公开(公告)号：US20130129835A1

公开(公告)日：2013-05-23

申请号：US13740712

申请日：2013-01-14

Applicant: ALLERGAN, INC.

Inventor： Jacob Pollock ,  Lauren Kokai ,  Cunqi Cui ,  Xiaojie Yu ,  Dennis Van Epps ,  Darin Messina

IPC: A61L27/24

CPC classification number: A61L27/52 ,  A61K8/042 ,  A61K8/735 ,  A61K2800/91 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26 ,  A61L27/3604 ,  A61L27/3804 ,  A61L27/54 ,  A61L27/58 ,  A61L2400/06 ,  A61L2430/34 ,  A61Q19/08 ,  C08L89/06 ,  C08L5/08

Abstract: Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a collagen component.

公开(公告)号：US20240350706A1

公开(公告)日：2024-10-24

申请号：US18527616

申请日：2023-12-04

Applicant: Allergan, Inc.

Inventor： Xiaojie Yu ,  Nicholas J. Manesis ,  Jacob Pollock

IPC: A61L27/24 ,  A61K8/04 ,  A61K8/73 ,  A61L27/26 ,  A61L27/36 ,  A61L27/52 ,  A61Q19/08

CPC classification number: A61L27/24 ,  A61K8/042 ,  A61K8/735 ,  A61L27/26 ,  A61L27/3695 ,  A61L27/52 ,  A61Q19/08 ,  A61K2800/91 ,  A61L2400/06 ,  A61L2430/34

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

公开(公告)号：US10154951B2

公开(公告)日：2018-12-18

申请号：US15244587

申请日：2016-08-23

Applicant: Allergan, Inc.

Inventor： Elizabeta Pavlovic ,  Monica A. Serban ,  Xiaojie Yu ,  Nicholas J. Manesis

IPC: A61K8/64 ,  A61Q19/08 ,  A61L27/20 ,  A61L27/36 ,  A61L27/52 ,  C08L5/08 ,  A61L27/22 ,  C08J3/075 ,  C08L89/00 ,  C08B37/08 ,  C08H1/00 ,  C08J3/24 ,  A61K8/73

Abstract: Compositions useful as dermal fillers and methods using such compositions to treat various skin and soft tissue conditions. The dermal fillers can comprise silk attached to hyaluronic acid using for example two cross linkers and can be used to treat of facial imperfections, facial defects, facial augmentations, breast imperfections, breast augmentations or breast reconstructions.

公开(公告)号：US20180193523A1

公开(公告)日：2018-07-12

申请号：US15914274

申请日：2018-03-07

Applicant: Allergan, Inc.

Inventor： Gabriel N. Njikang ,  Xiaojie Yu ,  Futian Liu ,  Sumit Paliwal ,  Nicholas J. Manesis

IPC: A61L27/20 ,  A61K8/73 ,  A61K8/33 ,  A61L27/54 ,  A61Q19/08

CPC classification number: A61L27/20 ,  A61K8/33 ,  A61K8/73 ,  A61K8/735 ,  A61K2800/262 ,  A61K2800/95 ,  A61L27/54 ,  A61L2300/402 ,  A61L2400/06 ,  A61Q19/08 ,  C08L5/08

Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions which are particularly advantageous for correction of fine lines in the face.

公开(公告)号：US20170224873A1

公开(公告)日：2017-08-10

申请号：US15494991

申请日：2017-04-24

Applicant: Allergan, Inc.

Inventor： Jacob F. Pollock ,  Lauren E. Kokai ,  Cunqi Cui ,  Xiaojie Yu ,  Dennis E. Van Epps ,  Darin J. Messina

IPC: A61L27/52 ,  A61L27/26 ,  A61L27/54 ,  A61L27/58 ,  A61L27/36 ,  A61L27/38

CPC classification number: A61L27/52 ,  A61K8/042 ,  A61K8/735 ,  A61K2800/91 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26 ,  A61L27/3604 ,  A61L27/3804 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/412 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2430/34 ,  A61Q19/08 ,  C08L89/06 ,  C08L5/08

Abstract: Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a collagen component.

公开(公告)号：US20170136145A1

公开(公告)日：2017-05-18

申请号：US15419542

申请日：2017-01-30

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Xiaojie Yu ,  Nicholas J. Manesis ,  Athene Wan Chie Chan

IPC: A61L27/20 ,  A61L27/52 ,  A61L27/50 ,  A61L27/00 ,  A61L27/54

CPC classification number: A61L27/20 ,  A61K8/042 ,  A61K8/676 ,  A61K8/735 ,  A61K47/60 ,  A61K47/61 ,  A61K2800/91 ,  A61L27/00 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2400/06 ,  A61Q19/08 ,  C08B37/0072

Abstract: Provided are injectable, hyaluronic acid-based hydrogel compositions including conjugated vitamins.

公开(公告)号：US20160310635A1

公开(公告)日：2016-10-27

申请号：US15199150

申请日：2016-06-30

Applicant: Allergan, Inc.

Inventor： Gabriel N. Njikang ,  Xiaojie Yu ,  Futian Liu ,  Sumit Paliwal ,  Nicholas J. Manesis

IPC: A61L27/20 ,  A61L27/54

CPC classification number: A61L27/20 ,  A61K8/33 ,  A61K8/73 ,  A61K8/735 ,  A61K2800/262 ,  A61K2800/95 ,  A61L27/54 ,  A61L2300/402 ,  A61L2400/06 ,  A61Q19/08 ,  C08L5/08

Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions which are particularly advantageous for correction of fine lines in the face.

公开(公告)号：US20160101200A1

公开(公告)日：2016-04-14

申请号：US14974270

申请日：2015-12-18

Applicant: Allergan, Inc.

Inventor： Kaustubh S. Chitre ,  Xiaojie Yu ,  Nicolas J. Manesis

IPC: A61L2/08 ,  A61L2/10 ,  A61L27/24 ,  A61L27/20 ,  A61L27/36 ,  A61L27/52

CPC classification number: A61L2/08 ,  A61L2/084 ,  A61L2/085 ,  A61L2/10 ,  A61L27/20 ,  A61L27/24 ,  A61L27/3604 ,  A61L27/52

Abstract: Method for sterilizing a hydrogel composition include subjecting the composition to pulsed light comprising broadband spectrum radiation, the pulsed light being at a dose effective to sterilize the composition without causing significant change in rheology of the composition.

Abstract translation: 用于对水凝胶组合物进行灭菌的方法包括使组合物经受包含宽带光谱辐射的脉冲光，脉冲光以有效消毒组合物的剂量而不引起组合物流变学的显着变化。

公开(公告)号：US20150064147A1

公开(公告)日：2015-03-05

申请号：US14535033

申请日：2014-11-06

Applicant: Allergan, Inc.

Inventor： Jacob F. Pollock ,  Lauren E. Kokai ,  CUNQI Cui ,  Xiaojie Yu ,  Dennis E. Van Epps ,  Darin J. Messina

IPC: A61L27/52 ,  A61L27/24 ,  A61L27/36 ,  A61L27/58 ,  A61L27/38 ,  A61L27/20 ,  A61L27/54

CPC classification number: A61L27/52 ,  A61K8/042 ,  A61K8/735 ,  A61K2800/91 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26 ,  A61L27/3604 ,  A61L27/3804 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/412 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2430/34 ,  A61Q19/08 ,  C08L89/06 ,  C08L5/08

Abstract: Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a collagen component.

Abstract translation: 包含大分子基质和水的水凝胶可用于增强人的软组织，促进或支持细胞或组织活力或增殖，在组织中产生空间以及用于其它目的。 大分子基质可以包含与胶原组分交联的透明质酸组分。

公开(公告)号：US20150057381A1

公开(公告)日：2015-02-26

申请号：US14504329

申请日：2014-10-01

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Nicholas J. Manesis ,  Xiaojie Yu ,  Athene Wan Chie Chan

IPC: C08J9/26 ,  B05D1/38 ,  B05D3/00 ,  B05D5/00

CPC classification number: C08J9/26 ,  A61L27/56 ,  A61L31/06 ,  A61L31/146 ,  A61L2400/08 ,  B01D39/1692 ,  B01D2239/1208 ,  B01D2239/1216 ,  B05D1/38 ,  B05D3/007 ,  B05D5/00 ,  C08J2201/04 ,  C08J2201/042 ,  C08J2201/0422 ,  C08J2201/0462 ,  C08J2201/0464 ,  C08J2201/05 ,  C08J2205/05 ,  C08J2207/10 ,  C08J2207/12 ,  C08J2325/10 ,  C08J2353/02 ,  C08J2375/04 ,  C08J2383/04 ,  C09D167/04 ,  C09D171/02

Abstract: Provided are porogen compositions and methods of using such porogen compositions in the manufacture of porous materials, for example, porous silicone elastomers. The porogens generally include comprising a core material and shell material different from the core material. The porogens can be used to form a scaffold for making a resulting porous elastomer when the scaffold is removed.

Abstract translation: 提供的是致孔剂组合物和在制造多孔材料例如多孔硅橡胶中使用这种致孔剂组合物的方法。 致孔剂通常包括芯材和与芯材不同的壳材料。 当去除支架时，致孔剂可用于形成用于制备所得多孔弹性体的支架。