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公开(公告)号：US09243085B2
公开(公告)日：2016-01-26
申请号：US13762941
申请日：2013-02-08
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Modahl , Nini Kjus , Astrid Evenroed Molteberg , Diem Tran , Jo Aaserud , M. Talha Gokmen , Steven Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F2/16 , C08F230/08 , C08F8/34 , C08F6/24 , C07F7/18 , C08F130/08 , C08F2/20 , C08F2/26 , C08F220/58 , C08F222/38 , C08F8/32 , C12Q1/68
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US09156925B2
公开(公告)日：2015-10-13
申请号：US14082419
申请日：2013-11-18
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete I. Modahl , Nini H. Kjus , Astrid E. Molteberg , Diem Tran , Jo Aaserud , Talha M. Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F6/24 , C08F8/34 , C08F2/20 , C08F2/26 , C07F7/18 , C08F130/08 , C08F220/58 , C08F230/08 , C08F222/38 , C08F8/32 , C12Q1/68
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US09062079B2
公开(公告)日：2015-06-23
申请号：US13762489
申请日：2013-02-08
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Nini Kjus , Geir Fonnum , Bruce Branchaud , Lai-Qiang Ying , Steven Menchen , Dmitriy Gremyachinskiy , Hee Chol Kang
IPC: C07F7/18 , C07F7/10 , C08F222/38 , C08F220/58 , C08F236/20 , C08K3/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
Abstract translation: 描述了甲硅烷基保护的二丙烯酰胺化合物。 形成这种化合物的方法包括在第一反应条件下将甲硅烷基化试剂与羟基化二胺化合物混合以在第一溶液中形成产物，将产物与第一溶液分离，并在第二反应条件下将产物与丙烯酰氯混合 形成甲硅烷基保护的二丙烯酰胺化合物的第二溶液。
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公开(公告)号：US20140179025A1
公开(公告)日：2014-06-26
申请号：US14190054
申请日：2014-02-25
Applicant: LIFE TECHNOLOGIES AS
Inventor： Ellen Weng , Geir Fonnum , Grete Modahl , Astrid Molteberg , Erling Finne
IPC: G01N33/543
CPC classification number: C09K11/06 , B82Y25/00 , B82Y40/00 , C08F220/18 , C09K11/025 , G01N33/5434 , H01F1/0018 , H01F1/01 , H01F1/26 , H01F41/00 , Y10T428/2991 , Y10T428/2998
Abstract: A coated magnetic particle comprising an optionally porous magnetic polymer particle of a matrix polymer, said polymer particle having on a surface and/or in the pores thereof superparamagnetic crystals, said coated particle having a coat formed of a coating polymer, wherein said coated magnetic particle is essentially non-autofluorescent.
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公开(公告)号：US20130035418A1
公开(公告)日：2013-02-07
申请号：US13649045
申请日：2012-10-10
Applicant: Life Technologies AS
Inventor： Arne JORGEDAL , Elin Asknes , Geir Fonnum , Astrid Molteberg , Rolf Nordal , Henning Pettersen , Tollef Taarneby , Solveig Staale , Ellen Weng , Finn Hansen , Silje Nordbo , Oddvar Aune , Arvid Berge , John Bjorgum , Turid Ellingsen , John Ugelstad
CPC classification number: C08J9/16 , C08F2/22 , C08F257/02 , C08F265/04 , C08F265/10 , C08F291/00 , C08J9/22 , C08J9/224 , C08J2203/14 , C08J2325/06 , C08J2347/00
Abstract: A process for the preparation of monodisperse polymer particles which are formed by contacting monomers with aqueous dispersions comprising monodisperse swellable seed polymers/oligomers, and initiating polymerization in the presence of a steric stabilizer. The resulting swollen seed particles are characterized by the particle mode diameter.
Abstract translation: 通过使单体与包含单分散可溶胀种子聚合物/低聚物的水性分散体接触而形成的单分散聚合物颗粒的制备方法，以及在空间稳定剂存在下引发聚合。 所得的溶胀种子颗粒的特征在于颗粒模式直径。
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Patent Agency Ranking
公开(公告)号：US20230272127A1
公开(公告)日：2023-08-31
申请号：US18143880
申请日：2023-05-05
Applicant: Life Technologies AS
Inventor： Per Nils Pontus Lundberg , Geir Fonnum , Kristian Andersson
IPC: C08F2/38 , C08F228/02 , C08F230/02 , C08K5/5333 , C08L33/26
CPC classification number: C08F2/38 , C08F228/02 , C08F230/02 , C08K5/5333 , C08L33/26 , C08K3/22
Abstract: This invention also relates to monodisperse coated hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer having a log Poct/wat (log P) of less than about 0.6; and (b) a crosslinker comprising at least two vinyl groups; and a coating. Also provided are methods of forming the monodisperse coated hydrogel polymer particles.
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公开(公告)号：US11130833B2
公开(公告)日：2021-09-28
申请号：US17066326
申请日：2020-10-08
Applicant: Life Technologies AS
Inventor： Geir Fonnum , Nils Pontus Lundberg , Muhammed Talha Gokmen , Synne Larsen , Wilhelm Glomm , Heidi Johnsen , Ruth Schmid , Lars Kilaas
IPC: C08F265/10 , C08F120/54 , C08F265/06
Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
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公开(公告)号：US10017586B2
公开(公告)日：2018-07-10
申请号：US15453750
申请日：2017-03-08
Applicant: LIFE TECHNOLOGIES AS
Inventor： Grete Modahl , Geir Fonnum , Astrid Molteberg , Silje Lien , Nini Kjus
CPC classification number: C08F2/22 , C08F8/30 , C08F12/08 , C08F212/36 , C08F257/02 , C08F2800/20 , C08J3/128 , C08J9/18 , C08J9/20 , C08J2325/08 , C12N11/08 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998 , C08F212/08
Abstract: This invention relates to monodisperse cross-linked polymer particles, comprising particles with a substantially smooth outer surface and an average diameter of less than 1 μm, wherein the particles are solid or porous, and wherein the coefficient of variation (CV) % of the particles, when measured by CPS disk centrifugation analysis, is less than 15%. These monodisperse cross-linked polymer particles may comprise magnetic material and are useful in various application. This invention also relates to monodisperse polymer particles for use as seed particles in the Ugelstad process.
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公开(公告)号：US11851514B2
公开(公告)日：2023-12-26
申请号：US17460058
申请日：2021-08-27
Applicant: LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Nils Pontus Lundberg , Muhammed Talha Gokmen , Synne Larsen , Wilhelm Glomm , Heidi Johnsen , Ruth Schmid , Lars Kilaas
IPC: C08F265/10 , C08F120/54 , C08F265/06
CPC classification number: C08F265/10 , C08F120/54 , C08F265/06 , C08F265/10 , C08F220/56
Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
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公开(公告)号：US11680113B2
公开(公告)日：2023-06-20
申请号：US16478452
申请日：2018-01-19
Applicant: Life Technologies AS
Inventor： Per Nils Pontus Lundberg , Geir Fonnum , Kristian Andersson
IPC: C08L33/26 , C08F2/38 , C08F228/02 , C08F230/02 , C08K5/5333 , C08K3/22 , C08K5/42
CPC classification number: C08F2/38 , C08F228/02 , C08F230/02 , C08K5/5333 , C08L33/26 , C08K3/22 , C08K5/42 , C08K2003/2275 , C08K2201/01 , C08L2312/00
Abstract: This invention relates to monodisperse magnetic hydrogel polymer particles comprising a magnetic material and a polymer formed from (a) a hydrophilic vinylic monomer having a log Poct/wat (log P) of less than about 0.5; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse coated hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer having a log Poct/wat (log P) of less than about 0.5; and (b) a crosslinker comprising at least two vinyl groups; and a coating. Also provided are methods of forming the monodisperse magnetic hydrogel polymer particles and monodisperse coated polymer particles.
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