公开(公告)号：US20080123106A1

公开(公告)日：2008-05-29

申请号：US11722878

申请日：2005-12-23

Applicant: Haishan Zeng ,  Lioudmila Tchvialeva ,  Tim K. Lee ,  David I. McLean ,  Harvey Lui

Inventor： Haishan Zeng ,  Lioudmila Tchvialeva ,  Tim K. Lee ,  David I. McLean ,  Harvey Lui

IPC: G01B11/30 ,  G01B11/02 ,  G06F19/00 ,  A61B5/00

CPC classification number: A61B5/0066 ,  A61B5/444 ,  A61B5/445 ,  G01B11/303 ,  G01J9/02 ,  G01N21/47 ,  G01N2021/479

Abstract: Surface roughness measurements are made by illuminating a surface with coherent light to generate a speckle pattern and studying characteristics of the speckle pattern. The disclosed techniques may be applied to measuring the surface roughness of skin or other biological surfaces. Skin roughness information may be used in the diagnosis of conditions such as malignant melanoma. Methods and apparatus for measuring the coherence length of optical sources involve extracting information about speckle patterns resulting when light from the optical sources interacts with a surface having a known roughness.

Abstract translation: 通过用相干光照射表面以产生斑点图案并研究斑点图案的特征来进行表面粗糙度测量。 所公开的技术可以用于测量皮肤或其他生物表面的表面粗糙度。 皮肤粗糙度信息可用于诊断恶性黑色素瘤等病症。 用于测量光源的相干长度的方法和装置包括提取关于来自光源的光与具有已知粗糙度的表面相互作用的斑点图案的信息。

公开(公告)号：US20050167621A1

公开(公告)日：2005-08-04

申请号：US11057965

申请日：2005-02-14

Applicant: Haishan Zeng ,  Stephen Lam ,  Branko Palcic

Inventor： Haishan Zeng ,  Stephen Lam ,  Branko Palcic

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  G01J3/02 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G21K1/12 ,  A61B6/00 ,  G01N23/00 ,  G01N23/04 ,  G03C5/16 ,  G21K4/00 ,  H05G1/60

CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N2223/076

Abstract: Optical systems that provide for simultaneous images and spectra from an object, such as a tissue sample, an industrial object such as a computer chip, or any other object that can be viewed with an optical system such as a microscope, endoscope, telescope or camera. In some embodiments, the systems provide multiple images corresponding to various desired wavelength ranges within an original image of the object, as well as, if desired, directional pointer(s) that can provide both an identification of the precise location from which a spectrum is being obtained, as well as enhancing the ability to point the device.

Abstract translation: 提供来自物体的同时图像和光谱的光学系统，例如组织样本，诸如计算机芯片的工业对象或可以用诸如显微镜，内窥镜，望远镜或照相机的光学系统观察的任何其它物体 。 在一些实施例中，系统提供对应于对象的原始图像内的各种期望波长范围的多个图像，以及如果需要的方向指针，其可以提供频谱的精确位置的识别 获得，以及增强指向设备的能力。

公开(公告)号：US06898458B2

公开(公告)日：2005-05-24

申请号：US10028568

申请日：2001-12-19

Applicant: Haishan Zeng ,  Stephen Lam ,  Branko Michael Palcic

Inventor： Haishan Zeng ,  Stephen Lam ,  Branko Michael Palcic

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  G01J3/02 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  A61B6/00

CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N2223/076

Abstract: Optical systems that provide for simultaneous images and spectra from an object, such as a tissue sample, an industrial object such as a computer chip, or any other object that can be viewed with an optical system such as a microscope, endoscope, telescope or camera. In some embodiments, the systems provide multiple images corresponding to various desired wavelength ranges within an original image of the object, as well as, if desired, directional pointer(s) that can provide both an identification of the precise location from which a spectrum is being obtained, as well as enhancing the ability to point the device.

Abstract translation: 提供来自物体的同时图像和光谱的光学系统，例如组织样本，诸如计算机芯片的工业对象或可以用诸如显微镜，内窥镜，望远镜或照相机的光学系统观察的任何其它物体 。 在一些实施例中，系统提供对应于对象的原始图像内的各种期望波长范围的多个图像，以及如果需要的方向指针，其可以提供频谱的精确位置的识别 获得，以及增强指向设备的能力。

公开(公告)号：US06201989B1

公开(公告)日：2001-03-13

申请号：US09041861

申请日：1998-03-12

Applicant: Peter D. Whitehead ,  Calum E. MacAulay ,  Nicholas B. MacKinnon ,  Haishan Zeng ,  Christopher R. Thompson ,  Bruce M. McManus

Inventor： Peter D. Whitehead ,  Calum E. MacAulay ,  Nicholas B. MacKinnon ,  Haishan Zeng ,  Christopher R. Thompson ,  Bruce M. McManus

IPC: A61B600

CPC classification number: A61B10/06 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/413 ,  A61B5/416 ,  A61B5/6848 ,  A61B5/7285 ,  A61B2017/2934 ,  A61B2090/3614 ,  A61B2090/373

Abstract: Methods and apparatus for detecting the possible rejection of a transplanted tissue by a host. The transplanted tissue is subjected to illumination with light to induce fluorescence. The light can be ultraviolet light, visible light or infrared light, which can be used alone or in any combination, which means one, two or three forms of light may be used together. The induced fluorescence is collected and analyzed, then compared with fluorescence that is obtained using the same procedure for a known, healthy tissue that is the same type of tissue as the transplanted tissue. Also provided are methods and apparatus related to the determination of probe orientation and the need for biopsy.

Abstract translation: 用于检测宿主可能排斥移植组织的方法和装置。 用光照射移植组织以诱导荧光。 光可以是紫外光，可见光或红外光，其可以单独使用或以任何组合使用，这意味着一种，两种或三种形式的光可以一起使用。 收集和分析诱导的荧光，然后与使用与移植组织相同类型的组织的已知健康组织相同的程序获得的荧光进行比较。 还提供了与确定探针取向和活检需要有关的方法和装置。

公开(公告)号：US6069689A

公开(公告)日：2000-05-30

申请号：US59885

申请日：1998-04-14

Applicant: Haishan Zeng ,  Harvey Lui ,  Calum MacAulay ,  Branko Palcic ,  David I. McLean

Inventor： Haishan Zeng ,  Harvey Lui ,  Calum MacAulay ,  Branko Palcic ,  David I. McLean

IPC: A61B5/00 ,  A61B5/103 ,  G01N21/64 ,  G01N21/65 ,  G01B9/02 ,  G01N11/00

CPC classification number: G01N21/474 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/444 ,  G01N21/645 ,  G01N21/6486 ,  G01N21/65 ,  G01N2021/475 ,  G01N2021/6417 ,  G01N2021/656 ,  G01N2201/0627

Abstract: Apparatus for diagnosis of a skin disease site using spectral analysis includes a light source for generating light to illuminate the disease site and a probe unit optically connected to the light source for exposing the disease site to light to generate fluorescence and reflectance light. The probe unit also collects the generated fluorescence and reflectance light and transmits this light to a spectrometer to be analyzed. The spectrometer generates and displays spectral measurements of the fluorescence light and the reflectance light which in together assist the user in diagnosing the disease site. The apparatus makes use of a conventional personal computer using a plug-in spectrometer card to provide a compact and low costs system. The system performs combined fluorescence and reflectance spectral analysis in a quick and efficient manner to provide a powerful tool for dermatologic diagnosis.

Abstract translation: 用于使用光谱分析诊断皮肤疾病部位的装置包括用于产生照亮疾病部位的光的光源和与光源光学连接的探针单元，用于将疾病部位暴露于光以产生荧光和反射光。 探针单元还收集产生的荧光和反射光，并将该光传输到要分析的光谱仪。 光谱仪产生和显示荧光和反射光的光谱测量，这些在一起协助用户诊断疾病部位。 该装置利用使用插入式光谱仪卡的常规个人计算机来提供紧凑且低成本的系统。 该系统以快速有效的方式进行组合荧光和反射光谱分析，为皮肤病诊断提供强大的工具。

公开(公告)号：US5647368A

公开(公告)日：1997-07-15

申请号：US608185

申请日：1996-02-28

Applicant: Haishan Zeng ,  Richard W. Cline ,  Calum E. MacAulay ,  Bruno W. Jaggi

Inventor： Haishan Zeng ,  Richard W. Cline ,  Calum E. MacAulay ,  Bruno W. Jaggi

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  A61B5/00 ,  G01N21/76 ,  G01N33/483

CPC classification number: A61B5/42 ,  A61B1/00009 ,  A61B1/00186 ,  A61B1/042 ,  A61B1/043 ,  A61B1/0646 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/4255

Abstract: A system for detecting cancerous or precancerous lesions directs light produced from a mercury arc lamp into an illumination guide of an endoscope. Autofluorescence light produced by the tissue under examination is divided into red and green spectral bands by a dichroic mirror. Light in the red and green spectral band is applied to a pair of image intensified CCD cameras. The output of the camera that receives light in the red spectral band is coupled to a red video input of a color video monitor. Light produced by the camera that receives light in the green spectral band is coupled to the blue and green video inputs of the video monitor. The system produces a false color display, whereby healthy tissue appears cyan in color and cancerous or precancerous lesions appear reddish in color. The image displayed allows the operator to see the lesions within the context of the underlying tissue structures. The color contrast is adjustable to account for the autofluorescence property changes from patient to patient and from location to location.

Abstract translation: 用于检测癌性或癌前病变的系统将从汞弧灯产生的光引导到内窥镜的照明引导件中。 由检查中的组织产生的自发荧光由分色镜分为红色和绿色光谱带。 红色和绿色光谱带中的光被应用于一对图像增强的CCD照相机。 在红色光谱带中接收光的相机的输出被耦合到彩色视频监视器的红色视频输入​​。 由接收绿色光谱带中的光的相机产生的光耦合到视频监视器的蓝色和绿色视频输入​​。 该系统产生假彩色显示，其中健康组织呈现青色，癌变或癌前病变呈现红色。 显示的图像允许操作者在下面的组织结构的上下文中看到病变。 颜色对比度是可调整的，以解释从患者到患者以及从位置到位置的自发荧光性质变化。

公开(公告)号：US20130231573A1

公开(公告)日：2013-09-05

申请号：US13521218

申请日：2011-01-21

Applicant: Haishan Zeng ,  Michael Short ,  Stephen Lam ,  Annette McWilliams

Inventor： Haishan Zeng ,  Michael Short ,  Stephen Lam ,  Annette McWilliams

IPC: A61B5/00

CPC classification number: A61B5/0075 ,  A61B5/0071 ,  A61B5/0084 ,  G01N21/65

Abstract: Near-infrared Raman spectroscopy can be applied to identify preneoplastic lesions of the bronchial tree. Real-time in vivo Raman spectra of lung tissues may be obtained with a fiber optic catheter passed down the instrument channel of a bronchoscope. Using prototype apparatus, preneoplastic lesions were detected with sensitivity and specificity of 96 and 91% respectively. The use of Raman spectroscopy apparatus and methods in conjunction with other bronchoscopy imaging modalities can substantially reduce the number of false positive results.

Abstract translation: 近红外拉曼光谱可用于鉴定支气管树瘤的肿瘤前病变。 肺组织的实时体内拉曼光谱可以通过沿支气管镜仪器通道向下传播的光纤导管获得。 使用原型装置，分别检测到96和91％的敏感性和特异性的癌前病变。 使用拉曼光谱设备和方法与其他支气管镜检查成像模式联合可以大大减少假阳性结果的数量。

公开(公告)号：US07253894B2

公开(公告)日：2007-08-07

申请号：US11053263

申请日：2005-02-07

Applicant: Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

Inventor： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

IPC: G01J3/28

CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N2223/076

Abstract: Optical systems that provide for simultaneous images and spectra from an object, such as a tissue sample, an industrial object such as a computer chip, or any other object that can be viewed with an optical system such as a microscope, endoscope, telescope or camera. In some embodiments, the systems provide multiple images corresponding to various desired wavelength ranges within an original image of the object, as well as, if desired, directional pointer(s) that can provide both an identification of the precise location from which a spectrum is being obtained, as well as enhancing the ability to point the device.

Abstract translation: 提供来自物体的同时图像和光谱的光学系统，例如组织样本，诸如计算机芯片的工业对象或可以用诸如显微镜，内窥镜，望远镜或照相机的光学系统观察的任何其它物体 。 在一些实施例中，系统提供对应于对象的原始图像内的各种期望波长范围的多个图像，以及如果需要的方向指针，其可以提供频谱的精确位置的识别 获得，以及增强指向设备的能力。

公开(公告)号：US07115841B2

公开(公告)日：2006-10-03

申请号：US11057965

申请日：2005-02-14

Applicant: Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

Inventor： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

IPC: H05B3/02

CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N2223/076

Abstract: Optical systems that provide for simultaneous images and spectra from an object, such as a tissue sample, an industrial object such as a computer chip, or any other object that can be viewed with an optical system such as a microscope, endoscope, telescope or camera. In some embodiments, the systems provide multiple images corresponding to various desired wavelength ranges within an original image of the object, as well as, if desired, directional pointer(s) that can provide both an identification of the precise location from which a spectrum is being obtained, as well as enhancing the ability to point the device.

Abstract translation: 提供来自物体的同时图像和光谱的光学系统，例如组织样本，诸如计算机芯片的工业对象或可以用诸如显微镜，内窥镜，望远镜或照相机的光学系统观察的任何其它物体 。 在一些实施例中，系统提供对应于对象的原始图像内的各种期望波长范围的多个图像，以及如果需要的方向指针，其可以提供频谱的精确位置的识别 获得，以及增强指向设备的能力。

公开(公告)号：US20050203423A1

公开(公告)日：2005-09-15

申请号：US11058045

申请日：2005-02-14

Applicant: Haishan Zeng ,  Stephen Lam ,  Branko Palcic

Inventor： Haishan Zeng ,  Stephen Lam ,  Branko Palcic

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  G01J3/02 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G21K1/12 ,  A61B6/00 ,  G01N23/00 ,  H05G1/60

CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N2223/076

Abstract: Optical systems that provide for simultaneous images and spectra from an object, such as a tissue sample, an industrial object such as a computer chip, or any other object that can be viewed with an optical system such as a microscope, endoscope, telescope or camera. In some embodiments, the systems provide multiple images corresponding to various desired wavelength ranges within an original image of the object, as well as, if desired, directional pointer(s) that can provide both an identification of the precise location from which a spectrum is being obtained, as well as enhancing the ability to point the device.

Abstract translation: 提供来自物体的同时图像和光谱的光学系统，例如组织样本，诸如计算机芯片的工业对象或可以用诸如显微镜，内窥镜，望远镜或照相机的光学系统观察的任何其它物体 。 在一些实施例中，系统提供对应于对象的原始图像内的各种期望波长范围的多个图像，以及如果需要的方向指针，其可以提供频谱的精确位置的识别 获得，以及增强指向设备的能力。