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公开(公告)号：US09689024B2
公开(公告)日：2017-06-27
申请号：US14624468
申请日：2015-02-17
Applicant: 10X Genomics, Inc.
Inventor： Benjamin Hindson , Serge Saxonov , Michael Schnall-Levin
IPC: C12Q1/68 , C12P19/34 , C07H21/04 , G01N15/06 , C40B40/06 , C40B50/14 , C12N15/10 , B01L3/00 , B01J19/00
CPC classification number: C12Q1/6806 , B01J19/0046 , B01L3/502715 , B01L3/508 , B01L3/523 , B01L2200/0647 , B01L2400/0677 , C12N15/1065 , C12Q2535/122 , C12Q2563/159
Abstract: This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis.
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公开(公告)号：US20170114390A1
公开(公告)日：2017-04-27
申请号：US15376582
申请日：2016-12-12
Applicant: 10X Genomics, Inc.
Inventor： Benjamin Hindson , Serge Saxonov , Kevin Ness , Paul Hardenbol , Michael Schnall-Levin , Mirna Jarosz
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , C12Q1/6806 , C12Q1/6855 , C12Q1/6869 , C12Q2525/161 , C12Q2535/122 , C12Q2563/159 , C12Q2563/179 , C12Q2565/514
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
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公开(公告)号：US20150376700A1
公开(公告)日：2015-12-31
申请号：US14752589
申请日：2015-06-26
Applicant: 10X Genomics, Inc.
Inventor： Michael Schnall-Levin , Mirna Jarosz , Christopher Hindson , Kevin Ness , Serge Saxonov , Benjamin Hindson , Grace X. Y. Zheng , Patrick Marks , John Stuelpnagel
CPC classification number: C12Q1/6883 , C12Q1/6827 , C12Q2600/156 , G16B30/00 , C12Q2535/122 , C12Q2537/16 , C12Q2563/159 , C12Q2565/629
Abstract: The present disclosure relates to methods, compositions and systems for haplotype phasing and copy number variation assays. Included within this disclosure are methods and systems for combining the barcode comprising beads with samples in multiple separate partitions, as well as methods of processing, sequencing and analyzing barcoded samples.
Abstract translation: 本公开涉及用于单倍型定相和拷贝数变异测定的方法，组合物和系统。 本公开内容包括用于将包含珠粒的条形码与多个单独分区中的样本组合的方法和系统，以及处理，排序和分析条形码样本的方法。
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公开(公告)号：US20150224466A1
公开(公告)日：2015-08-13
申请号：US14624484
申请日：2015-02-17
Applicant: 10X Genomics, Inc.
Inventor： Benjamin Hindson , Serge Saxonov
Abstract: This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis.
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25.发明申请公开(公告)号：US20250137025A1
公开(公告)日：2025-05-01
申请号：US18940636
申请日：2024-11-07
Applicant: 10x Genomics, Inc.
Inventor： Paul Hardenbol , Pranav Patel , Benjamin Hindson , Paul William Wyatt , Keith Bjornson , Indira Wu , Zahra Kamila Belhocine
IPC: C12P19/34 , C12Q1/6806 , C40B20/04
Abstract: This disclosure provides methods for preparing a sequencing library including the steps of providing a template nucleic acid sequence, dNTPs, dUTP, a primer, a polymerase, a dUTP excising enzyme, and a plurality of beads including oligonucleotide adapter sequence segments; amplifying the template nucleic acid with the polymerase, dNTPs, dUTP and random hexamer to provide a complementary nucleic acid sequence including occasional dUTPs; and excising the incorporated dUTPs with the dUTP excising enzyme to provide nicks in the complementary nucleic acid sequence to provide a sequencing library.
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Patent Agency Ranking
公开(公告)号：US20250027149A1
公开(公告)日：2025-01-23
申请号：US18760903
申请日：2024-07-01
Applicant: 10x Genomics, Inc.
Inventor： Benjamin Hindson , Christopher Hindson , Michael Schnall-Levin , Kevin Ness , Mirna Jarosz , Serge Saxonov
IPC: C12Q1/6874 , C12Q1/6806 , C12Q1/6855 , C12Q1/6869
Abstract: This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. Often, the beads provides herein are degradable. For example, they may contain disulfide bonds that are susceptible to reducing agents. The methods provided herein include methods of making libraries of barcoded beads as well as methods of combining the beads with a sample, such as by using a microfluidic device.
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27.发明公开公开(公告)号：US20240326052A1
公开(公告)日：2024-10-03
申请号：US18738471
申请日：2024-06-10
Applicant: 10x Genomics, Inc.
Inventor： Rajiv BHARADWAJ , Kevin Ness , Debkishore Mitra , Donald A. MASQUELIER , Anthony Makarewicz , Christopher Hindson , Benjamin Hindson , Serge Saxonov
CPC classification number: B01L3/502761 , B01L3/0241 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2400/049 , B01L2400/086 , G01N2035/00237 , G01N35/085 , G01N2035/1034
Abstract: The disclosure provides devices, systems and methods for the generation of encapsulated reagents and the partitioning of encapsulated reagents for use in subsequent analyses and/or processing, such as in the field of biological analyses and characterization.
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公开(公告)号：US11713457B2
公开(公告)日：2023-08-01
申请号：US17986764
申请日：2022-11-14
Applicant: 10x Genomics, Inc.
Inventor： Benjamin Hindson , Christopher Hindson , Michael Schnall-Levin , Kevin Ness , Mirna Jarosz , Serge Saxonov
IPC: C12Q1/6804 , C12Q1/6806 , C12Q1/683 , C12Q1/6874 , C12N15/10 , C40B50/16 , C40B20/04
CPC classification number: C12N15/1065 , C12Q1/683 , C12Q1/6804 , C12Q1/6806 , C12Q1/6874 , C40B20/04 , C40B50/16 , C12Q2525/191 , C12Q2535/122 , C12Q2537/143 , C12Q2537/149 , C12Q2563/149 , C12Q2563/159 , C12Q2563/179 , C12Q2565/629
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
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公开(公告)号：US11629344B2
公开(公告)日：2023-04-18
申请号：US17860880
申请日：2022-07-08
Applicant: 10x Genomics, Inc.
Inventor： Benjamin Hindson , Christopher Hindson , Michael Schnall-Levin , Kevin Ness , Mirna Jarosz , Serge Saxonov
IPC: C12Q1/6874 , C12Q1/6804 , C12Q1/6806 , C12Q1/683 , C12N15/10 , C40B50/16 , C40B20/04
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
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公开(公告)号：US20230031318A1
公开(公告)日：2023-02-02
申请号：US17749050
申请日：2022-05-19
Applicant: 10x Genomics, Inc.
Inventor： Paul Ryvkin , Jason Underwood , Michael Schnall-Levin , Tarjei Mikkelsen , Benjamin Hindson
IPC: C12Q1/6874 , C12Q1/6806 , C12Q1/6851
Abstract: Provided herein are compositions, systems and methods for tagging molecular events, reactions, species, etc., but without the need for complex, highly diverse libraries of tagging molecules. Provided are tagging moieties that can have a smaller number, a few, or even a single original “tagging” structure that may be transformed or transformable, in situ, into a collection of larger numbers of unique tagging or “barcode” moieties.
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