公开(公告)号：US06306922B1

公开(公告)日：2001-10-23

申请号：US09492011

申请日：2000-01-26

申请人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Jennifer L. Hill

发明人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Jennifer L. Hill

IPC分类号： C08G6308

CPC分类号： A61K9/0024 ,  A61K9/1635 ,  A61K9/1647 ,  A61K38/47 ,  A61K38/49 ,  A61K47/32 ,  A61K2035/128 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L27/34 ,  A61L27/36 ,  A61L27/38 ,  A61L27/3839 ,  A61L27/52 ,  A61L29/085 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/424 ,  A61L2300/602 ,  C08F290/00 ,  C08F290/06 ,  C08F291/00 ,  C09D153/00 ,  C09J153/00 ,  C12N5/0012 ,  C12N5/0677 ,  C12N11/04 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/40 ,  C12N2533/74 ,  C12Y302/01017 ,  C12Y304/21068 ,  Y10T428/29 ,  Y10T428/2913 ,  Y10T428/2967 ,  Y10T428/31786 ,  C08L71/02

摘要： Hydrogels of polymerized and crosslinked macromers comprising hydrophilic oligomers having biodegradable monomeric or oligomeric extensions, which biodegradable extensions are terminated on free ends with end cap monomers or oligomers capable of polymerization and cross linking are described. The hydrophilic core itself may be degradable, thus combining the core and extension functions. Macromers are polymerized using free radical initiators under the influence of long wavelength ultraviolet light, visible light excitation or thermal energy. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. Preferred applications for the hydrogels include prevention of adhesion formation after surgical procedures, controlled release of drugs and other bioactive species, temporary protection or separation of tissue surfaces, adhering of sealing tissues together, and preventing the attachment of cells to tissue surfaces.

摘要翻译： 描述了聚合和交联的大分子单体的水凝胶，其包含具有可生物降解的单体或低聚延伸的亲水性低聚物，其生物可降解的延伸部分在端基单体或能够聚合和交联的低聚物的自由端上终止。 亲水核心本身可以是可降解的，因此结合核心和延伸功能。 大分子单体在长波长紫外光，可见光激发或热能的影响下，使用自由基引发剂聚合。 生物降解发生在延伸低聚物内的连接处，并导致无毒且容易从体内去除的碎片。 水凝胶的优选应用包括防止外科手术后的粘连形成，药物和其他生物活性物质的控制释放，临时保护或组织表面分离，将密封组织粘附在一起，以及防止细胞附着到组织表面。

公开(公告)号：US5858746A

公开(公告)日：1999-01-12

申请号：US377911

申请日：1995-01-25

申请人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Jennifer L. Hill ,  Syed F. A. Hossainy

发明人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Jennifer L. Hill ,  Syed F. A. Hossainy

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K35/12 ,  A61K38/42 ,  A61K38/44 ,  A61L24/00 ,  A61L24/04 ,  A61L26/00 ,  A61L27/34 ,  A61L27/38 ,  A61L27/52 ,  A61L29/08 ,  A61L31/10 ,  A61L31/14 ,  C08B37/08 ,  C08F290/00 ,  C08F290/02 ,  C08F290/06 ,  C08F290/08 ,  C08F290/10 ,  C08F291/00 ,  C09D153/00 ,  C12N5/00 ,  C12N5/071 ,  C12N5/077 ,  C12N11/04 ,  C12N11/02 ,  C12N5/06 ,  C08J7/16

CPC分类号： C12N11/04 ,  A61K38/42 ,  A61K38/44 ,  A61K47/48315 ,  A61K47/48784 ,  A61K47/48876 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5073 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L27/34 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/52 ,  A61L29/085 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  B82Y5/00 ,  C08B37/003 ,  C08B37/0072 ,  C08B37/0084 ,  C08F290/00 ,  C08F290/02 ,  C08F290/06 ,  C08F290/062 ,  C08F290/08 ,  C08F290/10 ,  C08F291/00 ,  C09D153/00 ,  C12N5/0012 ,  C12N5/0677 ,  A61K2035/128 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/40 ,  C12N2533/74 ,  Y10S514/801 ,  Y10S530/812 ,  Y10S530/813 ,  Y10S530/815 ,  Y10S530/817 ,  Y10T428/2987 ,  Y10T428/2989

摘要： Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules.

摘要翻译： 通过添加可自由基聚合的基团（例如含有碳 - 碳双键或三键的那些基团）来修饰水溶性大分子单体，其可在温和条件下聚合以包封组织，细胞或生物活性材料。 聚合物材料特别可用作组织粘合剂，用于包括血管的组织腔的涂层，用于细胞的涂层，例如朗格汉斯岛，涂层，塞子，用于与生物材料例如身体接触的支撑体或基底，以及作为用于 生物活性分子。

公开(公告)号：US5820882A

公开(公告)日：1998-10-13

申请号：US336393

申请日：1994-11-10

申请人： Jeffrey A. Hubbell ,  Amarpreet S. Sawhney

发明人： Jeffrey A. Hubbell ,  Amarpreet S. Sawhney

IPC分类号： A61K9/50 ,  A61K9/52 ,  A61K47/48 ,  A61K9/54 ,  A61K9/62 ,  A61K9/64

CPC分类号： A61K9/5073 ,  A61K47/48215 ,  A61K47/48315 ,  A61K47/48869 ,  A61K9/5031

摘要： Biocompatible microcapsules useful for transplanting foreign material into an animal body, and the method of their production, are described, wherein the microcapsules contain an outermost layer of water soluble non-ionic polymers such as PEO to create resistance to cell adhesion on the surface of the microcapsules.

公开(公告)号：US5567435A

公开(公告)日：1996-10-22

申请号：US468364

申请日：1995-06-06

申请人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Jennifer L. Hill-West

发明人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Jennifer L. Hill-West

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K9/50 ,  A61K35/12 ,  A61K38/48 ,  A61K47/30 ,  A61K47/32 ,  A61L24/00 ,  A61L24/04 ,  A61L26/00 ,  A61L27/34 ,  A61L27/38 ,  A61L27/52 ,  A61L29/08 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  B82B1/00 ,  C08F290/00 ,  C08F290/06 ,  C08F291/00 ,  C09D153/00 ,  C09J153/00 ,  C12N5/00 ,  C12N5/071 ,  C12N11/04 ,  A61K9/58 ,  C08G63/08 ,  C08G67/00

CPC分类号： A61K9/0024 ,  A61K38/47 ,  A61K38/49 ,  A61K47/32 ,  A61K9/1635 ,  A61K9/1647 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L27/34 ,  A61L27/36 ,  A61L27/38 ,  A61L27/3839 ,  A61L27/52 ,  A61L29/085 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  A61L31/16 ,  C08F290/00 ,  C08F290/06 ,  C08F291/00 ,  C09D153/00 ,  C09J153/00 ,  C12N11/04 ,  C12N5/0012 ,  C12N5/0677 ,  C12Y302/01017 ,  C12Y304/21068 ,  A61K2035/128 ,  A61L2300/424 ,  A61L2300/602 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/40 ,  C12N2533/74 ,  Y10T428/29 ,  Y10T428/2913 ,  Y10T428/2967 ,  Y10T428/31786

摘要： Hydrogels of polymerized and crosslinked macromers comprising hydrophilic oligomers having biodegradable monomeric or oligomeric extensions, which biodegradable extensions are terminated on free ends with end cap monomers or oligomers capable of polymerization and cross linking are described. The hydrophilic core itself may be degradable, thus combining the core and extension functions. Macromers are polymerized using free radical initiators under the influence of long wavelength ultraviolet light, visible light excitation or thermal energy. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. Preferred applications for the hydrogels include prevention of adhesion formation after surgical procedures, controlled release of drugs and other bioactive species, temporary protection or separation of tissue surfaces, adhering of sealing tissues together, and preventing the attachment of cells to tissue surfaces.

公开(公告)号：US5529914A

公开(公告)日：1996-06-25

申请号：US958870

申请日：1992-10-07

申请人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Syed F. A. Hossainy

发明人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Syed F. A. Hossainy

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K35/12 ,  A61K38/42 ,  A61K38/44 ,  A61K47/48 ,  A61L24/00 ,  A61L24/04 ,  A61L26/00 ,  A61L27/34 ,  A61L27/38 ,  A61L27/52 ,  A61L29/08 ,  A61L31/10 ,  A61L31/14 ,  C08F290/00 ,  C08F290/02 ,  C08F290/06 ,  C08F291/00 ,  C09D153/00 ,  C12N5/00 ,  C12N5/071 ,  C12N11/04 ,  C12N11/02

CPC分类号： A61L27/36 ,  A61K38/42 ,  A61K38/44 ,  A61K47/48315 ,  A61K47/48869 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/5031 ,  A61K9/5073 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L27/34 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/52 ,  A61L29/085 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  C08F290/00 ,  C08F290/02 ,  C08F290/06 ,  C08F290/062 ,  C08F291/00 ,  C09D153/00 ,  C12N11/04 ,  C12N5/0012 ,  C12N5/0677 ,  A61K2035/128 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/40 ,  C12N2533/74

摘要： This invention provides novel methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as a "glue" to cause more than one biological substance to adhere together, or as carriers for biologically active species. Several methods for forming these membranes are provided. Each of these methods utilizes a polymerization system containing water-soluble macromers, species which are at once polymers and macromolecules capable of further polymerization. The macromers are polymerized using a photoinitiator (such as a dye), optionally a cocatalyst, optionally an accelerator, and radiation in the form of visible or long wavelength UV light. The reaction occurs either by suspension polymerization or by interfacial polymerization. The polymer membrane can be formed directly on the surface of the biological material, or it can be formed on material which is already encapsulated.

公开(公告)号：US5410016A

公开(公告)日：1995-04-25

申请号：US22687

申请日：1993-03-01

申请人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Jennifer L. Hill

发明人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Jennifer L. Hill

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K35/12 ,  A61K47/48 ,  A61L24/00 ,  A61L24/04 ,  A61L27/34 ,  A61L27/38 ,  A61L27/52 ,  A61L29/08 ,  A61L31/14 ,  C08F290/00 ,  C08F290/06 ,  C08F291/00 ,  C09D153/00 ,  C12N5/00 ,  C12N5/071 ,  C12N11/04 ,  C08G63/08 ,  C08G67/00 ,  A61K9/58

CPC分类号： C08F290/06 ,  A61K47/48315 ,  A61K47/48784 ,  A61K47/48876 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/5031 ,  A61K9/5073 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L27/34 ,  A61L27/38 ,  A61L27/52 ,  A61L29/085 ,  A61L31/145 ,  A61L31/148 ,  C08F290/00 ,  C08F291/00 ,  C09D153/00 ,  C12N11/04 ,  C12N5/0012 ,  C12N5/0677 ,  A61K2035/128 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/40 ,  C12N2533/74

摘要： Hydrogels of polymerized and crosslinked macromers comprising hydrophilic oligomers having biodegradable monomeric or oligomeric extensions, which biodegradable extensions are terminated on free ends with end cap monomers or oligomers capable of polymerization and cross linking are described. The hydrophilic core itself may be degradable, thus combining the core and extension functions. Macromers are polymerized using free radical initiators under the influence of long wavelength ultraviolet light, visible light excitation or thermal energy. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. Preferred applications for the hydrogels include prevention of adhesion formation after surgical procedures, controlled release of drugs and other bioactive species, temporary protection or separation of tissue surfaces, adhering of sealing tissues together, and preventing the attachment of cells to tissue surfaces.

公开(公告)号：US06258870B1

公开(公告)日：2001-07-10

申请号：US08783387

申请日：1997-01-13

申请人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Syed F. A. Hossainy

发明人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Syed F. A. Hossainy

IPC分类号： A61K950

CPC分类号： A61L27/36 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/5031 ,  A61K9/5073 ,  A61K38/42 ,  A61K38/44 ,  A61K47/645 ,  A61K47/6925 ,  A61K2035/128 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L27/34 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/52 ,  A61L29/085 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  C08F290/00 ,  C08F290/02 ,  C08F290/06 ,  C08F290/062 ,  C08F291/00 ,  C09D153/00 ,  C12N5/0012 ,  C12N5/0677 ,  C12N11/04 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/40 ,  C12N2533/74 ,  C08L71/02

摘要： This invention provides novel methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as a “glue” to cause more than one biological substance to adhere together, or as carriers for biologically active species. Several methods for forming these membranes are provided. Each of these methods utilizes a polymerization system containing water-soluble macromers, species which are at once polymers and macromolecules capable of further polymerization. The macromers are polymerized using a photoinitiator (such as a dye), optionally a cocatalyst, optionally an accelerator, and radiation in the form of visible or long wavelength UV light. The reaction occurs either by suspension polymerization or by interfacial polymerization. The polymer membrane can be formed directly on the surface of the biological material, or it can be formed on material which is already encapsulated.

摘要翻译： 本发明提供了使用水溶性分子的光聚合在生物材料周围形成生物相容性膜的新方法。 该膜可以用作包封生物材料或生物医学装置的覆盖物，作为使胶粘剂引起不止一种生物物质粘附在一起，或作为生物活性物质的载体。 提供了形成这些膜的几种方法。 这些方法中的每一种都使用含有水溶性大分子单体的聚合体系，它们是能够进一步聚合的聚合物和大分子的物质。 大分子单体使用光引发剂（例如染料），任选的助催化剂，任选的促进剂和可见或长波长UV光的形式的辐射聚合。 该反应通过悬浮聚合或通过界面聚合进行。 聚合物膜可以直接形成在生物材料的表面上，或者可以在已被包封的材料上形成。

公开(公告)号：US06231892B1

公开(公告)日：2001-05-15

申请号：US08969910

申请日：1997-11-13

申请人： Jeffrey A. Hubbell ,  Amarpreet S. Sawhney

发明人： Jeffrey A. Hubbell ,  Amarpreet S. Sawhney

IPC分类号： A61K950

CPC分类号： A61K9/5073 ,  A61K9/5031 ,  A61K47/60 ,  A61K47/645 ,  A61K47/6925

摘要： Biocompatible microcapsules useful for transplanting foreign material into an animal body, and the method of their production, are described, wherein the microcapsules contain an outermost layer of water soluble non-ionic polymers such as PEO to create resistance to cell adhesion on the surface of the microcapsules.

摘要翻译： 描述了可用于将异物移植到动物体内的生物相容性微胶囊及其制备方法，其中所述微胶囊含有最外层的水溶性非离子聚合物如PEO，以产生对细胞粘附在细胞表面上的抗性 微胶囊。

公开(公告)号：US6060582A

公开(公告)日：2000-05-09

申请号：US128917

申请日：1998-08-04

申请人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Jennifer L. Hill-West

发明人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Jennifer L. Hill-West

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K9/50 ,  A61K35/12 ,  A61K38/48 ,  A61K47/30 ,  A61K47/32 ,  A61L24/00 ,  A61L24/04 ,  A61L26/00 ,  A61L27/34 ,  A61L27/38 ,  A61L27/52 ,  A61L29/08 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  B82B1/00 ,  C08F290/00 ,  C08F290/06 ,  C08F291/00 ,  C09D153/00 ,  C09J153/00 ,  C12N5/00 ,  C12N5/071 ,  C12N11/04 ,  C08G63/00 ,  C08G67/00 ,  C08G69/00

CPC分类号： A61K9/0024 ,  A61K38/47 ,  A61K38/49 ,  A61K47/32 ,  A61K9/1635 ,  A61K9/1647 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L27/34 ,  A61L27/36 ,  A61L27/38 ,  A61L27/3839 ,  A61L27/52 ,  A61L29/085 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  A61L31/16 ,  C08F290/00 ,  C08F290/06 ,  C08F291/00 ,  C09D153/00 ,  C09J153/00 ,  C12N11/04 ,  C12N5/0012 ,  C12N5/0677 ,  C12Y302/01017 ,  C12Y304/21068 ,  A61K2035/128 ,  A61L2300/424 ,  A61L2300/602 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/40 ,  C12N2533/74 ,  Y10T428/29 ,  Y10T428/2913 ,  Y10T428/2967

摘要： Hydrogels of polymerized and crosslinked macromers comprising hydrophilic oligomers having biodegradable monomeric or oligomeric extensions, which biodegradable extensions are terminated on free ends with end cap monomers or oligomers capable of polymerization and cross linking are described. The hydrophilic core itself may be degradable, thus combining the core and extension functions. Macromers are polymerized using free radical initiators under the influence of long wavelength ultraviolet light, visible light excitation or thermal energy. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. Preferred applications for the hydrogels include prevention of adhesion formation after surgical procedures, controlled release of drugs and other bioactive species, temporary protection or separation of tissue surfaces, adhering of sealing tissues together, and preventing the attachment of cells to tissue surfaces.

公开(公告)号：US5849839A

公开(公告)日：1998-12-15

申请号：US826294

申请日：1997-03-27

申请人： Jeffrey A. Hubbell ,  Donald Elbert ,  Jennifer L. Hill-West ,  Paul D. Drumheller ,  Sanghamitra Chowdhury ,  Amarpreet S. Sawhney

发明人： Jeffrey A. Hubbell ,  Donald Elbert ,  Jennifer L. Hill-West ,  Paul D. Drumheller ,  Sanghamitra Chowdhury ,  Amarpreet S. Sawhney

IPC分类号： A61L27/00 ,  A61K9/50 ,  A61K47/48 ,  A61L31/06 ,  A61L33/00 ,  C08G63/91 ,  C08G73/00 ,  C08G81/00 ,  C08G81/02 ,  C08L77/00 ,  C08L79/00 ,  C08L101/00 ,  C09D187/00 ,  C08L1/00

CPC分类号： C08G81/00 ,  A61K47/48238 ,  A61K47/48315 ,  A61K9/5031 ,  A61K9/5073 ,  A61L31/06

摘要： Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, and the other component of the polymeric material does not adsorb well to tissues. A water-soluble polymer that does not bear charge (polynonion) is used as the non-binding component, and a water soluble polymer that is positively charged at physiological pH (polycation) is used as the tissue binding component. When the bi-functional polymeric material contacts a tissue, the tissue-binding component binds and thus immobilizes the attached non-binding component, which will then extend generally away from the tissue surface and sterically block the attachment of other tissues. The method and compositions are useful in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells.