公开(公告)号：US20150024974A1

公开(公告)日：2015-01-22

申请号：US14502320

申请日：2014-09-30

Applicant: BioArray Solutions, Ltd.

Inventor： Sukanta BANERJEE ,  Michael Seul ,  Alice X. Li

IPC: C12Q1/68 ,  B01J19/00

CPC classification number: C12Q1/6813 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00315 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00644 ,  B01J2219/00648 ,  B01J2219/00653 ,  B01J2219/00722 ,  B01J2219/00725 ,  C12Q1/6837 ,  C12Q1/6876 ,  G01N27/745 ,  G01N33/5434 ,  G01N33/54346 ,  G01N33/587 ,  G01N2035/00564 ,  G01N2035/00762 ,  G01N2446/20 ,  G01N2446/64 ,  Y10T436/11 ,  C12Q2565/513 ,  C12Q2563/143 ,  C12Q2563/107 ,  C12Q2563/155

Abstract: The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub-libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interations of a number of analyte molecules in a sample.

Abstract translation: 本发明提供了一种通过产生磁性纳米颗粒和编码颗粒的新型亚文库从子文库生成新的编码磁性颗粒文库的方法。 子库根据需要进行功能化在数组的形成中是有用的。 本发明特别可用于进行多个（并行）测定以定性和/或定量分析样品中多个分析物分子的结合位点。

公开(公告)号：US20140369579A1

公开(公告)日：2014-12-18

申请号：US14202357

申请日：2014-03-10

Applicant: Bioarray Solutions, Ltd.

Inventor： Michael Seul ,  Xiongwu Xia ,  Chiu Chau ,  Scott Determan

IPC: G06T7/00 ,  G06K9/00

CPC classification number: G06T7/0012 ,  G01N33/566 ,  G06K9/00 ,  G06K9/00147 ,  G06K2209/07 ,  G06T7/11 ,  G06T7/155 ,  G06T7/33 ,  G06T2207/10064 ,  G06T2207/20152 ,  G06T2207/30072

Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.

Abstract translation: 系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中 许多受体与微粒或微珠相关。 编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。 从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。 访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

公开(公告)号：US08691594B2

公开(公告)日：2014-04-08

申请号：US13664953

申请日：2012-10-31

Applicant: Bioarray Solutions, Ltd.

Inventor： Michael Seul

IPC: G01N33/553

CPC classification number: B01J19/0046 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00713 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0663 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0877 ,  B01L2300/089 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0454 ,  C12Q1/6825 ,  C12Q1/6837 ,  C40B40/00 ,  C40B40/04 ,  G01N15/1468 ,  G01N27/447 ,  G01N33/54313 ,  G01N33/54386 ,  G01N33/6845 ,  G01N2015/149 ,  G01N2015/1497 ,  G02B3/0012 ,  G02B3/0056 ,  G02B3/0075 ,  H05H3/04 ,  Y10S435/808 ,  Y10S435/81 ,  Y10S435/814 ,  Y10S436/806 ,  Y10S436/808 ,  Y10S436/809 ,  Y10T436/25125 ,  C12Q2565/501 ,  C12Q2563/155 ,  C12Q2565/607

Abstract: A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.

Abstract translation: 一种用于在诸如氧化硅的绝缘电极和电解质溶液之间的界面处操作胶体颗粒和生物分子的方法和装置。 表面附近颗粒的光控电动组装取决于三个功能元件的组合：交流电场引起的平面聚集体的组装; 电解质/氧化硅/硅界面的图案化以在组装过程上施加空间控制; 并通过外部照明实现对装配过程的实时控制。 本发明提供一组基本操作，使得能够对几种类型的颗粒和生物分子的平面阵列的创建和放置以及阵列形状和尺寸的操纵进行交互式控制。 本发明使得能够以阵列格式进行诊断测定和生化分析的样品制备和处理以及这些操作的功能整合。 此外，本发明提供了用于产生具有所需性质的材料表面和用于制造表面安装光学部件的步骤。