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21.发明申请公开(公告)号：US20210316043A1
公开(公告)日：2021-10-14
申请号：US17357652
申请日：2021-06-24
Applicant: FUJIFILM Corporation
Inventor： Ryo KOGAWA , Kentaro NAKAMURA
Abstract: An object of the present invention is to provide a cell transplantation kit capable of exhibiting a high medical treatment effect by transplanted cells, a method for producing a sac-shaped structure that is used in the cell transplantation kit, and a therapeutic agent for diabetes containing the cell transplantation kit. According to the present invention, there is provided a cell transplantation kit including a first sac-shaped structure consisting of a membrane having pores of an average pore diameter of 0.2 mm or less, and a plurality of second sac-shaped structures having an average long diameter larger than the average pore diameter of the pores of the first sac-shaped structure, in which at least a part of the plurality of second sac-shaped structures contain cells. According to the present invention, there is provided a method for producing a sac-shaped structure that is used in the cell transplantation kit. According to the present invention, there is provide a therapeutic agent for diabetes, including the cell transplantation kit.
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公开(公告)号：US20200268943A1
公开(公告)日：2020-08-27
申请号：US16804823
申请日：2020-02-28
Applicant: FUJIFILM Corporation
Inventor： Kentaro NAKAMURA , Ryo KOGAWA
Abstract: An object of the present invention is to provide an angiogenic agent that can sufficiently exhibit an angiogenic effect due to mesenchymal stem cells in a state where the angiogenic agent does not allow permeation of host cells while being protected from immune rejection, and a method for method for manufacturing the same. According to the present invention, an angiogenic agent including a mesenchymal stem cell (A); and an immunoisolation membrane (B) that encloses the mesenchymal stem cell is provided.
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公开(公告)号：US20200032183A1
公开(公告)日：2020-01-30
申请号：US16573126
申请日：2019-09-17
Inventor： Kentaro NAKAMURA , Rie HANDO , Satoshi GOJO , Daisuke KAMI
Abstract: An object of the present invention is to provide a method of manufacturing a large number of uniform cell structures for a short period of time. According to the present invention, provided is a method of manufacturing a cell structure, including: a step of adding a mixture of biocompatible macromolecular blocks, cells, and a liquid medium to a first culture container having a culture surface on which the plurality of recessed portions are formed and a side wall part standing on an outer periphery of the culture surface such that a liquid surface of the mixture is over the culture surface; a step of allowing a first culture container to stand and forming a cell structure in the recessed portion; and a step of stirring and culturing a content of the first culture container in a second culture container including stirring means.
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公开(公告)号：US20190216976A1
公开(公告)日：2019-07-18
申请号：US15705669
申请日：2017-09-15
Applicant: FUJIFILM Corporation , JAPAN TISSUE ENGINEERING CO., LTD.
Inventor： Kentaro NAKAMURA , Hayato MIYOSHI , Satoko HADA , Masatoki WATANABE
CPC classification number: A61L27/222 , A61L27/00 , A61L27/225 , A61L27/227 , A61L27/24 , A61L27/3612 , A61L27/3633 , A61L27/3654 , A61L27/3817 , A61L27/3852 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2430/06 , A61L2430/24
Abstract: An object of the invention is to provide a cartilage regenerative material that suppresses infiltration of fibrous soft tissue and brings about satisfactory cartilage regeneration, and a method for producing the cartilage regenerative material. Provided is a cartilage regenerative material including a porous body of a biocompatible polymer and a biocompatible polymer film, in which the porous body contains chondrocytes and cartilage matrix, and the cartilage matrix exists in a region of 10% or more of a region extending from the surface of the transplant face of the porous body to a depth of 150 μm along the thickness.
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公开(公告)号：US20170100519A1
公开(公告)日：2017-04-13
申请号：US15374604
申请日：2016-12-09
Applicant: FUJIFILM Corporation
Inventor： Reiko IWAZAWA , Kentaro NAKAMURA
CPC classification number: A61L27/3839 , A61K35/28 , A61L27/00 , A61L27/222 , A61L27/3808 , A61L27/3834 , A61L27/507 , A61L27/56 , A61L2430/22 , A61L2430/26 , C07K14/78
Abstract: An object of the present invention is to provide a cell structure which does not contain glutaraldehyde and can form blood vessels after transplantation, and a method for producing the above-described cell structure. According to the present invention, there is provided a cell structure which contains a biocompatible macromolecular block and at least one kind of cell and has voids and in which a plurality of the biocompatible macromolecular blocks are arranged in gaps between a plurality of the cells, in which a ratio of the volume of the biocompatible macromolecular blocks with respect to the volume of the cell structure is 10% to 30%, a ratio of the volume of the cells with respect to the volume of the cell structure is 20% to 50%, and a ratio of the volume of the voids with respect to the volume of the cell structure is 35% to 60%.
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Patent Agency Ranking
26.发明申请CELL CONSTRUCT FOR CELL TRANSPLANTATION, BIOCOMPATIBLE POLYMER BLOCK, AND METHOD FOR PRODUCING THE SAME 审中-公开用于细胞移植的细胞结构，生物成分聚合物块及其生产方法公开(公告)号：US20150352252A1
公开(公告)日：2015-12-10
申请号：US14836504
申请日：2015-08-26
Applicant: FUJIFILM CORPORATION
Inventor： Kentaro NAKAMURA , Reiko IWAZAWA , Hayato MIYOSHI , Kazuhiro YAMAGUCHI , Hideo FUSHIMI
CPC classification number: A61L27/222 , A61L27/3604 , A61L27/3608 , A61L27/38 , A61L27/3834 , A61L27/3886 , A61L27/56 , A61L27/58 , A61L2300/64 , A61L2430/22 , C12N5/0068 , Y10T428/2982
Abstract: It is an object of the present invention to provide a cell construct for cell transplantation that does not contain a substance having cytotoxicity, such as glutaraldehyde, and suppresses the necrosis of the transplanted cells in the construct (namely, having a high cell survival rate). The present invention provides a cell construct for cell transplantation comprising biocompatible polymer blocks that do not contain glutaraldehyde and at least one type of cells, wherein a plurality of biocompatible polymer blocks are disposed in gaps among a plurality of cells, and wherein the biocompatible polymer blocks have a tap density of 10 mg/cm3 or more and 500 mg/cm3 or less, or the value of the square root of the cross-sectional area/boundary length in the two-dimensional sectional image of the polymer block is 0.01 or more and 0.13 or less.
Abstract translation: 本发明的目的是提供一种不含有细胞毒性的物质的细胞移植用细胞构建体，例如戊二醛，抑制构建体中移植细胞的坏死（即具有高细胞存活率） 。 本发明提供了一种用于细胞移植的细胞构建体，其包含不含戊二醛和至少一种类型细胞的生物相容性聚合物嵌段，其中多个生物相容性聚合物嵌段设置在多个细胞之间的间隙中，并且其中生物相容性聚合物嵌段 具有10毫克/厘米3以上至500毫克/厘米3以下的振实密度，或聚合物嵌段的二维截面图中的截面积/边界长度的平方根的值为0.01以上 和0.13以下。
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公开(公告)号：US20230241117A1
公开(公告)日：2023-08-03
申请号：US18296652
申请日：2023-04-06
Applicant: FUJIFILM Corporation
Inventor： Kentaro NAKAMURA , Yuichi Yoshino , Atsushi Inada , Tsukasa Kitahashi
IPC: A61K35/28 , C12N5/0775
CPC classification number: A61K35/28 , C12N5/0668 , C12N2500/32 , C12N2500/38
Abstract: An object of the present invention is to provide a method of producing a cell preparation for a joint medical treatment, in which a cell proliferation ratio can be improved, an amount of serum required can be reduced, and karyotype abnormalities in a culture process can be suppressed, a method of culturing a mesenchymal stem cell, and a cell preparation for a joint medical treatment, which is produced by the above method. According to the present invention, there is provided a method of producing a cell preparation for a joint medical treatment, the method including culturing a mesenchymal stem cell in a culture medium containing an ascorbic acid-2-phosphate trisodium salt, alanyl glutamine, and pyridoxine.
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28.发明申请公开(公告)号：US20180171324A1
公开(公告)日：2018-06-21
申请号：US15887083
申请日：2018-02-02
Applicant: FUJIFILM Corporation
Inventor： Kentaro NAKAMURA , Shinji MIMA , Tsukasa KITAHASHI , Chihaya KAKINUMA
IPC: C12N11/02 , A01K67/027 , C12N5/095 , A61K49/00
CPC classification number: C12N11/02 , A01K67/0271 , A01K2207/12 , A01K2207/15 , A01K2207/30 , A01K2227/105 , A01K2267/0331 , A61K35/13 , A61K35/28 , A61K49/0008 , A61L27/00 , C12N5/0695 , C12N2533/54 , G01N33/50
Abstract: An object of the present invention is to provide a non-human model animal rich in stromal tissue, a cell structure useful for producing the above-described non-human model animal, a method for evaluating a test substance in which the above-described non-human model animal is used, and a method for producing the above-described non-human model animal. According to the present invention, a cell structure is provided which contains a biocompatible macromolecular block and at least a cancer cell and a mesenchymal cell, and in which a plurality of the above-described biocompatible macromolecular blocks are arranged in gaps between a plurality of the above-described cells.
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公开(公告)号：US20180140745A1
公开(公告)日：2018-05-24
申请号：US15866735
申请日：2018-01-10
Applicant: FUJIFILM Corporation
Inventor： Kentaro NAKAMURA
CPC classification number: A61L27/3886 , A61K35/28 , A61K35/33 , A61K35/34 , A61K35/407 , A61K35/44 , A61L27/00 , A61L27/222
Abstract: An object of the present invention is to provide a cell structure which can be produced within a short period of time and has a predetermined or larger size, and a method for producing the above-described cell structure. According to the present invention, there is provided a cell structure including: a biocompatible macromolecular block; and two or more kinds of cells, in which a plurality of the biocompatible macromolecular blocks are arranged in gaps between a plurality of the cells, and in which the two or more kinds of cells contain at least one kind of first cell selected from the group consisting of vascular endothelial cells, cardiac muscle cells, pancreatic islet cells, liver cells, epithelial cells, endothelial cells, nerve cells, embryonic stem cells, induced pluripotent stem cells, corneal epithelial cells, and retinal pigment epithelial cells, and at least one kind of second cell selected from the group consisting of mesenchymal cells, stromal cells, fibroblasts, smooth muscle cells, myoblasts, mesenchymal stem cells, adipose-derived stem cells, and umbilical cord-derived stem cells.
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公开(公告)号：US20170203005A1
公开(公告)日：2017-07-20
申请号：US15472855
申请日：2017-03-29
Applicant: FUJIFILM Corporation
Inventor： Reiko IWAZAWA , Kentaro NAKAMURA
CPC classification number: A61L27/3804 , A61K9/16 , A61K35/12 , A61K35/39 , A61K47/42 , A61L27/00 , A61L27/222 , A61L27/3886 , A61L27/56 , A61L2300/64 , A61L2430/22
Abstract: An object of the present invention is to provide a composition containing a pancreatic islet, a cell structure containing a pancreatic islet or a pancreatic islet cell, a pancreatic islet transplantation kit, a pancreatic islet transplantation treatment agent, and a hypoglycemic agent which improve at least one of glucose sensitivity or blood sugar level-reducing performance after transplantation, and to provide a composition containing a pancreatic islet, a kit containing a pancreatic islet, a pancreatic islet cell transplantation treatment agent, and a hypoglycemic agent which can improve glucose sensitivity. According to the present invention, a composition including A: a cell structure which contains a biocompatible macromolecular block and at least one kind of cell and in which a plurality of the above-described macromolecular blocks are arranged in gaps between a plurality of the above-described cells; and B: a pancreatic islet, and a composition containing a pancreatic islet; and a spheroid formed of at least one type of stem cell are provided.
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