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公开(公告)号:US20060247603A1
公开(公告)日:2006-11-02
申请号:US11477744
申请日:2006-06-28
申请人: Rebecca Gottlieb , Bradley Enegren , Rajiv Shah
发明人: Rebecca Gottlieb , Bradley Enegren , Rajiv Shah
CPC分类号: A61F2/90 , A61F2230/0054 , A61M2025/105
摘要: A system and method for restenosis mitigation at a trauma site within the vasculature. The system may include a catheter capable of delivering a restenosis mitigating drug and a sensor extending through a lumen in the catheter. The catheter may be positioned adjacent the trauma site and the restenosis mitigating drug may be delivered to the trauma site through the catheter. The restenosis mitigating drug or some other parameter may be sensed by the sensor.
摘要翻译: 在脉管系统内的创伤部位减轻再狭窄的系统和方法。 该系统可以包括能够递送再狭窄缓解药物的导管和延伸穿过导管内腔的传感器。 导管可以定位在创伤部位附近,并且再狭窄缓解药物可以通过导管输送到创伤部位。 再狭窄缓解药物或某些其他参数可由传感器检测。
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公开(公告)号:US20060076236A1
公开(公告)日:2006-04-13
申请号:US11034371
申请日:2005-01-12
申请人: Rajiv Shah , Shaun Pendo , Rebecca Gottlieb , Gil Bruso , Gopikrishnan Soundararajan , Katherine Wolfe
发明人: Rajiv Shah , Shaun Pendo , Rebecca Gottlieb , Gil Bruso , Gopikrishnan Soundararajan , Katherine Wolfe
IPC分类号: A61B5/05 , G01N33/487
CPC分类号: A61B5/14532 , A61B5/0031 , A61B5/14865 , A61B5/412 , C12Q1/006
摘要: The disclosure provides methods for fabricating a long-term analyte sensor for measuring at least one analyte in the body of a user. The analyte sensors made by these methods include a plurality of analyte contacting sensor elements and at least one structure for relaying information to and from the sensor. The analyte sensor so fabricated further includes at least one sensor protection membrane that is controllable in a manner such that sensor elements may be activated (e.g. exposed to the external environment) at different times so as to extend the useful life of the sensor. In illustrative analyte sensors, the analyte is glucose.
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公开(公告)号:US20050065556A1
公开(公告)日:2005-03-24
申请号:US10669426
申请日:2003-09-23
申请人: Bahar Reghabi , Rebecca Gottlieb , Rajiv Shah , Bradley Enegren
发明人: Bahar Reghabi , Rebecca Gottlieb , Rajiv Shah , Bradley Enegren
IPC分类号: A61B5/00 , A61B5/0205 , A61B5/0215 , A61N1/39
CPC分类号: A61B5/6852 , A61B5/02055 , A61B5/0215 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1473 , A61B5/412 , A61B5/7275
摘要: A system and method of sensing multiple parameters. The method may include implanting an implantable sensor in a patient and reading an output from at least one of the implantable sensing elements. The implantable sensor may have a housing within which are disposed a plurality of implantable sensing elements. At least one of the implantable sensing elements may respond to lactate. In addition, a medical professional may administer to the patient for myocardial ischemia, myocardial infarction angina, sepsis based on the output read. A medical professional may also administer to the patient having an implantable cardiovascular defibrillator or who is receiving extracorporeal membrane oxygenation. The method may be used in a surgical or intensive care environment.
摘要翻译: 一种感测多个参数的系统和方法。 该方法可以包括将可植入传感器植入患者体内并读取至少一个可植入感测元件的输出。 可植入传感器可以具有壳体,其中设置有多个可植入感测元件。 植入式感测元件中的至少一个可以响应于乳酸盐。 此外,医疗专业人员可以根据输出读取对患者进行心肌缺血,心肌梗塞心绞痛,败血症。 医疗专业人员还可以向具有可植入的心血管除颤器或正在接受体外膜氧合的患者施用。 该方法可用于外科或重症监护环境。
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公开(公告)号:US20110046457A1
公开(公告)日:2011-02-24
申请号:US12917162
申请日:2010-11-01
申请人: Rebecca Gottlieb , Rajiv Shah , Mary M. Morris , Victor Giron , Michael E. Miller , Bradley J. Enegren
发明人: Rebecca Gottlieb , Rajiv Shah , Mary M. Morris , Victor Giron , Michael E. Miller , Bradley J. Enegren
CPC分类号: A61M25/0032 , A61B5/028 , A61B5/14532 , A61B5/1486 , A61B5/415 , A61M5/14244 , A61M5/1723 , A61M25/0017 , A61M25/0023 , A61M2025/0003 , A61M2025/0046 , A61M2230/201 , Y10T29/49826
摘要: A multilumen catheter having tubings extending into lumens within the catheter. The lumens may be used for blood, drugs or other medicants. The lumens may also be used for sensors. The junction element, external to the patient, connects the tubings to the lumens. The tubings, also external to the patient, connect to infusion members, to which one or more infusion systems may be connected to deliver blood, drugs and other medicants to the patient. A sensor having a sensing element may extend through the sensor lumen and be positioned internal to the patient for physiological parameter sensing. An external portion of the sensor may be connected to associated electronics to provide automatic monitoring of the physiological parameters and automatic delivery and control of the infusants. Also, a central line catheter for delivering fluids directly into a main artery or vein near the heart, which contains a first lumen to deliver a fluid through the central line catheter and a second lumen containing a sensor capable indicating a characteristic level in blood. The first lumen delivers the fluid downstream of the sensor to prevent any interference between the fluid delivery and the sensor readings. In other versions, the central line catheter can have additional lumens for additional purposes. In addition, the central line catheter can further include a flush sleeve to remove debris around the sensor.
摘要翻译: 一种多管导管,其具有延伸到导管内腔内的管道。 流明可用于血液,药物或其他药物。 流明也可用于传感器。 患者外部的连接元件将管道连接到管腔。 也在患者外部的管连接到输注构件,一个或多个输注系统可以连接到输注构件,以向患者输送血液,药物和其他药剂。 具有感测元件的传感器可以延伸穿过传感器内腔并且位于患者的内部以用于生理参数感测。 传感器的外部部分可以连接到相关联的电子设备,以提供对生理参数的自动监测以及对输入的自动传送和控制。 另外,一种用于将流体直接输送到心脏附近的主动脉或静脉的中心线导管,其包含用于通过中心线导管输送流体的第一内腔和包含能够指示血液中的特征水平的传感器的第二腔。 第一个内腔在传感器的下游传送流体,以防止流体输送和传感器读数之间的任何干扰。 在其他版本中,中心线导管可以具有另外的流明用于其他目的。 此外,中心线导管还可以包括冲洗套筒以去除传感器周围的碎屑。
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公开(公告)号:US07166074B2
公开(公告)日:2007-01-23
申请号:US10452521
申请日:2003-06-02
申请人: Bahar Reghabi , Rajiv Shah , Eunjoo Jin , Rebecca Gottlieb , Michael E. Miller , Nannette M. Van Antwerp , Bradley J. Enegren , William P. Van Antwerp , John J. Mastrototaro
发明人: Bahar Reghabi , Rajiv Shah , Eunjoo Jin , Rebecca Gottlieb , Michael E. Miller , Nannette M. Van Antwerp , Bradley J. Enegren , William P. Van Antwerp , John J. Mastrototaro
CPC分类号: A61B5/14532 , A61B5/076 , A61B5/14503 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61M39/0208
摘要: A reusable analyte sensor site for use with a replaceable analyte sensor for determining a level of an analyte includes a site housing and a resealable insertion site coupled to one end of the site housing. Preferably, the site housing is formed to have an interior cavity, and includes an outer membrane made of a material selected to promote vascularization and having a first pore size, and an inner membrane made of a material selected to be free of tissue ingress. Also, the site housing permits the analyte to pass through the site housing to the interior cavity to permit measurement by the replaceable analyte sensor. The resealable insertion site is provided for inserting the replaceable analyte sensor into the interior cavity of the site housing.
摘要翻译: 与用于确定分析物水平的可更换分析物传感器一起使用的可重复使用的分析物传感器位点包括与站点外壳的一端连接的现场外壳和可重新密封的插入位置。 优选地,所述部位壳体形成为具有内部空腔,并且包括由选择用于促进血管形成并具有第一孔径的材料制成的外膜和由选择为不具有组织进入的材料制成的内膜。 此外,现场外壳允许分析物通过现场外壳进入内腔,以允许通过可更换的分析物传感器进行测量。 可重新密封的插入位置用于将可更换的分析物传感器插入到现场外壳的内部空腔中。
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公开(公告)号:US20060004272A1
公开(公告)日:2006-01-05
申请号:US10989038
申请日:2004-11-15
申请人: Rajiv Shah , Rebecca Gottlieb , Eric Grovender , Shaun Pendo , Paul Citron , William Van Antwerp
发明人: Rajiv Shah , Rebecca Gottlieb , Eric Grovender , Shaun Pendo , Paul Citron , William Van Antwerp
IPC分类号: A61B5/00
CPC分类号: A61B5/14865 , A61B5/14532 , A61B5/412 , G01N33/5438
摘要: A long term analyte sensor for measuring at least one analyte in the body of a user and which includes a housing, a plurality of analyte contacting sensor elements and at least one structure for relaying information away from the sensor. This plurality of analyte contacting sensor elements are typically disposed in an array. The analyte sensor further includes at least one sensor protection membrane that is controllable in a manner such that sensor elements may be activated (e.g. exposed to the external environment) at different times so as to extend the useful life of the sensor. In illustrative analyte sensors, the analyte is glucose.
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公开(公告)号:US07500949B2
公开(公告)日:2009-03-10
申请号:US10331949
申请日:2002-12-30
申请人: Rebecca Gottlieb , Rajiv Shah , Mary M. Morris , Victor Giron , Michael E. Miller , Bradley J. Enegren
发明人: Rebecca Gottlieb , Rajiv Shah , Mary M. Morris , Victor Giron , Michael E. Miller , Bradley J. Enegren
CPC分类号: A61M25/0032 , A61B5/028 , A61B5/14532 , A61B5/1486 , A61B5/415 , A61M5/14244 , A61M5/1723 , A61M25/0017 , A61M25/0023 , A61M2025/0003 , A61M2025/0046 , A61M2230/201 , Y10T29/49826
摘要: A multilumen catheter having tubings extending into lumens within the catheter. The lumens may be used for blood, drugs or other medicants. The lumens may also be used for sensors. The junction element, external to the patient, connects the tubings to the lumens. The tubings, also external to the patient, connect to infusion members, to which one or more infusion systems may be connected to deliver blood, drugs and other medicants to the patient. A sensor having a sensing element may extend through the sensor lumen and be positioned internal to the patient for physiological parameter sensing. An external portion of the sensor may be connected to associated electronics to provide automatic monitoring of the physiological parameters and automatic delivery and control of the infusants. Also, a central line catheter for delivering fluids directly into a main artery or vein near the heart, which contains a first lumen to deliver a fluid through the central line catheter and a second lumen containing a sensor capable indicating a characteristic level in blood. The first lumen delivers the fluid downstream of the sensor to prevent any interference between the fluid delivery and the sensor readings. In other versions, the central line catheter can have additional lumens for additional purposes. In addition, the central line catheter can further include a flush sleeve to remove debris around the sensor.
摘要翻译: 一种多管导管,其具有延伸到导管内腔内的管道。 流明可用于血液,药物或其他药物。 流明也可用于传感器。 患者外部的连接元件将管道连接到管腔。 也在患者外部的管连接到输注构件,一个或多个输注系统可以连接到输注构件,以向患者输送血液,药物和其他药剂。 具有感测元件的传感器可以延伸穿过传感器内腔并且位于患者的内部以用于生理参数感测。 传感器的外部部分可以连接到相关联的电子设备,以提供对生理参数的自动监测以及对输入的自动传送和控制。 另外,一种用于将流体直接输送到心脏附近的主动脉或静脉的中心线导管,其包含用于通过中心线导管输送流体的第一内腔和包含能够指示血液中的特征水平的传感器的第二腔。 第一个内腔在传感器的下游传送流体,以防止流体输送和传感器读数之间的任何干扰。 在其他版本中,中心线导管可以具有另外的流明用于其他目的。 此外,中心线导管还可以包括冲洗套筒以去除传感器周围的碎屑。
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公开(公告)号:US07514038B2
公开(公告)日:2009-04-07
申请号:US10861976
申请日:2004-06-04
申请人: Shaun Pendo , Rajiv Shah , Edward Chernoff
发明人: Shaun Pendo , Rajiv Shah , Edward Chernoff
CPC分类号: H05K3/28 , A61B5/0006 , H05K1/0306 , H05K3/4061 , H05K2201/0175 , H05K2201/0179 , H05K2201/0317 , H05K2201/09472 , H05K2203/082 , H05K2203/085 , H05K2203/1147 , H05K2203/1476 , H05K2203/1572 , H05K2203/308
摘要: A substrate with hermetically sealed vias extending from one side of the substrate to another and a method for fabricating same. The vias may be filled with a conductive material such as, for example, a fritless ink. The conductive path formed by the conductive material aids in sealing one side of the substrate from another. One side of the substrate may include a sensing element and another side of the substrate may include sensing electronics.
摘要翻译: 具有从衬底的一侧延伸到另一侧的气密密封通孔的衬底及其制造方法。 通孔可以填充有导电材料,例如无油墨。 由导电材料形成的导电路径有助于将基板的一侧与另一侧密封。 衬底的一侧可以包括感测元件,并且衬底的另一侧可以包括感测电子器件。
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公开(公告)号:US08821793B2
公开(公告)日:2014-09-02
申请号:US11924402
申请日:2007-10-25
申请人: Shaun Pendo , Rajiv Shah , Edward Chernoff
发明人: Shaun Pendo , Rajiv Shah , Edward Chernoff
CPC分类号: H05K3/28 , A61B5/0006 , H05K1/0306 , H05K3/4061 , H05K2201/0175 , H05K2201/0179 , H05K2201/0317 , H05K2201/09472 , H05K2203/082 , H05K2203/085 , H05K2203/1147 , H05K2203/1476 , H05K2203/1572 , H05K2203/308
摘要: A substrate with hermetically sealed vias extending from one side of the substrate to another and a method for fabricating same. The vias may be filled with a conductive material such as, for example, a fritless ink. The conductive path formed by the conductive material aids in sealing one side of the substrate from another. One side of the substrate may include a sensing element and another side of the substrate may include sensing electronics.
摘要翻译: 具有从衬底的一侧延伸到另一侧的气密密封通孔的衬底及其制造方法。 通孔可以填充有导电材料,例如无油墨。 由导电材料形成的导电路径有助于将基板的一侧与另一侧密封。 衬底的一侧可以包括感测元件,并且衬底的另一侧可以包括感测电子器件。
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公开(公告)号:US20110203923A1
公开(公告)日:2011-08-25
申请号:US12862690
申请日:2010-08-24
CPC分类号: A61N1/05 , A61B5/145 , A61B5/14532 , A61B5/1473 , A61B5/14865 , Y10T29/49204
摘要: A sensing apparatus with a connector, a sensor lead and a sensor module with a spacer placed over electrodes that have been deposited on a substrate. The spacer may have a space for receiving an enzyme. End portions of the sensor module may be encapsulated, such as with molded beads. A sensor lead may attach to the sensor module and may have an outer tubing that passes over the module and attaches to the beads at the end of the sensor module. The sensor lead may also attach to the connector such that the sensing apparatus may be electrically coupled to a pump, electronics or other devices. The sensing apparatus may be implanted into a vein or artery.
摘要翻译: 具有连接器,传感器引线和传感器模块的感测装置,其具有放置在已经沉积在基板上的电极上的隔离物。 间隔物可以具有用于接受酶的空间。 传感器模块的端部可以被封装,例如用模制的珠子。 传感器引线可以附接到传感器模块,并且可以具有穿过模块并且附接到传感器模块的端部处的珠的外管。 传感器引线还可以附接到连接器,使得感测装置可以电耦合到泵,电子设备或其他装置。 感测装置可以植入静脉或动脉。
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