-
公开(公告)号：US20220276169A1
公开(公告)日：2022-09-01
申请号：US17663476
申请日：2022-05-16
Applicant: Illumina, Inc.
Inventor： Yinghua Sun , Stanley S. Hong , Frederick Erie , Alex Nemiroski , M. Shane Bowen , Danilo Condello , Dietrich Dehlinger , Marco A. Krumbuegel , Anthony Lam , Aaron Liu , Bojan Obradovic , Mark Pratt
IPC: G01N21/64
Abstract: A system includes: an objective lens; a first light source to feed first illuminating light through the objective lens and into a flowcell (e.g., with a relatively thin film waveguide) to be installed in the system, the first illuminating light to be fed using a first grating on the flowcell; and a first image sensor to capture imaging light using the objective lens, wherein the first grating is positioned outside a field of view of the first image sensor. Dual-surface imaging can be performed. Flowcells with multiple swaths bounded by gratings can be used. An auto-alignment process can be performed.
-
公开(公告)号：US11190706B2
公开(公告)日：2021-11-30
申请号：US16859948
申请日：2020-04-27
Applicant: Illumina, Inc.
Inventor： Danilo Condello , Simon Prince , David Hargis , Jeffrey Bendick , Christophe Sigel
Abstract: Systems and methods disclosed herein include an imaging system that may include a laser diode source; an objective lens positioned to direct a focus tracking beam from the light source onto a location in a sample container and to receive the focus tracking beam reflected from the sample; and an image sensor that may include a plurality of pixel locations to receive focus tracking beam that is reflected off of the location in the sample container, where the reflected focus tracking beam may create a spot on the image sensor. Some examples may further include a laser diode light source that may be operated at a power level that is above a power level for operation at an Amplified Spontaneous Emission (“ASE”) mode, but below a power level for single mode operation.
-
公开(公告)号：US20180259760A1
公开(公告)日：2018-09-13
申请号：US15913903
申请日：2018-03-06
Applicant: ILLUMINA, INC.
Inventor： Danilo Condello , Simon Prince , John O'Shaughnessy , Christophe Sigel , Ashkan Arianpour
Abstract: Provided herein is an imaging system including a light source; a first focusing lens positioned to focus a beam from the light source to a beam waist at a predetermined location along an optical path of the beam in the imaging system; a beam splitter positioned relative to the first focusing lens to receive the beam from the first focusing lens and to create first and second beams; a second focusing lens positioned to receive the first and second beams output by the beam splitter, to focus the received first and second beams to a spot sized dimensioned to fall within a sample to be image, and further positioned to receive first and second beams reflected from the sample; an image sensor positioned to receive the light beams reflected from the sample; and a roof prism positioned in the optical path between the second focusing lens and the image sensor.
-
公开(公告)号：US20180259758A1
公开(公告)日：2018-09-13
申请号：US15913892
申请日：2018-03-06
Applicant: ILLUMINA, INC.
Inventor： Danilo Condello , Simon Prince , David Hargis , John O'Shaughnessy , William Butterfield , Jeffrey Bendick , Peter Clarke Newman
CPC classification number: G02B21/002 , G02B21/06 , G02B21/18 , G02B21/245 , G02B21/36 , G02B21/361
Abstract: Systems and methods disclosed herein include an optical blocking structure that may include a frame defining an aperture, first and second elongate structural members each comprising first and second ends such that the first and second elongate structural members may be connected at their first ends to opposite sides of the aperture, and further such that the first and second elongate structural members may extend from the frame parallel to and in the same direction as one another; and an optically opaque blocking member positioned to extend between the respective second ends of the first and second blocking members.
-
公开(公告)号：US20250004244A1
公开(公告)日：2025-01-02
申请号：US18759291
申请日：2024-06-28
Applicant: ILLUMINA, INC.
Inventor： Dustin Blair , Gregory Holst , Merek Siu , Paul Sangiorgio , Dakota Watson , Danilo Condello , John Earney , Peter Newman
Abstract: An imaging system includes a focus tracking module including: a light source to project a first pair of spots on a sample; and a first image sensor to obtain one or more first images of the first pair of spots; a second image sensor to obtain one or more second images of the sample; one or more mirrors optically coupled to the second image sensor, the one or more mirrors positioned in an optical path from the sample to the second image sensor; and a controller to: determine, using at least a first separation distance measurement of the first pair of spots from the one or more first images, a first sample tilt of the sample about a first axis of the imaging system; and actuate, based at least on the first sample tilt, the one or more mirrors to offset the first sample tilt about the first axis.
-
Patent Agency Ranking
公开(公告)号：US20220308354A1
公开(公告)日：2022-09-29
申请号：US17704485
申请日：2022-03-25
Applicant: ILLUMINA, INC.
Inventor： Steven Boege , Simon Prince , Danilo Condello
Abstract: Apparatus and methods for transmitting light are disclosed. In an implementation, an apparatus includes a collimator at an input end positioned to receive an input beam from a fiber beam source and to produce a collimated beam. The apparatus further includes a beam shaping group having one or more optical elements and positioned to receive the collimated beam from the collimator and format the collimated beam into a shaped propagation beam having a substantially rectangular cross-section in a far field. The apparatus further includes an objective stage for optically probing a sample, such as a flow cell, using substantially rectangular cross-section sampling beam, where fluorescence from the sample is captured by a line sensor for detecting properties of the sample, such as chemical reactions therein.
-
公开(公告)号：US11226475B2
公开(公告)日：2022-01-18
申请号：US16621111
申请日：2019-01-14
Applicant: Illumina, Inc. , Illumina Cambridge Limited
Inventor： Peter Clarke Newman , Danilo Condello , Shaoping Lu , Simon Prince , Merek C. Siu , Stanley S. Hong , Aaron Liu , Gary Mark Skinner , Geraint Wyn Evans
IPC: G02B21/06 , G02B5/18 , G02B21/00 , G02B21/16 , G02B21/26 , G02B21/36 , G02B27/10 , G02B27/28 , G02B27/42 , H04N5/235 , G02B21/02
Abstract: The disclosure provides for structured illumination microscopy (SIM) imaging systems. In one set of implementations, a SIM imaging system may be implemented as a multi-arm SIM imaging system, whereby each arm of the system includes a light emitter and a beam splitter (e.g., a transmissive diffraction grating) having a specific, fixed orientation with respect to the system's optical axis. In a second set of implementations, a SIM imaging system may be implemented as a multiple beam splitter slide SIM imaging system, where one linear motion stage is mounted with multiple beam splitters having a corresponding, fixed orientation with respect to the system's optical axis. In a third set of implementations, a SIM imaging system may be implemented as a pattern angle spatial selection SIM imaging system, whereby a fixed two-dimensional diffraction grating is used in combination with a spatial filter wheel to project one-dimensional fringe patterns on a sample.
-
公开(公告)号：US11143856B2
公开(公告)日：2021-10-12
申请号：US16542640
申请日：2019-08-16
Applicant: ILLUMINA, INC.
Inventor： Danilo Condello , Simon Prince , John O'Shaughnessy , Christophe Sigel , Ashkan Arianpour
Abstract: An imaging system including a light source; a first focusing lens positioned to focus a beam from the light source to a beam waist at a predetermined location along an optical path of the beam in the imaging system; a beam splitter positioned relative to the first focusing lens to receive the beam from the first focusing lens and to create first and second beams; a second focusing lens positioned to receive the first and second beams output by the beam splitter, to focus the received first and second beams to a spot sized dimensioned to fall within a sample to be image, and further positioned to receive first and second beams reflected from the sample; an image sensor positioned to receive the light beams reflected from the sample; and a roof prism positioned in the optical path between the second focusing lens and the image sensor.
-
公开(公告)号：US20210294083A1
公开(公告)日：2021-09-23
申请号：US17339587
申请日：2021-06-04
Applicant: ILLUMINA, INC.
Inventor： Ashkan Arianpour , John Bailey , Dustin Blair , Xiangling (Steve) Chen , Stanley S. Hong , Simon Prince , Merek C. Siu , Chunhong (Allen) Zhou , Danilo Condello
Abstract: An imaging system may include a sample stage comprising a surface to support a sample container, the sample container including a sample having a plurality of sample locations; an optical stage to image the sample at the plurality of sample locations; one or more actuators physically coupled to at least one of the sample stage and the optical stage to move the sample stage relative to the optical stage to focus the optical stage onto a current sample location of the plurality of sample locations; a first light source to illuminate the current sample location; a second light source to project a pair of spots on a next sample location of the plurality of sample locations; and a controller to determine, based on an image of the pair of spots projected on the next sample location, a focus setting for the next sample location.
-
公开(公告)号：US10996453B2
公开(公告)日：2021-05-04
申请号：US16626113
申请日：2019-01-14
Applicant: ILLUMINA, INC.
Inventor： Peter Clarke Newman , Danilo Condello , Shaoping Lu , Simon Prince , Merek C. Siu , Stanley S. Hong , Aaron Liu
Abstract: The disclosure provides for structured illumination microscopy (SIM) imaging systems. In one set of implementations, a SIM imaging system may be implemented as a multi-arm SIM imaging system, whereby each arm of the system includes a light emitter and a beam splitter (e.g., a transmissive diffraction grating) having a specific, fixed orientation with respect to the system's optical axis. In a second set of implementations, a SIM imaging system may be implemented as a multiple beam splitter slide SIM imaging system, where one linear motion stage is mounted with multiple beam splitters having a corresponding, fixed orientation with respect to the system's optical axis. In a third set of implementations, a SIM imaging system may be implemented as a pattern angle spatial selection SIM imaging system, whereby a fixed two-dimensional diffraction grating is used in combination with a spatial filter wheel to project one-dimensional fringe patterns on a sample.
-
-
-
-
-
-
-
-
-
Search Results
32
records
(took 0.017 seconds)
