-02

    申请号：US13930512

    申请日：2013-06-28

    Applicant: SurModics, Inc.

    Inventor： Joseph S. McGonigle

    IPC: C12N11/06

    CPC classification number: C12N11/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/64 ,  A61L2420/08 ,  C12N2303/00 ,  C08L71/00 ,  C08L89/06

    Abstract: Cell attachment coatings for articles such as implantable medical devices and cell culture vessels are disclosed. The coatings include an intermediate coater layer which includes a phosphorous-containing component that is bonded in the coating by reacted photoreactive functional groups. The coating also include a second coated layer including an immobilized ECM protein or peptide that includes an active portion of an ECM protein that is able to serve as an outer layer to contact cells during use. The coatings promoted enhanced cell binding and growth.

    Abstract translation: 公开了用于诸如可植入医疗装置和细胞培养容器的制品的细胞附着涂层。 涂层包括中间涂布机层，其包括通过反应的光反应性官能团在涂层中结合的含磷组分。 该涂层还包括第二涂层，其包括固定的ECM蛋白或肽，其包括ECM蛋白的活性部分，其能够用作在使用期间接触细胞的外层。 涂层促进增强的细胞结合和生长。

    APPARATUS AND METHODS FOR COATING MEDICAL DEVICES
    29.
    发明申请
    APPARATUS AND METHODS FOR COATING MEDICAL DEVICES 有权
    用于涂敷医疗器械的装置和方法

    公开(公告)号：US20130337147A1

    公开(公告)日：2013-12-19

    申请号：US13906599

    申请日：2013-05-31

    Applicant: SurModics, Inc.

    Inventor： Ralph A. Chappa ,  Andrew G. Bach ,  Mark MacGregor

    IPC: A61M25/10 ,  A61L29/08

    CPC classification number: A61M25/1029 ,  A61L29/08 ,  A61M25/1027 ,  A61M2025/1031 ,  A61M2025/105 ,  B05B13/0442

    Abstract: Embodiments of the invention include apparatus and methods for coating drug eluting medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit comprising a movement restriction structure; a fluid applicator; and an air nozzle. The apparatus can further include a rotation mechanism and an axial motion mechanism, the axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.

    Abstract translation: 本发明的实施方案包括用于涂敷药物洗脱医学装置的装置和方法。 在一个实施例中，本发明包括涂覆装置，其包括包括运动限制结构的涂布施加单元; 流体施加器; 和空气喷嘴。 该装置还可包括旋转机构和轴向运动机构，所述轴向运动机构构造成使涂层施加单元和旋转机构中的至少一个相对于彼此移动。 本文还包括其它实施例。

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