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    Medical Devices Having Nanostructured Regions For Controlled Tissue Biocompatibility And Drug Delivery
    21.
    发明申请
    Medical Devices Having Nanostructured Regions For Controlled Tissue Biocompatibility And Drug Delivery 审中-公开
    具有控制组织生物相容性和药物递送的纳米结构区域的医疗器械

    公开(公告)号：US20110014264A1

    公开(公告)日：2011-01-20

    申请号：US12888864

    申请日：2010-09-23

    Applicant: Michael N. Helmus ,  Yixin Xu ,  Shrirang V. Ranade

    Inventor： Michael N. Helmus ,  Yixin Xu ,  Shrirang V. Ranade

    IPC: A61F2/82 ,  A61M31/00 ,  A61K38/02 ,  A61K31/726 ,  A61P43/00 ,  A61P35/00

    CPC classification number: B82Y30/00 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/45 ,  A61L2300/624 ,  A61N1/05 ,  B82Y5/00

    Abstract: According to certain aspects of the invention, implantable or insertable medical devices are provided that contain one or more nanoporous regions, which may further comprise interconnected nanopores. Other aspects of the invention are directed to implantable or insertable medical devices that contain one or more nanostructured regions, which are formed by a variety of methods. Still other aspects of the invention are directed to implantable or insertable medical devices having nanotextured surface regions, in which cell-adhesion-promoting biomolecules (e.g., glycosaminoglycans, proteoglycans, cell adhesion peptides, and adhesive proteins) are provided on, within or beneath the nanotextured surface regions.

    Abstract translation: 根据本发明的某些方面，提供了可植入或可插入的医疗装置，其包含一个或多个纳米多孔区域，其可以进一步包括互连的纳米孔。 本发明的其它方面涉及含有一个或多个纳米结构区域的可植入或可插入的医疗装置，其通过多种方法形成。 本发明的另外其它方面涉及具有纳米纹理表面区域的可植入或可插入的医疗装置，其中提供细胞粘附促进生物分子（例如，糖胺聚糖，蛋白聚糖，细胞粘附肽和粘合蛋白），其中， 纳米纹理表面区域。

    MEDICAL DEVICES HAVING A FILTER INSERT FOR CONTROLLED DIFFUSION
    23.
    发明申请
    MEDICAL DEVICES HAVING A FILTER INSERT FOR CONTROLLED DIFFUSION 有权
    具有用于控制扩散的过滤器插件的医疗装置

    公开(公告)号：US20090081271A1

    公开(公告)日：2009-03-26

    申请号：US11860188

    申请日：2007-09-24

    Applicant: John Clarke ,  Tim O'Connor ,  Yixin Xu ,  Barry J. O'Brien

    Inventor： John Clarke ,  Tim O'Connor ,  Yixin Xu ,  Barry J. O'Brien

    IPC: A61F2/04 ,  A61F2/02

    CPC classification number: A61F2/82 ,  A61F2/00 ,  A61F2/01 ,  A61F2/04 ,  A61F2/91 ,  A61F2220/0058 ,  A61F2250/0068

    Abstract: An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent, and (b) a pre-formed filter insert disposed in the depression such that it regulates transport of chemical species between the depression and the exterior of the device upon implantation or insertion of the device in vivo.

    Abstract translation: 提供了一种植入式或可插入的医疗装置，其包括作为部件：（a）底物组分，其包含至少部分地填充有包含第一治疗剂的治疗剂材料的凹陷，和（b）预形成 过滤器插入件设置在凹陷中，使得其在体内植入或插入装置时调节化学物质在装置的凹陷和外部之间的运输。

    Medical articles for long term implantation
    24.
    发明申请
    Medical articles for long term implantation 审中-公开
    医疗用品长期植入

    公开(公告)号：US20080208325A1

    公开(公告)日：2008-08-28

    申请号：US12072141

    申请日：2008-02-25

    Applicant: Michael N. Helmus ,  Barron Tenney ,  Yixin Xu ,  Kevin M. Alves ,  Frederick H. Strickler ,  Kathleen M. Miller ,  Mark Boden

    Inventor： Michael N. Helmus ,  Barron Tenney ,  Yixin Xu ,  Kevin M. Alves ,  Frederick H. Strickler ,  Kathleen M. Miller ,  Mark Boden

    IPC: A61F2/06

    CPC classification number: A61F2/07 ,  A61F2/06 ,  A61F2/915 ,  A61F2002/009 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2250/0024 ,  A61L27/427 ,  A61L27/56 ,  A61L31/128 ,  A61L31/146

    Abstract: According to an aspect of the present invention, long term medical articles are provided which include the following: (a) first and second body contacting (e.g., tissue and/or body-fluid contacting) porous polymeric layers; (b) a polymeric barrier layer disposed between the first and second porous polymer layers; and (c) a reinforcement element. According to another aspect of the present invention, tubular medical articles for long term implantation are provided, which comprise: (a) a reinforcement element; (b) a blood contacting porous polymeric layer having a surface energy ranging between 20 and 30 dynes/cm disposed over an inner surface of the reinforcement element; and (c) an additional porous polymeric layer formed over an outer surface of the reinforcement element.

    Abstract translation: 根据本发明的一个方面，提供了长期的医疗制品，其包括以下：（a）第一和第二体接触（例如组织和/或体液接触）多孔聚合物层; （b）设置在第一和第二多孔聚合物层之间的聚合物阻挡层; 和（c）增强元件。 根据本发明的另一方面，提供了用于长期植入的管状医疗制品，其包括：（a）增强元件; （b）设置在增强元件的内表面上的表面能范围在20和30达因/厘米之间的血液接触多孔聚合物层; 和（c）在增强元件的外表面上形成的另外的多孔聚合物层。

    Fatigue resistant medical devices
    25.
    发明申请
    Fatigue resistant medical devices 审中-公开
    耐疲劳医疗器械

    公开(公告)号：US20050059994A1

    公开(公告)日：2005-03-17

    申请号：US10666863

    申请日：2003-09-17

    Applicant: Steven Walak ,  Yixin Xu

    Inventor： Steven Walak ,  Yixin Xu

    IPC: A61L27/06 ,  A61L31/02 ,  A61F2/06

    CPC classification number: A61L27/06 ,  A61F2/01 ,  A61F2250/0042 ,  A61L31/022

    Abstract: A flexible device comprises a metallic element including high strain portions and lesser strain portions, wherein the high strain portions are to be subjected to levels of strain during use increased with respect to strain levels in the lesser strain portions. The high strain portions comprise a material which, under predetermined operating conditions, is stabilized in a martensite phase and the lesser strain portions comprise a material which, under the predetermined operating conditions, is in an austenite phase. A method of forming an element of a medical device comprises the steps of forming an element of the device of Nitinol and impressing a memorized shape on the element, wherein the memorized shape is a shape the element is to assume when in an operational configuration. A high strain portion of the element is treated so that it is substantially Martensite phase stabilized under expected operating conditions of the device, wherein untreated portions of the element are in a substantially austenitic phase under the expected operating conditions.

    Abstract translation: 柔性装置包括包括高应变部分和较小应变部分的金属元件，其中高应变部分在使用期间将受到应变水平的影响，相对于较小应变部分中的应变水平而言。 高应变部分包括在预定操作条件下稳定在马氏体相中的材料，较小应变部分包括在预定操作条件下处于奥氏体相的材料。 一种形成医疗装置的元件的方法包括以下步骤：形成镍钛诺装置的元件，并将记忆形状压印在元件上，其中所记忆的形状是当处于操作构型时元件要呈现的形状。 对该元件的高应变部分进行处理，使得其在装置的预期操作条件下基本上是马氏体相稳定的，其中元件的未处理部分在预期的操作条件下处于基本奥氏体相。

    Medical Devices Having Nanoporous Coatings for Controlled Therapeutic Agent Delivery
    27.
    发明申请
    Medical Devices Having Nanoporous Coatings for Controlled Therapeutic Agent Delivery 有权
    具有用于受控治疗剂递送的纳米多孔涂层的医疗装置

    公开(公告)号：US20100233238A1

    公开(公告)日：2010-09-16

    申请号：US12787209

    申请日：2010-05-25

    Applicant: Barron Tenney ,  Yixin Xu ,  Michael N. Helmus

    Inventor： Barron Tenney ,  Yixin Xu ,  Michael N. Helmus

    IPC: A61F2/00 ,  A61K31/727 ,  A61K38/49 ,  A61K39/395 ,  A61K38/19 ,  A61P43/00 ,  A61P41/00

    CPC classification number: A61F2/02 ,  A61F2/30767 ,  A61F2/82 ,  A61F2/91 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2002/3084 ,  A61F2210/0076 ,  A61F2250/0068 ,  A61L29/146 ,  A61L29/16 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/00 ,  A61L2400/12 ,  A61N1/375 ,  B82Y30/00

    Abstract: According to an aspect of the present invention, implantable or insertable medical devices are provided which contain (a) one or more depressions that contain at least one therapeutic agent, and (b) a nanoporous coating, disposed over the therapeutic-agent-containing depressions, which regulate transport of species between the therapeutic-agent-containing depressions and the exterior of the device. The implantable or insertable devices are configured to preform a role beyond mere drug delivery, for example, providing mechanical and/or electrical functions within the body, among other functions. An advantage of the present invention is that medical devices may be provided, which release therapeutic agents in quantities far exceeding the void volume within the nanoporous coating, while at the same time providing functionality that extends beyond drug delivery. Such release may further approach or achieve a zero order kinetic drug release profile.

    Abstract translation: 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含（a）含有至少一种治疗剂的一种或多种凹陷，和（b）在含治疗剂的凹陷上设置的纳米多孔涂层 ，其调节物质在含治疗剂的凹陷和装置的外部之间的运输。 可植入或可插入的装置被配置为预防仅仅药物递送的作用，例如在体内提供机械和/或电功能等功能。 本发明的一个优点是可以提供医疗装置，其释放的量远远超过纳米多孔涂层内的空隙体积，同时提供延伸超出药物递送的功能。 这种释放可以进一步接近或实现零级动力学药物释放曲线。

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