-
公开(公告)号：US07414046B2
公开(公告)日：2008-08-19
申请号：US10444588
申请日：2003-05-23
申请人： Anne-Laure Grillot , Paul Charifson , Dean Stamos , Yusheng Liao , Michael Badia , Martin Trudeau
发明人： Anne-Laure Grillot , Paul Charifson , Dean Stamos , Yusheng Liao , Michael Badia , Martin Trudeau
IPC分类号： C07D403/04 , C07D413/04 , C07D235/30 , A61K31/55
CPC分类号： C07D403/12 , A61K31/00 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/12 , C07D233/56 , C07D235/30 , C07D249/08 , C07D263/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/14 , C07D491/04 , C07F9/65583 , C07F9/6561 , Y02A50/393 , Y02A50/473 , A61K2300/00
摘要： The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammala. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.
-
22.发明申请Novel CD40:CD154 binding interruptor compounds and use thereof to treat immunological complications 审中-公开新型CD40：CD154结合阻断剂及其用于治疗免疫并发症的药物公开(公告)号：US20070249682A1
公开(公告)日：2007-10-25
申请号：US11701983
申请日：2007-02-02
申请人： Zhongli Zheng , Mary Carter , YuSheng Liao , Lihong Sun , Leonid Kirkovsky , Susan Mrose , Yen-Ming Hsu , David Thomas , Gerald Shipps , Satish Jindal , George Lenz , Huw Nash
发明人： Zhongli Zheng , Mary Carter , YuSheng Liao , Lihong Sun , Leonid Kirkovsky , Susan Mrose , Yen-Ming Hsu , David Thomas , Gerald Shipps , Satish Jindal , George Lenz , Huw Nash
IPC分类号： A61K31/44 , A61P37/08 , C07C303/00 , C07D213/44
CPC分类号： A61K31/444 , C07C311/47 , C07D401/14 , F25B9/10 , F25B9/145 , F25B2309/1408 , F25B2309/1411 , F25B2309/1418 , F25B2309/1424 , F25B2309/14241
摘要： The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with inappropriate CD154 activation in a subject. Specifically, this invention provides compounds which are identified by screening a library of small molecules for those that are capable of specifically binding CD154 and interrupting CD40:CD154 interaction.
摘要翻译： 本发明涉及新的CD40：CD154结合中断剂化合物，以及这些化合物和包含它们的药物组合物的用途，以治疗与受试者中不适当的CD154活化相关的病症。 具体地，本发明提供了通过筛选能够特异性结合CD154并中断CD40：CD154相互作用的那些的小分子文库来鉴定的化合物。
-
公开(公告)号：US20130023525A1
公开(公告)日：2013-01-24
申请号：US13454510
申请日：2012-04-24
申请人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号： A61K31/4184 , C07D401/14 , A61K31/4439 , A61K31/506 , C07D405/14 , A61P31/04 , A61K31/4545 , C07D491/056 , A61K31/4355 , C07D413/14 , A61K31/5377 , A61K31/5513 , C07D403/14 , C07D403/10
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
-
公开(公告)号：US20120202784A1
公开(公告)日：2012-08-09
申请号：US13349868
申请日：2012-01-13
申请人： Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, JR. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
发明人： Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, JR. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
IPC分类号： A61K31/437 , A61K31/5377 , C12N9/99 , A61K31/496 , A61K31/551 , C07D471/20 , C07D471/04 , C07D491/20
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
-
公开(公告)号：US20120010222A1
公开(公告)日：2012-01-12
申请号：US13234634
申请日：2011-09-16
申请人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号： A61K31/506 , A61K31/4184 , A61P31/04 , A61K31/4439
CPC分类号： C07D413/14 , A61K31/4439 , A61K31/506 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods of using compounds of formula I or formula VII in combination with one or more additional antibacterial agents and/or one or more additional therapeutic agents that increase the susceptibility of bacterial organisms to antibiotics.
摘要翻译： 本发明涉及使用式I或式VII化合物或其药学上可接受的方法治疗，预防或减轻哺乳动物中抗性细菌感染的严重性。 本发明还涉及使用式I或式VII化合物与一种或多种另外的抗菌剂和/或一种或多种增加细菌生物体对抗生素敏感性的其它治疗剂的组合的方法。
-
公开(公告)号：US07569591B2
公开(公告)日：2009-08-04
申请号：US10901928
申请日：2004-07-29
申请人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven M. Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
发明人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven M. Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
IPC分类号： A61K31/4439 , C07D401/00
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
-
公开(公告)号：US20090176769A1
公开(公告)日：2009-07-09
申请号：US11955874
申请日：2007-12-13
申请人： Corey Anderson , Andreas Termin , Sara Hadida-Ruah , Pramod Joshi , Sanghee Yoo , Daniele Bergeron , Hayley Binch , Jon Come , Jingrong Cao , Suganthi Nanthakumar , Elaine Krueger , John Maxwell , Arnaud Le Tiran , Yusheng Liao
发明人： Corey Anderson , Andreas Termin , Sara Hadida-Ruah , Pramod Joshi , Sanghee Yoo , Daniele Bergeron , Hayley Binch , Jon Come , Jingrong Cao , Suganthi Nanthakumar , Elaine Krueger , John Maxwell , Arnaud Le Tiran , Yusheng Liao
IPC分类号： A61K31/551 , C07D417/14 , C07D471/04 , A61K31/496 , A61K31/437 , A61P25/06 , A61P19/02
CPC分类号： C07D277/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D471/10 , C07D498/10 , C07D513/10
摘要： The present invention relates to CGRP receptor antagonists, pharmaceutical compositions thereof, and methods therewith for treating CGRP receptor-mediated diseases and conditions.
-
28.发明授权CD40:CD154 binding interrupter compounds and use thereof to treat immunological complications 失效CD40：CD154结合中断剂化合物及其用于治疗免疫并发症的用途公开(公告)号：US07173046B2
公开(公告)日：2007-02-06
申请号：US10377928
申请日：2003-02-28
申请人： Zhongli Zheng , Mary-Beth Carter , YuSheng Liao , Lihong Sun , Leonid Kirkovsky , Susan Mrose , Yen-Ming Hsu , David Thomas , Gerald W. Shipps, Jr. , Satish Jindal , George R. Lenz , Huw M. Nash
发明人： Zhongli Zheng , Mary-Beth Carter , YuSheng Liao , Lihong Sun , Leonid Kirkovsky , Susan Mrose , Yen-Ming Hsu , David Thomas , Gerald W. Shipps, Jr. , Satish Jindal , George R. Lenz , Huw M. Nash
IPC分类号： A61K31/4439 , C07D401/14
CPC分类号： A61K31/444 , C07C311/47 , C07D401/14 , F25B9/10 , F25B9/145 , F25B2309/1408 , F25B2309/1411 , F25B2309/1418 , F25B2309/1424 , F25B2309/14241
摘要： The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with inappropriate CD154 activation in a subject. Specifically, this invention provides compounds which are identified by screening a library of small molecules for those that are capable of specifically binding CD154 and interrupting CD40:CD154 interaction.
摘要翻译： 本发明涉及新的CD40：CD154结合中断剂化合物，以及这些化合物和包含它们的药物组合物的用途，以治疗与受试者中不适当的CD154活化相关的病症。 具体地，本发明提供了通过筛选能够特异性结合CD154并中断CD40：CD154相互作用的那些的小分子文库来鉴定的化合物。
-
公开(公告)号：US20130030004A1
公开(公告)日：2013-01-31
申请号：US11593418
申请日：2006-11-06
申请人： Paul Charifson , David Deininger , Joseph Drumm , Anne-Laure Grillot , Arnaud LeTiran , Yusheng Liao , Emanuele Perola , Steven Ronkin , Dean Stamos , Tiansheng Wang
发明人： Paul Charifson , David Deininger , Joseph Drumm , Anne-Laure Grillot , Arnaud LeTiran , Yusheng Liao , Emanuele Perola , Steven Ronkin , Dean Stamos , Tiansheng Wang
IPC分类号： A61K31/506 , C07D403/10 , A61K31/4184 , A61P31/04 , A61K31/4439 , C07D401/14 , A61K31/4545 , C07D403/14 , C07D401/10
CPC分类号： C07D403/04 , C07D401/04 , C07D403/14
摘要： The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt thereof, that inhibit bacterial gyrase and/or TopoIV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
摘要翻译： 本发明涉及抑制细菌促旋酶和/或TopoIV的式I化合物或其药学上可接受的盐以及包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此，本发明还涉及用于治疗哺乳动物细菌感染的方法。
-
![SOLID FORMS OF GYRASE INHIBITOR (R)-1-ETHYL-3-[5-[2-(1-HYDROXY-METHYL-ETHYL)PYRIMIDIN-5-YL]-7-(TETRAHYDROFURAN-2-YL)-1H-BENZIMIDAZOL-2-YL]UREA](/abs-image/US/2012/07/19/US20120184741A1/abs.jpg.150x150.jpg)
30.发明申请SOLID FORMS OF GYRASE INHIBITOR (R)-1-ETHYL-3-[5-[2-(1-HYDROXY-METHYL-ETHYL)PYRIMIDIN-5-YL]-7-(TETRAHYDROFURAN-2-YL)-1H-BENZIMIDAZOL-2-YL]UREA 有权γ-乙基-3- [5- [2-（1-羟基 - 甲基）乙基]嘧啶-5-基] -7-（四氢呋喃-2-基）-1H-苯并咪唑的固体形式 -2-YL]尿素公开(公告)号：US20120184741A1
公开(公告)日：2012-07-19
申请号：US13349845
申请日：2012-01-13
申请人： Dean Shannon , Brian Luisi , Yusheng Liao , Mariusz Krawiec
发明人： Dean Shannon , Brian Luisi , Yusheng Liao , Mariusz Krawiec
IPC分类号： C07D405/14
CPC分类号： C07D405/14 , C07D407/04
摘要： The present application is directed to solid forms of compounds of formula (I): and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical compositions comprising said compounds and salts. These compounds and salts are useful in treating bacterial infection.
摘要翻译： 本申请涉及抑制细菌促旋酶和/或Topo IV的式（I）化合物及其药学上可接受的盐的固体形式，以及包含所述化合物和盐的药物组合物。 这些化合物和盐可用于治疗细菌感染。
-
-
-
-
-
-
-
-
-
搜索结果
39 条记录 (耗时 0.038 秒)
