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公开(公告)号：US11352329B2
公开(公告)日：2022-06-07
申请号：US16925096
申请日：2020-07-09
Applicant: Gilead Sciences, Inc.
Inventor： Zhenhong R. Cai , Aesop Cho , Ana Zurisadai Gonzalez Buenrostro , Xiaochun Han , Salman Y. Jabri , Ryan McFadden , Yingmei Qi , Johannes Voigt , Jie Xu , Lianhong Xu , Hong Yang
IPC: C07D247/00 , A61P31/18 , C07D401/10 , C07D403/14 , C07D233/88 , C07D487/04 , C07D417/10 , C07D471/04 , C07D417/14 , C07D491/107 , C07D401/14 , C07D405/14 , C07D413/14 , C07D403/10 , C07D413/10 , A61K45/06
Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
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公开(公告)号：US11318119B2
公开(公告)日：2022-05-03
申请号：US16849747
申请日：2020-04-15
Applicant: Gilead Sciences, Inc.
Inventor： Aesop Cho , John O. Link , Jie Xu
IPC: A61K31/4196 , A61K31/52 , A61K31/537 , A61K31/675 , A61K45/06 , A61P31/18 , A61K31/7076 , C07D403/10 , C07D403/14
Abstract: The present disclosure provides compounds, or a pharmaceutically acceptable salt thereof as described herein, useful for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a subject. The disclosure also provides pharmaceutical compositions comprising these compounds, processes for preparing them, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a subject using these compounds. The present disclosure also provides compounds, or a pharmaceutically acceptable salt thereof as described herein, useful for treating the proliferation of a coronavirus, treating coronavirus symptoms or delaying the onset of coronavirus symptoms in a subject. The disclosure also provides pharmaceutical compositions comprising these compounds, processes for preparing them, therapeutic methods for treating the proliferation of a coronavirus, treating coronavirus symptoms or delaying the onset of coronavirus symptoms in a subject using these compounds.
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公开(公告)号：US20210323922A1
公开(公告)日：2021-10-21
申请号：US17098171
申请日：2020-11-13
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Todd Appleby , Aesop Cho , Zhimin Du , Michael Graupe , Juan A. Guerrero , Salman Y. Jabri , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Prasenjit Kumar Mukherjee , Devan Naduthambi , Gregory Notte , Eric Q. Parkhill , Barton W. Phillips , Scott Preston Simonovich , Neil H. Squires , Chandrasekar Venkataramani , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC: C07D213/69 , A61K45/06 , A61K31/444 , C07D401/14 , A61K31/5377 , C07D213/85 , A61K31/44 , C07D213/30 , C07D295/088 , A61K31/4545 , C07D401/04 , A61K31/497 , C07D519/00 , C07D487/10 , C07D487/08 , C07D213/64 , C07D491/107 , C07D498/04 , C07D213/61 , C07D405/14
Abstract: Compounds according to formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US10774071B2
公开(公告)日：2020-09-15
申请号：US16510647
申请日：2019-07-12
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Aesop Cho , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Devan Naduthambi , Barton W. Phillips , Scott Preston Simonovich , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC: C07D401/14 , C07D471/08 , A61K31/444 , A61K31/497 , A61K31/704 , A61K31/7068 , A61K39/395 , A61P31/20
Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US10710986B2
公开(公告)日：2020-07-14
申请号：US16274106
申请日：2019-02-12
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Aesop Cho , Zhimin Du , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Prasenjit Kumar Mukherjee , Devan Naduthambi , Eric Q. Parkhill , Barton W. Phillips , Scott Preston Simonovich , Neil H. Squires , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC: C07D403/14 , A61P31/20 , A61P35/02 , A61K31/496 , C07D519/00 , C07D241/20 , C07D487/10 , C07D405/14 , C07D487/08 , A61K31/497 , C07D491/107 , C07D241/18 , A61P35/00 , C07K16/28
Abstract: Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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Patent Agency Ranking
26.发明申请公开(公告)号：US20180327437A1
公开(公告)日：2018-11-15
申请号：US16011055
申请日：2018-06-18
Applicant: GILEAD SCIENCES, INC.
Inventor： Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang
CPC classification number: C07H1/00 , A61K31/7052 , A61K31/7056 , A61K31/706 , C07H19/23
Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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公开(公告)号：USRE46762E1
公开(公告)日：2018-03-27
申请号：US15288271
申请日：2016-10-07
Applicant: Gilead Sciences, Inc.
Inventor： Thomas Butler , Aesop Cho , Choung U. Kim , Jay P. Parrish , Oliver L. Saunders , Lijun Zhang
CPC classification number: C07H19/23 , C07D487/04
Abstract: Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
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公开(公告)号：US08809266B2
公开(公告)日：2014-08-19
申请号：US13794389
申请日：2013-03-11
Applicant: Gilead Sciences, Inc.
Inventor： Aesop Cho , Michael O'Neil Hanrahan Clarke , Choung U. Kim , John O. Link , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
IPC: A61K38/00
CPC classification number: C07D417/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D487/04 , C07K5/0804 , C07K5/0808 , C07K5/0819 , C07K5/0821
Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20130274439A1
公开(公告)日：2013-10-17
申请号：US13794389
申请日：2013-03-11
Applicant: Gilead Sciences, Inc.
Inventor： Aesop Cho , Michael O'Neil Hanrahan Clarke , Choung U. Kim , John O. Link , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
CPC classification number: C07D417/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D487/04 , C07K5/0804 , C07K5/0808 , C07K5/0819 , C07K5/0821
Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US12269812B2
公开(公告)日：2025-04-08
申请号：US16923750
申请日：2020-07-08
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Aesop Cho , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Devan Naduthambi , Barton W. Phillips , Scott Preston Simonovich , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC: C07D401/14 , A61K31/444 , A61K31/497 , A61K31/704 , A61K31/7068 , A61K39/395 , C07D471/08
Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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