公开(公告)号：US09935318B1

公开(公告)日：2018-04-03

申请号：US14318880

申请日：2014-06-30

Applicant: Wayne A. Surdoval ,  David A. Berry ,  Travis Shultz

Inventor： Wayne A. Surdoval ,  David A. Berry ,  Travis Shultz

IPC: H01M8/12 ,  H01M4/90 ,  H01M8/124 ,  H01M8/1213 ,  H01M4/86 ,  H01M8/1246

CPC classification number: H01M4/9033 ,  H01M4/8657 ,  H01M4/8807 ,  H01M4/8846 ,  H01M4/8889 ,  H01M4/9025 ,  H01M8/1213 ,  H01M8/1246 ,  H01M2004/8689 ,  H01M2008/1293 ,  H01M2300/0094

Abstract: The disclosure provides a SOFC comprised of an electrolyte, anode, and cathode, where the cathode comprises an MIEC and an oxygen-reducing layer. The oxygen-reducing layer is in contact with the MIEC, and the MIEC is generally between and separating the oxygen-reducing layer and the electrolyte. The oxygen-reducing layer is comprised of single element oxides, single element carbonates, or mixtures thereof, and has a thickness of less than about 30 nm. In a particular embodiment, the thickness is less than 5 nm. In another embodiment, the thickness is about 3 monolayers or less. The oxygen-reducing layer may be a continuous film or a discontinuous film with various coverage ratios. The oxygen-reducing layer at the thicknesses described may be generated on the MIEC surface using means known in the art such as, for example, ALD processes.

公开(公告)号：US09598644B1

公开(公告)日：2017-03-21

申请号：US14834487

申请日：2015-08-25

Applicant: Dushyant Shekhawat ,  David A. Berry ,  Daniel J. Haynes ,  Victor Abdelsayed ,  Mark W. Smith ,  James J. Spivey

Inventor： Dushyant Shekhawat ,  David A. Berry ,  Daniel J. Haynes ,  Victor Abdelsayed ,  Mark W. Smith ,  James J. Spivey

IPC: C10G2/00

CPC classification number: C10G2/333 ,  C07C1/043 ,  C07C29/158 ,  C07C2521/06 ,  C07C2523/46 ,  C07C2523/63 ,  C10G2/33 ,  C10G2/50 ,  C07C31/04 ,  C07C9/00 ,  C07C11/02

Abstract: A method of hydrogenation utilizing a reactant gas mixture comprising a carbon oxide and a hydrogen agent, and a hydrogenation catalyst comprising a mixed-metal oxide containing metal sites supported and/or incorporated into the lattice. The mixed-metal oxide comprises a pyrochlore, a brownmillerite, or mixtures thereof doped at the A-site or the B-site. The metal site may comprise a deposited metal, where the deposited metal is a transition metal, an alkali metal, an alkaline earth metal, or mixtures thereof. Contact between the carbon oxide, hydrogen agent, and hydrogenation catalyst under appropriate conditions of temperature, pressure and gas flow rate generate a hydrogenation reaction and produce a hydrogenated product made up of carbon from the carbon oxide and some portion of the hydrogen agent. The carbon oxide may be CO, CO2, or mixtures thereof and the hydrogen agent may be H2. In a particular embodiment, the hydrogenated product comprises olefins, paraffins, or mixtures thereof.

公开(公告)号：US08529889B2

公开(公告)日：2013-09-10

申请号：US11171490

申请日：2005-06-29

Applicant: Aarthi Chandrasekaran ,  Shiladitya Sengupta ,  David A. Berry ,  Kristine Holley ,  Ganlin Zhao ,  Ram Sasisekharan

Inventor： Aarthi Chandrasekaran ,  Shiladitya Sengupta ,  David A. Berry ,  Kristine Holley ,  Ganlin Zhao ,  Ram Sasisekharan

IPC: A61K38/47

CPC classification number: A61K38/51 ,  A61K31/00 ,  A61K31/726 ,  A61K31/727 ,  A61K31/737 ,  A61K38/45 ,  A61K45/06 ,  A61K47/36 ,  A61K2300/00

Abstract: The invention relates to compositions and methods for the modulation of the permeability of the epithelial cell barrier complex. In particular, the invention provides compositions and methods for using polysaccharides, preferably glycosaminoglycans, and agents that modify cell surface glycosaminoglycans, preferably glycosaminoglycan-degrading enzymes to modulate intercellular junctions. The compositions and methods provided can be used to facilitate the delivery of biologically active molecules.

Abstract translation: 本发明涉及调节上皮细胞屏障复合物渗透性的组合物和方法。 特别地，本发明提供使用多糖，优选糖胺聚糖的组合物和方法，以及修饰细胞表面糖胺聚糖（优选为糖胺聚糖降解酶）以调节细胞间连接的试剂。 所提供的组合物和方法可用于促进生物活性分子的递送。

公开(公告)号：US08368402B2

公开(公告)日：2013-02-05

申请号：US12514250

申请日：2007-11-08

Applicant: W. David Lee ,  David A. Berry

Inventor： W. David Lee ,  David A. Berry

IPC: G01V3/00

CPC classification number: G01R33/465 ,  A61B5/0075 ,  A61B5/055 ,  A61B5/062 ,  A61B5/076 ,  A61B5/14503 ,  A61B5/14507 ,  A61B5/14528 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/686 ,  A61B5/7257 ,  A61B5/7264 ,  A61B5/7278 ,  A61B6/12 ,  A61B8/0841 ,  A61B90/90 ,  A61B90/98 ,  A61B2576/00 ,  G01N24/08 ,  G01N24/088 ,  G01R33/285 ,  G01R33/287 ,  G01R33/30 ,  G01R33/34092 ,  G01R33/383 ,  G01R33/50 ,  G01R33/5601

Abstract: This invention relates generally to NMR systems for in vivo detection of analytes. More particularly, in certain embodiments, the invention relates to systems in which superparamagnetic nanoparticles are exposed to a magnetic field and radio frequency (RF) excitation at or near the Larmor frequency, such that the aggregation and/or disaggregation of the nanoparticles caused by the presence and/or concentration of a given analyte in a biological fluid is detected in vivo from a monitored RF echo response.

Abstract translation: 本发明一般涉及用于体内检测分析物的NMR系统。 更具体地说，在某些实施方案中，本发明涉及其中超顺磁性纳米颗粒暴露于Larmor频率处或接近拉莫尔频率处的磁场和射频（RF）激发的系统，使得纳米粒子的聚集和/或解聚 在生物流体中的给定分析物的存在和/或浓度是从所监测的RF回波响应体内检测的。

公开(公告)号：US20120142908A1

公开(公告)日：2012-06-07

申请号：US13306430

申请日：2011-11-29

Applicant: David A. Berry ,  Lana L. Berry ,  John C. Hodges

Inventor： David A. Berry ,  Lana L. Berry ,  John C. Hodges

IPC: C07H1/00 ,  C07H19/173 ,  C07H19/073

CPC classification number: C07H19/073 ,  C07H19/173 ,  C07H21/04 ,  C07H23/00

Abstract: The present invention provides for compounds of Formula I: wherein X—N and R1-R4 have any of the values disclosed in the specification. The compounds of Formula I are useful as reagents to introduce N-alkyl nucleosides into DNA oligonucleotides. The present invention also provides for methods of synthesizing the compounds of Formula I.

Abstract translation: 本发明提供式I化合物：其中X-N和R 1 -R 4具有说明书中公开的任何值。 式I的化合物可用作将N-烷基核苷引入DNA寡核苷酸的试剂。 本发明还提供了合成式I化合物的方法。

公开(公告)号：US20110262975A1

公开(公告)日：2011-10-27

申请号：US13174580

申请日：2011-06-30

Applicant: David A. Berry ,  Dan E. Robertson ,  Frank A. Skraly ,  Brian D. Green ,  Christian P. Ridley ,  Sriram Kosuri ,  Nikos B. Reppas ,  Martha Sholl ,  Noubar B. Afeyan

Inventor： David A. Berry ,  Dan E. Robertson ,  Frank A. Skraly ,  Brian D. Green ,  Christian P. Ridley ,  Sriram Kosuri ,  Nikos B. Reppas ,  Martha Sholl ,  Noubar B. Afeyan

IPC: C12P19/12 ,  C12P7/02

CPC classification number: C12P7/065 ,  C12N1/20 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/0083 ,  C12N9/1007 ,  C12N9/1029 ,  C12N9/88 ,  C12N15/74 ,  C12P1/04 ,  C12P5/00 ,  C12P5/02 ,  C12P5/026 ,  C12P7/00 ,  C12P7/6409 ,  C12P7/6427 ,  C12P7/6436 ,  C12P7/6463 ,  C12P7/6472 ,  C12P7/649 ,  C12P13/04 ,  C12R1/01 ,  C12Y103/03006 ,  Y02E50/13 ,  Y02E50/17 ,  Y02E50/18 ,  Y02E50/343

Abstract: The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.

Abstract translation: 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些有机物用于商业生产乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体。

公开(公告)号：US20110044895A1

公开(公告)日：2011-02-24

申请号：US12852973

申请日：2010-08-09

Applicant: David A. Berry ,  Eric J. Devroe ,  Noubar B. Afeyan ,  Brett Chevalier ,  Sashank K. Reddy

Inventor： David A. Berry ,  Eric J. Devroe ,  Noubar B. Afeyan ,  Brett Chevalier ,  Sashank K. Reddy

IPC: A61K51/00 ,  C12N5/09 ,  A61K39/395 ,  A61K31/7105 ,  A61K49/00 ,  C12N5/095 ,  A61K31/7088 ,  A61P35/00

CPC classification number: A61K39/39558 ,  A61K31/00 ,  A61K31/713 ,  A61K2300/00

Abstract: The invention provides methods and compositions for reducing the number of cancer stem cells in a mixed population of differentiated cells (for example, cancer cells) and cancer stem cells. The cancer stem cells, if present, can be more resistant to traditional drug-based therapies and can provide a source for new, differentiated cancer cells associated with the development of drug-resistance and more aggressive phenotypes. When combined with traditional cancer therapies, for example, drug-based therapies, the methods and compositions of the invention provide a more effective way for treating cancer and can provide a model system for developing new cancer therapies and new treatment modalities.

Abstract translation: 本发明提供了用于减少分化细胞（例如癌细胞）和癌干细胞的混合群体中的癌干细胞数目的方法和组合物。 癌症干细胞（如果存在）可以更好地抵抗传统的基于药物的疗法，并且可以为与耐药性和更具侵袭性的表型的发展相关联的新的分化癌细胞提供来源。 当与传统的癌症疗法结合时，例如基于药物的疗法，本发明的方法和组合提供了治疗癌症的更有效的方法，并且可以提供用于开发新的癌症疗法和新的治疗方式的模型系统。

公开(公告)号：US20090105463A1

公开(公告)日：2009-04-23

申请号：US11887559

申请日：2006-03-29

Applicant: David A. Berry ,  Kevin Pojasek ,  Dongfang Liu ,  Chi-Pong Kwan ,  Yiwei Qi ,  Ram Sasisekharan

Inventor： David A. Berry ,  Kevin Pojasek ,  Dongfang Liu ,  Chi-Pong Kwan ,  Yiwei Qi ,  Ram Sasisekharan

IPC: C07K14/475

CPC classification number: A61K31/737

Abstract: The invention relates, in part, to compositions comprising glycosaminoglycans, fragments of glycosaminoglycans or glycosaminoglycan fractions. The compositions provided can be used in various methods of modulating FGF and/or VEGF activity. The method can be in vitro or in vivo methods. Therefore, the invention also relates, in part, to methods of treating a subject with the compositions provided.

Abstract translation: 本发明部分涉及包含糖胺聚糖，糖胺聚糖片段或糖胺聚糖部分的组合物。 所提供的组合物可用于调节FGF和/或VEGF活性的各种方法中。 该方法可以是体外或体内的方法。 因此，本发明还部分涉及用所提供的组合物治疗受试者的方法。

公开(公告)号：US20080314220A1

公开(公告)日：2008-12-25

申请号：US11820827

申请日：2007-06-21

Applicant: Gregory S. Ferry ,  David A. Berry

Inventor： Gregory S. Ferry ,  David A. Berry

IPC: B26F1/14

CPC classification number: B44B5/026 ,  B21D28/12 ,  B44B5/0057 ,  Y10T83/9423

Abstract: A punch press tool for stamping successive multicharacter impressions into a workpiece such as a piece of steel, sheet metal, or other workpiece, includes a guide body in which a stamp driver is slidably mounted for being driven downwardly toward the workpiece by a punch press ram which is a standard part of a high speed commercial punch press. A multicharacter marking stamp is supported at the lower end of the stamp driver for reciprocal movement therewith. The marking stamp includes multicharacter wheels that are rotated automatically during operation for advancing characters in sequence responsive to the movement of a character advancing arm. At least one character stamp operating lever is operatively associated with the punch press tool for articulation responsive to motion imparted to the tool by the ram. The lever has an operating element that is operatively associated with the character advancing arm of the multicharacter stamp for indexing the arm to enable successive characters thereof to be placed in an operating position responsive to a stroke of the punch press ram.

Abstract translation: 用于将连续的多焦点印模冲压成诸如一块钢，金属片或其它工件的工件的冲压工具包括导向体，其中印模驱动器可滑动地安装，以便通过冲压压头向下朝向工件 这是高速商业冲压机的标准部件。 在印章驱动器的下端支撑多字符标记印章，用于与之相互移动。 标记印章包括多字符轮，其在操作期间自动旋转，以响应于字符前进臂的移动顺序前进字符。 至少一个字符印记操作杆与冲压工具可操作地相关联，用于响应于由冲头施加到工具的运动而进行铰接。 杠杆具有操作性地与多焦头印字机的字符前进臂相关联的操作元件，用于对臂进行分度，以使得其连续的字符能够响应于冲压压头的行程而被放置在操作位置。

公开(公告)号：US4346469A

公开(公告)日：1982-08-24

申请号：US284785

申请日：1981-07-20

Applicant: Louis J. Hillenbrand ,  Joseph R. Preston ,  David A. Berry

Inventor： Louis J. Hillenbrand ,  Joseph R. Preston ,  David A. Berry

IPC: C08L83/04 ,  G11B3/68 ,  B32B3/02 ,  G11B5/74

CPC classification number: G11B3/682 ,  C08L83/04 ,  Y10T428/31663 ,  Y10T428/31667

Abstract: High density information discs comprising a conductive carbon-loaded polyvinylchloride disc lubricated with a fractionated methyl alkyl siloxane lubricant which contains a hexaalkyldisilazane additive.

Abstract translation: 高密度信息盘包括用含有六烷基二硅氮烷添加剂的分馏的甲基烷基硅氧烷润滑剂润滑的导电碳负载聚氯乙烯盘。