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公开(公告)号：US08962275B2
公开(公告)日：2015-02-24
申请号：US13335632
申请日：2011-12-22
申请人： Wei-Ching Liang , Gregory D. Plowman , Yan Wu , Weilan Ye
发明人： Wei-Ching Liang , Gregory D. Plowman , Yan Wu , Weilan Ye
IPC分类号： C07H21/04 , C12P21/06 , C12N15/87 , C12N1/20 , C12N15/74 , C07K16/28 , C07K16/22 , A61K39/00
CPC分类号： C07K16/2842 , A61K47/6835 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412
摘要： The present invention provides new anti-α5β1 antibodies, compositions and kits comprising the antibodies, and methods of making and using the antibodies.
摘要翻译： 本发明提供新的抗α5和bgr1抗体，包含抗体的组合物和试剂盒，以及制备和使用抗体的方法。
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公开(公告)号：US08840887B2
公开(公告)日：2014-09-23
申请号：US13112839
申请日：2011-05-20
申请人： Wei-Ching Liang , Gregory D. Plowman , Yan Wu , Weilan Ye
发明人： Wei-Ching Liang , Gregory D. Plowman , Yan Wu , Weilan Ye
CPC分类号： C07K16/2842 , A61K2039/505 , A61K2039/507 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to the use of VEGF antagonists and a novel anti-α5β1 antibody for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to compositions and kits comprising novel anti-α5β1 antibodies and methods of making and using them.
摘要翻译： 本发明涉及VEGF拮抗剂和新型抗α5抗体用于治疗癌症并抑制血管生成和/或血管通透性的用途，包括抑制疾病中的异常血管生成。 本发明还涉及包含新型抗α5和bgr1抗体的组合物和试剂盒，以及制备和使用它们的方法。
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公开(公告)号：US08268548B2
公开(公告)日：2012-09-18
申请号：US11788379
申请日：2007-04-18
申请人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danix Li , Roel P. Funke
发明人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danix Li , Roel P. Funke
IPC分类号： C12Q1/68
CPC分类号： C12Q1/485 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57407 , G01N2333/91215 , G01N2500/02
摘要： Human MAP3K genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MAP3K are provided.
摘要翻译： 人MAP3K基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节MAP3K活性的试剂。
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公开(公告)号：US20120156129A1
公开(公告)日：2012-06-21
申请号：US13112839
申请日：2011-05-20
申请人： Wei-Ching Liang , Gregory D. Plowman , Yan Wu , Weilan Ye
发明人： Wei-Ching Liang , Gregory D. Plowman , Yan Wu , Weilan Ye
IPC分类号： A61K39/395 , A61K51/10 , A61P35/00
CPC分类号： C07K16/2842 , A61K2039/505 , A61K2039/507 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to the use of VEGF antagonists and a novel anti-α5β1 antibody for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to compositions and kits comprising novel anti-α5β1 antibodies and methods of making and using them.
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公开(公告)号：US20110159508A1
公开(公告)日：2011-06-30
申请号：US12900340
申请日：2010-10-07
申请人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke
发明人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke
IPC分类号： C12Q1/68 , C12Q1/52 , G01N33/574
CPC分类号： G01N33/57484 , G01N33/5011 , G01N2510/00
摘要： Human GFAT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of GFAT are provided.
摘要翻译： 人GFAT基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节GFAT活性的试剂。
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公开(公告)号：US20100325743A1
公开(公告)日：2010-12-23
申请号：US12802748
申请日：2010-06-10
申请人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke , Mario N. Lioubin
发明人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke , Mario N. Lioubin
CPC分类号： G01N33/57423 , C12Q1/42 , C12Q1/485 , C12Q1/527 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/5308 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/4739 , G01N2333/62 , G01N2333/705 , G01N2333/82 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human MARK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MARK are provided.
摘要翻译： 人MARK基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节MARK活性的药剂。
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公开(公告)号：US20090220504A1
公开(公告)日：2009-09-03
申请号：US12293382
申请日：2007-03-21
IPC分类号： A61K39/395 , C07K16/28 , C07H21/00 , C12N15/63 , C12N5/00 , G01N33/53 , A61P35/00 , A61P37/00 , A61P27/02
CPC分类号： A61K39/3955 , A61K45/06 , A61K51/1093 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K16/2842 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/74
摘要： The present invention relates to the use of VEGF antagonists and alpha5beta1 antagonists for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to use of a VEGFR agonists and alpha5beta1 agonists to promote angiogenesis and vascular permeability. The present invention also relates to new anti-alpha5beta1 antibodies, compositions and kits comprising them and methods of making and using them.
摘要翻译： 本发明涉及VEGF拮抗剂和α5β1拮抗剂用于治疗癌症并抑制血管生成和/或血管通透性的用途，包括抑制疾病中的异常血管发生。 本发明还涉及VEGFR激动剂和α5β1激动剂促进血管生成和血管通透性的用途。 本发明还涉及新的抗α5β1抗体，包含它们的组合物和试剂盒以及制备和使用它们的方法。
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公开(公告)号：US06388063B1
公开(公告)日：2002-05-14
申请号：US09099053
申请日：1998-06-17
IPC分类号： C07H2104
CPC分类号： C12N9/1205 , C07K14/705 , C07K2319/00 , C12N9/16
摘要： The present invention relates to SAD polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for SAD related diseases or conditions characterized by an abnormal interaction between a SAD polypeptide and a SAD binding partner.
摘要翻译： 本发明涉及SAD多肽，编码此类多肽的核酸，含有此类核酸的细胞，组织和动物，此类多肽的抗体，利用此类多肽的测定法，以及与上述所有相关的方法。 提供了治疗，诊断和筛选的方法用于SAD相关疾病或特征为SAD多肽和SAD结合配偶体之间异常相互作用的病症。
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公开(公告)号：US5830648A
公开(公告)日：1998-11-03
申请号：US436065
申请日：1995-05-05
申请人： Gregory D. Plowman
发明人： Gregory D. Plowman
CPC分类号： C12Q1/6876 , C12Q2600/158 , C12Q2600/16
摘要： The invention is directed to assays and methods for transcript imaging. More particularly, the invention is directed to assays and methods for detecting, determining and quantifying the expression level of all known biomolecules in a family of biomolecules, including tyrosine kinases, tyrosine phosphatases and serine/threonine kinases, in uncharacterized biological samples, regardless of species. Such assays and methods may be used as a diagnostic, therapeutic and/or a research tools.
摘要翻译： 本发明涉及用于转录成像的测定和方法。 更具体地，本发明涉及用于检测，确定和定量生物分子家族中的所有已知生物分子的表达水平的测定和方法，所述生物分子包括酪氨酸激酶，酪氨酸磷酸酶和丝氨酸/苏氨酸激酶，而不考虑物种 。 这样的测定和方法可以用作诊断，治疗和/或研究工具。
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公开(公告)号：US5804396A
公开(公告)日：1998-09-08
申请号：US322868
申请日：1994-10-12
申请人： Gregory D. Plowman
发明人： Gregory D. Plowman
IPC分类号： C12Q1/48 , G01N33/50 , G01N33/566 , G01N33/574 , G01N33/48 , G01N33/53 , G01N33/567
CPC分类号： G01N33/5011 , C12Q1/48 , G01N33/566 , G01N2333/705 , G01N2333/9121
摘要： Method for identifying an agent for treatment of a proliferative disorder, comprising the steps of assaying a potential agent for activity in inhibition of signal transduction by a HER2/HER3 or HER2/HER4 or HER3/HER4 heterodimer. Method of screening for an agent that selectively inhibits the kinase activity of a heterodimer having one catalytically inactive component.
摘要翻译： 用于鉴定用于治疗增殖性疾病的药剂的方法，包括以下步骤：测定潜在药物用于抑制HER2 / HER3或HER2 / HER4或HER3 / HER4异型二聚体信号转导的活性。 筛选选择性抑制具有一个催化无活性组分的异二聚体的激酶活性的试剂的方法。
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