公开(公告)号：US08413507B2

公开(公告)日：2013-04-09

申请号：US12801405

申请日：2010-06-08

申请人： Tetsuo Fujii ,  Hisanori Yokura ,  Hirofumi Higuchi

发明人： Tetsuo Fujii ,  Hisanori Yokura ,  Hirofumi Higuchi

IPC分类号： G01C19/56 ,  G01P15/125

CPC分类号： H01L27/1203 ,  B81B2201/025 ,  B81B2201/0257 ,  B81B2201/0285 ,  B81B2201/047 ,  B81C1/00182 ,  G01C19/5755 ,  G01P15/0802 ,  G01P15/125 ,  G01P2015/0814 ,  H01L21/84

摘要： A semiconductor dynamic quantity sensor has a substrate including a semiconductor substrate, an insulation layer on a main surface of the semiconductor substrate, and a semiconductor layer on the insulation layer. The main surface has a projection that is trapezoidal or triangular in cross section. The semiconductor layer is divided by a through hole into a movable portion. A tip of the projection is located directly below the movable portion and spaced from the movable portion by a predetermined distance in a thickness direction of the substrate. A width of the tip of the projection is less than a width of the movable portion in a planar direction of the substrate. The distance between the tip of the projection and the movable portion is equal to a thickness of the insulation layer.

摘要翻译： 半导体动态量传感器具有包括半导体衬底，半导体衬底的主表面上的绝缘层和绝缘层上的半导体层的衬底。 主表面具有横截面为梯形或三角形的突起。 半导体层由通孔分割成可动部。 突出部的尖端位于可动部的正下方，与基板的厚度方向与可动部隔开预定的距离。 突起的尖端的宽度小于基板的平面方向上的可动部的宽度。 突起的尖端和可动部之间的距离等于绝缘层的厚度。

公开(公告)号：US20110059077A1

公开(公告)日：2011-03-10

申请号：US12812341

申请日：2009-01-09

申请人： Kenji Uehara ,  Hirofumi Higuchi ,  Toshihiro Nakashima ,  Daisuke Ishikawa ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Fumihiko Sakai

发明人： Kenji Uehara ,  Hirofumi Higuchi ,  Toshihiro Nakashima ,  Daisuke Ishikawa ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Fumihiko Sakai

IPC分类号： C07K16/28 ,  C12N15/13 ,  C12N15/70 ,  C12N1/21 ,  C12P21/08 ,  A61K39/395

CPC分类号： C07K16/2839 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.

摘要翻译： 本发明提供与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体，即包含重链可变区的人源化抗人α9整联蛋白抗体，其包含 的SEQ ID NO：11所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，含有重链可变区的人源化抗人α9整联蛋白抗体由 由SEQ ID NO：13所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，包含由SEQ ID NO：17所示的重链可变区组成的人源化抗人α9整联蛋白抗体 由SEQ ID NO：15所示的氨基酸序列和由SEQ ID NO：9所示的氨基酸序列组成的轻链可变区，以及用于预防或治疗涉及人α9整数的各种疾病的手段 rin在发病机制中，其使用抗体。

公开(公告)号：US20110014193A1

公开(公告)日：2011-01-20

申请号：US12812368

申请日：2009-07-09

申请人： Kenji Uehara ,  Hirofumi Higuchi ,  Toshihiro Nakashima ,  Daisuke Ishikawa ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Fumihiko Sakai

发明人： Kenji Uehara ,  Hirofumi Higuchi ,  Toshihiro Nakashima ,  Daisuke Ishikawa ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Fumihiko Sakai

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C12P21/06 ,  A61P19/02

CPC分类号： C07K16/2839 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 1 or the amino acid sequence shown by SEQ ID NO: 1 wherein one or several amino acids are substituted, deleted, inserted and/or added and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 61 or the amino acid sequence shown by SEQ ID NO: 61 wherein one or several amino acids are substituted, deleted, inserted and/or added, as well as a means for preventing or treating various diseases involving human α9 integrin in their pathogenesis, which uses the antibody.

摘要翻译： 本发明提供了与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体，即人源化抗人α9整联蛋白抗体，其包含由以下组成的重链可变区： SEQ ID NO：1所示的氨基酸序列或SEQ ID NO：1所示的氨基酸序列，其中一个或几个氨基酸被取代，缺失，插入和/或添加，以及由氨基酸组成的轻链可变区 SEQ ID NO：61所示的酸序列或SEQ ID NO：61所示的氨基酸序列，其中一个或几个氨基酸被取代，缺失，插入和/或添加，以及用于预防或治疗涉及 人α9整合素在其发病机制中，其使用抗体。

公开(公告)号：US07807161B2

公开(公告)日：2010-10-05

申请号：US11755671

申请日：2007-05-30

申请人： Nobuchika Yamamoto ,  Fumihiko Sakai ,  Hirofumi Higuchi ,  Masaharu Torikai ,  Toshihiro Nakashima

发明人： Nobuchika Yamamoto ,  Fumihiko Sakai ,  Hirofumi Higuchi ,  Masaharu Torikai ,  Toshihiro Nakashima

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/46 ,  C07K16/24

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56

摘要： The present invention provides a humanized anti-human osteopontin antibody having better activities (antigen binding activity, leukocyte migration inhibitory activity and the like) and/or stability (resistance to heat, low-pH conditions, denaturants and the like) than those of conventional anti-human osteopontin antibodies.

摘要翻译： 本发明提供具有比常规的更好的活性（抗原结合活性，白细胞迁移抑制活性等）和/或稳定性（耐热，低pH条件，变性剂等）的人源化抗人骨桥蛋白抗体 抗人骨桥蛋白抗体。

公开(公告)号：US20100050767A1

公开(公告)日：2010-03-04

申请号：US12585052

申请日：2009-09-01

申请人： Hirofumi Higuchi ,  Tetsuo Fujii ,  Masaki Inoue

发明人： Hirofumi Higuchi ,  Tetsuo Fujii ,  Masaki Inoue

IPC分类号： G01C19/56

CPC分类号： G01C19/5719

摘要： An angular velocity sensor includes first and second oscillators and a coupling beam. The coupling beam couples the first and second oscillators together in such a manner that the first and second oscillators vibrate relative to each other in a predetermined direction. The coupling beam includes a first post portion joined to a surface of the first oscillator, a second post portion joined to a surface of the second oscillator, and a spring portion that joins the first post portion to the second post portion. The spring portion is spaced from the first and second oscillators and has elasticity in the predetermined direction.

摘要翻译： 角速度传感器包括第一和第二振荡器和耦合梁。 耦合光束以第一和第二振荡器在预定方向上相对于彼此振动的方式将第一和第二振荡器耦合在一起。 耦合梁包括接合到第一振荡器的表面的第一柱部分，与第二振荡器的表面接合的第二柱部分，以及将第一柱部分连接到第二柱部分的弹簧部分。 弹簧部分与第一和第二振荡器间隔开，并且在预定方向上具有弹性。

公开(公告)号：US07276834B2

公开(公告)日：2007-10-02

申请号：US11489682

申请日：2006-07-20

申请人： Hirofumi Higuchi

发明人： Hirofumi Higuchi

IPC分类号： H02N1/00 ,  G01P15/125 ,  G01P15/00 ,  G01P3/44

CPC分类号： G01C19/5762

摘要： An oscillator is oscillatable in a predetermined direction. First and second driving electrodes are secured to the base and apply an electrostatic force to the oscillator to make drive oscillation of the oscillator in the predetermined direction. At the time of the drive oscillation of the oscillator, a predetermined electric charge is accumulated in the oscillator, and electric charges of opposite polarities are alternately and periodically accumulated in the first and second driving electrodes, respectively, to exert an attractive force between the oscillator and a corresponding one of the first and second driving electrodes and also to exert a repulsive force between the oscillator and the other one of the first and second driving electrodes, and vice versa.

摘要翻译： 振荡器可在预定方向上振荡。 第一驱动电极和第二驱动电极固定到基座并向振荡器施加静电力，以使振荡器在预定方向上的驱动振荡。 在振荡器的驱动振荡时，在振荡器中累积预定的电荷，相反极性的电荷分别交替地周期地累积在第一和第二驱动电极中，以在振荡器之间施加吸引力 以及第一和第二驱动电极中的相应一个，并且还在振荡器和第一和第二驱动电极中的另一个之间施加排斥力，反之亦然。

公开(公告)号：US07028548B2

公开(公告)日：2006-04-18

申请号：US10811877

申请日：2004-03-30

申请人： Hirofumi Higuchi ,  Takeshi Ito

发明人： Hirofumi Higuchi ,  Takeshi Ito

IPC分类号： G01P9/04

CPC分类号： G01C19/5719

摘要： To cancel in-phase components acting on vibrators of first and second sensor units in an angular velocity sensing direction Y, a differential amplification circuit obtains a differential waveform between a first angular velocity sensing waveform J1 and a second angular velocity waveform J2. Furthermore, to reduce a residual in-phase component of the obtained differential waveform, input gain adjusting circuits adjust an input gain of the first angular velocity sensing waveform J1 and an input gain of the second angular velocity sensing waveform J2 before these waveforms J1 and J2 are entered into the differential amplification circuit.

摘要翻译： 为了抵消作用在角速度感测方向Y上的第一和第二传感器单元的振动器的同相分量，差分放大电路获得第一角速度感测波形J 1和第二角速度波形J 2之间的差分波形。此外 为了减小获得的差分波形的残余同相分量，输入增益调整电路在这些波形J 1之前调整第一角速度检测波形J 1的输入增益和第二角速度检测波形J 2的输入增益 和J 2进入差分放大电路。

公开(公告)号：US6151966A

公开(公告)日：2000-11-28

申请号：US304849

申请日：1999-05-05

申请人： Minekazu Sakai ,  Yukihiro Takeuchi ,  Kazuhiko Kano ,  Seiji Fujino ,  Tsuyoshi Fukada ,  Hiroshige Sugito ,  Minoru Murata ,  Hiroshi Muto ,  Hirofumi Higuchi ,  Kenichi Ao

发明人： Minekazu Sakai ,  Yukihiro Takeuchi ,  Kazuhiko Kano ,  Seiji Fujino ,  Tsuyoshi Fukada ,  Hiroshige Sugito ,  Minoru Murata ,  Hiroshi Muto ,  Hirofumi Higuchi ,  Kenichi Ao

IPC分类号： G01P15/08 ,  G01P15/125 ,  H01L29/84 ,  G01L1/00

CPC分类号： G01P15/125 ,  G01P15/0802 ,  G01P2015/0814

摘要： A semiconductor accelerometer device is formed on an SOI substrate by micro-machining. A movable unit is supported at both ends, and a weight portion is movable in response to acceleration exerted in the detection direction. A movable electrode is formed in a comb shape integrally with the weight portion. A pair of fixed electrodes in a comb shape are cantilevered and interleaved with the movable electrode to face the movable electrode. A plurality of through holes is provided in the electrodes so that the electrodes have Rahmen structure which is a series of rectangular frames. This structure reduces the weight of each electrode while increasing the strength against twist force. The electrodes are less likely from breaking in response to an acceleration exerted in a direction perpendicular to the normal detection direction because of reduced weight.

摘要翻译： 通过微加工在SOI衬底上形成半导体加速度计装置。 可移动单元被支撑在两端，并且重量部分可响应于沿检测方向施加的加速度而移动。 可动电极与配重部一体地形成为梳形。 一对梳状的固定电极是悬臂式的，与可动电极交错而面对可动电极。 多个通孔设置在电极中，使得电极具有Rahmen结构，其是一系列矩形框架。 这种结构减小了每个电极的重量，同时增加了抗扭力的强度。 由于重量减轻，电极响应于垂直于正常检测方向的方向的加速度而不太可能破裂。

公开(公告)号：US08794069B2

公开(公告)日：2014-08-05

申请号：US13531680

申请日：2012-06-25

申请人： Takashi Katsumata ,  Hirofumi Higuchi

发明人： Takashi Katsumata ,  Hirofumi Higuchi

IPC分类号： G01C19/56

CPC分类号： G01C19/5712

摘要： An angular velocity sensor includes a vibrator, a support substrate, an anchor section, a connection beam section, a driving section, and a detection section. The vibrator includes an inner vibrator and an outer vibrator, which vibrate in opposite circumferential directions when driven by the driving section. The connection beam section couples the vibrator to the anchor section, and is elastic in a z-direction and a circumferential direction. The connection beam section includes first connection beams, each of which is coupled to the outer vibrator at one end and is coupled to the inner vibrator at the other end, and second connection beams, each of which is coupled to a vibration node of a corresponding first connection beam at one end and is coupled to the anchor section at the other end.

摘要翻译： 角速度传感器包括振动器，支撑基板，锚固部分，连接梁部分，驱动部分和检测部分。 振动器包括内部振动器和外部振动器，当由驱动部驱动时振动器在外周振动。 连接梁部分将振动器连接到锚固部分，并且在z方向和圆周方向上是弹性的。 连接梁部分包括第一连接梁，每个连接梁在一端连接到外部振动器，并在另一端连接到内部振动器;第二连接梁，每个连接梁连接到相应的振动节点 第一连接梁在一端并且在另一端耦合到锚固部分。

公开(公告)号：US08332159B2

公开(公告)日：2012-12-11

申请号：US10546293

申请日：2004-02-18

申请人： Toshio Murakami ,  Hirofumi Higuchi ,  Keiichi Makizumi ,  Toshihiro Maeda ,  Hiroshi Mizokami

发明人： Toshio Murakami ,  Hirofumi Higuchi ,  Keiichi Makizumi ,  Toshihiro Maeda ,  Hiroshi Mizokami

IPC分类号： G06F7/00

CPC分类号： C07K16/00 ,  A61K2039/505 ,  C07K16/1063 ,  C07K2317/34

摘要： A method of enhancing the efficacy of a monoclonal antibody preparation wherein antigens from patients are tested for their reactivity with the antibody. An amino acid sequence of an expressed protein is deuced from a nucleotide sequence determined by isolation and analysis of a target molecule gene in a biopsy from a patient. This is compared with the previously determined amino acid sequence recognized by the monoclonal antibody preparation in order to assess the fitness of patients for administration of the monoclonal antibody preparation.

摘要翻译： 一种提高单克隆抗体制剂的功效的方法，其中测试来自患者的抗原与抗体的反应性。 通过从患者的活组织检查中分离和分析靶分子基因而确定的核苷酸序列，从表达的蛋白质的氨基酸序列中去除。 将其与由单克隆抗体制剂识别的先前确定的氨基酸序列进行比较，以评估患者施用单克隆抗体制剂的适合性。