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    Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
    21.
    发明授权
    Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates 失效
    使用在高流速下具有高动态吸附容量的复合色谱介质从稀溶液中分离分子

    公开(公告)号：US5906747A

    公开(公告)日：1999-05-25

    申请号：US556313

    申请日：1995-11-13

    Applicant: Jonathan L. Coffman ,  Pierre Girot ,  Egisto Boschetti

    Inventor： Jonathan L. Coffman ,  Pierre Girot ,  Egisto Boschetti

    IPC: B01D15/08 ,  C07K1/18

    CPC classification number: B01D15/08 ,  B01D15/361 ,  C07K1/18

    Abstract: This invention relates generally to modified porous solid chromatographic media and processes for the preparation and use of same. In particular, chromatographic media of porous mineral oxide, polymeric, or polymer-coated mineral oxide supports are disclosed which are characterized by a reversible high sorptive capacity and high intraparticle mass transfer rates. In order to prevent non-specific adsorption of or interaction with biomolecules, these supports may be passivated by use of a passivation mixture comprising a main monomer, a passivating monomer, and a crosslinking agent, which mixture upon polymerization results in substantial elimination of the undesirable non-specific interaction with biomolecules.

    Abstract translation: 本发明一般涉及改性多孔固体色谱介质及其制备和使用方法。 特别地，公开了多孔矿物氧化物，聚合物或聚合物涂覆的矿物氧化物载体的色谱介质，其特征在于可逆的高吸附能力和高的颗粒内传质速率。 为了防止非特异性吸附或与生物分子的相互作用，这些载体可以通过使用包含主单体，钝化单体和交联剂的钝化混合物进行钝化，该聚合物上的该混合物导致基本上不需要的 与生物分子的非特异性相互作用。

    Automatic installation for liquid chromatography
    23.
    发明授权
    Automatic installation for liquid chromatography 失效
    自动安装液相色谱仪

    公开(公告)号：US4478713A

    公开(公告)日：1984-10-23

    申请号：US535308

    申请日：1983-09-23

    Applicant: Pierre Girot ,  Egisto Boschetti

    Inventor： Pierre Girot ,  Egisto Boschetti

    IPC: B01D15/08 ,  G01N30/24 ,  G01N30/82

    CPC classification number: B01D15/08 ,  B01D15/14 ,  B01D15/247 ,  G01N30/24 ,  G01N30/82

    Abstract: In the automatic installation for liquid chromatography according to the invention, the container of product to be fractionated is associated to a measuring container and is provided, as are the containers of eluents, with low level detector means; feed valves are interposed between said containers and the injection pump whereas output valves are interposed between the outlet from the column and the collector containers; a control unit comprises a safety device connected to the low level detectors to control the stoppage of the pump whenever necessary, and a control device receiving the signals from detection means connected to the output of the column and controlling the measuring container and said valves to perform successive cycles of chromatography each one including the steps of injecting a quantity of product, admitting at least one eluent and collecting the or each corresponding fraction.

    Abstract translation: 在根据本发明的液相色谱的自动安装中，要分级的产品的容器与测量容器相关联，并且与洗涤液的容器一样设置有低水平检测器装置; 进料阀介于所述容器和注射泵之间，而输出阀插入在塔的出口和收集容器之间; 控制单元包括连接到低电平检测器的安全装置，以在必要时控制泵的停止;以及控制装置，其接收来自连接到列的输出的检测装置的信号，并控制测量容器和所述阀执行 连续的色谱层析每个包括以下步骤：注入一定数量的产物，允许至少一种洗脱剂并收集或相应的部分。

    Detection of ion concentration in a liquid
    30.
    发明授权
    Detection of ion concentration in a liquid 失效
    检测液体中的离子浓度

    公开(公告)号：US4590424A

    公开(公告)日：1986-05-20

    申请号：US535307

    申请日：1983-09-23

    Applicant: Pierre Girot ,  Egisto Boschetti

    Inventor： Pierre Girot ,  Egisto Boschetti

    IPC: G01N27/06 ,  G01N27/02 ,  G01N27/74

    CPC classification number: G01N27/023

    Abstract: A detector of ion concentration in a liquid is composed of a detection cell comprising a tubular piece formed from an electrically insulating material with a central passage which is fed with a liquid whose ion concentration is to be measured. A conducting coil is placed around the tubular piece, and is part of a first resonant circuit. A second reference resonant circuit is also provided, and signals of fixed frequency are applied in parallel to the two resonant circuits, and a comparator delivers a signal having a magnitude representative of the difference between the output signals from the two resonant circuits. Such a detector finds a use for example in liquid chromatography.

    Abstract translation: 液体中的离子浓度检测器由检测单元构成，该检测单元由具有中间通道的电绝缘材料形成的管状件构成，该中间通道供给被测量离子浓度的液体。 导电线圈放置在管状件周围，并且是第一谐振电路的一部分。 还提供了第二参考谐振电路，并且固定频率的信号并联施加到两个谐振电路，并且比较器输出具有表示来自两个谐振电路的输出信号之间的差的幅度的信号。 这种检测器可用于例如液相色谱法。

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