摘要:
The present invention provides devices, apparatuses and methods for automated processing of biological samples. This invention provides automated devices and automated methods of sequentially treating a biological sample with processing fluids in more than one washing basin. In some embodiments, the invention provides automated devices and automated methods of western blot processing. In some embodiments, the invention provides automated devices and automated methods of Southern blot processing. In some embodiments, the invention provides automated devices and automated methods of northern blot processing. In some embodiments, the invention provides automated devices and automated methods of staining biomolecules on solid supports. In some embodiments, the invention provides automated devices and automated methods of nucleic acid separation and isolation.
摘要:
The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinase activator activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucokinase activator is indicated, including Type 1 and 2 diabetes, impaired glucose tolerance, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formulas I and II, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.
摘要:
A method for controlling pulsed power that includes measuring a first pulse of power from a power amplifier to obtain data. The method also includes generating a first signal to adjust a second pulse of delivered power, the first signal correlated to the data to minimize a power difference between a power set point and a substantially stable portion of the second pulse. The method also includes generating a second signal to adjust the second pulse of delivered power, the second signal correlated to the data to minimize an amplitude difference between a peak of the second pulse and the substantially stable portion of the second pulse.
摘要:
A power converter includes first and second circuit modules, a first capacitor, a second diode and a control module. The first circuit module includes a switching element in parallel with a first diode. The second circuit module includes a first inductor and the first circuit module. The inductor is in series with the first circuit module. The first capacitor is in parallel with the second circuit module. The second diode includes a first terminal and a second terminal, where the first terminal is in series with the second circuit module and the first capacitor, and the second terminal is coupled to a second power terminal. The control module varies one or more of the first capacitor and the first inductor based on at least one of a current of a load circuit or an input voltage. A resonating waveform is generated by a resonant circuit of the second circuit and is used by the control module to turn off the switching element under zero-current and zero-voltage conditions.
摘要:
A power converter includes first and second circuit modules, a first capacitor, a second diode and a control module. The first circuit module includes a switching element in parallel with a first diode. The second circuit module includes a first inductor and the first circuit module. The inductor is in series with the first circuit module. The first capacitor is in parallel with the second circuit module. The second diode includes a first terminal and a second terminal, where the first terminal is in series with the second circuit module and the first capacitor, and the second terminal is coupled to a second power terminal. The control module varies one or more of the first capacitor and the first inductor based on at least one of a current of a load circuit or an input voltage. A resonating waveform is generated by a resonant circuit of the second circuit and is used by the control module to turn off the switching element under zero-current and zero-voltage conditions.
摘要:
A switching apparatus includes a first transistor, a second transistor, a first circuit module, a first current sensor and a control circuit. The first transistor includes first, second and third terminals. The first terminal of the first transistor is coupled to a first power terminal. The third terminal of the first transistor includes a gate or base of the first transistor. The second transistor includes first, second and third terminals. The first terminal of the second transistor is coupled to a second power terminal. The second terminal of the second transistor is coupled to the second terminal of the first transistor. The third terminal of the second transistor includes a gate or base of the second transistor. The first circuit module includes an inductor in parallel with a diode. The first circuit module is connected between the first terminal of the second transistor and the second power terminal.
摘要:
An LED lamp includes an optical part, a heat dissipation part and an electric part. The optical part includes main and auxiliary LED light sources thermally attached to the heat dissipation part. The electric part includes a rechargeable battery and a circuitry for converting an external AC power source into first and second DC power sources. The auxiliary LED light source is connected to the first DC power source for providing an auxiliary illumination when the external AC power source is normally supplied or to the rechargeable battery for providing an emergency illumination when the external AC power source is interrupted. The main LED light source is connected to the second DC power source for providing normal illumination when the external AC power source is supplied normally. Photoelectric switches are also provided for controlling the action of the auxiliary LED light source.
摘要:
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided.
摘要:
Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-containing compound can each be a non-natural amino acid or a non-natural amino acid polypeptide. Also disclosed is the use of such accelerants to form oxime-containing compounds, the resulting oxime-containing compounds, and reaction mixtures containing such accelerants.